KEGG   PATHWAY: bta03320Help
Entry
bta03320                    Pathway                                

Name
PPAR signaling pathway - Bos taurus (cow)
Description
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.
Class
Organismal Systems; Endocrine system
BRITE hierarchy
Pathway map
PPAR signaling pathway
bta03320

All organismsOrtholog table
Organism
Bos taurus (cow) [GN:bta]
Gene
281052  
CD36; CD36 molecule (thrombospondin receptor) [KO:K06259]
513787  
SLC27A1; solute carrier family 27 (fatty acid transporter), member 1 [KO:K08745] [EC:6.2.1.-]
514427  
SLC27A4; solute carrier family 27 (fatty acid transporter), member 4 [KO:K08745] [EC:6.2.1.-]
long-chain fatty acid transport protein 4-like; K08745 solute carrier family 27 (fatty acid transporter), member 1/4 [EC:6.2.1.-] [KO:K08745] [EC:6.2.1.-]
535727  
SLC27A2; solute carrier family 27 (fatty acid transporter), member 2 [KO:K08746] [EC:6.2.1.3 6.2.1.-]
533016  
SLC27A5; solute carrier family 27 (fatty acid transporter), member 5 [KO:K08748] [EC:6.2.1.7]
537062  
SLC27A6; solute carrier family 27 (fatty acid transporter), member 6 [KO:K08749]
327700  
FABP1; fatty acid binding protein 1, liver [KO:K08750]
515768  
FABP2; fatty acid binding protein 2, intestinal [KO:K08751]
281758  
FABP3; fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) [KO:K08752]
281759  
FABP4; fatty acid binding protein 4, adipocyte [KO:K08753]
281760  
FABP5; fatty acid binding protein 5 (psoriasis-associated) [KO:K08754]
514650  
FABP6; fatty acid binding protein 6, ileal [KO:K08755]
777787  
FABP7; fatty acid binding protein 7, brain [KO:K08756]
281992  
PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
507554  
RXRA; retinoid X receptor, alpha [KO:K08524]
504943  
RXRB; retinoid X receptor, beta [KO:K08525]
509500  
RXRG; retinoid X receptor, gamma [KO:K08526]
353106  
PPARD; peroxisome proliferator-activated receptor delta [KO:K04504]
281993  
PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
281631  
APOA1; apolipoprotein A-I [KO:K08757]
505394  
APOA2; apolipoprotein A-II [KO:K08758]
408009  
APOC3; apolipoprotein C-III [KO:K08759]
538914  
APOA5; apolipoprotein A-V [KO:K09025]
505640  
PLTP; phospholipid transfer protein [KO:K08761]
521822  
FADS2; fatty acid desaturase 2 [KO:K10226] [EC:1.14.19.-]
280924  
SCD; stearoyl-CoA desaturase (delta-9-desaturase) [KO:K00507] [EC:1.14.19.1]
617419  
SCD5; stearoyl-CoA desaturase 5 [KO:K00507] [EC:1.14.19.1]
510507  
CYP7A1; cytochrome P450, family 7, subfamily A, polypeptide 1 [KO:K00489] [EC:1.14.13.17]
538964  
CYP8B1; cytochrome P450, family 8, subfamily B, polypeptide 1 [KO:K07431] [EC:1.14.13.96 1.14.13.95]
507176  
NR1H3; nuclear receptor subfamily 1, group H, member 3 [KO:K08536]
511960  
CYP27A1; cytochrome P450, family 27, subfamily A, polypeptide 1 [KO:K00488] [EC:1.14.13.15]
768330  
DBI; diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) [KO:K08762]
280843  
LPL; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
537161  
ACSL1; acyl-CoA synthetase long-chain family member 1 [KO:K01897] [EC:6.2.1.3]
514159  
ACSL5; acyl-CoA synthetase long-chain family member 5 [KO:K01897] [EC:6.2.1.3]
536628  
ACSL4; acyl-CoA synthetase long-chain family member 4 [KO:K01897] [EC:6.2.1.3]
506059  
ACSL6; acyl-CoA synthetase long-chain family member 6 [KO:K01897] [EC:6.2.1.3]
ACSL3; acyl-CoA synthetase long-chain family member 3 [KO:K01897] [EC:6.2.1.3]
515577  
ACSBG1; acyl-CoA synthetase bubblegum family member 1 [KO:K15013] [EC:6.2.1.3]
526688  
ACSBG2; acyl-CoA synthetase bubblegum family member 2 [KO:K15013] [EC:6.2.1.3]
281368  
OLR1; oxidized low density lipoprotein (lectin-like) receptor 1 [KO:K08763]
518852  
EHHADH; enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase [KO:K07514] [EC:5.3.3.8 1.1.1.35 4.2.1.17]
516085  
CYP4A22; cytochrome P450, family 4, subfamily A, polypeptide 22 [KO:K07425] [EC:1.14.15.3]
508324  
