| Entry |
|
|---|
| Name |
Homologous recombination - Bacillus thuringiensis MC28
|
|---|
| Description |
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
|
|---|
| Class |
Genetic Information Processing; Replication and repair
 |
|---|
| Pathway map |
  |
|---|
| Module |
| DNA polymerase III complex, bacteria [PATH: btm03440] | | | | | | | | BRCA1-associated genome surveillance complex (BASC) [PATH: btm03440] |
|
|---|
| Other DBs |
|
|---|
| Organism |
Bacillus thuringiensis MC28 [GN: btm]
|
|---|
| Gene |
| hypothetical protein; K07462 single-stranded-DNA-specific exonuclease [EC:3.1.-.-] [KO: K07462] [EC:3.1.-.-] | | acetyltransferase; K03111 single-strand DNA-binding protein [KO: K03111] | | Cobalt transport protein; K03111 single-strand DNA-binding protein [KO: K03111] | | acylamino-acid-releasing enzyme; K03629 DNA replication and repair protein RecF [KO: K03629] | | exonuclease RecJ; K03584 DNA repair protein RecO (recombination protein O) [KO: K03584] | | oligopeptide ABC transporter substrate-binding protein; K06187 recombination protein RecR [KO: K06187] | | trmFO; methylenetetrahydrofolate--tRNA--methyltransferase trmFO [KO: K03553] | | DNA protecting protein DprA; K03553 recombination protein RecA [KO: K03553] | | DeoR family transcriptional regulator; K02335 DNA polymerase I [EC: 2.7.7.7] [KO: K02335] [EC: 2.7.7.7] | | | | periplasmic binding protein; K03551 holliday junction DNA helicase RuvB [EC: 3.6.4.12] [KO: K03551] [EC: 3.6.4.12] | | | | | | moaC; Molybdenum cofactor biosynthesis protein C [KO: K02337] [EC: 2.7.7.7] | | hypothetical protein; K03763 DNA polymerase III subunit alpha, Gram-positive type [EC: 2.7.7.7] [KO: K03763] [EC: 2.7.7.7] | | | | glmS; glucosamine--fructose-6-phosphate aminotransferase [KO: K02338] [EC: 2.7.7.7] | | oligopeptide ABC transporter permease; K02343 DNA polymerase III subunit gamma/tau [EC: 2.7.7.7] [KO: K02343] [EC: 2.7.7.7] | | ABC transporter permease; K02340 DNA polymerase III subunit delta [EC: 2.7.7.7] [KO: K02340] [EC: 2.7.7.7] | | pyrroline-5-carboxylate reductase; K02341 DNA polymerase III subunit delta' [EC: 2.7.7.7] [KO: K02341] [EC: 2.7.7.7] | | glycosyl transferase group 1; K02342 DNA polymerase III subunit epsilon [EC: 2.7.7.7] [KO: K02342] [EC: 2.7.7.7] | | prophage LambdaBa02; K04066 primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:3.6.4.-] [KO: K04066] [EC:3.6.4.-] |
|
|---|
| Reference |
|
|---|
| Authors |
Maloisel L, Fabre F, Gangloff S. |
|---|
| Title |
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension. |
|---|
| Journal |
Mol Cell Biol 28:1373-82 (2008) |
|---|
| Reference |
|
|---|
| Authors |
Haruta-Takahashi N, Iwasaki H. |
|---|
| Title |
[Recombination mediators] Japanese |
|---|
| Journal |
Seikagaku 79:449-53 (2007) |
|---|
| Reference |
|
|---|
| Authors |
Ouyang KJ, Woo LL, Ellis NA. |
|---|
| Title |
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases. |
|---|
| Journal |
Mech Ageing Dev 129:425-40 (2008) |
|---|
| Reference |
|
|---|
| Authors |
Kawabata M, Kawabata T, Nishibori M. |
|---|
| Title |
Role of recA/RAD51 family proteins in mammals. |
|---|
| Journal |
Acta Med Okayama 59:1-9 (2005) |
|---|
| Reference |
|
|---|
| Authors |
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A. |
|---|
| Title |
Mitotic recombination in Saccharomyces cerevisiae. |
|---|
| Journal |
Curr Genet 42:185-98 (2003) |
|---|
| Reference |
|
|---|
| Authors |
Heyer WD, Li X, Rolfsmeier M, Zhang XP. |
|---|
| Title |
Rad54: the Swiss Army knife of homologous recombination? |
|---|
| Journal |
Nucleic Acids Res 34:4115-25 (2006) |
|---|
| Reference |
|
|---|
| Authors |
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R. |
|---|
| Title |
Recombination proteins and rescue of arrested replication forks. |
|---|
| Journal |
DNA Repair (Amst) 6:967-80 (2007) |
|---|
| Reference |
|
|---|
| Authors |
Hanaoka F. |
|---|
| Title |
[DNA Replication and Repair] (In Japanese) |
|---|
| Journal |
Yodosha (2004) |
|---|
| Reference |
|
|---|
| Authors |
Ohashi E, Ohmori H. |
|---|
| Title |
[The cross talk of the DNA replication and repair in Escherichia coli.] ( In Japanese) |
|---|
| Journal |
Cell Technology 19:1449-53 (2000) |
|---|
| KO pathway |
|
|---|
