KEGG   PATHWAY: bta04666
Entry
bta04666                    Pathway                                
Name
Fc gamma R-mediated phagocytosis - Bos taurus (cow)
Description
Phagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes take part in this process in higher organisms. After opsonization with antibodies (IgG), foreign extracellular materials are recognized by Fc gamma receptors. Cross-linking of Fc gamma receptors initiates a variety of signals mediated by tyrosine phosphorylation of multiple proteins, which lead through the actin cytoskeleton rearrangements and membrane remodeling to the formation of phagosomes. Nascent phagosomes undergo a process of maturation that involves fusion with lysosomes. The acquisition of lysosomal proteases and release of reactive oxygen species are crucial for digestion of engulfed materials in phagosomes.
Class
Organismal Systems; Immune system
Pathway map
bta04666  Fc gamma R-mediated phagocytosis
bta04666

Other DBs
GO: 0006909
Organism
Bos taurus (cow) [GN:bta]
Gene
524810  IgM precursor [KO:K06856]
100300716  immunoglobulin heavy variable 4-38-2 [KO:K06856]
100300806  immunoglobulin heavy variable 4-59 isoform X1 [KO:K06856]
104968484  immunoglobulin heavy variable 4-59 [KO:K06856]
282227  FCGR1A; high affinity immunoglobulin gamma Fc receptor I precursor [KO:K06498]
782652  FCGR2A; low affinity immunoglobulin gamma Fc region receptor II-a [KO:K06472]
281766  FCGR3A; low affinity immunoglobulin gamma Fc region receptor III-A isoform 1 precursor [KO:K06463]
407152  PTPRC; receptor-type tyrosine-protein phosphatase C precursor [KO:K06478] [EC:3.1.3.48]
280814  HCK; tyrosine-protein kinase HCK isoform 2 [KO:K08893] [EC:2.7.10.2]
534996  LYN; tyrosine-protein kinase Lyn [KO:K05854] [EC:2.7.10.2]
515515  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
282306  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
517948  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
504531  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
282308  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
286865  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
282307  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
534923  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
280991  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100137872  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
404181  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
506083  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
281987  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
100337091  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
505708  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
507041  PRKCE; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
521196  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
533199  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101905399  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
327672  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
531391  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
526364  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
505485  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
522866  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
531209  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
525072  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
535381  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
613548  MARCKS; myristoylated alanine-rich C-kinase substrate [KO:K12561]
539555  MARCKSL1; MARCKS-related protein [KO:K13536]
522159  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
514554  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
504545  PLPP2; phospholipid phosphatase 2 precursor [KO:K01080] [EC:3.1.3.4]
617707  PLPP3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
617172  PLPP1; phospholipid phosphatase 1 [KO:K01080] [EC:3.1.3.4]
101905992  uncharacterized protein LOC101905992 isoform X1 [KO:K01080] [EC:3.1.3.4]
618605  SPHK1; sphingosine kinase 1 isoform X3 [KO:K04718] [EC:2.7.1.91]
533103  SPHK2; sphingosine kinase 2 isoform X2 [KO:K04718] [EC:2.7.1.91]
282001  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
282325  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
282002  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
281345  NCF1; neutrophil cytosol factor 1 [KO:K08011]
535077  GSN; gelsolin isoform b [KO:K05768]
281478  SCIN; scinderin [KO:K05768]
521961  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
617345  VAV1; proto-oncogene vav [KO:K05730]
