KEGG   PATHWAY: bta03440Help
Entry
bta03440                    Pathway                                

Name
Homologous recombination - Bos taurus (cow)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
Homologous recombination
bta03440

All organismsOrtholog table
Module
RPA complex [PATH:bta03440]
MRN complex [PATH:bta03440]
BRCA1-associated genome surveillance complex (BASC) [PATH:bta03440]
Other DBs
BSID: 
GO: 
Organism
Bos taurus (cow) [GN:bta]
Gene
515765  
SSBP1; single stranded DNA binding protein 1 [KO:K03111]
788127  
RAD50; RAD50 double strand break repair protein [KO:K10866] [EC:3.6.-.-]
525093  
MRE11A; MRE11 homolog A, double strand break repair nuclease [KO:K10865]
522943  
NBN; nibrin [KO:K10867]
526824  
ATM; ATM serine/threonine kinase [KO:K04728] [EC:2.7.11.1]
353120  
BRCA1; BRCA1, DNA repair associated [KO:K10605] [EC:2.3.2.27]
530961  
BARD1; BRCA1 associated RING domain 1 [KO:K10683]
512977  
RBBP8; RB binding protein 8, endonuclease [KO:K20773] [EC:3.1.-.-]
783256  
BRIP1; BRCA1 interacting protein C-terminal helicase 1 [KO:K15362] [EC:3.6.4.12]
540574  
TOPBP1; topoisomerase (DNA) II binding protein 1 [KO:K10728]
504796  
FAM175A; family with sequence similarity 175 member A [KO:K20774]
508607  
UIMC1; ubiquitin interaction motif containing 1 [KO:K20775]
504517  
BABAM1; BRISC and BRCA1 A complex member 1 [KO:K20776]
614152  
BRE; brain and reproductive organ-expressed (TNFRSF1A modulator) [KO:K12173]
519513  
BRCC3; BRCA1/BRCA2-containing complex subunit 3 [KO:K11864] [EC:3.4.19.-]
507620  
PALB2; partner and localizer of BRCA2 [KO:K10897]
507069  
BRCA2; BRCA2, DNA repair associated [KO:K08775]
767981  
SHFM1; split hand/foot malformation (ectrodactyly) type 1 [KO:K10881]
26S proteasome complex subunit DSS1 [KO:K10881]
615896  
SYCP3; synaptonemal complex protein 3 [KO:K19528]
504844  
RPA1; replication protein A1 [KO:K07466]
507912  
RPA2; replication protein A2 [KO:K10739]
512754  
RPA3; replication protein A3 [KO:K10740]
RPA4; replication protein A4 [KO:K10741]
514749  
RAD51; RAD51 recombinase [KO:K04482]
512897  
RAD52; RAD52 homolog, DNA repair protein [KO:K10873]
617007  
RAD51B; RAD51 paralog B [KO:K10869]
540886  
RAD51C; RAD51 paralog C [KO:K10870]
529507  
RAD51D; RAD51 paralog D [KO:K10871]
789410  
XRCC2; X-ray repair cross complementing 2 [KO:K10879]
768244  
XRCC3; X-ray repair cross complementing 3 [KO:K10880]
RAD54L; RAD54-like (S. cerevisiae) [KO:K10875] [EC:3.6.4.-]
533414  
RAD54B; RAD54 homolog B (S. cerevisiae) [KO:K10877] [EC:3.6.4.-]
281990  
POLD1; DNA polymerase delta 1, catalytic subunit [KO:K02327] [EC:2.7.7.7]
281991  
POLD2; DNA polymerase delta 2, accessory subunit [KO:K02328]
537616  
POLD3; DNA polymerase delta 3, accessory subunit [KO:K03504]
617899  
POLD4; DNA polymerase delta 4, accessory subunit [KO:K03505]
534148  
BLM; Bloom syndrome RecQ like helicase [KO:K10901] [EC:3.6.4.12]
527411  
TOP3A; topoisomerase (DNA) III alpha [KO:K03165] [EC:5.99.1.2]
537418  
TOP3B; topoisomerase (DNA) III beta [KO:K03165] [EC:5.99.1.2]
528432  
MUS81; MUS81 structure-specific endonuclease subunit [KO:K08991] [EC:3.1.22.-]
EME1; essential meiotic structure-specific endonuclease 1 [KO:K10882] [EC:3.1.22.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
Reference
  Authors
Hanaoka F.
  Title
[DNA Replication and Repair] (In Japanese)
  Journal
Yodosha (2004)
Reference
  Authors
Ohashi E, Ohmori H.
  Title
[The cross talk of the DNA replication and repair in Escherichia coli.] ( In Japanese)
  Journal
Cell Technology 19:1449-53 (2000)
KO pathway
 

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