KEGG PATHWAY: bta04530

PATHWAY: bta04530

Entry

bta04530 Pathway

Name

Tight junction - Bos taurus (cow)

Description

Epithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. The transmembrane proteins mediate cell adhesion and are thought to constitute the intramembrane and paracellular diffusion barriers. The cytoplasmic 'plaque' contains three major multi-protein complexes consisting largely of scaffolding proteins, the ZO protein complex, the CRB3-Pals1-PATJ complex and the PAR-3-aPKC-PAR-6 complex. The ZO protein complex appears to organize the transmembrane proteins and couple them to other cytoplasmic proteins and to actin microfilaments. Two evolutionarily conserved protein complexes, the CRB3 and PAR complexes are involved in the establishment and maintenance of epithelial cell polarity. Besides these three protein complexes which seem to be constitutively associated at TJs, a number of proteins with different functions has been identified at TJs. These include additional scaffolding proteins like MUPP1 and MAGI-1, adaptor proteins, transcription regulators and RNA processing factors, regulatory proteins like small GTPases and G-proteins, kinases and phosphatases, and heat shock proteins. These are proposed to be involved in junction assembly, barrier regulation, gene transcription, and perhaps other, presently undefined pathways.

Class

Cellular Processes; Cell communication

Pathway map

bta04530

Tight junction

Other DBs

BSID:

84310

GO:

0005923

Organism

Bos taurus (cow) [GN:bta]

