KEGG PATHWAY: bta04514

PATHWAY: bta04514

Entry

bta04514 Pathway

Name

Cell adhesion molecules (CAMs) - Bos taurus (cow)

Description

Cell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.

Class

Environmental Information Processing; Signaling molecules and interaction

Pathway map

bta04514

Cell adhesion molecules (CAMs)

Other DBs

BSID:

84308

GO:

0050839

Organism

Bos taurus (cow) [GN:bta]

Gene

782186	CD58; CD58 molecule [KO:K06492]
497022	CD2; CD2 molecule [KO:K06449]
407131	CD80; CD80 molecule [KO:K05412]
533834	CD274; CD274 molecule [KO:K06745]
281050	CD28; CD28 molecule [KO:K06470]
414345	CD86; CD86 molecule [KO:K05413]
281732	CTLA4; cytotoxic T-lymphocyte-associated protein 4 [KO:K06538]
507857	ICOSLG; inducible T-cell co-stimulator ligand [KO:K06710]
507026	ICOS; inducible T-cell co-stimulator [KO:K06713]
282490	BOLA-DMA; major histocompatibility complex, class II, DM alpha [KO:K06752]
282491	BOLA-DMB; major histocompatibility complex, class II, DM beta [KO:K06752]
282493	BOLA-DOB; major histocompatibility complex, class II, DO beta [KO:K06752]
282494	BOLA-DQA5; major histocompatibility complex, class II, DQ alpha 5 [KO:K06752]
282495	BOLA-DQB; major histocompatibility complex, class II, DQ beta [KO:K06752]
282498	BOLA-DYB; major histocompatibility complex, class II, DY beta [KO:K06752]
282534	BOLA-DQA1; major histocompatibility complex, class II, DQ alpha, type 1 [KO:K06752]
282535	BOLA-DQA2; major histocompatibility complex, class II, DQ alpha 2 [KO:K06752]
282530	BOLA-DRB3; major histocompatibility complex, class II, DRB3 [KO:K06752]
525727	BOLA-DOA; major histocompatibility complex, class II, DO alpha [KO:K06752]
506214	BOLA-DRA; major histocompatibility complex, class II, DR alpha [KO:K06752]
539241	BLA-DQB; MHC class II antigen [KO:K06752]
790858	LA-DQB; MHC cell surface glycoprotein [KO:K06752]
100848815	SLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
100296598	uncharacterized LOC100296598; K10784 T cell receptor alpha chain V region [KO:K10784]
785283	uncharacterized LOC785283; K10784 T cell receptor alpha chain V region [KO:K10784]
509513	uncharacterized LOC509513; K10785 T-cell receptor beta chain V region [KO:K10785]
100335899	T-cell receptor beta chain T17T-22-like; K10785 T-cell receptor beta chain V region [KO:K10785]
100850620	T-cell receptor beta chain T17T-22-like; K10785 T-cell receptor beta chain V region [KO:K10785]
100850312	T-cell receptor beta chain T17T-22-like; K10785 T-cell receptor beta chain V region [KO:K10785]
100300282	T-cell receptor beta chain T17T-22-like; K10785 T-cell receptor beta chain V region [KO:K10785]
100336183	uncharacterized LOC100336183; K10785 T-cell receptor beta chain V region [KO:K10785]
510649	immunoglobulin iota chain-like; K10785 T-cell receptor beta chain V region [KO:K10785]
407098	CD4; CD4 molecule [KO:K06454]
407173	JSP.1; MHC Class I JSP.1 [KO:K06751]
512672	major histocompatibility complex; K06751 major histocompatibility complex, class I [KO:K06751]
100126048	BOLA-N; MHC class I antigen [KO:K06751]
515712	BOLA; MHC class I heavy chain [KO:K06751]
782684	BOLA-A; major histocompatibility complex, class I, A [KO:K06751]
