KEGG   PATHWAY: cal04111Help
Entry
cal04111                    Pathway                                

Name
Cell cycle - yeast - Candida albicans
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps (G1 and G2 phases). G1, S, and G2 phases are collectively known as interphase. In yeast Cdc28 is the catalytic subunit of the cyclin-dependent kinase (CDK). At G1 phase Cdc28 associates with G1-cyclins Cln1 to Cln3, while B-type cyclins Clb1 to Clb6 regulate Cdc28 during S, G2, and M phases. Cln3/Cdc28 activity is required for cells to pass through 'start', the commitment point in G1. When Cln3/Cdc28 accumulates more than a certain threshold, SBF (Swi4/Swi6) and MBF (Mbp1/Swi6) are activated, promoting transcription of Cln1, Cln2, and other genes required for S-phase progression. Cln1 and Cln2 interacting with Cdc28 promote activation of B-type cyclin associated CDK, which drives DNA replication and entry into mitosis. Specifically, Cdc28 association with Clb2 and Clb1 promotes entry into mitosis. Cells suffering from DNA damage, spindle misorientation, or spindle assembly defect do not undergo the metaphase-anaphase transition for chromosome segregation and fail to exit from mitosis. The spindle assembly checkpoint activates Mad2, which in turn prevents chromosome segregation by inhibiting degradation of the securin Pds1. Moreover, Pds1 is phosphorylated and stabilized in response to DNA damage in a Chk1-dependent manner. The spindle checkpoint is also involved in the Cdc14 release from the nucleolus. Cdc14 dephosphorylates Swi5, Sic1, and Cdh1, leading to inhibition of Cdc28 and degradation of cyclin required for mitotic exit.
Class
Cellular Processes; Cell growth and death
BRITE hierarchy
Pathway map
Cell cycle - yeast
cal04111

All organismsOrtholog table
Module
Origin recognition complex [PATH:cal04111]
MCM complex [PATH:cal04111]
Other DBs
BSID: 
GO: 
Organism
Candida albicans [GN:cal]
Gene
CLN2; G1 cyclin most similar to S. cerevisiae CLN3 (YAL040C) cyclin-dependent protein kinase involved in G1/S transition [KO:K06646]
CLN2; G1 cyclin most similar to S. cerevisiae CLN3 (YAL040C) cyclin-dependent protein kinase involved in G1/S transition [KO:K06646]
CDC28; Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase [KO:K04563] [EC:2.7.11.22]
CDC28; Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase [KO:K04563] [EC:2.7.11.22]
SWI4; similar to S. cerevisiae SWI4 (YER111C) DNA binding subunit of cyclin gene-controlling transcription factor SBF [KO:K06649]
SWI4; similar to S. cerevisiae SWI4 (YER111C) DNA binding subunit of cyclin gene-controlling transcription factor SBF [KO:K06649]
SWI6; potential ankyrin repeat protein similar to S. cerevisiae SWI6 (YLR182W) transcriptional co-activator subunit of the SBF and MBF cell cycle control transcription factors [KO:K06648]
SWI6; potential ankyrin repeat protein similar to S. cerevisiae SWI6 (YLR182W) transcriptional co-activator subunit of the SBF and MBF cell cycle control transcription factors [KO:K06648]
MBP1; similar to S. cerevisiae MBP1 (YDL056W) DNA binding subunit of transcription factor MBF which governs genes required for DNA replication [KO:K06647]
MBP1; similar to S. cerevisiae MBP1 (YDL056W) DNA binding subunit of transcription factor MBF which governs genes required for DNA replication [KO:K06647]
CDC6; similar to S. cerevisiae CDC6 (YJL194W) component of DNA replication initiation complex [KO:K02213]
ORC1; Origin recognition complex 1 protein [KO:K02603]
ORC1; Origin recognition complex 1 protein [KO:K02603]
ORC2; DNA replication origin binding [KO:K02604]