Gene

404089	CLDN2; claudin 2 [KO:K06087]
404153	CLDN3; claudin 3 [KO:K06087]
414921	CLDN4; claudin 4 [KO:K06087]
414922	CLDN1; claudin 1 [KO:K06087]
511460	CLDN18; claudin 18 [KO:K06087]
282184	CLDN16; claudin 16 [KO:K06087]
508268	CLDN11; claudin 11 [KO:K06087]
512703	CLDN17; claudin 17 [KO:K06087]
512975	CLDN7; claudin 7 [KO:K06087]
513034	CLDN19; claudin 19 [KO:K06087]
617453	CLDN5; claudin 5 [KO:K06087]
783180	CLDN14; claudin 14 [KO:K06087]
511318	CLDN6; claudin 6 [KO:K06087]
514634	CLDN23; claudin 23 [KO:K06087]
514998	CLDN15; claudin 15 [KO:K06087]
538761	CLDN8; claudin 8 [KO:K06087]
506545	CLDN10; claudin 10 [KO:K06087]
616036	CLDN22; claudin 22 [KO:K06087]
617449	CLDN9; claudin 9 [KO:K06087]
522679	CLDN25; claudin 25 [KO:K06087]
536739	CLDN24; claudin 24 [KO:K06087]
512405	OCLN; occludin [KO:K06088]
281258	F11R; F11 receptor [KO:K06089]
538846	JAM2; junctional adhesion molecule 2 [KO:K06735]
513412	JAM3; junctional adhesion molecule 3 [KO:K06785]
511594	IGSF5; immunoglobulin superfamily, member 5 [KO:K06786]
787466	CRB3; crumbs homolog 3 (Drosophila) [KO:K06090]
528109	MPP5; membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) [KO:K06091]
536993	INADL; InaD-like (Drosophila) [KO:K06092]
539292	PARD6G; par-6 partitioning defective 6 homolog gamma (C. elegans) [KO:K06093]
539687	PARD6B; par-6 partitioning defective 6 homolog beta (C. elegans) [KO:K06093]
524653	PARD6A; par-6 partitioning defective 6 homolog alpha (C. elegans) [KO:K06093]
286877	PRKCZ; protein kinase C, zeta [KO:K06069] [EC:2.7.11.13]
528478	PRKCI; protein kinase C, iota [KO:K06069] [EC:2.7.11.13]
527964	PARD3; par-3 partitioning defective 3 homolog (C. elegans) [KO:K04237]
781865	LLGL1; lethal giant larvae homolog 1 (Drosophila) [KO:K06094]
539545	LLGL2; lethal giant larvae homolog 2 (Drosophila) [KO:K06094]
532712	CDC42; cell division cycle 42 (GTP binding protein, 25kDa) [KO:K04393]
282320	PPP2CA; protein phosphatase 2, catalytic subunit, alpha isozyme [KO:K04382] [EC:3.1.3.16]
524361	PPP2CB; protein phosphatase 2, catalytic subunit, beta isozyme [KO:K04382] [EC:3.1.3.16]
616695	protein phosphatase 2; K03456 protein phosphatase 2 (formerly 2A), regulatory subunit A [KO:K03456]
535321	PPP2R1A; protein phosphatase 2, regulatory subunit A, alpha [KO:K03456]
100138150	PPP2R1B; protein phosphatase 2, regulatory subunit A, beta [KO:K03456]
508045	PPP2R2A; protein phosphatase 2, regulatory subunit B, alpha [KO:K04354]
509290	PPP2R2B; protein phosphatase 2, regulatory subunit B, beta [KO:K04354]
782110	PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
282002	PRKCG; protein kinase C, gamma [KO:K02677] [EC:2.7.11.13]
282001	PRKCA; protein kinase C, alpha [KO:K02677] [EC:2.7.11.13]
282325	PRKCB; protein kinase C, beta [KO:K02677] [EC:2.7.11.13]
505708	PRKCD; protein kinase C, delta [KO:K06068] [EC:2.7.11.13]
518542	PRKCH; protein kinase C, eta [KO:K06068] [EC:2.7.11.13]
505901	PRKCQ; protein kinase C, theta [KO:K06068] [EC:2.7.11.13]
507041	PRKCE; protein kinase C, epsilon [KO:K06068] [EC:2.7.11.13]
282419	CSNK2A1; casein kinase 2, alpha 1 polypeptide [KO:K03097] [EC:2.7.11.1]
282420	CSNK2A2; casein kinase 2, alpha prime polypeptide [KO:K03097] [EC:2.7.11.1]
539235	CSNK2B; casein kinase 2, beta polypeptide [KO:K03115]
281790	GNAI1; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 [KO:K04630]
281791	GNAI2; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 [KO:K04630]
539521	GNAI3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 [KO:K04630]
536863	MPDZ; multiple PDZ domain protein [KO:K06095]
516024	VAPA; VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa [KO:K06096]
407100	TJP3; tight junction protein 3 (zona occludens 3) [KO:K06097]
407102	TJP1; tight junction protein 1 [KO:K05701]
407101	TJP2; tight junction protein 2 (zona occludens 2) [KO:K06098]
519251	ZAK; sterile alpha motif and leucine zipper containing kinase AZK [KO:K04424] [EC:2.7.11.25]
539003	CTNNB1; catenin (cadherin-associated protein), beta 1, 88kDa [KO:K02105]
533297	CSDA; cold shock domain protein A [KO:K06099]
100337373	SYMPK; symplekin [KO:K06100]
540563	ASH1L; ash1 (absent, small, or homeotic)-like (Drosophila) [KO:K06101] [EC:2.1.1.43]
510618	CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
533725	CGN; cingulin [KO:K06102]
404122	ACTG1; actin, gamma 1 [KO:K05692]
280979	ACTB; actin, beta [KO:K05692]
505519	MYL2; myosin, light chain 2, regulatory, cardiac, slow [KO:K10351]
508257	MYL7; myosin, light chain 7, regulatory [KO:K12754]
505964	MYL9; myosin, light chain 9, regulatory [KO:K12755]
617357	MYL10; myosin, light chain 10, regulatory [KO:K12756]
531505	MYL12A; myosin, light chain 12A, regulatory, non-sarcomeric [KO:K12757]
614055	MYL12B; myosin, light chain 12B, regulatory [KO:K12757]
514106	MYLPF; myosin light chain, phosphorylatable, fast skeletal muscle [KO:K12758]
281337	MYH1; myosin, heavy chain 1, skeletal muscle, adult [KO:K10352]
281338	MYH3; myosin, heavy chain 3, skeletal muscle, embryonic [KO:K10352]
281339	MYH8; myosin, heavy chain 8, skeletal muscle, perinatal [KO:K10352]
282714	MYH7; myosin, heavy chain 7, cardiac muscle, beta [KO:K10352]
317655	MYH10; myosin, heavy chain 10, non-muscle [KO:K10352]
404108	MYH9; myosin, heavy chain 9, non-muscle [KO:K10352]
408020	MYH4; myosin, heavy chain 4, skeletal muscle [KO:K10352]
511687	MYH13; myosin, heavy chain 13, skeletal muscle [KO:K10352]
514212	MYH14; myosin, heavy chain 14, non-muscle [KO:K10352]
530050	MYH11; myosin, heavy chain 11, smooth muscle [KO:K10352]
788772	MYH2; myosin, heavy chain 2, skeletal muscle, adult [KO:K10352]
526674	MYH15; myosin, heavy chain 15 [KO:K10352]
100296004	MYH6; myosin, heavy chain 6, cardiac muscle, alpha [KO:K10352]
521764	myosin-7B-like; K10352 myosin heavy chain [KO:K10352]
338049	RHOA; ras homolog gene family, member A [KO:K04513]
504856	MLLT4; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) [KO:K05702]
100298939	HRAS; v-Ha-ras Harvey rat sarcoma viral oncogene homolog [KO:K02833]
541140	KRAS; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
506322	NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog [KO:K07828]
616503	RRAS; related RAS viral (r-ras) oncogene homolog [KO:K07829]
519269	RRAS2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
540803	MRAS; muscle RAS oncogene homolog [KO:K07831]
404149	CASK; calcium/calmodulin-dependent serine protein kinase (MAGUK family) [KO:K06103] [EC:2.7.11.1]
541209	AMOTL1; angiomotin like 1 [KO:K06104]
515620	TJAP1; tight junction associated protein 1 (peripheral) [KO:K06105]
506939	CTTN; cortactin [KO:K06106]
508445	HCLS1; hematopoietic cell-specific Lyn substrate 1 [KO:K06106]
526848	CTNNA1; catenin (cadherin-associated protein), alpha 1, 102kDa [KO:K05691]
780777	CTNNA3; catenin (cadherin-associated protein), alpha 3 [KO:K05691]
281753	EPB41; erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) [KO:K06107]
532616	EPB41L3; erythrocyte membrane protein band 4.1-like 3 [KO:K06107]
515919	EPB41L1; erythrocyte membrane protein band 4.1-like 1 [KO:K06107]
538959	EPB41L2; erythrocyte membrane protein band 4.1-like 2 [KO:K06107]
522269	ACTN4; actinin, alpha 4 [KO:K05699]
524770	ACTN1; actinin, alpha 1 [KO:K05699]
536607	ACTN2; actinin, alpha 2 [KO:K05699]
539375	ACTN3; actinin, alpha 3 [KO:K05699]
535742	SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [KO:K05704] [EC:2.7.10.2]
507632	YES1; v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 [KO:K05705] [EC:2.7.10.2]
282030	RAB3B; RAB3B, member RAS oncogene family [KO:K06108]
514541	RAB13; RAB13, member RAS oncogene family [KO:K06109]
513138	EXOC3; exocyst complex component 3 [KO:K06110]
537690	EXOC4; exocyst complex component 4 [KO:K06111]
783484	MAGI1; membrane associated guanylate kinase, WW and PDZ domain containing 1 [KO:K05631]
100298336	MAGI2; membrane associated guanylate kinase, WW and PDZ domain containing 2 [KO:K05629]
532952	MAGI3; membrane associated guanylate kinase, WW and PDZ domain containing 3 [KO:K06112]
540786	PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.67 3.1.3.48 3.1.3.16]
534923	AKT2; v-akt murine thymoma viral oncogene homolog 2 [KO:K04456] [EC:2.7.11.1]
280991	AKT1; v-akt murine thymoma viral oncogene homolog 1 [KO:K04456] [EC:2.7.11.1]
100137872	AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) [KO:K04456] [EC:2.7.11.1]

