KEGG   PATHWAY: cbo03440Help
Entry
cbo03440                    Pathway                                

Name
Homologous recombination - Clostridium botulinum A ATCC 3502
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
cbo03440  Homologous recombination
cbo03440

Ortholog table
Module
cbo_M00260  DNA polymerase III complex, bacteria [PATH:cbo03440]
Other DBs
BSID: 52848
GO: 0000724
Organism
Clostridium botulinum A ATCC 3502 [GN:cbo]
Gene
CBO2763  recJ; single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
CBO3627  ssBb; single-strand binding protein [KO:K03111]
CBO0004  recF; recombination protein F [KO:K03629]
CBO2945  recO; DNA repair protein RecO [KO:K03584]
CBO0033  recR; recombination protein RecR [KO:K06187]
CBO2405  recA; recombinase A [KO:K03553]
CBO3014  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
CBO3071  ruvA; Holliday junction DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
CBO3070  ruvB; Holliday junction DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
CBO2496  ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
CBO0169  helicase, RecD/TraA family [KO:K03581] [EC:3.1.11.5]
CBOP01  dnaE; DNA polymerase III DnaE [KO:K02337] [EC:2.7.7.7]
CBO3374  dnaE; DNA polymerase III DnaE [KO:K02337] [EC:2.7.7.7]
CBO2423  polC; DNA polymerase III PolC [KO:K03763] [EC:2.7.7.7]
CBO0002  dnaG; DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
CBO0031  dnaH; DNA polymerase III subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
CBO2968  holA; DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
CBO0056  DNA polymerase III subunit delta' [KO:K02341] [EC:2.7.7.7]
CBO0256  DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
CBO2511  primosome assembly protein PriA [KO:K04066] [EC:3.6.4.-]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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