KEGG PATHWAY: bta04720

PATHWAY: bta04720

Entry

bta04720 Pathway

Name

Long-term potentiation - Bos taurus (cow)

Description

Hippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippocampus induces glutamate release and activation of glutamate receptors in dendritic spines. A large increase in [Ca2+]i resulting from influx through NMDA receptors leads to constitutive activation of CaM kinase II (CaM KII) . Constitutively active CaM kinase II phosphorylates AMPA receptors, resulting in potentiation of the ionic conductance of AMPA receptors. Early-phase LTP (E-LTP) expression is due, in part, to this phosphorylation of the AMPA receptor. It is hypothesized that postsynaptic Ca2+ increases generated through NMDA receptors activate several signal transduction pathways including the Erk/MAP kinase and cAMP regulatory pathways. The convergence of these pathways at the level of the CREB/CRE transcriptional pathway may increase expression of a family of genes required for late-phase LTP (L-LTP).

Class

Organismal Systems; Nervous system

Pathway map

bta04720

Long-term potentiation

Other DBs

BSID:

84324

GO:

0048169

Organism

Bos taurus (cow) [GN:bta]

Gene

529618	GRIA1; glutamate receptor, ionotropic, AMPA 1 [KO:K05197]
614283	GRIA2; glutamate receptor, ionotropic, AMPA 2 [KO:K05198]
281601	ADCY1; adenylate cyclase 1 (brain) [KO:K08041] [EC:4.6.1.1]
535017	ADCY8; adenylate cyclase 8 (brain) [KO:K08048] [EC:4.6.1.1]
282322	PRKACA; protein kinase, cAMP-dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
282323	PRKACB; protein kinase, cAMP-dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
505773	PRKX; protein kinase, X-linked [KO:K04345] [EC:2.7.11.11]
767949	PPP1R1A; protein phosphatase 1, regulatory (inhibitor) subunit 1A [KO:K08050]
282318	PPP1CC; protein phosphatase 1, catalytic subunit, gamma isozyme [KO:K06269] [EC:3.1.3.16]
516175	PPP1CA; protein phosphatase 1, catalytic subunit, alpha isozyme [KO:K06269] [EC:3.1.3.16]
538829	PPP1CB; protein phosphatase 1, catalytic subunit, beta isozyme [KO:K06269] [EC:3.1.3.16]
538606	PPP1R12A; protein phosphatase 1, regulatory subunit 12A [KO:K06270]
282162	CAMK2G; calcium/calmodulin-dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
525416	CAMK2B; calcium/calmodulin-dependent protein kinase II beta [KO:K04515] [EC:2.7.11.17]
530719	CAMK2A; calcium/calmodulin-dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17]
532713	CAMK2D; calcium/calmodulin-dependent protein kinase II delta [KO:K04515] [EC:2.7.11.17]
535383	RAPGEF3; Rap guanine nucleotide exchange factor (GEF) 3 [KO:K08014]
282031	RAP1A; RAP1A, member of RAS oncogene family [KO:K04353]
327708	RAP1B; RAP1B, member of RAS oncogene family [KO:K07836]
789148	rAP1B; K07836 Ras-related protein Rap-1B [KO:K07836]
286852	PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme [KO:K04348] [EC:3.1.3.16]
533527	PPP3CC; protein phosphatase 3, catalytic subunit, gamma isozyme [KO:K04348] [EC:3.1.3.16]
790867	PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme [KO:K04348] [EC:3.1.3.16]
282321	PPP3R1; protein phosphatase 3, regulatory subunit B, alpha [KO:K06268]
617585	PPP3R2; protein phosphatase 3, regulatory subunit B, beta [KO:K06268]
515280	CHP2; calcineurin B homologous protein 2 [KO:K06268]
512662	CHP1; calcium binding protein P22 [KO:K06268]
100336579	GRIN1; glutamate receptor, ionotropic, N-methyl D-aspartate 1 [KO:K05208]
524212	GRIN2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A [KO:K05209]
537804	GRIN2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B [KO:K05210]
535158	GRIN2C; glutamate receptor, ionotropic, N-methyl D-aspartate 2C [KO:K05211]
618181	GRIN2D; glutamate receptor, ionotropic, N-methyl D-aspartate 2D [KO:K05212]
408015	CACNA1C; calcium channel, voltage-dependent, L type, alpha 1C subunit [KO:K04850]
326597	CALM; calmodulin-like [KO:K02183]
520277	CALM3; calmodulin 3 (phosphorylase kinase, delta) [KO:K02183]
617095	CALM1; calmodulin 1 (phosphorylase kinase, delta) [KO:K02183]
520404	CALML5; calmodulin-like 5 [KO:K02183]
100297344	CALM2; calmodulin 2 (phosphorylase kinase, delta) [KO:K02183]
617412	CALML6; calmodulin-like 6 [KO:K02183]
505453	CREBBP; CREB binding protein [KO:K04498] [EC:2.3.1.48]
784935	histone acetyltransferase p300-like; K04498 E1A/CREB-binding protein [EC:2.3.1.48] [KO:K04498] [EC:2.3.1.48]
509107	ATF4; activating transcription factor 4 (tax-responsive enhancer element B67) [KO:K04374]
100337083	CAMK4; calcium/calmodulin-dependent protein kinase IV [KO:K05869] [EC:2.7.11.17]
100298939	HRAS; v-Ha-ras Harvey rat sarcoma viral oncogene homolog [KO:K02833]
541140	KRAS; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
506322	NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog [KO:K07828]
540421	ARAF; v-raf murine sarcoma 3611 viral oncogene homolog [KO:K08845] [EC:2.7.11.1]
536051	BRAF; v-raf murine sarcoma viral oncogene homolog B1 [KO:K04365] [EC:2.7.11.1]
521196	RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [KO:K04366] [EC:2.7.11.1]
533199	MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
510434	MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
327672	MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
531391	MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
533908	RPS6KA1; ribosomal protein S6 kinase, 90kDa, polypeptide 1 [KO:K04373] [EC:2.7.11.1]
511190	RPS6KA3; ribosomal protein S6 kinase, 90kDa, polypeptide 3 [KO:K04373] [EC:2.7.11.1]
526227	RPS6KA6; ribosomal protein S6 kinase, 90kDa, polypeptide 6 [KO:K04373] [EC:2.7.11.1]
517953	RPS6KA2; ribosomal protein S6 kinase, 90kDa, polypeptide 2 [KO:K04373] [EC:2.7.11.1]
317697	ITPR1; inositol 1,4,5-trisphosphate receptor, type 1 [KO:K04958]
281878	ITPR2; inositol 1,4,5-trisphosphate receptor, type 2 [KO:K04959]
281879	ITPR3; inositol 1,4,5-trisphosphate receptor, type 3 [KO:K04960]
282002	PRKCG; protein kinase C, gamma [KO:K02677] [EC:2.7.11.13]
282001	PRKCA; protein kinase C, alpha [KO:K02677] [EC:2.7.11.13]
282325	PRKCB; protein kinase C, beta [KO:K02677] [EC:2.7.11.13]
540485	GRM1; glutamate receptor, metabotropic 1 [KO:K04603]
100336861	GRM5; glutamate receptor, metabotropic 5 [KO:K04604]
536654	GNAQ; guanine nucleotide binding protein (G protein), q polypeptide [KO:K04634]
287026	PLCB1; phospholipase C, beta 1 (phosphoinositide-specific) [KO:K05858] [EC:3.1.4.11]
281985	PLCB4; phospholipase C, beta 4 [KO:K05858] [EC:3.1.4.11]
515669	PLCB3; phospholipase C, beta 3 (phosphatidylinositol-specific) [KO:K05858] [EC:3.1.4.11]
508888	PLCB2; phospholipase C, beta 2 [KO:K05858] [EC:3.1.4.11]