Compound

C05981

Phosphatidylinositol-3,4,5-trisphosphate

Reference

PMID:15151915

Authors

Schneeberger EE, Lynch RD.

Title

The tight junction: a multifunctional complex.

Journal

Am J Physiol Cell Physiol 286:C1213-28 (2004)

Reference

PMID:15269339

Authors

Bazzoni G, Dejana E.

Title

Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis.

Journal

Physiol Rev 84:869-901 (2004)

Reference

PMID:12612641

Authors

Matter K, Balda MS.

Title

Signalling to and from tight junctions.

Journal

Nat Rev Mol Cell Biol 4:225-36 (2003)

Reference

PMID:11283726

Authors

Tsukita S, Furuse M, Itoh M.

Title

Multifunctional strands in tight junctions.

Journal

Nat Rev Mol Cell Biol 2:285-93 (2001)

Reference

PMID:12475568

Authors

Gonzalez-Mariscal L, Betanzos A, Nava P, Jaramillo BE.

Title

Tight junction proteins.

Journal

Prog Biophys Mol Biol 81:1-44 (2003)

Reference

PMID:12270945

Authors

Cheng CY, Mruk DD.

Title

Cell junction dynamics in the testis: Sertoli-germ cell interactions and male contraceptive development.

Journal

Physiol Rev 82:825-74 (2002)

Reference

PMID:15551862

Authors

Nakanishi H, Takai Y.

Title

Roles of nectins in cell adhesion, migration and polarization.

Journal

Biol Chem 385:885-92 (2004)

Reference

PMID:12791297

Authors

Balda MS, Matter K.

Title

Epithelial cell adhesion and the regulation of gene expression.

Journal

Trends Cell Biol 13:310-8 (2003)

KO pathway

ko04530

All links

Pathway (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (130)   
   KEGG GENES (130)   
All databases (132)   

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