| Entry |
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| Name |
Homologous recombination - Bos taurus (cow)
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| Description |
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
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| Class |
Genetic Information Processing; Replication and repair
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| Pathway map |
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| Module |
| DNA polymerase III complex, bacteria [PATH: bta03440] | | | | | | | | BRCA1-associated genome surveillance complex (BASC) [PATH: bta03440] |
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| Other DBs |
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| Organism |
Bos taurus (cow) [GN: bta]
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| Gene |
| SSBP1; single-stranded DNA binding protein 1 [KO: K03111] | | RAD50; RAD50 homolog (S. cerevisiae) [KO: K10866] [EC:3.6.-.-] | | MRE11A; MRE11 meiotic recombination 11 homolog A (S. cerevisiae) [KO: K10865] | | | | RPA1; replication protein A1, 70kDa [KO: K07466] | | RPA2; replication protein A2, 32kDa [KO: K10739] | | RPA3; replication protein A3, 14kDa [KO: K10740] | | replication protein A 14 kDa subunit-like; K10740 replication factor A3 [KO: K10740] | | RAD51; RAD51 homolog (S. cerevisiae) [KO: K04482] | | RAD52; RAD52 homolog (S. cerevisiae) [KO: K10873] | | BRCA2; breast cancer 2, early onset [KO: K08775] | | SHFM1; split hand/foot malformation (ectrodactyly) type 1 [KO: K10881] | | RAD51B; RAD51 homolog B (S. cerevisiae) [KO: K10869] | | RAD51C; RAD51 homolog C (S. cerevisiae) [KO: K10870] | | RAD51D; RAD51 homolog D (S. cerevisiae) [KO: K10871] | | XRCC2; X-ray repair complementing defective repair in Chinese hamster cells 2 [KO: K10879] | | XRCC3; X-ray repair complementing defective repair in Chinese hamster cells 3 [KO: K10880] | | RAD54L; RAD54-like (S. cerevisiae) [KO: K10875] [EC:3.6.4.-] | | RAD54B; RAD54 homolog B (S. cerevisiae) [KO: K10877] [EC:3.6.4.-] | | POLD1; polymerase (DNA directed), delta 1, catalytic subunit [KO: K02327] [EC: 2.7.7.7] | | POLD2; polymerase (DNA directed), delta 2, regulatory subunit 50kDa [KO: K02328] | | POLD3; polymerase (DNA-directed), delta 3, accessory subunit [KO: K03504] | | POLD4; polymerase (DNA-directed), delta 4 [KO: K03505] | | | | | | | | MUS81; MUS81 endonuclease homolog (S. cerevisiae) [KO: K08991] [EC:3.1.22.-] | | EME1; essential meiotic endonuclease 1 homolog 1 (S. pombe) [KO: K10882] [EC:3.1.22.-] |
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| Reference |
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| Authors |
Maloisel L, Fabre F, Gangloff S. |
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| Title |
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension. |
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| Journal |
Mol Cell Biol 28:1373-82 (2008) |
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| Reference |
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| Authors |
Haruta-Takahashi N, Iwasaki H. |
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| Title |
[Recombination mediators] Japanese |
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| Journal |
Seikagaku 79:449-53 (2007) |
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| Reference |
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| Authors |
Ouyang KJ, Woo LL, Ellis NA. |
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| Title |
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases. |
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| Journal |
Mech Ageing Dev 129:425-40 (2008) |
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| Reference |
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| Authors |
Kawabata M, Kawabata T, Nishibori M. |
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| Title |
Role of recA/RAD51 family proteins in mammals. |
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| Journal |
Acta Med Okayama 59:1-9 (2005) |
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| Reference |
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| Authors |
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A. |
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| Title |
Mitotic recombination in Saccharomyces cerevisiae. |
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| Journal |
Curr Genet 42:185-98 (2003) |
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| Reference |
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| Authors |
Heyer WD, Li X, Rolfsmeier M, Zhang XP. |
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| Title |
Rad54: the Swiss Army knife of homologous recombination? |
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| Journal |
Nucleic Acids Res 34:4115-25 (2006) |
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| Reference |
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| Authors |
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R. |
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| Title |
Recombination proteins and rescue of arrested replication forks. |
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| Journal |
DNA Repair (Amst) 6:967-80 (2007) |
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| Reference |
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| Authors |
Hanaoka F. |
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| Title |
[DNA Replication and Repair] (In Japanese) |
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| Journal |
Yodosha (2004) |
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| Reference |
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| Authors |
Ohashi E, Ohmori H. |
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| Title |
[The cross talk of the DNA replication and repair in Escherichia coli.] ( In Japanese) |
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| Journal |
Cell Technology 19:1449-53 (2000) |
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| KO pathway |
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