KEGG   PATHWAY: bta05162
Entry
bta05162                    Pathway                                
Name
Measles - Bos taurus (cow)
Description
Measles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. MV infection is characterized by virus-induced immune suppression that can lead to increased susceptibility to secondary bacterial and viral infections. The P, V and C proteins act as virulence factors to suppress innate immune response in host by inhibiting signaling for both type I IFN induction and JAK/STAT-mediated interferon-stimulated gene (ISG) induction. Moreover,  H protein expressed on viral particles and binding to SLAM or CD46,  as well as N protein liberated from infected cells and interacting with Fc-gamma R, causes an inhibition of IL-12 synthesis in dendritic cells. IL-12 is a key cytokine inducing cellular immune responses to protect host from the harm caused by pathogenic infections.
Class
Human Diseases; Infectious disease: viral
Pathway map
bta05162  Measles
bta05162

Organism
Bos taurus (cow) [GN:bta]
Gene
280851  CD46; membrane cofactor protein isoform 2 precursor [KO:K04007]
616002  membrane cofactor protein isoform X1 [KO:K04007]
518224  membrane cofactor protein [KO:K04007]
618087  membrane cofactor protein [KO:K04007]
540426  MSN; moesin [KO:K05763]
281489  SLAMF1; signaling lymphocytic activation molecule precursor [KO:K06536]
513266  CD209; CD209 antigen [KO:K06563]
504760  RIGI; antiviral innate immune response receptor RIG-I isoform X1 [KO:K12646] [EC:3.6.4.13]
535490  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:3.6.4.13]
618508  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
506182  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
533216  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
533141  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
516979  IRF3; interferon regulatory factor 3 [KO:K05411]
281073  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
281854  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
281855  IKBKG; NF-kappa-B essential modulator [KO:K07210]
525408  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
282291  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
616115  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
508233  RELA; transcription factor p65 [KO:K04735]
493686  TLR7; toll-like receptor 7 [KO:K05404]
282602  TLR9; toll-like receptor 9 precursor [KO:K10161]
444881  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
533953  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
533692  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
100125591  IRF7; interferon regulatory factor 7 [KO:K09447]
281236  IFNAC; interferon alpha-C precursor [KO:K05414]
510726  IFNA16; interferon alpha-H [KO:K05414]
523244  interferon alpha-B-like [KO:K05414]
517108  interferon alpha-2 [KO:K05414]
618947  interferon alpha-B-like [KO:K05414]
787343  interferon alpha-2 [KO:K05414]
515951  IFNAA; interferon alpha-A precursor [KO:K05414]
100329207  IFNAH; interferon alpha-H precursor [KO:K05414]
100335490  interferon alpha-G-like [KO:K05414]
100329204  IFNAD; interferon alpha-D [KO:K05414]
100329206  IFNAG; interferon alpha-G precursor [KO:K05414]
100329210  INFAF; interferon alpha-F precursor [KO:K05414]
783912  interferon alpha-H [KO:K05414]
281845  IFNB1; interferon beta precursor [KO:K05415]
525550  interferon beta-2 [KO:K05415]
517016  interferon beta-2 precursor [KO:K05415]
784525  interferon beta-2 [KO:K05415]
618946  IFNB3; interferon beta-3 precursor [KO:K05415]
100848709  interferon beta-3 [KO:K05415]
616977  interferon beta-2 [KO:K05415]
112441480  interferon beta-3 [KO:K05415]
112447877  interferon beta-3 [KO:K05415]
112447878  interferon beta-3 [KO:K05415]
112447879  interferon beta-3 [KO:K05415]
112447880  interferon beta-3 [KO:K05415]
112441471  interferon beta [KO:K05415]
281534  TLR2; toll-like receptor 2 precursor [KO:K10159]
281536  TLR4; toll-like receptor 4 precursor [KO:K10160]
539124  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
282419  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
282420  CSNK2A2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
539235  CSNK2B; casein kinase II subunit beta [KO:K03115]
508105  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
529146  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
540203  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
539941  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
534125  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
537631  MAPK10; mitogen-activated protein kinase 10 isoform 2 [KO:K04440] [EC:2.7.11.24]
280831  JUN; transcription factor Jun [KO:K04448]
280795  FOS; protein c-Fos [KO:K04379]
281250  IL1A; interleukin-1 alpha precursor [KO:K04383]
281251  IL1B; interleukin-1 beta precursor [KO:K04519]
280826  IL6; interleukin-6 precursor [KO:K05405]
281856  IL12A; interleukin-12 subunit alpha precursor [KO:K05406]
281857  IL12B; interleukin-12 subunit beta precursor [KO:K05425]
282257  IFNAR1; interferon alpha/beta receptor 1 precursor [KO:K05130]
282258  IFNAR2; interferon alpha/beta receptor 2 precursor [KO:K05131]
327682  RACK1; small ribosomal subunit protein RACK1 [KO:K14753]
537201  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
512484  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
510814  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
511023  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
509855  IRF9; interferon regulatory factor 9 [KO:K04693]
654488  OAS1Y; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
529660  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