ORC2; DNA replication origin binding [KO:K02604]
ORC3; origin recognition complex, 62kDa unit [KO:K02605]
ORC3; origin recognition complex, 62kDa unit [KO:K02605]
ORC4; Origin recognition complex 56 kDa subunit [KO:K02606]
ORC4; Origin recognition complex 56 kDa subunit [KO:K02606]
ORC5; similar to S. cerevisiae origin recognition complex fifth largest subunit ORC5 (YNL261W) [KO:K02607]
ORC5; similar to S. cerevisiae origin recognition complex fifth largest subunit ORC5 (YNL261W) [KO:K02607]
ORC6; similar to S. cerevisiae origin recognition complex (ORC) component [KO:K02608]
ORC6; similar to S. cerevisiae origin recognition complex (ORC) component [KO:K02608]
MCM2; ATP-dependent DNA helicase [KO:K02540] [EC:3.6.4.12]
MCM2; ATP-dependent DNA helicase [KO:K02540] [EC:3.6.4.12]
MCM3; initiation of replication [KO:K02541] [EC:3.6.4.12]
MCM3; initiation of replication [KO:K02541] [EC:3.6.4.12]
CDC54; DNA synthesis initiation [KO:K02212] [EC:3.6.4.12]
CDC54; DNA synthesis initiation [KO:K02212] [EC:3.6.4.12]
CDC46; part of ARS replication initiation complex [KO:K02209] [EC:3.6.4.12]
CDC46; part of ARS replication initiation complex [KO:K02209] [EC:3.6.4.12]
MCM6; DNA replication [KO:K02542] [EC:3.6.4.12]
MCM6; DNA replication [KO:K02542] [EC:3.6.4.12]
CDC47; chromatin binding/ DNA replication [KO:K02210] [EC:3.6.4.12]
CDC47; chromatin binding/ DNA replication [KO:K02210] [EC:3.6.4.12]
CDC7; protein serine/threonine kinase [KO:K02214] [EC:2.7.11.1]
CaJ7_0336; hypothetical protein [KO:K02309]
DBF4; regulator of Cdc7 kinase [KO:K02309]
CDC45; N terminal fragment of Chromosomal DNA replication initiation protein CDC45 [KO:K06628]
CDC45; Similar to S. cerevisiae CDC45 (YLR103C) chromosomal DNA replication initiation protein [KO:K06628]
cell-type-specific transc.; K12412 pheromone receptor transcription factor [KO:K12412]
CaJ7_0107; hypothetical protein [KO:K12412]
FAR1; cyclin-dependent protein kinase inhibitor [KO:K06652]
APC1; similar to S. cerevisiae APC1 (YNL172W) anaphase promoting complex ubiquitin ligase subunit [KO:K03348]
APC1; similar to S. cerevisiae APC1 (YNL172W) anaphase promoting complex ubiquitin ligase subunit [KO:K03348]
APC2; similar to S. cerevisiae APC2 (YLR127C) anaphase promoting complex subunit [KO:K03349]
APC2; similar to S. cerevisiae APC2 (YLR127C) anaphase promoting complex subunit [KO:K03349]
CDC27; similar to S. cerevisiae CDC27 (YBL084C) anaphase promoting complex TPR repeat subunit [KO:K03350]
CDC27; similar to S. cerevisiae CDC27 (YBL084C) anaphase promoting complex TPR repeat subunit [KO:K03350]
hypothetical protein; K03351 anaphase-promoting complex subunit 4 [KO:K03351]
APC5; similar to S. cerevisiae APC5 (YOR249C) anaphase-promoting complex subunit [KO:K03352]
APC5; similar to S. cerevisiae APC5 (YOR249C) anaphase-promoting complex subunit [KO:K03352]
CDC16; similar to S. cerevisiae CDC16 (YKL022C) anaphase-promoting complex metal-binding, nucleic acid-binding subunit [KO:K03353]
CDC16; similar to S. cerevisiae CDC16 (YKL022C) anaphase-promoting complex metal-binding, nucleic acid-binding subunit [KO:K03353]
CDC23; similar to S. cerevisiae CDC23 (YHR166C) anaphase-promoting complex subunit [KO:K03355]
CDC23; similar to S. cerevisiae CDC23 (YHR166C) anaphase-promoting complex subunit [KO:K03355]
APC10; similar to S. pombe APC10 (SPBC1A4.01) and S. cerevisiae APC10 (YGL240W) anaphase promoting complex processivity factor [KO:K03357]
APC10; similar to S. pombe APC10 (SPBC1A4.01) and S. cerevisiae APC10 (YGL240W) anaphase promoting complex processivity factor [KO:K03357]
APC11; similar to S. cerevisiae APC11 (YDL008W) anaphase promoting complex subunit [KO:K03358]