515718  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
532712  CDC42; cell division control protein 42 homolog [KO:K04393]
107131173  WAS; actin nucleation-promoting factor WAS [KO:K05747]
514902  VASP; vasodilator-stimulated phosphoprotein [KO:K06274]
538486  ACTR2; actin-related protein 2 [KO:K17260]
616404  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
281597  ACTR3; actin-related protein 3 [KO:K18584]
326600  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
508402  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
540838  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
506596  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
539459  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
614345  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
613421  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
281440  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
327671  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
531488  WASF1; actin-binding protein WASF1 [KO:K05753]
504482  WASF2; actin-binding protein WASF2 [KO:K05748]
540674  WASF3; actin-binding protein WASF3 [KO:K06083]
533729  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
535225  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
513539  LIMK2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
534553  CFL1; cofilin-1 [KO:K05765]
539332  CFL2; cofilin-2 [KO:K05765]
508819  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
100125224  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
537654  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X5 [KO:K00889] [EC:2.7.1.68]
100294979  ARF6; ADP-ribosylation factor 6 [KO:K07941]
512841  CRK; adapter molecule crk [KO:K04438]
518180  CRKL; crk-like protein [KO:K04438]
537203  DOCK1; dedicator of cytokinesis protein 1 isoform X2 [KO:K13708]
523797  ASAP3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 [KO:K12488]
618009  ASAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
327705  ASAP1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 [KO:K12488]
282229  FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b precursor [KO:K12560]
507329  INPP5D; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 [KO:K03084] [EC:3.1.3.86]
783833  INPPL1; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 [KO:K15909] [EC:3.1.3.86]
529346  GAB2; GRB2-associated-binding protein 2 isoform X3 [KO:K08091]
514735  LAT; linker for activation of T-cells family member 1 precursor [KO:K07362]
511691  DNM2; dynamin-2 [KO:K23484] [EC:3.6.5.5]
614722  AMPH; amphiphysin [KO:K12562]
614576  BIN1; myc box-dependent-interacting protein 1 [KO:K12562]
281935  MYO10; unconventional myosin-X [KO:K12559]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00416  Phosphatidate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06124  Sphingosine 1-phosphate
Reference
PMID:12488490
  Authors
Garcia-Garcia E, Rosales C
  Title
Signal transduction during Fc receptor-mediated phagocytosis.
  Journal
J Leukoc Biol 72:1092-108 (2002)
DOI:10.1189/jlb.72.6.1092
Reference
PMID:11708889
  Authors
Cox D, Greenberg S
  Title
Phagocytic signaling strategies: Fc(gamma)receptor-mediated phagocytosis as a model system.
  Journal
Semin Immunol 13:339-45 (2001)
DOI:10.1006/smim.2001.0330
Reference
PMID:15466916
  Authors
Swanson JA, Hoppe AD
  Title
The coordination of signaling during Fc receptor-mediated phagocytosis.
  Journal
J Leukoc Biol 76:1093-103 (2004)
DOI:10.1189/jlb.0804439
Reference
PMID:11244038
  Authors
Ravetch JV, Bolland S
  Title
IgG Fc receptors.
  Journal
Annu Rev Immunol 19:275-90 (2001)
DOI:10.1146/annurev.immunol.19.1.275
Reference
PMID:18322649
  Authors
Groves E, Dart AE, Covarelli V, Caron E
  Title
Molecular mechanisms of phagocytic uptake in mammalian cells.
  Journal
Cell Mol Life Sci 65:1957-76 (2008)
DOI:10.1007/s00018-008-7578-4
Reference
PMID:10376013
  Authors
Kwiatkowska K, Sobota A
  Title
Signaling pathways in phagocytosis.
  Journal
Bioessays 21:422-31 (1999)
DOI:10.1002/(SICI)1521-1878(199905)21:5<422::AID-BIES9>3.0.CO;2-#
Reference
PMID:10577498
  Authors
Greenberg S
  Title
Modular components of phagocytosis.
  Journal
J Leukoc Biol 66:712-7 (1999)
DOI:10.1002/jlb.66.5.712
Reference
PMID:10224668
  Authors
Lennartz MR
  Title
Phospholipases and phagocytosis: the role of phospholipid-derived second messengers in phagocytosis.
  Journal
Int J Biochem Cell Biol 31:415-30 (1999)
DOI:10.1016/S1357-2725(98)00108-3
Reference
PMID:11228151
  Authors
May RC, Machesky LM
  Title
Phagocytosis and the actin cytoskeleton.
