KEGG PATHWAY: bta05100

PATHWAY: bta05100

Entry

bta05100 Pathway

Name

Bacterial invasion of epithelial cells - Bos taurus (cow)

Description

Many pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-phagocytic host cells (e.g. epithelial cells) using two mechanisms referred to as zipper model and trigger model. Listeria, Staphylococcus, Streptococcus, and Yersinia are examples of bacteria that enter using the zipper model. These bacteria express proteins on their surfaces that interact with cellular receptors, initiating signalling cascades that result in close apposition of the cellular membrane around the entering bacteria. Shigella and Salmonella are the examples of bacteria entering cells using the trigger model. These bacteria use type III secretion systems to inject protein effectors that interact with the actin cytoskeleton.

Class

Human Diseases; Infectious diseases

Pathway map

bta05100

Bacterial invasion of epithelial cells

Organism

Bos taurus (cow) [GN:bta]

Gene

282637	CDH1; cadherin 1, type 1, E-cadherin (epithelial) [KO:K05689]
539003	CTNNB1; catenin (cadherin-associated protein), beta 1, 88kDa [KO:K02105]
526848	CTNNA1; catenin (cadherin-associated protein), alpha 1, 102kDa [KO:K05691]
780777	CTNNA3; catenin (cadherin-associated protein), alpha 3 [KO:K05691]
510704	ARHGAP10; Rho GTPase activating protein 10 [KO:K13736]
280855	MET; met proto-oncogene (hepatocyte growth factor receptor) [KO:K05099] [EC:2.7.10.1]
540085	GAB1; GRB2-associated binding protein 1 [KO:K09593]
282308	PIK3R2; phosphoinositide-3-kinase, regulatory subunit 2 (beta) [KO:K02649]
286865	PIK3R3; phosphoinositide-3-kinase, regulatory subunit 3 (gamma) [KO:K02649]
614838	PIK3R5; phosphoinositide-3-kinase, regulatory subunit 5 [KO:K02649]
282307	PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [KO:K02649]
282306	PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
517948	PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide [KO:K00922] [EC:2.7.1.153]
504531	PIK3CD; phosphoinositide-3-kinase, catalytic, delta polypeptide [KO:K00922] [EC:2.7.1.153]
530001	PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide [KO:K00922] [EC:2.7.1.153]
512841	CRK; v-crk sarcoma virus CT10 oncogene homolog (avian) [KO:K04438]
518180	CRKL; v-crk sarcoma virus CT10 oncogene homolog (avian)-like [KO:K04438]
537203	DOCK1; dedicator of cytokinesis 1 [KO:K13708]
532712	CDC42; cell division cycle 42 (GTP binding protein, 25kDa) [KO:K04393]
281440	RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
281577	WASL; Wiskott-Aldrich syndrome-like [KO:K05747]
100336547	wiskott-Aldrich syndrome protein-like; K05747 Wiskott-Aldrich syndrome protein [KO:K05747]
531488	WASF1; WAS protein family, member 1 [KO:K05753]
504482	WASF2; WAS protein family, member 2 [KO:K05748]
326600	ARPC1B; actin related protein 2/3 complex, subunit 1B, 41kDa [KO:K05757]
508402	ARPC1A; actin related protein 2/3 complex, subunit 1A, 41kDa [KO:K05757]
540838	ARPC2; actin related protein 2/3 complex, subunit 2, 34kDa [KO:K05758]
506596	ARPC3; actin related protein 2/3 complex, subunit 3, 21kDa [KO:K05756]
539459	ARPC4; actin related protein 2/3 complex, subunit 4, 20kDa [KO:K05755]
614345	ARPC5; actin related protein 2/3 complex, subunit 5, 16kDa [KO:K05754]
613421	ARPC5L; actin related protein 2/3 complex, subunit 5-like [KO:K05754]
404122	ACTG1; actin, gamma 1 [KO:K05692]
280979	ACTB; actin, beta [KO:K05692]
512478	SEPT1; septin 1 [KO:K13737]
511612	SEPT2; septin 2 [KO:K16942]
100140583	SEPT9; septin 9 [KO:K16938]
618235	SEPT3; septin 3 [KO:K16938]
618676	SEPT12; septin 12 [KO:K16938]
540783	SEPT6; septin 6 [KO:K16939]
535746	SEPT11; septin 11 [KO:K16939]
540614	SEPT8; septin 8 [KO:K16939]
615866	CBLC; Cas-Br-M (murine) ecotropic retroviral transforming sequence c [KO:K04707] [EC:6.3.2.19]
527418	CBL; Cas-Br-M (murine) ecotropic retroviral transforming sequence [KO:K04707] [EC:6.3.2.19]
525906	CBLB; Cas-Br-M (murine) ecotropic retroviral transforming sequence b [KO:K04707] [EC:6.3.2.19]
533455	SHC2; SHC (Src homology 2 domain containing) transforming protein 2 [KO:K06279]
524734	SHC4; SHC (Src homology 2 domain containing) family, member 4 [KO:K06279]
507196	SHC1; SHC (Src homology 2 domain containing) transforming protein 1 [KO:K06279]
512696	SHC3; SHC (Src homology 2 domain containing) transforming protein 3 [KO:K06279]
533188	CD2AP; CD2-associated protein [KO:K13738]
508794	DNM1; dynamin 1 [KO:K01528] [EC:3.6.5.5]
511691	DNM2; dynamin 2 [KO:K01528] [EC:3.6.5.5]
506315	DNM3; dynamin 3 [KO:K01528] [EC:3.6.5.5]
281078	CLTA; clathrin, light chain A [KO:K04644]
281698	CLTB; clathrin, light chain B [KO:K04645]
281080	CLTC; clathrin, heavy chain (Hc) [KO:K04646]
281040	CAV1; caveolin 1, caveolae protein, 22kDa [KO:K06278]
493642	CAV2; caveolin 2 [KO:K12958]
615310	CAV3; caveolin 3 [KO:K12959]
506939	CTTN; cortactin [KO:K06106]
508445	HCLS1; hematopoietic cell-specific Lyn substrate 1 [KO:K06106]
535742	SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [KO:K05704] [EC:2.7.10.2]
506270	PTK2; PTK2 protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
527550	BCAR1; breast cancer anti-estrogen resistance 1 [KO:K05726]
517456	PXN; paxillin [KO:K05760]
280794	FN1; fibronectin 1 [KO:K05717]
281873	ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide) [KO:K06484]
281876	ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) [KO:K05719]
540207	ILK; integrin-linked kinase [KO:K06272] [EC:2.7.11.1]
506605	MAD2L2; MAD2 mitotic arrest deficient-like 2 (yeast) [KO:K13728]
531741	ARHGEF26; Rho guanine nucleotide exchange factor (GEF) 26 [KO:K13744]
531038	ras homolog gene family; K07863 Ras homolog gene family, member G [KO:K07863]
538559	RHOG; ras homolog gene family, member G (rho G) [KO:K07863]
509821	ELMO1; engulfment and cell motility 1 [KO:K12366]
338049	RHOA; ras homolog gene family, member A [KO:K04513]
783645	VCL; vinculin [KO:K05700]

