KEGG   PATHWAY: cal04141Help
Entry
cal04141                    Pathway                                

Name
Protein processing in endoplasmic reticulum - Candida albicans
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
BRITE hierarchy
Pathway map
Protein processing in endoplasmic reticulum
cal04141

All organismsOrtholog table
Module
p97-Ufd1-Npl4 complex [PATH:cal04141]
COPII complex [PATH:cal04141]
Other DBs
Organism
Candida albicans [GN:cal]
Gene
SEC61; similar to S. cerevisiae SEC61 (YLR378C) membrane component of ER protein translocation apparatus [KO:K10956]
SSH1; protein translocation [KO:K10956]
SSH1; protein translocation [KO:K10956]
SEC62; membrane unit of ER protein translocation apparatus [KO:K12275]
SEC62; membrane unit of ER protein translocation apparatus [KO:K12275]
SEC63; DnaJ-like protein similar to S. cerevisiae SEC63 (YOR254C) signal recognition particle receptor [KO:K09540]
SEC63; DnaJ-like protein similar to S. cerevisiae SEC63 (YOR254C) signal recognition particle receptor [KO:K09540]
OST1; 64-kDa subunit of oligosaccharyltransferase [KO:K12666]
SWP1; oligosaccharyltransferase delta subunit [KO:K12667]
SWP1; oligosaccharyltransferase delta subunit [KO:K12667]
OST2; oligosaccharyltransferase [KO:K12668]
OST2; oligosaccharyltransferase [KO:K12668]
OST6; subunit of N-oligosaccharyltransferase complex [KO:K12669]
OST3; oligosaccharyltransferase subunit [KO:K12669]
OST3; oligosaccharyltransferase subunit [KO:K12669]
WBP1; oligosaccharyl transferase, beta subunit [KO:K12670]
WBP1; oligosaccharyl transferase, beta subunit [KO:K12670]
STT3; subunit of oligosaccharyltransferase [KO:K07151] [EC:2.4.99.18]
STT3; subunit of oligosaccharyltransferase [KO:K07151] [EC:2.4.99.18]
CWH41; similar to C terminus of S. cerevisiae CWH41 (YGL027C) glucosidase I [KO:K01228] [EC:3.2.1.106]
CWH41; similar to N terminus of S. cerevisiae CWH41 (YGL027C) glucosidase I [KO:K01228] [EC:3.2.1.106]
CWH41; similar to N terminus of S. cerevisiae CWH41 (YGL027C) glucosidase I [KO:K01228] [EC:3.2.1.106]
similar to Y. lipolytica Sls1 protein precursor; K14001 nucleotide exchange factor SIL1 [KO:K14001]
similar to Y. lipolytica Sls1 protein precursor; K14001 nucleotide exchange factor SIL1 [KO:K14001]
LHS1; translocation of protein precursors across ER [KO:K09486]
LHS1; translocation of protein precursors across ER [KO:K09486]
KAR2; similar to S. cerevisiae KAR2 (YJL034W) HSP70/ BiP family ATPase and chaperone involved in translocation of nascent polypeptides across ER membrane and in nuclear fusion during mating [KO:K09490]
KAR2; heat shock protein [KO:K09490]
JEM1; similar to S. cerevisiae JEM1 (YJL073W) BiP-interacting DNAJ-like co-chaperone involved in ER-associated protein degradation of misfolded proteins [KO:K09523]
SCJ1; similar to S. cerevisiae SCJ1 (YMR214W) BiP-interacting DnaJ-like co-chaperone involved in ER-associated protein degradation of misfolded proteins [KO:K14002]
SCJ1; similar to S. cerevisiae SCJ1 (YMR214W) BiP-interacting DnaJ-like co-chaperone involved in ER-associated protein degradation of misfolded proteins [KO:K14002]
