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brh03440                    Pathway                                

Homologous recombination - Paraburkholderia rhizoxinica
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Genetic Information Processing; Replication and repair
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Homologous recombination

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DNA polymerase III complex, bacteria [PATH:brh03440]
Other DBs
Paraburkholderia rhizoxinica [GN:brh]
Single-stranded-DNA-specific exonuclease recJ (EC 3.1.-.-) [KO:K07462] [EC:3.1.-.-]
Single-strand DNA binding protein [KO:K03111]
DNA repair protein recO [KO:K03584]
Recombination protein recR [KO:K06187]
RecA protein [KO:K03553]
DNA polymerase I (EC [KO:K02335] [EC:]
Holliday junction DNA helicase ruvA [KO:K03550] [EC:]
Holliday junction DNA helicase ruvB [KO:K03551] [EC:]
Crossover junction endodeoxyribonuclease ruvC (EC [KO:K01159] [EC:]
ATP-dependent DNA helicase recG (EC 3.6.1.-) [KO:K03655] [EC:]
Exodeoxyribonuclease V beta chain (EC [KO:K03582] [EC:]
Exodeoxyribonuclease V gamma chain (EC [KO:K03583] [EC:]
Exodeoxyribonuclease V alpha chain (EC [KO:K03581] [EC:]
DNA polymerase III alpha subunit (EC [KO:K02337] [EC:]
DNA polymerase III, beta chain (EC [KO:K02338] [EC:]
DNA polymerase III subunit gamma/tau (EC [KO:K02343] [EC:]
DNA polymerase III, delta subunit (EC [KO:K02340] [EC:]
DNA polymerase III, delta' subunit (EC [KO:K02341] [EC:]
Exonuclease family protein [KO:K02342] [EC:]
DNA polymerase III, epsilon chain (EC [KO:K02342] [EC:]
DNA polymerase III, chi subunit (EC [KO:K02339] [EC:]
Primosomal protein N' [KO:K04066] [EC:3.6.4.-]
Primosomal replication protein N [KO:K02686]
Maloisel L, Fabre F, Gangloff S.
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
Mol Cell Biol 28:1373-82 (2008)
Haruta-Takahashi N, Iwasaki H.
[Recombination mediators] Japanese
Seikagaku 79:449-53 (2007)
Ouyang KJ, Woo LL, Ellis NA.
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
Mech Ageing Dev 129:425-40 (2008)
Kawabata M, Kawabata T, Nishibori M.
Role of recA/RAD51 family proteins in mammals.
Acta Med Okayama 59:1-9 (2005)
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
Mitotic recombination in Saccharomyces cerevisiae.
Curr Genet 42:185-98 (2003)
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
Rad54: the Swiss Army knife of homologous recombination?
Nucleic Acids Res 34:4115-25 (2006)
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
Recombination proteins and rescue of arrested replication forks.
DNA Repair (Amst) 6:967-80 (2007)
KO pathway

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