KEGG   PATHWAY: cal04141Help
cal04141                    Pathway                                

Protein processing in endoplasmic reticulum - Candida albicans
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Genetic Information Processing; Folding, sorting and degradation
BRITE hierarchy
Pathway map
Protein processing in endoplasmic reticulum

All organismsOrtholog table
p97-Ufd1-Npl4 complex [PATH:cal04141]
Sec61 complex [PATH:cal04141]
COPII complex [PATH:cal04141]
Other DBs
Candida albicans [GN:cal]
SEC61; translocon subunit [KO:K10956]
SSH1; Ssh1p [KO:K10956]
Arf family guanine nucleotide exchange factor [KO:K09481]
translocon subunit [KO:K07342]
SEC62; Sec63 complex subunit [KO:K12275]
CaO19.491; protein-transporting protein [KO:K09540]
OST1; dolichyl-diphosphooligosaccharide--protein glycotransferase subunit [KO:K12666]
CaO19.3060; dolichyl-diphosphooligosaccharide-protein glycotransferase [KO:K12667]
CaO19.1761; dolichyl-diphosphooligosaccharide-protein glycotransferase [KO:K12668]
CaO19.7426; dolichyl-diphosphooligosaccharide--protein glycotransferase [KO:K12669]
CaO19.3994; dolichyl-diphosphooligosaccharide--protein glycotransferase [KO:K12669]
WBP1; dolichyl-diphosphooligosaccharide-protein glycotransferase [KO:K12670]
STT3; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit [KO:K07151] [EC:]
CWH41; Cwh41p [KO:K01228] [EC:]
CaO19.6403; hypothetical protein [KO:K14001]
LHS1; Hsp70 family chaperone [KO:K09486]
KAR2; Hsp70 family ATPase [KO:K09490]
JEM1; Jem1p [KO:K09523]
CaO19.3438; hypothetical protein [KO:K14002]
ROT2; glucan 1\3-alpha-glucosidase ROT2 [KO:K05546] [EC:]
CaO19.3286; hypothetical protein [KO:K08288]
CaO19.5300; calnexin [KO:K08054]
MNS1; mannosyl-oligosaccharide 1,2-alpha-mannosidase [KO:K01230] [EC:]
EMP46; Emp46p [KO:K10080]
SEC12; Sec12p [KO:K14003]
SAR1; Arf family GTPase [KO:K07953] [EC:3.6.5.-]
SEC13; GTPase-activating protein [KO:K14004]
PGA63; Pga63p [KO:K14005]
CaO19.1638; hypothetical protein [KO:K14006]
CaO19.6558; hypothetical protein [KO:K14006]
SEC23; GTPase-activating protein [KO:K14006]
CaO19.880; hypothetical protein [KO:K14007]
SEC24; COPII subunit [KO:K14007]
KRE5; Kre5p [KO:K11718] [EC:2.4.1.-]
PDI1; protein disulfide isomerase [KO:K09580] [EC:]
CaO19.3920; protein disulfide isomerase [KO:K09584] [EC:]
CaO19.2516; hypothetical protein [KO:K09584] [EC:]
CaO19.1392; protein disulfide isomerase [KO:K13996] [EC:]
CaO19.7578; hypothetical protein [KO:K10088]
CaO19.7672; hypothetical protein [KO:K13989]
CaO19.4247; hypothetical protein [KO:K13989]
SHP1; protein phosphatase regulator [KO:K14012]
CaO19.3135; hypothetical protein [KO:K14013]
CDC48; AAA family ATPase [KO:K13525]
NPL4; Npl4p [KO:K14015]
CaO19.5833; polyubiquitin-binding protein [KO:K14016]
HSP70; Hsp70 family chaperone [KO:K03283]
SSB1; Hsp70 family ATPase [KO:K03283]
SSA2; Hsp70 family chaperone [KO:K03283]
YDJ1; type I HSP40 co-chaperone [KO:K09503]
CaO19.6408; hypothetical protein [KO:K09503]
CaO19.954; hypothetical protein [KO:K09503]
HLJ1; type I HSP40 co-chaperone [KO:K09518]
HSP90; Hsp90 family chaperone [KO:K04079]
MSI3; adenyl-nucleotide exchange factor [KO:K09485]
CaO19.3649; hypothetical protein [KO:K09562]
SNL1; Snl1p [KO:K14017]
CaO19.2933; ubiquitin-specific protease [KO:K13719] [EC:3.1.2.-]
DOA1; Doa1p [KO:K14018]
RAD23; Rad23p [KO:K10839]
CaO19.5345; hypothetical protein [KO:K04523]
CaO19.26; peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase [KO:K01456] [EC:]
CaO19.5965; ubiquitin-ubiquitin ligase [KO:K10597] [EC:]
GCN2; serine/threonine-protein kinase [KO:K16196] [EC:]
SUI2; translation initiation factor eIF2 subunit alpha [KO:K03237]
IRE1; bifunctional endoribonuclease/protein kinase [KO:K08852] [EC:3.1.26.-]
CaO19.5175; E3 ubiquitin-protein ligase [KO:K10661] [EC:]
CaO19.7347; E2 ubiquitin-conjugating protein [KO:K04554] [EC:]
CaO19.7329; E2 ubiquitin-conjugating protein [KO:K04555] [EC:]
CaO19.6668; hypothetical protein [KO:K14022]
CaO19.1191; ubiquitin ligase complex subunit [KO:K14023]
CaO19.719; E3 ubiquitin-protein ligase [KO:K10601] [EC:]
CaO19.6864; hypothetical protein [KO:K09561] [EC:]
UBC4; E2 ubiquitin-conjugating protein [KO:K06689] [EC:]
HRT1; SCF ubiquitin ligase complex subunit [KO:K03868] [EC:]
CDC53; cullin [KO:K03347]
SKP1; SCF ubiquitin ligase subunit [KO:K03094]
Calcium cation
Naidoo N
ER and aging-Protein folding and the ER stress response.
Ageing Res Rev 8:150-9 (2009)
Malhotra JD, Kaufman RJ
The endoplasmic reticulum and the unfolded protein response.
Semin Cell Dev Biol 18:716-31 (2007)
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
Protein quality control in the ER: the recognition of misfolded proteins.
Semin Cell Dev Biol 21:500-11 (2010)
Stolz A, Wolf DH
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
Biochim Biophys Acta 1803:694-705 (2010)
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
J Proteome Res 9:1763-71 (2010)
KO pathway

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