ACAA1; acetyl-CoA acyltransferase 1 [KO:K07513] [EC:2.3.1.16]
508918  
SCP2; sterol carrier protein 2 [KO:K08764] [EC:2.3.1.176]
513996  
ACOX1; acyl-CoA oxidase 1, palmitoyl [KO:K00232] [EC:1.3.3.6]
510065  
ACOX3; acyl-CoA oxidase 3, pristanoyl [KO:K00232] [EC:1.3.3.6]
514969  
ACOX2; acyl-CoA oxidase 2, branched chain [KO:K10214] [EC:1.17.99.3]
509459  
CPT1B; carnitine palmitoyltransferase 1B (muscle) [KO:K08765] [EC:2.3.1.21]
513710  
CPT1C; carnitine palmitoyltransferase 1C [KO:K08765] [EC:2.3.1.21]
506812  
CPT1A; carnitine palmitoyltransferase 1A (liver) [KO:K08765] [EC:2.3.1.21]
504502  
CPT2; carnitine palmitoyltransferase 2 [KO:K08766] [EC:2.3.1.21]
614508  
ACADL; acyl-CoA dehydrogenase, long chain [KO:K00255] [EC:1.3.8.8]
505968  
ACADM; acyl-CoA dehydrogenase, C-4 to C-12 straight chain [KO:K00249] [EC:1.3.8.7]
509963  
ANGPTL4; angiopoietin-like 4 [KO:K08767]
504625  
SORBS1; sorbin and SH3 domain containing 1 [KO:K06086]
520598  
PLIN1; perilipin 1 [KO:K08768]
282865  
ADIPOQ; adiponectin, C1Q and collagen domain containing [KO:K07296]
281308  
MMP1; matrix metallopeptidase 1 (interstitial collagenase) [KO:K01388] [EC:3.4.24.7]
interstitial collagenase-like; K01388 matrix metalloproteinase-1 (interstitial collagenase) [EC:3.4.24.7] [KO:K01388] [EC:3.4.24.7]
281561  
UCP1; uncoupling protein 1 (mitochondrial, proton carrier) [KO:K08769]
540207  
ILK; integrin-linked kinase [KO:K06272] [EC:2.7.11.1]
PDPK1; 3-phosphoinositide dependent protein kinase-1 [KO:K06276] [EC:2.7.11.1]
444874  
UBC; ubiquitin C [KO:K08770]
282855  
PCK1; phosphoenolpyruvate carboxykinase 1 (soluble) [KO:K01596] [EC:4.1.1.32]
282856  
PCK2; phosphoenolpyruvate carboxykinase 2 (mitochondrial) [KO:K01596] [EC:4.1.1.32]
538702  
glycerol kinase 2-like; K00864 glycerol kinase [EC:2.7.1.30] [KO:K00864] [EC:2.7.1.30]
505987  
GK; glycerol kinase [KO:K00864] [EC:2.7.1.30]
540143  
GK2; glycerol kinase 2 [KO:K00864] [EC:2.7.1.30]
615498  
AQP7; aquaporin 7 [KO:K08771]
Compound
C02165  
Leukotriene B4
C14762  
13(S)-HODE
C14767  
9(S)-HODE
C14776  
8(S)-HETE
C15493  
9-cis-Retinoic acid
Reference
  Authors
Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T.
  Title
[The structures and functions of peroxisome proliferator-activated receptors (PPARs)]
  Journal
Nippon Rinsho 63:557-64 (2005)
Reference
  Authors
Fujii H.
  Title
[PPARs-mediated intracellular signal transduction]
  Journal
Nippon Rinsho 63:565-71 (2005)
Reference
  Authors
Takada I, Kato S.
  Title
[PPARs target genes]
  Journal
Nippon Rinsho 63:573-7 (2005)
Reference
  Authors
Inoue H.
  Title
[Endogenous ligands for PPARs]
  Journal
Nippon Rinsho 63:578-83 (2005)
Reference
  Authors
Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W.
  Title
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.
  Journal
Prog Lipid Res 45:120-59 (2006)
Reference
  Authors
Desvergne B, Michalik L, Wahli W.
  Title
Transcriptional regulation of metabolism.
  Journal
Physiol Rev 86:465-514 (2006)
Reference
  Authors
Mandard S, Muller M, Kersten S.
  Title
Peroxisome proliferator-activated receptor alpha target genes.
  Journal
Cell Mol Life Sci 61:393-416 (2004)
Reference
  Authors
Desvergne B, Wahli W.
  Title
Peroxisome proliferator-activated receptors: nuclear control of metabolism.
  Journal
Endocr Rev 20:649-88 (1999)
Reference
  Authors
Savage DB.
  Title
PPARgamma as a metabolic regulator: insights from genomics and pharmacology.
  Journal
Expert Rev Mol Med 2005:1-16 (2005)
Reference
  Authors
Semple RK, Chatterjee VK, O'Rahilly S.
  Title
PPAR gamma and human metabolic disease.
  Journal
J Clin Invest 116:581-9 (2006)
Reference
  Authors
Lehrke M, Lazar MA.
  Title
The many faces of PPARgamma.
  Journal
Cell 123:993-9 (2005)
Reference
  Authors
Hauner H.
  Title
The mode of action of thiazolidinediones.
  Journal
Diabetes Metab Res Rev 18 Suppl 2:S10-5 (2002)
KO pathway
 

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