Reference

PMID:19296488

Authors

Mostowy S, Cossart P

Title

Cytoskeleton rearrangements during Listeria infection: clathrin and septins as new players in the game.

Journal

Cell Motil Cytoskeleton 66:816-23 (2009)

Reference

PMID:16406780

Authors

Hauck CR, Ohlsen K

Title

Sticky connections: extracellular matrix protein recognition and integrin-mediated cellular invasion by Staphylococcus aureus.

Journal

Curr Opin Microbiol 9:5-11 (2006)

Reference

PMID:17298394

Authors

Wang B, Li S, Dedhar S, Cleary PP

Title

Paxillin phosphorylation: bifurcation point downstream of integrin-linked kinase (ILK) in streptococcal invasion.

Journal

Cell Microbiol 9:1519-28 (2007)

Reference

PMID:19185531

Authors

Matsumoto H, Young GM

Title

Translocated effectors of Yersinia.

Journal

Curr Opin Microbiol 12:94-100 (2009)

Reference

PMID:19157959

Authors

McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V

Title

Salmonella takes control: effector-driven manipulation of the host.

Journal

Curr Opin Microbiol 12:117-24 (2009)

Reference

PMID:17719540

Authors

Iwai H, Kim M, Yoshikawa Y, Ashida H, Ogawa M, Fujita Y, Muller D, Kirikae T, Jackson PK, Kotani S, Sasakawa C

Title

A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling.

Journal

Cell 130:611-23 (2007)

Reference

Authors

Ohno H, Yoshimori T (eds).

Title

[Current Stream in Membrane Traffic] (in Japanese)

Journal

Tanpakushitsu Kakusan Koso 53 (2008)

KO pathway

ko05100

All links

Pathway (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (75)   
   KEGG GENES (75)   
All databases (77)   

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