347699  OAS1X; 2',5'-oligoadenylate synthetase 1, 40/46kDa [KO:K14216] [EC:2.7.7.84]
519922  OAS1Z; 2',5'-oligoadenylate synthetase 1 [KO:K14216] [EC:2.7.7.84]
505134  ADAR; double-stranded RNA-specific adenosine deaminase isoform X2 [KO:K12968] [EC:3.5.4.37]
280872  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
280873  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
507689  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
347700  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
535820  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 precursor [KO:K08860] [EC:2.7.11.1]
513829  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X2 [KO:K16196] [EC:2.7.11.1]
511776  RAB9A; ras-related protein Rab-9A [KO:K07899]
511866  RAB9B; ras-related protein Rab-9B [KO:K07900]
282254  HSPA1A; heat shock 70 kDa protein 1B [KO:K03283]
281831  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
540190  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
539835  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
506873  EIF3H; eukaryotic translation initiation factor 3 subunit H [KO:K03247]
327694  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
540733  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
281542  TP53; cellular tumor antigen p53 [KO:K04451]
515105  TP73; tumor protein p73 isoform X1 [KO:K10148]
782359  BBC3; bcl-2-binding component 3 isoform X3 [KO:K10132]
407111  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
282488  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
504707  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
493720  FADD; FAS-associated death domain protein [KO:K02373]
507481  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
510373  BID; BH3-interacting domain death agonist [KO:K04726]
280730  BAX; apoptosis regulator BAX [KO:K02159]
514090  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
281020  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
282152  BCL2L1; bcl-2-like protein 1 [KO:K04570]
615013  BAD; bcl2-associated agonist of cell death [KO:K02158]
510767  CYCS; cytochrome c [KO:K08738]
781996  CYCT; cytochrome c 2 [KO:K08738]
100847700  cytochrome c [KO:K08738]
537782  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
100140945  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
408016  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
512613  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
524530  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
615414  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
540547  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
533526  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
538436  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
510618  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
511754  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
519217  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
100300850  T cell receptor alpha variable 18 [KO:K10784]
509513  uncharacterized LOC509513 precursor [KO:K10785]
100300510  T cell receptor beta constant 1 [KO:K10785]
281053  CD3D; T-cell surface glycoprotein CD3 delta chain precursor [KO:K06450]
281054  CD3E; T-cell surface glycoprotein CD3 epsilon chain precursor [KO:K06451]
281055  CD3G; T-cell surface glycoprotein CD3 gamma chain precursor [KO:K06452]
281050  CD28; T-cell-specific surface glycoprotein CD28 precursor [KO:K06470]
280822  IL2; interleukin-2 precursor [KO:K05429]
281861  IL2RA; interleukin-2 receptor subunit alpha precursor [KO:K05068]
510185  interleukin-2 receptor subunit beta isoform X2 [KO:K05069]
104968644  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
281862  IL2RG; cytokine receptor common subunit gamma precursor [KO:K05070]
282308  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
286865  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
282307  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
282306  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
517948  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
504531  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
525906  CBLB; E3 ubiquitin-protein ligase CBL-B [KO:K22517] [EC:2.3.2.27]
534923  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
280991  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100137872  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
790875  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
538276  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
508541  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
282375  STAT5A; signal transducer and activator of transcription 5A [KO:K11223]
282376  STAT5B; signal transducer and activator of transcription 5B [KO:K11224]
282229  FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b precursor [KO:K12560]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Schneider-Schaulies S, Schneider-Schaulies J
  Title
Measles virus-induced immunosuppression.
  Journal
Curr Top Microbiol Immunol 330:243-69 (2009)
DOI:10.1007/978-3-540-70617-5_12
Reference
  Authors
Hahm B
  Title
Hostile communication of measles virus with host innate immunity and dendritic cells.
  Journal
Curr Top Microbiol Immunol 330:271-87 (2009)
DOI:10.1007/978-3-540-70617-5_13
Reference
  Authors
Gerlier D, Valentin H
  Title
Measles virus interaction with host cells and impact on innate immunity.
  Journal
Curr Top Microbiol Immunol 329:163-91 (2009)
DOI:10.1007/978-3-540-70523-9_8
Reference
  Authors
Schneider-Schaulies S, Dittmer U
  Title
Silencing T cells or T-cell silencing: concepts in virus-induced immunosuppression.
