KEGG PATHWAY: bta03320

PATHWAY: bta03320

Entry

bta03320 Pathway

Name

PPAR signaling pathway - Bos taurus (cow)

Description

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.

Class

Organismal Systems; Endocrine system

Pathway map

bta03320

PPAR signaling pathway

Organism

Bos taurus (cow) [GN:bta]

Gene

281052	CD36; CD36 molecule (thrombospondin receptor) [KO:K06259]
513787	SLC27A1; solute carrier family 27 (fatty acid transporter), member 1 [KO:K08745] [EC:6.2.1.-]
514427	SLC27A4; solute carrier family 27 (fatty acid transporter), member 4 [KO:K08745] [EC:6.2.1.-]
100851032	long-chain fatty acid transport protein 4-like; K08745 solute carrier family 27 (fatty acid transporter), member 1/4 [EC:6.2.1.-] [KO:K08745] [EC:6.2.1.-]
535727	SLC27A2; solute carrier family 27 (fatty acid transporter), member 2 [KO:K08746] [EC:6.2.1.3 6.2.1.-]
533016	SLC27A5; solute carrier family 27 (fatty acid transporter), member 5 [KO:K08748] [EC:6.2.1.7]
537062	SLC27A6; solute carrier family 27 (fatty acid transporter), member 6 [KO:K08749]
327700	FABP1; fatty acid binding protein 1, liver [KO:K08750]
515768	FABP2; fatty acid binding protein 2, intestinal [KO:K08751]
281758	FABP3; fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) [KO:K08752]
281759	FABP4; fatty acid binding protein 4, adipocyte [KO:K08753]
281760	FABP5; fatty acid binding protein 5 (psoriasis-associated) [KO:K08754]
514650	FABP6; fatty acid binding protein 6, ileal [KO:K08755]
777787	FABP7; fatty acid binding protein 7, brain [KO:K08756]
281992	PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
507554	RXRA; retinoid X receptor, alpha [KO:K08524]
504943	RXRB; retinoid X receptor, beta [KO:K08525]
509500	RXRG; retinoid X receptor, gamma [KO:K08526]
353106	PPARD; peroxisome proliferator-activated receptor delta [KO:K04504]
281993	PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
281631	APOA1; apolipoprotein A-I [KO:K08757]
505394	APOA2; apolipoprotein A-II [KO:K08758]
408009	APOC3; apolipoprotein C-III [KO:K08759]
538914	APOA5; apolipoprotein A-V [KO:K09025]
505640	PLTP; phospholipid transfer protein [KO:K08761]
521822	FADS2; fatty acid desaturase 2 [KO:K10226] [EC:1.14.19.-]
280924	SCD; stearoyl-CoA desaturase (delta-9-desaturase) [KO:K00507] [EC:1.14.19.1]
617419	SCD5; stearoyl-CoA desaturase 5 [KO:K00507] [EC:1.14.19.1]
510507	CYP7A1; cytochrome P450, family 7, subfamily A, polypeptide 1 [KO:K00489] [EC:1.14.13.17]
538964	CYP8B1; cytochrome P450, family 8, subfamily B, polypeptide 1 [KO:K07431] [EC:1.14.13.95]
507176	NR1H3; nuclear receptor subfamily 1, group H, member 3 [KO:K08536]
511960	CYP27A1; cytochrome P450, family 27, subfamily A, polypeptide 1 [KO:K00488] [EC:1.14.13.15]
768330	DBI; diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) [KO:K08762]
280843	LPL; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
537161	ACSL1; acyl-CoA synthetase long-chain family member 1 [KO:K01897] [EC:6.2.1.3]
514159	ACSL5; acyl-CoA synthetase long-chain family member 5 [KO:K01897] [EC:6.2.1.3]
536628	ACSL4; acyl-CoA synthetase long-chain family member 4 [KO:K01897] [EC:6.2.1.3]
506059	ACSL6; acyl-CoA synthetase long-chain family member 6 [KO:K01897] [EC:6.2.1.3]
100138312	ACSL3; acyl-CoA synthetase long-chain family member 3 [KO:K01897] [EC:6.2.1.3]
515577	ACSBG1; acyl-CoA synthetase bubblegum family member 1 [KO:K15013] [EC:6.2.1.3]
526688	ACSBG2; acyl-CoA synthetase bubblegum family member 2 [KO:K15013] [EC:6.2.1.3]
281368	OLR1; oxidized low density lipoprotein (lectin-like) receptor 1 [KO:K08763]
518852	EHHADH; enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase [KO:K07514] [EC:5.3.3.8 1.1.1.35 4.2.1.17]
511890	CYP4A11; cytochrome P450, family 4, subfamily A, polypeptide 11 [KO:K07425] [EC:1.14.15.3]
516085	CYP4A22; cytochrome P450, family 4, subfamily A, polypeptide 22 [KO:K07425] [EC:1.14.15.3]
508324	ACAA1; acetyl-CoA acyltransferase 1 [KO:K07513] [EC:2.3.1.16]
508918	SCP2; sterol carrier protein 2 [KO:K08764] [EC:2.3.1.176]
513996	ACOX1; acyl-CoA oxidase 1, palmitoyl [KO:K00232] [EC:1.3.3.6]
510065	ACOX3; acyl-CoA oxidase 3, pristanoyl [KO:K00232] [EC:1.3.3.6]
514969	ACOX2; acyl-CoA oxidase 2, branched chain [KO:K10214] [EC:1.17.99.3]
509459	CPT1B; carnitine palmitoyltransferase 1B (muscle) [KO:K08765] [EC:2.3.1.21]
513710	CPT1C; carnitine palmitoyltransferase 1C [KO:K08765] [EC:2.3.1.21]
506812	CPT1A; carnitine palmitoyltransferase 1A (liver) [KO:K08765] [EC:2.3.1.21]
504502	CPT2; carnitine palmitoyltransferase 2 [KO:K08766] [EC:2.3.1.21]
614508	ACADL; acyl-CoA dehydrogenase, long chain [KO:K00255] [EC:1.3.8.8]
505968	ACADM; acyl-CoA dehydrogenase, C-4 to C-12 straight chain [KO:K00249] [EC:1.3.8.7]
509963	ANGPTL4; angiopoietin-like 4 [KO:K08767]
504625	SORBS1; sorbin and SH3 domain containing 1 [KO:K06086]
520598	PLIN1; perilipin 1 [KO:K08768]
282865	ADIPOQ; adiponectin, C1Q and collagen domain containing [KO:K07296]
281308	MMP1; matrix metallopeptidase 1 (interstitial collagenase) [KO:K01388] [EC:3.4.24.7]
100848085	interstitial collagenase-like; K01388 matrix metalloproteinase-1 (interstitial collagenase) [EC:3.4.24.7] [KO:K01388] [EC:3.4.24.7]
281561	UCP1; uncoupling protein 1 (mitochondrial, proton carrier) [KO:K08769]
540207	ILK; integrin-linked kinase [KO:K06272] [EC:2.7.11.1]
100138102	PDPK1; 3-phosphoinositide dependent protein kinase-1 [KO:K06276] [EC:2.7.11.1]
444874	UBC; ubiquitin C [KO:K08770]
282855	PCK1; phosphoenolpyruvate carboxykinase 1 (soluble) [KO:K01596] [EC:4.1.1.32]
282856	PCK2; phosphoenolpyruvate carboxykinase 2 (mitochondrial) [KO:K01596] [EC:4.1.1.32]
538702	glycerol kinase 2-like; K00864 glycerol kinase [EC:2.7.1.30] [KO:K00864] [EC:2.7.1.30]
505987	GK; glycerol kinase [KO:K00864] [EC:2.7.1.30]
540143	GK2; glycerol kinase 2 [KO:K00864] [EC:2.7.1.30]
615498	AQP7; aquaporin 7 [KO:K08771]