Compound

C00025	L-Glutamate
C00076	Calcium cation
C00165	Diacylglycerol
C00305	Magnesium cation
C00575	3',5'-Cyclic AMP
C01245	D-myo-Inositol 1,4,5-trisphosphate
C01330	Sodium cation

Reference

PMID:15652868

Authors

Blitzer RD, Iyengar R, Landau EM.

Title

Postsynaptic signaling networks: cellular cogwheels underlying long-term plasticity.

Journal

Biol Psychiatry 57:113-9 (2005)

Reference

PMID:10652548

Authors

Soderling TR, Derkach VA.

Title

Postsynaptic protein phosphorylation and LTP.

Journal

Trends Neurosci 23:75-80 (2000)

Reference

PMID:11378299

Authors

Poser S, Storm DR.

Title

Role of Ca2+-stimulated adenylyl cyclases in LTP and memory formation.

Journal

Int J Dev Neurosci 19:387-94 (2001)

Reference

PMID:15803158

Authors

Xia Z, Storm DR.

Title

The role of calmodulin as a signal integrator for synaptic plasticity.

Journal

Nat Rev Neurosci 6:267-76 (2005)

Reference

Authors

Purves D, Augustine GJ (ed).

Title

Neuroscience

Journal

Sunderland, Mass.:Sinauer Associates (2004)

Reference

(Japanese)

Authors

Futai K, Hayashi Y.

Title

[Molecular mechanisms of hippocampal long-term potentiation.] (In Japanese)

Journal

Experimental Medicine 21(17):2361-2369 (2003)

Reference

PMID:14715912

Authors

Lynch MA.

Title

Long-term potentiation and memory.

Journal

Physiol Rev 84:87-136 (2004)

Reference

PMID:15857686

Authors

Kelly PT, Mackinnon RL 2nd, Dietz RV, Maher BJ, Wang J.

Title

Postsynaptic IP3 receptor-mediated Ca2+ release modulates synaptic transmission in hippocampal neurons.

Journal

Brain Res Mol Brain Res 135:232-48 (2005)

Reference

PMID:9697848

Authors

Berridge MJ.

Title

Neuronal calcium signaling.

Journal

Neuron 21:13-26 (1998)

KO pathway

ko04720

All links

Pathway (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (70)   
   KEGG GENES (70)   
All databases (72)   

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