507917	BOLA; MHC class I heavy chain [KO:K06751]
509006	class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
767904	uncharacterized protein MGC126945; K06751 major histocompatibility complex, class I [KO:K06751]
281060	CD8A; CD8a molecule [KO:K06458]
508633	CD8B; CD8b molecule [KO:K06459]
539392	PDCD1LG2; programmed cell death 1 ligand 2 [KO:K06708]
508656	CD276; CD276 molecule [KO:K06746]
539919	VTCN1; V-set domain containing T cell activation inhibitor 1 [KO:K06747]
613842	PDCD1; programmed cell death 1 [KO:K06744]
286849	CD40; CD40 molecule, TNF receptor superfamily member 5 [KO:K03160]
282387	CD40LG; CD40 ligand [KO:K03161]
281614	ALCAM; activated leukocyte cell adhesion molecule [KO:K06547]
282881	CD6; CD6 molecule [KO:K06456]
526865	PVR; poliovirus receptor [KO:K06539]
615496	CD226; CD226 molecule [KO:K06567]
505580	PVRL2; poliovirus receptor-related 2 (herpesvirus entry mediator B) [KO:K06531]
100140801	TIGIT; T cell immunoreceptor with Ig and ITIM domains [KO:K16350]
281874	ITGAL; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1 [KO:K05718]
281877	ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) [KO:K06464]
281839	ICAM1; intercellular adhesion molecule 1 [KO:K06490]
506088	intercellular adhesion molecule 2-like; K06523 intercellular adhesion molecule 2 [KO:K06523]
100301003	intercellular adhesion molecule 2-like; K06523 intercellular adhesion molecule 2 [KO:K06523]
281840	ICAM3; intercellular adhesion molecule 3 [KO:K06486]
514582	CD22; CD22 molecule [KO:K06467]
407152	PTPRC; protein tyrosine phosphatase, receptor type, C [KO:K06478] [EC:3.1.3.48]
539759	SIGLEC1; sialic acid binding Ig-like lectin 1, sialoadhesin [KO:K06548]
614645	SPN; sialophorin [KO:K06477]
534360	PVRL3; poliovirus receptor-related 3-like [KO:K06592]
404089	CLDN2; claudin 2 [KO:K06087]
404153	CLDN3; claudin 3 [KO:K06087]
414921	CLDN4; claudin 4 [KO:K06087]
414922	CLDN1; claudin 1 [KO:K06087]
511460	CLDN18; claudin 18 [KO:K06087]
282184	CLDN16; claudin 16 [KO:K06087]
508268	CLDN11; claudin 11 [KO:K06087]
512703	CLDN17; claudin 17 [KO:K06087]
512975	CLDN7; claudin 7 [KO:K06087]
513034	CLDN19; claudin 19 [KO:K06087]
617453	CLDN5; claudin 5 [KO:K06087]
783180	CLDN14; claudin 14 [KO:K06087]
511318	CLDN6; claudin 6 [KO:K06087]
514634	CLDN23; claudin 23 [KO:K06087]
514998	CLDN15; claudin 15 [KO:K06087]
538761	CLDN8; claudin 8 [KO:K06087]
506545	CLDN10; claudin 10 [KO:K06087]
616036	CLDN22; claudin 22 [KO:K06087]
617449	CLDN9; claudin 9 [KO:K06087]
522679	CLDN25; claudin 25 [KO:K06087]
536739	CLDN24; claudin 24 [KO:K06087]
512405	OCLN; occludin [KO:K06088]
281258	F11R; F11 receptor [KO:K06089]
538846	JAM2; junctional adhesion molecule 2 [KO:K06735]
513412	JAM3; junctional adhesion molecule 3 [KO:K06785]
616926	ESAM; endothelial cell adhesion molecule [KO:K06787]
414735	CDH5; cadherin 5, type 2 (vascular endothelium) [KO:K06533]
282303	PECAM1; platelet/endothelial cell adhesion molecule [KO:K06471]
509230	CD99; CD99 molecule [KO:K06520]
407124	ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit) [KO:K06461]
617434	SELPLG; selectin P ligand [KO:K06544]
281486	SELP; selectin P (granule membrane protein 140kDa, antigen CD62) [KO:K06496]
