KEGG   PATHWAY: btm03440Help
Entry
btm03440                    Pathway                                

Name
Homologous recombination - Bacillus thuringiensis MC28
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
btm03440  Homologous recombination
btm03440

Ortholog table
Module
btm_M00260  DNA polymerase III complex, bacteria [PATH:btm03440]
Other DBs
BSID: 696320
GO: 0000724
Organism
Bacillus thuringiensis MC28 [GN:btm]
Gene
MC28_3701  Exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
MC28_4705  ssb; Single-stranded DNA-binding protein [KO:K03111]
MC28_4724  recF; DNA replication and repair protein recF [KO:K03629]
MC28_3589  recO; DNA repair protein recO [KO:K03584]
MC28_4740  recR; recombination protein RecR [KO:K06187]
MC28_2948  recA; recombinase A [KO:K03553]
MC28_3865  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
MC28_3713  ruvA; Holliday junction ATP-dependent DNA helicase ruvA [KO:K03550] [EC:3.6.4.12]
MC28_3712  ruvB; Holliday junction DNA helicase B [KO:K03551] [EC:3.6.4.12]
MC28_3078  ATP-dependent DNA helicase recG [KO:K03655] [EC:3.6.4.12]
MC28_3685  Helicase, RecD/TraA [KO:K03581] [EC:3.1.11.5]
MC28_3882  DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
MC28_3041  polC; DNA polymerase III polC-type [KO:K03763] [EC:2.7.7.7]
MC28_1884  DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
MC28_4722  DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
MC28_4738  DNA polymerase III subunit gamma/tau [KO:K02343] [EC:2.7.7.7]
MC28_3614  DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
MC28_4746  DNA polymerase III, delta prime subunit [KO:K02341] [EC:2.7.7.7]
MC28_2759  DNA polymerase III alpha subunit [KO:K02342] [EC:2.7.7.7]
MC28_3091  primosomal protein N` [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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