  Journal
J Gen Virol 87:1423-38 (2006)
DOI:10.1099/vir.0.81713-0
Reference
  Authors
Avota E, Gassert E, Schneider-Schaulies S
  Title
Cytoskeletal dynamics: concepts in measles virus replication and immunomodulation.
  Journal
Viruses 3:102-17 (2011)
DOI:10.3390/v3020102
Reference
  Authors
Jiang Y, Qin Y, Chen M
  Title
Host-Pathogen Interactions in Measles Virus Replication and Anti-Viral Immunity.
  Journal
Viruses 8:E308 (2016)
DOI:10.3390/v8110308
Reference
  Authors
Pfaller CK, Conzelmann KK
  Title
Measles virus V protein is a decoy substrate for IkappaB kinase alpha and prevents Toll-like receptor 7/9-mediated interferon induction.
  Journal
J Virol 82:12365-73 (2008)
DOI:10.1128/JVI.01321-08
Reference
  Authors
Yokota S, Okabayashi T, Yokosawa N, Fujii N
  Title
Measles virus P protein suppresses Toll-like receptor signal through up-regulation of ubiquitin-modifying enzyme A20.
  Journal
FASEB J 22:74-83 (2008)
DOI:10.1096/fj.07-8976com
Reference
  Authors
Delpeut S, Noyce RS, Siu RW, Richardson CD
  Title
Host factors and measles virus replication.
  Journal
Curr Opin Virol 2:773-83 (2012)
DOI:10.1016/j.coviro.2012.10.008
Reference
  Authors
Shah M, Anwar MA, Kim JH, Choi S
  Title
Advances in Antiviral Therapies Targeting Toll-like Receptors.
  Journal
Expert Opin Investig Drugs 25:437-53 (2016)
DOI:10.1517/13543784.2016.1154040
Reference
  Authors
Yokota S, Saito H, Kubota T, Yokosawa N, Amano K, Fujii N
  Title
Measles virus suppresses interferon-alpha signaling pathway: suppression of Jak1 phosphorylation and association of viral accessory proteins, C and V, with interferon-alpha receptor complex.
  Journal
Virology 306:135-46 (2003)
DOI:10.1016/S0042-6822(02)00026-0
Reference
  Authors
Takeuchi K, Kadota SI, Takeda M, Miyajima N, Nagata K
  Title
Measles virus V protein blocks interferon (IFN)-alpha/beta but not IFN-gamma signaling by inhibiting STAT1 and STAT2 phosphorylation.
  Journal
FEBS Lett 545:177-82 (2003)
DOI:10.1016/S0014-5793(03)00528-3
Reference
  Authors
Palosaari H, Parisien JP, Rodriguez JJ, Ulane CM, Horvath CM
  Title
STAT protein interference and suppression of cytokine signal transduction by measles virus V protein.
  Journal
J Virol 77:7635-44 (2003)
DOI:10.1128/JVI.77.13.7635-7644.2003
Reference
  Authors
Shaffer JA, Bellini WJ, Rota PA
  Title
The C protein of measles virus inhibits the type I interferon response.
  Journal
Virology 315:389-97 (2003)
DOI:10.1016/S0042-6822(03)00537-3
Reference
  Authors
Carsillo T, Traylor Z, Choi C, Niewiesk S, Oglesbee M
  Title
hsp72, a host determinant of measles virus neurovirulence.
  Journal
J Virol 80:11031-9 (2006)
DOI:10.1128/JVI.01438-06
Reference
  Authors
Zhang X, Bourhis JM, Longhi S, Carsillo T, Buccellato M, Morin B, Canard B, Oglesbee M
  Title
Hsp72 recognizes a P binding motif in the measles virus N protein C-terminus.
  Journal
Virology 337:162-74 (2005)
DOI:10.1016/j.virol.2005.03.035
Reference
  Authors
Ke Z, Strauss JD, Hampton CM, Brindley MA, Dillard RS, Leon F, Lamb KM, Plemper RK, Wright ER
  Title
Promotion of virus assembly and organization by the measles virus matrix protein.
  Journal
Nat Commun 9:1736 (2018)
DOI:10.1038/s41467-018-04058-2
Reference
  Authors
Pfaller CK, Radeke MJ, Cattaneo R, Samuel CE
  Title
Measles virus C protein impairs production of defective copyback double-stranded viral RNA and activation of protein kinase R.
  Journal
J Virol 88:456-68 (2014)
DOI:10.1128/JVI.02572-13
Reference
  Authors
Sato H, Masuda M, Kanai M, Tsukiyama-Kohara K, Yoneda M, Kai C
  Title
Measles virus N protein inhibits host translation by binding to eIF3-p40.