ROT2; similar to S. cerevisiae ROT2 (YBR229C) ER alpha-glucosidase involved in cell wall biosynthesis [KO:K05546] [EC:3.2.1.84]
ROT2; similar to S. cerevisiae ROT2 (YBR229C) ER alpha-glucosidase involved in cell wall biosynthesis [KO:K05546] [EC:3.2.1.84]
similar to S. cerevisiae YDR221W; K08288 protein kinase C substrate 80K-H [KO:K08288]
similar to S. cerevisiae YDR221W; K08288 protein kinase C substrate 80K-H [KO:K08288]
CNE1; calnexin and calreticulin-like orf [KO:K08054]
CNE1; calnexin and calreticulin-like orf [KO:K08054]
MNS1; alpha mannosidase [KO:K01230] [EC:3.2.1.113]
MNS1; alpha mannosidase [KO:K01230] [EC:3.2.1.113]
SAR1; likely COPII vesicle coat component similar to S. cerevisiae SAR1 (YPL218W) ARF family GTP binding protein [KO:K07953] [EC:3.6.5.-]
SAR1; likely COPII vesicle coat component similar to S. cerevisiae SAR1 (YPL218W) ARF family GTP binding protein [KO:K07953] [EC:3.6.5.-]
SEC13; WD domain protein similar to S. cerevisiae SEC13 (YLR208W) secretory pathway vesicle COPII coat component [KO:K14004]
SEC13; WD domain protein similar to S. cerevisiae SEC13 (YLR208W) secretory pathway vesicle COPII coat component [KO:K14004]
SEC31; WD domain protein similar to S. cerevisiae SEC31 (YDL195W) secretory pathway vesicle COPII coat component [KO:K14005]
SEC31; WD domain protein similar to S. cerevisiae SEC31 (YDL195W) secretory pathway vesicle COPII coat component [KO:K14005]
SEC231; one of three genes similar to S. cerevisiae SEC23 (YPR181C) cytoplasmic GTPase-activating protein involved in COP II vesicle coat assembly [KO:K14006]
sec231; one of three genes similar to S. cerevisiae SEC23 (YPR181C) cytoplasmic GTPase-activating protein involved in COP II vesicle coat assembly [KO:K14006]
SEC24; similar to S. cerevisiae SEC24 (YIL109C) secretory pathway vesicle COPII coat component [KO:K14007]
SEC24; similar to S. cerevisiae SEC24 (YIL109C) secretory pathway vesicle COPII coat component [KO:K14007]
SFB3; transports ATPase Pmap from ER to Golgi [KO:K14007]
SFB3; transports ATPase Pmap from ER to Golgi [KO:K14007]
GPT1; similar to S. pombe stress-induced UDP-glucose-glycoprotein glucosyltransferase gpt1 (SPBPJ4664.06) [KO:K11718] [EC:2.4.1.-]
GPT1; similar to S. pombe stress-induced UDP-glucose-glycoprotein glucosyltransferase gpt1 (SPBPJ4664.06) [KO:K11718] [EC:2.4.1.-]
PDI1; one of two genes similar to S. cerevisiae PDI1 (YCL043C) ER protein disulfide isomerase and foldase [KO:K09580] [EC:5.3.4.1]
CaJ7_0374; hypothetical protein [KO:K09580] [EC:5.3.4.1]
MPD1; potential protein disulfide isomerase similar to S. cerevisiae MPD1 (YOR288C) [KO:K09584] [EC:5.3.4.1]
similar to N terminus of S. pombe SPAC17H9.14c putative protein disulfide isomerase (EC 5.3.4.1); one of two genes similar to S. cerevisiae PDI1 (YCL043C) [KO:K09584] [EC:5.3.4.1]
MPD1; potential protein disulfide isomerase similar to S. cerevisiae MPD1 (YOR288C) [KO:K09584] [EC:5.3.4.1]
similar to N terminus of S. pombe SPAC17H9.14c putative protein disulfide isomerase (EC 5.3.4.1); one of two genes similar to S. cerevisiae PDI1 (YCL043C) [KO:K09584] [EC:5.3.4.1]
EPS1; potential thioredoxin similar to S. cerevisiae EPS1 (YIL005W) protein disulfide isomerase-related protein implicated in protein-ER retention [KO:K13996] [EC:5.3.4.1]
