| Entry |
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| Name |
Regulation of autophagy - Candida albicans
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| Class |
Cellular Processes; Transport and catabolism
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| Pathway map |
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| Other DBs |
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| Organism |
Candida albicans [GN: cal]
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| Gene |
| ATG1; likely protein kinase similar to S. cerevisiae ATG1 (YGL180W) protein kinase required for autophagy and cytoplasm-to-vacuole targeting [KO: K08269] [EC: 2.7.11.1] | | ATG1; likely protein kinase similar to S. cerevisiae ATG1 (YGL180W) protein kinase required for autophagy and cytoplasm-to-vacuole targeting [KO: K08269] [EC: 2.7.11.1] | | ATG17; weak similarity to S. cerevisiae ATG17 (YLR423C) activator of Atg1 protein kinase [KO: K08329] | | ATG17; weak similarity to S. cerevisiae ATG17 (YLR423C) activator of Atg1 protein kinase [KO: K08329] | | ATG11; similar to S. cerevisiae ATG11 (YPR049C) involved in protein-vacuolar targeting and pexophagy [KO: K08330] | | ATG11; similar to S. cerevisiae ATG11 (YPR049C) involved in protein-vacuolar targeting and pexophagy [KO: K08330] | | similar to S. pombe SPAC4F10.07c; K08331 autophagy-related protein 13 [KO: K08331] | | similar to S. pombe SPAC4F10.07c; K08331 autophagy-related protein 13 [KO: K08331] | | VAC8; vacuolar inheritance and protein targeting [KO: K08332] | | VAC8; vacuolar inheritance and protein targeting [KO: K08332] | | VPS15; similar to N terminal half of VPS15 protein kinase involved in vacuolar protein sorting [KO: K08333] [EC: 2.7.11.1] | | VPS15; similar to N terminal half of VPS15 protein kinase involved in vacuolar protein sorting [KO: K08333] [EC: 2.7.11.1] | | VPS30; weak similarity to VPS30, role in vacuolar protein sorting [KO: K08334] | | | | | | ATG12; similar to S. cerevisiae ATG12 (YBR217W) which nucleates preautophagosome formation as a conjugate with Atg5 [KO: K08336] | | ATG12; similar to S. cerevisiae ATG12 (YBR217W) which nucleates preautophagosome formation as a conjugate with Atg5 [KO: K08336] | | ATG7; similar to S. cerevisiae ATG7 (YHR171W) protein-conjugating enzyme of the Apg12p-Apg5p conjugation pathway of autophagy [KO: K08337] | | ATG5; similar to S. cerevisiae ATG5 (YPL149W) which nucleates preautophagosome formation as a conjugate with Atg12 [KO: K08339] | | ATG5; similar to S. cerevisiae ATG5 (YPL149W) which nucleates preautophagosome formation as a conjugate with Atg12 [KO: K08339] | | ATG4; potential protease similar to S. cerevisiae ATG4 (YNL223W) microtubule-binding anchor protein involved in attachment of autophagosomes to microtubules. [KO: K08342] [EC:3.4.22.-] | | ATG4; potential protease similar to S. cerevisiae ATG4 (YNL223W) microtubule-binding anchor protein involved in attachment of autophagosomes to microtubules. [KO: K08342] [EC:3.4.22.-] | | ATG3; similar to S. cerevisiae ATG3 (YNR007C) part of ubiquitin-like system that mediates Atg8-phosphatidylethanolamine conjugation required for protein-vacuolar targeting and autophagy [KO: K08343] |
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| Compound |
| Phosphatidylethanolamine | | 3-Methyladenine | | 1-Phosphatidyl-D-myo-inositol | | 1-Phosphatidyl-1D-myo-inositol 3-phosphate | | Wortmannin |
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| Reference |
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| Authors |
Meijer AJ, Codogno P. |
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| Title |
Regulation and role of autophagy in mammalian cells. |
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| Journal |
Int J Biochem Cell Biol 36:2445-62 (2004) |
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| Reference |
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| Authors |
Deretic V. |
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| Title |
Autophagy in innate and adaptive immunity. |
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| Journal |
Trends Immunol 26:523-8 (2005) |
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| Reference |
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| Authors |
Thompson AR, Vierstra RD. |
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| Title |
Autophagic recycling: lessons from yeast help define the process in plants. |
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| Journal |
Curr Opin Plant Biol 8:165-73 (2005) |
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| Reference |
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| Authors |
Levine B, Yuan J. |
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| Title |
Autophagy in cell death: an innocent convict? |
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| Journal |
J Clin Invest 115:2679-88 (2005) |
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| Reference |
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| Authors |
Tanida I, Ueno T, Kominami E. |
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| Title |
LC3 conjugation system in mammalian autophagy. |
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| Journal |
Int J Biochem Cell Biol 36:2503-18 (2004) |
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| Reference |
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| Authors |
Lum JJ, DeBerardinis RJ, Thompson CB. |
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| Title |
Autophagy in metazoans: cell survival in the land of plenty. |
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| Journal |
Nat Rev Mol Cell Biol 6:439-48 (2005) |
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| Reference |
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| Authors |
Reggiori F, Klionsky DJ. |
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| Title |
Autophagosomes: biogenesis from scratch? |
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| Journal |
Curr Opin Cell Biol 17:415-22 (2005) |
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| Reference |
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| Authors |
Klionsky DJ, Emr SD. |
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| Title |
Autophagy as a regulated pathway of cellular degradation. |
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| Journal |
Science 290:1717-21 (2000) |
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| Reference |
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| Authors |
Bechet D, Tassa A, Taillandier D, Combaret L, Attaix D. |
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| Title |
Lysosomal proteolysis in skeletal muscle. |
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| Journal |
Int J Biochem Cell Biol 37:2098-114 (2005) |
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| KO pathway |
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