KEGG PATHWAY: bta05332

PATHWAY: bta05332

Entry

bta05332 Pathway

Name

Graft-versus-host disease - Bos taurus (cow)

Description

Graft-versus-host disease (GVHD) is a lethal complication of allogeneic hematopoietic stem cell transplantation (HSCT) where immunocompetent donor T cells attack the genetically disparate host cells. GVHD pathophysiology can be summerized in a three-step process. Step 1 involves the development of an inflammatory milieu resulting from damage in the host tissues induced by the preparative chemotherapy or radiotherapy regimen. Damaged tissues secrete inflammatory cytokines, including interleukin 1 (IL-1), and tumor necrosis factor (TNF-alpha ). During step 2, antigen-presenting cells (APCs) trigger the activation of donor-derived T cells, which induce further T-cell expansion, induce cytotoxic T lymphocytes (CTL) and natural killer (NK) cells responses and prime additional mononuclear phagocytes to produce TNF-alpha and IL-1. Also, nitric oxide (NO) is produced by activated macrophages, and it may contribute to the tissue damage seen during step 3. During step 3, the effector phase, activated CTL and NK cells mediate cytotoxicity against target host cells through Fas-Fas ligand interactions and perforin-granzyme B.

Class

Human Diseases; Immune diseases

Pathway map

bta05332

Graft-versus-host disease

Organism

Bos taurus (cow) [GN:bta]

Gene

280826	IL6; interleukin 6 (interferon, beta 2) [KO:K05405]
281250	IL1A; interleukin 1, alpha [KO:K04383]
281251	IL1B; interleukin 1, beta [KO:K04519]
280943	TNF; tumor necrosis factor [KO:K03156]
282490	BOLA-DMA; major histocompatibility complex, class II, DM alpha [KO:K06752]
282491	BOLA-DMB; major histocompatibility complex, class II, DM beta [KO:K06752]
282493	BOLA-DOB; major histocompatibility complex, class II, DO beta [KO:K06752]
282494	BOLA-DQA5; major histocompatibility complex, class II, DQ alpha 5 [KO:K06752]
282495	BOLA-DQB; major histocompatibility complex, class II, DQ beta [KO:K06752]
282498	BOLA-DYB; major histocompatibility complex, class II, DY beta [KO:K06752]
282534	BOLA-DQA1; major histocompatibility complex, class II, DQ alpha, type 1 [KO:K06752]
282535	BOLA-DQA2; major histocompatibility complex, class II, DQ alpha 2 [KO:K06752]
282530	BOLA-DRB3; major histocompatibility complex, class II, DRB3 [KO:K06752]
525727	BOLA-DOA; major histocompatibility complex, class II, DO alpha [KO:K06752]
506214	BOLA-DRA; major histocompatibility complex, class II, DR alpha [KO:K06752]
539241	BLA-DQB; MHC class II antigen [KO:K06752]
790858	LA-DQB; MHC cell surface glycoprotein [KO:K06752]
100848815	SLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
100296598	uncharacterized LOC100296598; K10784 T cell receptor alpha chain V region [KO:K10784]
785283	uncharacterized LOC785283; K10784 T cell receptor alpha chain V region [KO:K10784]
509513	uncharacterized LOC509513; K10785 T-cell receptor beta chain V region [KO:K10785]
100335899	T-cell receptor beta chain T17T-22-like; K10785 T-cell receptor beta chain V region [KO:K10785]
100850620	T-cell receptor beta chain T17T-22-like; K10785 T-cell receptor beta chain V region [KO:K10785]
100850312	T-cell receptor beta chain T17T-22-like; K10785 T-cell receptor beta chain V region [KO:K10785]
100300282	T-cell receptor beta chain T17T-22-like; K10785 T-cell receptor beta chain V region [KO:K10785]
100336183	uncharacterized LOC100336183; K10785 T-cell receptor beta chain V region [KO:K10785]
510649	immunoglobulin iota chain-like; K10785 T-cell receptor beta chain V region [KO:K10785]
407131	CD80; CD80 molecule [KO:K05412]
414345	CD86; CD86 molecule [KO:K05413]
281050	CD28; CD28 molecule [KO:K06470]
280822	IL2; interleukin 2 [KO:K05429]
407173	JSP.1; MHC Class I JSP.1 [KO:K06751]
512672	major histocompatibility complex; K06751 major histocompatibility complex, class I [KO:K06751]
100126048	BOLA-N; MHC class I antigen [KO:K06751]
515712	BOLA; MHC class I heavy chain [KO:K06751]
782684	BOLA-A; major histocompatibility complex, class I, A [KO:K06751]
507917	BOLA; MHC class I heavy chain [KO:K06751]
509006	class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
767904	uncharacterized protein MGC126945; K06751 major histocompatibility complex, class I [KO:K06751]
407111	FASLG; Fas ligand (TNF superfamily, member 6) [KO:K04389]
100852284	tumor necrosis factor ligand superfamily member 6-like; K04389 tumor necrosis factor ligand superfamily member 6 [KO:K04389]
282488	FAS; Fas (TNF receptor superfamily, member 6) [KO:K04390]
369025	PRF1; perforin 1 (pore forming protein) [KO:K07818]
508646	GZMB; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) [KO:K01353] [EC:3.4.21.79]
281731	GZMB; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) [KO:K01353] [EC:3.4.21.79]
281237	IFNG; interferon, gamma [KO:K04687]

Compound

C00338	Lipopolysaccharide
C00533	Nitric oxide

Reference

PMID:16412784

Authors

Ferrara JL, Reddy P.

Title

Pathophysiology of graft-versus-host disease.

Journal

Semin Hematol 43:3-10 (2006)

Reference

PMID:14735553

Authors

Reddy P.

Title

Pathophysiology of acute graft-versus-host disease.

Journal

Hematol Oncol 21:149-61 (2003)

Reference

PMID:17900507

Authors

Sun Y, Tawara I, Toubai T, Reddy P.

Title

Pathophysiology of acute graft-versus-host disease: recent advances.

Journal

Transl Res 150:197-214 (2007)

Reference

PMID:15882431

Authors

Jaksch M, Mattsson J.

Title

The pathophysiology of acute graft-versus-host disease.

Journal

Scand J Immunol 61:398-409 (2005)

Reference

PMID:12359826

Authors

Vogelsang GB, Lee L, Bensen-Kennedy DM.

Title

Pathogenesis and treatment of graft-versus-host disease after bone marrow transplant.

Journal

Annu Rev Med 54:29-52 (2003)

Reference

PMID:14556773

Authors

Reddy P, Ferrara JL.

Title

Immunobiology of acute graft-versus-host disease.

Journal

Blood Rev 17:187-94 (2003)

Reference

PMID:16147539

Authors

Blazar BR, Murphy WJ.

Title

Bone marrow transplantation and approaches to avoid graft-versus-host disease (GVHD).

Journal

Philos Trans R Soc Lond B Biol Sci 360:1747-67 (2005)

Reference

PMID:15372473

Authors

Couriel D, Caldera H, Champlin R, Komanduri K.

Title

Acute graft-versus-host disease: pathophysiology, clinical manifestations, and management.

Journal

Cancer 101:1936-46 (2004)

Reference

PMID:17784964

Authors

Jacobsohn DA, Vogelsang GB.

Title

Acute graft versus host disease.

Journal

Orphanet J Rare Dis 2:35 (2007)

KO pathway

ko05332

All links

Pathway (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (48)   
   KEGG GENES (48)   
All databases (50)   

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