CDC20; similar to S. cerevisiae CDC20 (YGL116W) activator of anaphase promoting complex [KO:K03363]
CDC20; similar to S. cerevisiae CDC20 (YGL116W) activator of anaphase promoting complex [KO:K03363]
SKP1; kinetochore complex [KO:K03094]
SKP1; kinetochore complex [KO:K03094]
CDC53; cullin component of SCF ubiquitin ligase complex [KO:K03347]
CDC53; cullin component of SCF ubiquitin ligase complex [KO:K03347]
GRR1; ubiquitin-protein ligase [KO:K03360]
GRR1; ubiquitin-protein ligase [KO:K03360]
CDC4; similar to S. cerevisiae CDC4 (YFL009W) ubiquitin ligase subunit [KO:K03361]
CDC4; similar to S. cerevisiae CDC4 (YFL009W) ubiquitin ligase subunit [KO:K03361]
PCL1; G1 cyclin [KO:K06656]
PCL2; G1 cyclin [KO:K06657]
PHO85; cyclin-dependent kinase, negative regulator of PHO system [KO:K06655] [EC:2.7.11.22]
PHO85; cyclin-dependent kinase, negative regulator of PHO system [KO:K06655] [EC:2.7.11.22]
PHO81; similar to S. cerevisiae positive regulatory protein of phosphate pathway PHO81, but PHO81-specific C terminal region does not match [KO:K06653]
PHO80; similar to S. cerevisiae Pho80p cyclin: negative regulator of PHO81 and PHO5 [KO:K06654]
PHO80; similar to S. cerevisiae Pho80p cyclin: negative regulator of PHO81 and PHO5 [KO:K06654]
similar to conserved hypothetical protein; potential Helix-loop-helix DNA-binding domain [KO:K06658]
PHO2; similar to homeobox transcription factor, positive regulator of PHO5 and other genes [KO:K02646]
PHO2; similar to homeobox transcription factor, positive regulator of PHO5 and other genes [KO:K02646]
CYB2; likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition [KO:K06659]
CaJ7_0452; hypothetical protein [KO:K06659]
MPS1; protein threonine/tyrosine kinase [KO:K08866] [EC:2.7.12.1]
MAD1; coiled-coil protein [KO:K06679]
MAD1; coiled-coil protein [KO:K06679]
MAD2; spindle-assembly checkpoint protein [KO:K02537]
MAD2; spindle-assembly checkpoint protein [KO:K02537]
BUB1; kinase/cell cycle arrest/microtubule function [KO:K02178] [EC:2.7.11.1]
BUB1; kinase/cell cycle arrest/microtubule function [KO:K02178] [EC:2.7.11.1]
BUB3; Role in cell cycle arrest at microtubule failure [KO:K02180]
BUB3; Role in cell cycle arrest at microtubule failure [KO:K02180]
similar to S. cerevisiae YGR113W; K02307 DASH complex subunit DAM1 [KO:K02307]
similar to S. cerevisiae YGR113W; K02307 DASH complex subunit DAM1 [KO:K02307]
ESP1; separin protein [KO:K02365] [EC:3.4.22.49]
ESP1; separin protein [KO:K02365] [EC:3.4.22.49]
CDC55; subunit of protein phosphatase 2A [KO:K04354]
CDC55; subunit of protein phosphatase 2A [KO:K04354]
PPH21; Serine-Threonine protein phosphatase 2A. [KO:K04382] [EC:3.1.3.16]
PPH21; Serine-Threonine protein phosphatase 2A. [KO:K04382] [EC:3.1.3.16]
TPD3; protein phosphatase 2A regulatory subunit A [KO:K03456]
TPD3; protein phosphatase 2A regulatory subunit A [KO:K03456]
CDC5; protein serine/threonine kinase [KO:K06660] [EC:2.7.11.21]
CDC5; protein serine/threonine kinase [KO:K06660] [EC:2.7.11.21]
BFA1; weak similarity to C termini of S. pombe byr4 (SPAC222.10c) and S. cerevisiae BFA1 (YJR053W) which both function in spindle checkpoint [KO:K02181]
BUB2; spindle pole body component [KO:K02179]
BUB2; spindle pole body component [KO:K02179]
LTE1; GDP/GTP exchange factor [KO:K06681]
LTE1; GDP/GTP exchange factor [KO:K06681]
SPG1; potential Ras family GTPase similar to S. pombe septation regulator spg1 (SPAC1565.06c) and to S. cerevisiae TEM1 (YML064C) involved in termination of M phase [KO:K06682]
SEP; potential protein kinase similar to A.nidulans gene (sepH) required for septation in cytokinesis [KO:K06683] [EC:2.7.11.1]