282882	ITGA4; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) [KO:K06483]
281876	ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) [KO:K05719]
532127	ITGA9; integrin, alpha 9 [KO:K06585]
534578	VCAM1; vascular cell adhesion molecule 1 [KO:K06527]
282118	VCAM1; vascular cell adhesion molecule 1 [KO:K06527]
514031	ITGB7; integrin, beta 7 [KO:K06590]
527275	MADCAM1; mucosal vascular addressin cell adhesion molecule 1 [KO:K06779]
789849	MADCAM1; mucosal vascular addressin cell adhesion molecule 1-like [KO:K06779]
281485	SELL; selectin L [KO:K06495]
282430	GLYCAM1; glycosylation-dependent cell adhesion molecule 1 [KO:K06815]
281051	CD34; CD34 molecule [KO:K06474]
281196	GLG1; golgi glycoprotein 1 [KO:K06816]
281484	SELE; selectin E [KO:K06494]
533492	PVRL1; poliovirus receptor-related 1 (herpesvirus entry mediator C) [KO:K06081]
281062	CDH2; cadherin 2, type 1, N-cadherin (neuronal) [KO:K06736]
281941	NCAM1; neural cell adhesion molecule 1 [KO:K06491]
535613	NCAM2; neural cell adhesion molecule 2 [KO:K06491]
516017	L1CAM; L1 cell adhesion molecule [KO:K06550]
529873	CADM1; cell adhesion molecule 1 [KO:K06781]
781106	NEGR1; neuronal growth regulator 1 [KO:K06775]
787473	NTNG1; netrin G2 [KO:K07522]
528664	LRRC4C; leucine rich repeat containing 4C [KO:K07523]
523720	NTNG2; netrin G2 [KO:K16359]
525767	LRRC4; leucine rich repeat containing 4 [KO:K16351]
512072	PTPRF; protein tyrosine phosphatase, receptor type, F [KO:K05695] [EC:3.1.3.48]
539607	LRRC4B; leucine rich repeat containing 4B [KO:K16360]
529759	SDC1; syndecan 1 [KO:K06257]
615785	SDC2; syndecan 2 [KO:K16336]
618198	SDC3; syndecan 3 [KO:K16337]
508133	SDC4; syndecan 4 [KO:K16338]
281875	ITGAV; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) [KO:K06487]
536286	ITGB8; integrin, beta 8 [KO:K06591]
511976	ITGA8; integrin, alpha 8 [KO:K06584]
281950	NRXN1; neurexin 1 [KO:K07377]
537808	NRXN2; neurexin 2 [KO:K07377]
614412	NRXN3; neurexin 3 [KO:K07377]
511251	NLGN3; neuroligin 3 [KO:K07378]
787986	NLGN2; neuroligin 2 [KO:K07378]
530042	NLGN1; neuroligin 1 [KO:K07378]
100300059	NLGN4Y; neuroligin 4, Y-linked-like [KO:K07378]
531178	CADM3; cell adhesion molecule 3 [KO:K06780]
534500	NRCAM; neuronal cell adhesion molecule [KO:K06756]
281705	CNTN1; contactin 1 [KO:K06759]
536092	PTPRM; protein tyrosine phosphatase, receptor type, M [KO:K05693] [EC:3.1.3.48]
100140960	contactin-2-like; K06760 contactin 2 [KO:K06760]
512796	NFASC; neurofascin [KO:K06757]
540997	CNTNAP1; contactin associated protein 1 [KO:K07379]
100337375	CNTNAP2; contactin associated protein-like 2 [KO:K07380]
539387	MPZL1; myelin protein zero-like 1 [KO:K06770]
539462	MPZ; myelin protein zero [KO:K06770]
540576	MAG; myelin associated glycoprotein [KO:K06771]
282637	CDH1; cadherin 1, type 1, E-cadherin (epithelial) [KO:K05689]
282662	VCAN; versican [KO:K06793]
535043	ITGA6; integrin, alpha 6 [KO:K06485]
281063	CDH3; cadherin 3, type 1, P-cadherin (placental) [KO:K06796]
525796	CDH4; cadherin 4, type 1, R-cadherin (retinal) [KO:K06797]
522202	CDH15; cadherin 15, type 1, M-cadherin (myotubule) [KO:K06809]
100297058	NEO1; neogenin 1 [KO:K06766]