  Journal
J Virol 81:11569-76 (2007)
DOI:10.1128/JVI.00570-07
Reference
  Authors
Sion-Vardy N, Lasarov I, Delgado B, Gopas J, Benharroch D, Ariad S
  Title
Measles virus: evidence for association with lung cancer.
  Journal
Exp Lung Res 35:701-12 (2009)
DOI:10.3109/01902140902853176
Reference
  Authors
Chen M, Cortay JC, Logan IR, Sapountzi V, Robson CN, Gerlier D
  Title
Inhibition of ubiquitination and stabilization of human ubiquitin E3 ligase PIRH2 by measles virus phosphoprotein.
  Journal
J Virol 79:11824-36 (2005)
DOI:10.1128/JVI.79.18.11824-11836.2005
Reference
  Authors
Cruz CD, Palosaari H, Parisien JP, Devaux P, Cattaneo R, Ouchi T, Horvath CM
  Title
Measles virus V protein inhibits p53 family member p73.
  Journal
J Virol 80:5644-50 (2006)
DOI:10.1128/JVI.02400-05
Reference
  Authors
Servet-Delprat C, Vidalain PO, Azocar O, Le Deist F, Fischer A, Rabourdin-Combe C
  Title
Consequences of Fas-mediated human dendritic cell apoptosis induced by measles virus.
  Journal
J Virol 74:4387-93 (2000)
DOI:10.1128/JVI.74.9.4387-4393.2000
Reference
  Authors
Kushwah R, Hu J
  Title
Dendritic cell apoptosis: regulation of tolerance versus immunity.
  Journal
J Immunol 185:795-802 (2010)
DOI:10.4049/jimmunol.1000325
Reference
  Authors
Vidalain PO, Azocar O, Lamouille B, Astier A, Rabourdin-Combe C, Servet-Delprat C
  Title
Measles virus induces functional TRAIL production by human dendritic cells.
  Journal
J Virol 74:556-9 (2000)
DOI:10.1128/JVI.74.1.556-559.2000
Reference
  Authors
Vidalain PO, Azocar O, Rabourdin-Combe C, Servet-Delprat C
  Title
Measle virus-infected dendritic cells develop immunosuppressive and cytotoxic activities.
  Journal
Immunobiology 204:629-38 (2001)
DOI:10.1078/0171-2985-00102
Reference
  Authors
Engelking O, Fedorov LM, Lilischkis R, ter Meulen V, Schneider-Schaulies S
  Title
Measles virus-induced immunosuppression in vitro is associated with deregulation of G1 cell cycle control proteins.
  Journal
J Gen Virol 80 ( Pt 7):1599-608 (1999)
DOI:10.1099/0022-1317-80-7-1599
Reference
  Authors
Fan Y, Sanyal S, Bruzzone R
  Title
Breaking Bad: How Viruses Subvert the Cell Cycle.
  Journal
Front Cell Infect Microbiol 8:396 (2018)
DOI:10.3389/fcimb.2018.00396
Reference
  Authors
Griffin DE
  Title
Measles virus-induced suppression of immune responses.
  Journal
Immunol Rev 236:176-89 (2010)
DOI:10.1111/j.1600-065X.2010.00925.x
Reference
  Authors
Avota E, Avots A, Niewiesk S, Kane LP, Bommhardt U, ter Meulen V, Schneider-Schaulies S
  Title
Disruption of Akt kinase activation is important for immunosuppression induced by measles virus.
  Journal
Nat Med 7:725-31 (2001)
DOI:10.1038/89106
Reference
  Authors
Avota E, Muller N, Klett M, Schneider-Schaulies S
  Title
Measles virus interacts with and alters signal transduction in T-cell lipid rafts.
  Journal
J Virol 78:9552-9 (2004)
DOI:10.1128/JVI.78.17.9552-9559.2004
Reference
  Authors
Yanagi Y, Takeda M, Ohno S
  Title
Measles virus: cellular receptors, tropism and pathogenesis.
  Journal
J Gen Virol 87:2767-79 (2006)
DOI:10.1099/vir.0.82221-0
Reference
  Authors
Kerdiles YM, Sellin CI, Druelle J, Horvat B
  Title
Immunosuppression caused by measles virus: role of viral proteins.
  Journal
Rev Med Virol 16:49-63 (2006)
DOI:10.1002/rmv.486
Related
pathway
bta04110  Cell cycle
bta04115  p53 signaling pathway
bta04120  Ubiquitin mediated proteolysis
bta04210  Apoptosis
bta04620  Toll-like receptor signaling pathway
bta04622  RIG-I-like receptor signaling pathway
bta04630  JAK-STAT signaling pathway
bta04658  Th1 and Th2 cell differentiation
bta04660  T cell receptor signaling pathway
KO pathway
ko05162   

DBGET integrated database retrieval system