KEGG   PATHWAY: cao03440
Entry
cao03440                    Pathway                                
Name
Homologous recombination - Cellulophaga algicola
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
cao03440  Homologous recombination
cao03440

Other DBs
GO: 0000724
Organism
Cellulophaga algicola [GN:cao]
Gene
Celal_1312  exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
Celal_0208  single-strand binding protein [KO:K03111]
Celal_1093  single-strand binding protein [KO:K03111]
Celal_2763  DNA replication and repair protein recF [KO:K03629]
Celal_1203  DNA repair protein recO [KO:K03584]
Celal_2420  Recombination protein recR [KO:K06187]
Celal_1517  Protein recA [KO:K03553]
Celal_2048  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
Celal_2074  Holliday junction DNA helicase subunit RuvA [KO:K03550]
Celal_2068  Holliday junction ATP-dependent DNA helicase ruvB [KO:K03551] [EC:5.6.2.4]
Celal_1991  Crossover junction endodeoxyribonuclease ruvC [KO:K01159] [EC:3.1.21.10]
Celal_3763  ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
Celal_3609  putative transcriptional regulator [KO:K03655] [EC:5.6.2.4]
Celal_1922  DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
Celal_3230  DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
Celal_3239  DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
Celal_2897  DNA polymerase III, subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
Celal_3782  DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
Celal_1504  putative DNA polymerase III, delta subunit [KO:K02341] [EC:2.7.7.7]
Celal_2422  Exonuclease RNase T and DNA polymerase III [KO:K02342] [EC:2.7.7.7]
Celal_0559  DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
Celal_4251  DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
Celal_3244  Exonuclease RNase T and DNA polymerase III [KO:K02342] [EC:2.7.7.7]
Celal_3233  Excinuclease ABC C subunit domain protein [KO:K02342] [EC:2.7.7.7]
Celal_0034  primosomal protein N' [KO:K04066] [EC:5.6.2.4]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (25)   
   KEGG GENES (25)   
All databases (26)   

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