Reference

PMID:14690046

Authors

Barclay AN.

Title

Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.

Journal

Semin Immunol 15:215-23 (2003)

Reference

PMID:11910893

Authors

Sharpe AH, Freeman GJ.

Title

The B7-CD28 superfamily.

Journal

Nat Rev Immunol 2:116-26 (2002)

Reference

PMID:9597126

Authors

Grewal IS, Flavell RA.

Title

CD40 and CD154 in cell-mediated immunity.

Journal

Annu Rev Immunol 16:111-35 (1998)

Reference

PMID:16034094

Authors

Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.

Title

CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.

Journal

J Immunol 175:1558-65 (2005)

Reference

PMID:12234363

Authors

Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.

Title

Cell adhesion and polarity during immune interactions.

Journal

Immunol Rev 186:68-82 (2002)

Reference

PMID:15071551

Authors

Dejana E.

Title

Endothelial cell-cell junctions: happy together.

Journal

Nat Rev Mol Cell Biol 5:261-70 (2004)

Reference

PMID:14519386

Authors

Bazzoni G.

Title

The JAM family of junctional adhesion molecules.

Journal

Curr Opin Cell Biol 15:525-30 (2003)

Reference

PMID:10798271

Authors

Becker BF, Heindl B, Kupatt C, Zahler S.

Title

Endothelial function and hemostasis.

Journal

Z Kardiol 89:160-7 (2000)

Reference

PMID:9150551

Authors

Elangbam CS, Qualls CW Jr, Dahlgren RR.

Title

Cell adhesion molecules--update.

Journal

Vet Pathol 34:61-73 (1997)

Reference

PMID:12810109

Authors

Muller WA.

Title

Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.

Journal

Trends Immunol 24:327-34 (2003)

Reference

PMID:14519398

Authors

Yamagata M, Sanes JR, Weiner JA.

Title

Synaptic adhesion molecules.

Journal

Curr Opin Cell Biol 15:621-32 (2003)

Reference

PMID:15882774

Authors

Ethell IM, Pasquale EB.

Title

Molecular mechanisms of dendritic spine development and remodeling.

Journal

Prog Neurobiol 75:161-205 (2005)

Reference

PMID:11050419

Authors

Benson DL, Schnapp LM, Shapiro L, Huntley GW.

Title

Making memories stick: cell-adhesion molecules in synaptic plasticity.

Journal

Trends Cell Biol 10:473-82 (2000)

Reference

PMID:11860281

Authors

Rosdahl JA, Mourton TL, Brady-Kalnay SM.

Title

Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.

Journal

Mol Cell Neurosci 19:292-306 (2002)

Reference

PMID:10964748

Authors

Dunican DJ, Doherty P.

Title

The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.

Journal

Mol Cell Biol Res Commun 3:255-63 (2000)

Reference

PMID:12367625

Authors

Girault JA, Peles E.

Title

Development of nodes of Ranvier.

Journal

Curr Opin Neurobiol 12:476-85 (2002)

Reference

PMID:10664064

Authors

Arroyo EJ, Scherer SS.

Title

On the molecular architecture of myelinated fibers.

Journal

Histochem Cell Biol 113:1-18 (2000)

Reference

PMID:14556710

Authors

Salzer JL.

Title

Polarized domains of myelinated axons.

Journal

Neuron 40:297-318 (2003)

Reference

PMID:15561584

Authors

Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.

Title

Roles and modes of action of nectins in cell-cell adhesion.

Journal

Semin Cell Dev Biol 15:643-56 (2004)

Reference

PMID:15551862

Authors

Nakanishi H, Takai Y.

Title

Roles of nectins in cell adhesion, migration and polarization.

Journal

Biol Chem 385:885-92 (2004)

Reference

PMID:15115723

Authors

Siu MK, Cheng CY.

Title

Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.

Journal

Biol Reprod 71:375-91 (2004)

Reference

PMID:15056568

Authors

Lee NP, Cheng CY.

Title

Adaptors, junction dynamics, and spermatogenesis.

Journal

Biol Reprod 71:392-404 (2004)

Reference

PMID:15728677

Authors

Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.

Title

Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.

Journal

Development 132:1525-37 (2005)

Reference

PMID:12500939

Authors

Marthiens V, Gavard J, Lambert M, Mege RM.

Title

Cadherin-based cell adhesion in neuromuscular development.

Journal

Biol Cell 94:315-26 (2002)

Reference

PMID:15923648

Authors

Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.

Title

Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.

Journal

J Cell Sci 118:2355-62 (2005)

KO pathway

ko04514

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Genome (1)   
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Gene (156)   
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