KEGG   PATHWAY: cbl00030Help
Entry
cbl00030                    Pathway                                

Name
Pentose phosphate pathway - Clostridium botulinum A3 Loch Maree
Description
The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated [MD:M00006]. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P [MD:M00007]. Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P [MD:M00005] is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. This pathway map also shows the Entner-Doudoroff pathway where 6-P-gluconate is dehydrated and then cleaved into pyruvate and glyceraldehyde-3P [MD:M00008].
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
cbl00030  Pentose phosphate pathway
cbl00030

Ortholog table
Module
cbl_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:cbl00030]
cbl_M00007  Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:cbl00030]
Other DBs
BSID: 65442
GO: 0006098
Organism
Clostridium botulinum A3 Loch Maree [GN:cbl]
Gene
CLK_2695  pgi; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
CLK_1884  rpe; ribulose-phosphate 3-epimerase [KO:K01783] [EC:5.1.3.1]
CLK_2826  transketolase, pyridine binding subunit [KO:K00615] [EC:2.2.1.1]
CLK_2827  transketolase, thiamine diphosphate binding subunit [KO:K00615] [EC:2.2.1.1]
CLK_1611  transaldolase [KO:K00616] [EC:2.2.1.2]
CLK_0735  transaldolase [KO:K00616] [EC:2.2.1.2]
CLK_3319  rpiB; ribose 5-phosphate isomerase B [KO:K01808] [EC:5.3.1.6]
CLK_1039  deoC; deoxyribose-phosphate aldolase [KO:K01619] [EC:4.1.2.4]
CLK_1040  rbsK; ribokinase [KO:K00852] [EC:2.7.1.15]
CLK_2509  phosphoglucomutase/phosphomannomutase family protein [KO:K01835] [EC:5.4.2.2]
CLK_3103  phosphoglucomutase/phosphomannomutase family protein [KO:K01835] [EC:5.4.2.2]
CLK_3013  prsA; ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
CLK_3485  eda; 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase [KO:K01625] [EC:4.1.3.42 4.1.2.14]
CLK_0693  gapN; glyceraldehyde-3-phosphate dehydrogenase (NADP+) [KO:K00131] [EC:1.2.1.9]
CLK_3486  kinase, pfkB family [KO:K00874] [EC:2.7.1.45]
CLK_1393  aor; aldehyde ferredoxin oxidoreductase, tungsten-containing [KO:K03738] [EC:1.2.7.5]
CLK_3372  fba; fructose-1,6-bisphosphate aldolase, class II [KO:K01624] [EC:4.1.2.13]
CLK_2002  glpX; fructose-1,6-bisphosphatase, class II [KO:K02446] [EC:3.1.3.11]
CLK_3727  fructose-1,6-bisphosphatase [KO:K04041] [EC:3.1.3.11]
CLK_2805  pfkA; 6-phosphofructokinase [KO:K00850] [EC:2.7.1.11]
CLK_1445  pfkB; 1-phosphofructokinase [KO:K16370] [EC:2.7.1.11]
Compound
C00022  Pyruvate
C00031  D-Glucose
C00117  D-Ribose 5-phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00121  D-Ribose
C00197  3-Phospho-D-glycerate
C00198  D-Glucono-1,5-lactone
C00199  D-Ribulose 5-phosphate
C00204  2-Dehydro-3-deoxy-D-gluconate
C00221  beta-D-Glucose
C00231  D-Xylulose 5-phosphate
C00257  D-Gluconic acid
C00258  D-Glycerate
C00279  D-Erythrose 4-phosphate
C00345  6-Phospho-D-gluconate
C00577  D-Glyceraldehyde
C00620  alpha-D-Ribose 1-phosphate
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C00672  2-Deoxy-D-ribose 1-phosphate
C00673  2-Deoxy-D-ribose 5-phosphate
C01151  D-Ribose 1,5-bisphosphate
C01172  beta-D-Glucose 6-phosphate
C01218  6-Phospho-2-dehydro-D-gluconate
C01236  D-Glucono-1,5-lactone 6-phosphate
C01801  Deoxyribose
C03752  2-Amino-2-deoxy-D-gluconate
C04442  2-Dehydro-3-deoxy-6-phospho-D-gluconate
C05345  beta-D-Fructose 6-phosphate
C05378  beta-D-Fructose 1,6-bisphosphate
C05382  Sedoheptulose 7-phosphate
C06019  D-arabino-Hex-3-ulose 6-phosphate
C06473  2-Keto-D-gluconic acid
C20589  D-Glucosaminate-6-phosphate
Reference
(map 3)
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
(map 4)
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Reference
  Authors
Hove-Jensen B, Rosenkrantz TJ, Haldimann A, Wanner BL.
  Title
Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways.
  Journal
J Bacteriol 185:2793-801 (2003)
DOI:10.1128/JB.185.9.2793-2801.2003
Reference
  Authors
Orita I, Sato T, Yurimoto H, Kato N, Atomi H, Imanaka T, Sakai Y
  Title
The ribulose monophosphate pathway substitutes for the missing pentose phosphate pathway in the archaeon Thermococcus kodakaraensis.
  Journal
J Bacteriol 188:4698-704 (2006)
DOI:10.1128/JB.00492-06
Reference
  Authors
Kato N, Yurimoto H, Thauer RK
  Title
The physiological role of the ribulose monophosphate pathway in bacteria and archaea.
  Journal
Biosci Biotechnol Biochem 70:10-21 (2006)
DOI:10.1271/bbb.70.10
Reference
  Authors
Kouril T, Wieloch P, Reimann J, Wagner M, Zaparty M, Albers SV, Schomburg D, Ruoff P, Siebers B
  Title
Unraveling the function of the two Entner-Doudoroff branches in the thermoacidophilic Crenarchaeon Sulfolobus solfataricus P2.
  Journal
FEBS J 280:1126-38 (2013)
DOI:10.1111/febs.12106
Reference
  Authors
Reher M, Schonheit P
  Title
Glyceraldehyde dehydrogenases from the thermoacidophilic euryarchaeota Picrophilus torridus and Thermoplasma acidophilum, key enzymes of the non-phosphorylative Entner-Doudoroff pathway, constitute a novel enzyme family within the aldehyde dehydrogenase superfamily.
  Journal
FEBS Lett 580:1198-204 (2006)
DOI:10.1016/j.febslet.2006.01.029
Reference
  Authors
Reher M, Fuhrer T, Bott M, Schonheit P
  Title
The nonphosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate- specific aldolase.
  Journal
J Bacteriol 192:964-74 (2010)
DOI:10.1128/JB.01281-09
KO pathway
ko00030   

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