CDC15; MAPKKK essential for late nuclear division [KO:K06683] [EC:2.7.11.1]
DBF2; kinase required for late nuclear division [KO:K06684] [EC:2.7.11.-]
DBF2; kinase required for late nuclear division [KO:K06684] [EC:2.7.11.-]
MOB1; similar to C terminus of S. cerevisiae MOB1 [KO:K06685]
MOB1; similar to C terminus of S. cerevisiae MOB1 [KO:K06685]
CDC14; similar to S. cerevisiae CDC14 (YFR028C) protein phosphatase involved in exit from mitosis [KO:K06639] [EC:3.1.3.48 3.1.3.16]
CDC14; similar to S. cerevisiae CDC14 (YFR028C) protein phosphatase involved in exit from mitosis [KO:K06639] [EC:3.1.3.48 3.1.3.16]
CDH1; Clb2p cyclin proteolysis [KO:K03364]
CDH1; Clb2p cyclin proteolysis [KO:K03364]
CYB1; likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction [KO:K02220]
CYB1; likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction [KO:K02220]
MIH1; similar to A.nidulans mitotic inducer phosphatase NIMT/CDC25 and to S. cerevisiae MIH1 (YMR036C) [KO:K02555] [EC:3.1.3.48]
CAK1; similar to S. cerevisiae CAK1 (YFL029C) cyclin-dependent kinase-activating kinase [KO:K06667] [EC:2.7.11.22]
CAK1; similar to S. cerevisiae CAK1 (YFL029C) cyclin-dependent kinase-activating kinase [KO:K06667] [EC:2.7.11.22]
CKS1; subunit of Cdc28 protein kinase [KO:K02219]
CKS1; subunit of Cdc28 protein kinase [KO:K02219]
SWE1; similar to S. cerevisiae serine/tyrosine dual-specificity protein kinase that inhibits G2/M transition [KO:K03114] [EC:2.7.11.1]
SWE1; similar to S. cerevisiae serine/tyrosine dual-specificity protein kinase that inhibits G2/M transition [KO:K03114] [EC:2.7.11.1]
MET30; WD40 domain/F-box protein similar to N. crassa SCON2 negative regulator of sulfur catabolism genes and to S. cerevisiae MET30 (YIL046W) regulator of MET4 [KO:K10259]
MET30; WD40 domain/F-box protein similar to N. crassa SCON2 negative regulator of sulfur catabolism genes and to S. cerevisiae MET30 (YIL046W) regulator of MET4 [KO:K10259]
HSL1; similar to S. cerevisiae HSL1 (YKL101W) serine/threonine-protein kinase involved in cell cycle control [KO:K02515] [EC:2.7.11.-]
HSL1; similar to S. cerevisiae HSL1 (YKL101W) serine/threonine-protein kinase involved in cell cycle control [KO:K02515] [EC:2.7.11.-]
GIN4; bud neck kinase [KO:K06668] [EC:2.7.11.-]
GIN4; bud neck kinase [KO:K06668] [EC:2.7.11.-]
MEC3; checkpoint control and DNA repair [KO:K02544]
MEC3; checkpoint control and DNA repair [KO:K02544]
DDC1; DNA damage checkpoint gene [KO:K06663]
DDC1; DNA damage checkpoint gene [KO:K06663]
RAD17; putative 3'-5exonuclease [KO:K02830] [EC:3.1.11.2]
RAD17; putative 3'-5exonuclease [KO:K02830] [EC:3.1.11.2]
RAD24; similar to S. cerevisiae nucleotide excision repair, checkpoint protein [KO:K06662]
RAD24; similar to S. cerevisiae nucleotide excision repair, checkpoint protein [KO:K06662]
MEC1; potential phosphatidylinositol kinase similar to S. cerevisiae MEC1 (YBR136W) involved in DNA repair and recombination [KO:K02543]
MEC1; potential phosphatidylinositol kinase similar to S. cerevisiae MEC1 (YBR136W) involved in DNA repair and recombination [KO:K02543]
hypothetical protein; K12578 DNA damage checkpoint protein LCD1 [KO:K12578]
hypothetical protein; K12578 DNA damage checkpoint protein LCD1 [KO:K12578]
RAD9; contains BRCT domain found in cell cycle checkpoint proteins responsive to DNA damage [KO:K06661]
RAD9; contains BRCT domain found in cell cycle checkpoint proteins responsive to DNA damage [KO:K06661]
similar to S. cerevisiae Mediator of Replication Checkpoint MRC1 (YCL061C) involved in chromatin silencing at telomeres; K11272 mediator of replication checkpoint protein 1 [KO:K11272]