EPS1; potential thioredoxin similar to S. cerevisiae EPS1 (YIL005W) protein disulfide isomerase-related protein implicated in protein-ER retention [KO:K13996] [EC:5.3.4.1]
YOS9; weak similarity to S. cerevisiae YOS9 (YDR057W) involved in transport of GPI-anchored proteins to the Golgi apparatus. [KO:K10088]
similar to S. cerevisiae YDR411C; K13989 Derlin-2/3 [KO:K13989]
weak similarity to S. cerevisiae YDR411C and conserved hypothetical protein; K13989 Derlin-2/3 [KO:K13989]
SHP1; potential UBX domain protein similar to S. cerevisiae SHP1 (YBL058W) regulatory subunit for Protein Phosphatase I (Glc7p) [KO:K14012]
similar to S. cerevisiae YML013W; K14013 UBX domain-containing protein 2 [KO:K14013]
similar to S. cerevisiae YML013W; K14013 UBX domain-containing protein 2 [KO:K14013]
CDC48; microsomal protein of CDC48 family of ATPases [KO:K13525]
CDC48; microsomal protein of CDC48 family of ATPases [KO:K13525]
NPL4; nuclear pore-associated protein [KO:K14015]
UFD1; ubiquitin fusion degradation protein [KO:K14016]
UFD1; ubiquitin fusion degradation protein [KO:K14016]
HSP70; heat shock protein 70 [KO:K03283]
SSB1; HSP70 [KO:K03283]
SSA2; Cytoplasmic chaperone [KO:K03283]
HSP70; heat shock protein 70 [KO:K03283]
SSA2; Cytoplasmic chaperone [KO:K03283]
SSB1; HSP70 [KO:K03283]
YDJ1; likely heat-shock protein (DnaJ) similar to S. cerevisiae YDJ1 (YNL064C) [KO:K09503]
HLJ1; DnaJ-like protein similar to S. cerevisiae HLJ1 (YMR161W) tail-anchored ER membrane protein [KO:K09518]
CaJ7_0464; hypothetical protein [KO:K09518]
HSP90; heat shock protein [KO:K04079]
HSP90; heat shock protein [KO:K04079]
CaJ7_0234; hypothetical protein [KO:K04079]
SSE1; HSP70 family chaperone, HSP90 co-chaperone [KO:K09485]
SSE1; HSP70 family chaperone, HSP90 co-chaperone [KO:K09485]
SNL1; integral membrane protein [KO:K14017]
SNL1; integral membrane protein [KO:K14017]
potential OTU-like cysteine protease; K13719 ubiquitin thioesterase OTU1 [EC:3.1.2.-] [KO:K13719] [EC:3.1.2.-]
potential OTU-like cysteine protease; K13719 ubiquitin thioesterase OTU1 [EC:3.1.2.-] [KO:K13719] [EC:3.1.2.-]
DOA1; ubiquitin proteolysis [KO:K14018]
DOA1; ubiquitin proteolysis [KO:K14018]
RAD23; similar to S. cerevisiae repairosome nucleotide excision repair protein (Ubiquitin-like protein) [KO:K10839]
RAD23; similar to S. cerevisiae repairosome nucleotide excision repair protein (Ubiquitin-like protein) [KO:K10839]
DSK2; protein degradation tagging [KO:K04523]
DSK2; protein degradation tagging [KO:K04523]
PNG1; similar to S. cerevisiae PNG1 (YPL096W) peptide:N-glycanase de-N-glycosylation enzyme [KO:K01456] [EC:3.5.1.52]
PNG1; similar to S. cerevisiae PNG1 (YPL096W) peptide:N-glycanase de-N-glycosylation enzyme [KO:K01456] [EC:3.5.1.52]
UFD2; U-box protein similar to S. cerevisiae UFD2 (YDL190C) ubiquitin conjugating factor e4 [KO:K10597] [EC:6.3.2.19]
UFD2; U-box protein similar to S. cerevisiae UFD2 (YDL190C) ubiquitin conjugating factor e4 [KO:K10597] [EC:6.3.2.19]
GCN2; likely protein kinase similar to S. cerevisiae GCN2 (YDR283C) eukaryotic initiation factor 2 alpha kinase [KO:K16196] [EC:2.7.11.1]