Compound

C02165	Leukotriene B4
C14762	13(S)-HODE
C14767	9(S)-HODE
C14776	8(S)-HETE
C15493	9-cis-Retinoic acid

Reference

PMID:15828220

Authors

Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T.

Title

[The structures and functions of peroxisome proliferator-activated receptors (PPARs)]

Journal

Nippon Rinsho 63:557-64 (2005)

Reference

PMID:15828221

Authors

Fujii H.

Title

[PPARs-mediated intracellular signal transduction]

Journal

Nippon Rinsho 63:565-71 (2005)

Reference

PMID:15828222

Authors

Takada I, Kato S.

Title

[PPARs target genes]

Journal

Nippon Rinsho 63:573-7 (2005)

Reference

PMID:15828223

Authors

Inoue H.

Title

[Endogenous ligands for PPARs]

Journal

Nippon Rinsho 63:578-83 (2005)

Reference

PMID:16476485

Authors

Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W.

Title

From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.

Journal

Prog Lipid Res 45:120-59 (2006)

Reference

PMID:16601267

Authors

Desvergne B, Michalik L, Wahli W.

Title

Transcriptional regulation of metabolism.

Journal

Physiol Rev 86:465-514 (2006)

Reference

PMID:14999402

Authors

Mandard S, Muller M, Kersten S.

Title

Peroxisome proliferator-activated receptor alpha target genes.

Journal

Cell Mol Life Sci 61:393-416 (2004)

Reference

PMID:10529898

Authors

Desvergne B, Wahli W.

Title

Peroxisome proliferator-activated receptors: nuclear control of metabolism.

Journal

Endocr Rev 20:649-88 (1999)

Reference

PMID:15673477

Authors

Savage DB.

Title

PPARgamma as a metabolic regulator: insights from genomics and pharmacology.

Journal

Expert Rev Mol Med 2005:1-16 (2005)

Reference

PMID:16511590

Authors

Semple RK, Chatterjee VK, O'Rahilly S.

Title

PPAR gamma and human metabolic disease.

Journal

J Clin Invest 116:581-9 (2006)

Reference

PMID:16360030

Authors

Lehrke M, Lazar MA.

Title

The many faces of PPARgamma.

Journal

Cell 123:993-9 (2005)

Reference

PMID:11921433

Authors

Hauner H.

Title

The mode of action of thiazolidinediones.

Journal

Diabetes Metab Res Rev 18 Suppl 2:S10-5 (2002)

KO pathway

ko03320

All links

Pathway (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (72)   
   KEGG GENES (72)   
All databases (74)   

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