similar to S. cerevisiae Mediator of Replication Checkpoint MRC1 (YCL061C) involved in chromatin silencing at telomeres; K11272 mediator of replication checkpoint protein 1 [KO:K11272]
RAD53; protein kinase [KO:K02831] [EC:2.7.11.-]
RAD53; protein kinase [KO:K02831] [EC:2.7.11.-]
DUN1; kinase involved in DNA repair [KO:K06641] [EC:2.7.11.1]
DUN1; kinase involved in DNA repair [KO:K06641] [EC:2.7.11.1]
RFX1; likely RFX family DNA binding protein similar to S. cerevisiae RFX1 involved in DNA damage response [KO:K09175]
RFX1; likely RFX family DNA binding protein similar to S. cerevisiae RFX1 involved in DNA damage response [KO:K09175]
CYC8; General repressor of transcription [KO:K06665]
CYC8; General repressor of transcription [KO:K06665]
TUP1; transcriptional repressor of filamentous growth [KO:K06666]
TUP1; transcriptional repressor of filamentous growth [KO:K06666]
SMC1; potential SMC chromosomal ATPase similar to S. cerevisiae SMC1 (YFL008W) nuclear cohesin complex ATPase [KO:K06636]
SMC1; potential SMC chromosomal ATPase similar to S. cerevisiae SMC1 (YFL008W) nuclear cohesin complex ATPase [KO:K06636]
SMC3; N terminal fragment of SMC3-like CaP19.7895 [KO:K06669]
SMC3; potential SMC chromosomal ATPase similar to S. cerevisiae SMC3 (YJL074C) nuclear cohesin complex ATPase [KO:K06669]
MCD1; similar to S. cerevisiae MCD1 (YDL003W) sister chromatid cohesin complex subunit [KO:K06670]
IRR1; similar to N terminus of S. cerevisiae IRR1 (YIL026C) cohesin complex subunit [KO:K06671]
SCC2; similar to S. cerevisiae SCC2 (YDR180W) mitotic sister chromatid cohesin protein [KO:K06672]
SMC2; potential SMC chromosomal ATPase similar to S. cerevisiae SMC2 (YFR031C) nuclear condensin complex ATPase [KO:K06674]
SMC2; potential SMC chromosomal ATPase similar to S. cerevisiae SMC2 (YFR031C) nuclear condensin complex ATPase [KO:K06674]
SMC4; potential SMC chromosomal ATPase similar to S. cerevisiae SMC4 (YLR086W) nuclear condensin complex ATPase [KO:K06675]
SMC4; potential SMC chromosomal ATPase similar to S. cerevisiae SMC4 (YLR086W) nuclear condensin complex ATPase [KO:K06675]
BRN1; similar to S. pombe cnd2 (SPCC306.03c) and S. cerevisiae BRN1 (YBL097W) nuclear condensin complex subunit [KO:K06676]
BRN1; similar to S. pombe cnd2 (SPCC306.03c) and S. cerevisiae BRN1 (YBL097W) nuclear condensin complex subunit [KO:K06676]
YCS4; similar to S. cerevisiae YCS4 (YLR272C) nuclear condensin complex subunit [KO:K06677]
YCS4; similar to S. cerevisiae YCS4 (YLR272C) nuclear condensin complex subunit [KO:K06677]
YCG1; similar to S. cerevisiae YCG1 (YDR325W) Condensin G, mitotic chromosome condensation factor [KO:K06678]
YCG1; similar to S. cerevisiae YCG1 (YDR325W) Condensin G, mitotic chromosome condensation factor [KO:K06678]
DBF4; regulator of Cdc7 kinase [KO:K02309]
Compound
C00009  
Orthophosphate
C00575  
3',5'-Cyclic AMP
Reference
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Reference
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Reference
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Reference
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Reference
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Reference
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Reference
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Reference
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Reference
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Reference
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  Title
Together until separin do us part.
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