KEGG   PATHWAY: bpz03440
Entry
bpz03440                    Pathway                                
Name
Homologous recombination - Burkholderia pseudomallei 1026b
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
bpz03440  Homologous recombination
bpz03440

Other DBs
GO: 0000724
Organism
Burkholderia pseudomallei 1026b [GN:bpz]
Gene
BP1026B_I1051  single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
BP1026B_I2948  ssb; single-stranded DNA-binding protein [KO:K03111]
BP1026B_I0891  recO; DNA repair protein RecO [KO:K03584]
BP1026B_I1435  recR; recombination protein RecR [KO:K06187]
BP1026B_I2774  recA; recombinase A [KO:K03553]
BP1026B_II1897  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
BP1026B_I0413  ruvA; Holliday junction DNA helicase RuvA [KO:K03550]
BP1026B_I0412  ruvB; Holliday junction DNA helicase RuvB [KO:K03551] [EC:5.6.2.4]
BP1026B_I0414  ruvC; Holliday junction resolvase [KO:K01159] [EC:3.1.21.10]
BP1026B_I0444  recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
BP1026B_I2263  exodeoxyribonuclease V, beta subunit [KO:K03582] [EC:3.1.11.5]
BP1026B_I2264  Exodeoxyribonuclease V gamma chain [KO:K03583] [EC:3.1.11.5]
BP1026B_I2262  exodeoxyribonuclease V, alpha subunit [KO:K03581] [EC:3.1.11.5]
BP1026B_I2420  dnaE; DNA polymerase III, alpha subunit, form 1 [KO:K02337] [EC:2.7.7.7]
BP1026B_I0076  dnaN; DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
BP1026B_I1433  dnaX; DNA polymerase III subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
BP1026B_I0374  holA; DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
BP1026B_I1372  DNA polymerase III delta prime subunit [KO:K02341] [EC:2.7.7.7]
BP1026B_I2198  dnaQ; DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
BP1026B_I0753  DNA polymerase/helicase [KO:K02342] [EC:2.7.7.7]
BP1026B_I2575  DNA polymerase III subunit chi [KO:K02339] [EC:2.7.7.7]
BP1026B_I3679  priA; primosome assembly protein PriA [KO:K04066] [EC:5.6.2.4]
BP1026B_I1393  primosomal replication protein n [KO:K02686]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (23)   
   KEGG GENES (23)   
All databases (24)   

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