  Journal
J Cell Sci 114:1061-77 (2001)
Reference
PMID:17050193
  Authors
Joshi T, Butchar JP, Tridandapani S
  Title
Fcgamma receptor signaling in phagocytes.
  Journal
Int J Hematol 84:210-6 (2006)
DOI:10.1532/IJH97.06140
Reference
PMID:17308335
  Authors
Lee WL, Cosio G, Ireton K, Grinstein S
  Title
Role of CrkII in Fcgamma receptor-mediated phagocytosis.
  Journal
J Biol Chem 282:11135-43 (2007)
DOI:10.1074/jbc.M700823200
Reference
PMID:11304556
  Authors
Uchida H, Kondo A, Yoshimura Y, Mazaki Y, Sabe H
  Title
PAG3/Papalpha/KIAA0400, a GTPase-activating protein for ADP-ribosylation factor (ARF), regulates ARF6 in Fcgamma receptor-mediated phagocytosis of macrophages.
  Journal
J Exp Med 193:955-66 (2001)
DOI:10.1084/jem.193.8.955
Reference
PMID:15485887
  Authors
Ganesan LP, Wei G, Pengal RA, Moldovan L, Moldovan N, Ostrowski MC, Tridandapani S
  Title
The serine/threonine kinase Akt Promotes Fc gamma receptor-mediated phagocytosis in murine macrophages through the activation of p70S6 kinase.
  Journal
J Biol Chem 279:54416-25 (2004)
DOI:10.1074/jbc.M408188200
Reference
PMID:9545263
  Authors
Melendez A, Floto RA, Gillooly DJ, Harnett MM, Allen JM
  Title
FcgammaRI coupling to phospholipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular trafficking.
  Journal
J Biol Chem 273:9393-402 (1998)
DOI:10.1074/jbc.273.16.9393
Reference
PMID:12821647
  Authors
Gu H, Botelho RJ, Yu M, Grinstein S, Neel BG
  Title
Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosis.
  Journal
J Cell Biol 161:1151-61 (2003)
DOI:10.1083/jcb.200212158
Reference
PMID:9417101
  Authors
Dana R, Leto TL, Malech HL, Levy R
  Title
Essential requirement of cytosolic phospholipase A2 for activation of the phagocyte NADPH oxidase.
  Journal
J Biol Chem 273:441-5 (1998)
DOI:10.1074/jbc.273.1.441
Reference
PMID:10601359
  Authors
Gold ES, Underhill DM, Morrissette NS, Guo J, McNiven MA, Aderem A
  Title
Dynamin 2 is required for phagocytosis in macrophages.
  Journal
J Exp Med 190:1849-56 (1999)
DOI:10.1084/jem.190.12.1849
Reference
PMID:10755615
  Authors
Gold ES, Morrissette NS, Underhill DM, Guo J, Bassetti M, Aderem A
  Title
Amphiphysin IIm, a novel amphiphysin II isoform, is required for macrophage phagocytosis.
  Journal
Immunity 12:285-92 (2000)
DOI:10.1016/S1074-7613(00)80181-8
Reference
PMID:10586078
  Authors
Raeder EM, Mansfield PJ, Hinkovska-Galcheva V, Shayman JA, Boxer LA
  Title
Syk activation initiates downstream signaling events during human polymorphonuclear leukocyte phagocytosis.
  Journal
J Immunol 163:6785-93 (1999)
Reference
PMID:9581795
  Authors
Sanchez-Mejorada G, Rosales C
  Title
Signal transduction by immunoglobulin Fc receptors.
  Journal
J Leukoc Biol 63:521-33 (1998)
DOI:10.1002/jlb.63.5.521
Reference
  Authors
Rosales C (ed).
  Title
Molecular Mechanisms of Phagocytosis
  Journal
Springer (2005)
Related
pathway
bta04020  Calcium signaling pathway
bta04142  Lysosome
bta04144  Endocytosis
bta04810  Regulation of actin cytoskeleton
KO pathway
ko04666   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (98)   
   KEGG GENES (98)   
All databases (99)   

Download RDF
DBGET integrated database retrieval system