CaJ7_0147; hypothetical protein [KO:K16196] [EC:2.7.11.1]
SUI2; similar to S. cerevisiae SUI2 (YJR007W) translation initiation factor eIF2 alpha subunit [KO:K03237]
SUI2; similar to S. cerevisiae SUI2 (YJR007W) translation initiation factor eIF2 alpha subunit [KO:K03237]
IRE1; likely protein kinase/endoribonuclease similar to S. cerevisiae IRE1 (YHR079C) multifunctional serine-threonine kinase, ER transmembrane protein sensor of unfolded proteins and nonconventional splicing factor for HAC1 pre-mRNA [KO:K08852] [EC:3.1.26.- 2.7.11.1]
IRE1; likely protein kinase/endoribonuclease similar to S. cerevisiae IRE1 (YHR079C) multifunctional serine-threonine kinase, ER transmembrane protein sensor of unfolded proteins and nonconventional splicing factor for HAC1 pre-mRNA [KO:K08852] [EC:3.1.26.- 2.7.11.1]
CaJ7_0325; hypothetical protein [KO:K10661] [EC:6.3.2.19]
SSM4; potential transmembrane zinc finger protein similar to S. cerevisiae SSM4 (YIL030C) integral membrane protein involved in mRNA turnover [KO:K10661] [EC:6.3.2.19]
UBC6; ubiquitin-conjugating enzyme [KO:K04554] [EC:6.3.2.19]
QRI8; ubiquitin conjugating enzyme [KO:K04555] [EC:6.3.2.19]
similar to hypothetical protein; K14022 coupling of ubiquitin conjugation to ER degradation protein 1 [KO:K14022]
HRD3; degradation of Hmg CoA reductase isozyme Hmg2 [KO:K14023]
HRD3; degradation of Hmg CoA reductase isozyme Hmg2 [KO:K14023]
similar to putative zinc finger C3H4 type; K10601 E3 ubiquitin-protein ligase synoviolin [EC:6.3.2.19] [KO:K10601] [EC:6.3.2.19]
similar to putative zinc finger C3H4 type; K10601 E3 ubiquitin-protein ligase synoviolin [EC:6.3.2.19] [KO:K10601] [EC:6.3.2.19]
similar to carboxy terminus of Hsp70-interacting protein; K09561 STIP1 homology and U-box containing protein 1 [EC:6.3.2.19] [KO:K09561] [EC:6.3.2.19]
similar to carboxy terminus of Hsp70-interacting protein; K09561 STIP1 homology and U-box containing protein 1 [EC:6.3.2.19] [KO:K09561] [EC:6.3.2.19]
UBC4; likely ubiquitin-conjugating enzyme similar to S. cerevisiae UBC4 (YBR082C) and UBC5 (YDR059C) proteasome complex ubiquitin conjugating enzyme e2 [KO:K06689] [EC:6.3.2.19]
CDC53; cullin component of SCF ubiquitin ligase complex [KO:K03347]
CDC53; cullin component of SCF ubiquitin ligase complex [KO:K03347]
SKP1; kinetochore complex [KO:K03094]
SKP1; kinetochore complex [KO:K03094]
PDI1; one of two genes similar to S. cerevisiae PDI1 (YCL043C) ER protein disulfide isomerase and foldase [KO:K09580] [EC:5.3.4.1]
SSM4; potential transmembrane zinc finger protein similar to S. cerevisiae SSM4 (YIL030C) integral nuclear/ER membrane ubiquitin-protein ligase E3 that targets MATalpha2 [KO:K10661] [EC:6.3.2.19]
Compound
C00076  
Calcium cation
G00009  
 
G00010  
 
G00011  
 
G00012  
 
G10694  
 
Reference
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
Reference
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
Reference
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
Reference
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
Reference
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
KO pathway
 

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