KEGG   PATHWAY: bra00480
Entry
bra00480                    Pathway                                
Name
Glutathione metabolism - Bradyrhizobium sp. ORS 278
Class
Metabolism; Metabolism of other amino acids
Pathway map
bra00480  Glutathione metabolism
bra00480

Module
bra_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:bra00480]
Other DBs
GO: 0006749
Organism
Bradyrhizobium sp. ORS 278 [GN:bra]
Gene
BRADO0336  ggt; Gamma-glutamyltranspeptidase precursor [Contains: Gamma-glutamyltransferase large chain; Gamma-glutamyltransferase small chain] [KO:K00681] [EC:2.3.2.2 3.4.19.13]
BRADO1399  Gamma-glutamyltranspeptidase family protein, similar to ACY1 bifunctional acylase [KO:K00681] [EC:2.3.2.2 3.4.19.13]
BRADO1534  Putative gamma-glutamyltranspeptidase [KO:K00681] [EC:2.3.2.2 3.4.19.13]
BRADO1881  putative gamma-glutamyltranspeptidase [KO:K00681] [EC:2.3.2.2 3.4.19.13]
BRADO2507  putative gamma-glutamyltranspeptidase [KO:K00681] [EC:2.3.2.2 3.4.19.13]
BRADO6466  putative cation transport protein chaC-related [KO:K07232] [EC:4.3.2.7]
BRADO3796  putative lactam utilization protein [KO:K07160] [EC:3.5.2.9]
BRADO3798  putative carboxylase [KO:K23123] [EC:3.5.2.9]
BRADO3797  putative carboxylase, like RuBisCO, small subunit [KO:K23124] [EC:3.5.2.9]
BRADO0861  Carboxylate-amine ligase [KO:K06048] [EC:6.3.2.2 6.3.-.-]
BRADO6718  gshA; gamma-glutamylcysteine synthetase (Glutamate--cysteine ligase) [KO:K01919] [EC:6.3.2.2]
BRADO0180  gshB; glutathione synthetase [KO:K01920] [EC:6.3.2.3]
BRADO1011  Leucine aminopeptidase [KO:K01255] [EC:3.4.11.1]
BRADO3328  Putative cytosol aminopeptidase (Leucine aminopeptidase) (LAP) (Leucyl aminopeptidase) PepA [KO:K01255] [EC:3.4.11.1]
BRADO5718  putative glutathione S-transferase (gstA/gst-like) [KO:K00799] [EC:2.5.1.18]
BRADO6720  gst; glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
BRADO6428  putative Glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
BRADO3663  putative glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
BRADO5020  putative glutathione S-transferase P subunit [KO:K00799] [EC:2.5.1.18]
BRADO4454  putative glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
BRADO3534  putative Glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
BRADO4939  putative glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
BRADO1419  gst1; glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
BRADO0130  putative Glutathione S-transferase family protein [KO:K00799] [EC:2.5.1.18]
BRADO1131  Putative glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
BRADO1151  Putative glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
BRADO1164  putative Glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
BRADO0334  putative Glutathione S-transferase III (GST-III) [KO:K00799] [EC:2.5.1.18]
BRADO1844  putative Glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
BRADO2006  gst; Glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
BRADO2929  putative glutathione S-transferase GSTF2 (GST-II) [KO:K00799] [EC:2.5.1.18]
BRADO4808  putative glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
BRADO5975  putative glutathione S-transferase (GST); putative maleylacetoacetate isomerase [KO:K00799] [EC:2.5.1.18]
BRADO4559  putative glutathione S-transferase (GST) [KO:K00799] [EC:2.5.1.18]
BRADO5768  putative maleylacetoacetate isomerase (MAAI) (Glutathione S-transferase) [KO:K00799] [EC:2.5.1.18]
BRADO6867  MAPEG family protein (Membrane-associated protein in eicosanoid and glutathione metabolism) [KO:K00799] [EC:2.5.1.18]
BRADO4712  gor; glutathione reductase [KO:K00383] [EC:1.8.1.7]
BRADO2759  icd; isocitrate dehydrogenase [NADP] (Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP) [KO:K00031] [EC:1.1.1.42]
BRADO5810  putative 6-phosphogluconate dehydrogenase (gnd-like) [KO:K00033] [EC:1.1.1.44 1.1.1.343]
BRADO5811  zwf; glucose-6-phosphate 1-dehydrogenase [KO:K00036] [EC:1.1.1.49 1.1.1.363]
BRADO5788  gpx; glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
BRADO3371  putative glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
BRADO6585  Putative peroxiredoxin [KO:K24138] [EC:1.11.1.25 1.11.1.27]
BRADO6260  putative ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
BRADO4919  speF; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
BRADO6330  putative Spermine/spermidine synthase family protein [KO:K00797] [EC:2.5.1.16]
BRADO0662  putative Spermidine synthase (methyl transferase) [KO:K00797] [EC:2.5.1.16]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
PMID:12675513
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
PMID:18482986
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
PMID:14583094
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
PMID:11157967
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
PMID:15610825
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
PMID:12049631
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
PMID:12750367
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
PMID:12967709
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
PMID:12121990
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
PMID:15537651
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
PMID:12751784
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
PMID:18395526
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
PMID:11150302
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
PMID:12949079
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
PMID:12446213
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
PMID:10713147
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
PMID:17922848
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
PMID:12466271
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
PMID:14982633
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
bra00220  Arginine biosynthesis
bra00250  Alanine, aspartate and glutamate metabolism
bra00270  Cysteine and methionine metabolism
bra00430  Taurine and hypotaurine metabolism
bra00460  Cyanoamino acid metabolism
KO pathway
ko00480   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (47)   
   KEGG GENES (47)   
All databases (48)   

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