KEGG   PATHWAY: cbu00010
Entry
cbu00010                    Pathway                                
Name
Glycolysis / Gluconeogenesis - Coxiella burnetii RSA 493
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
Pathway map
cbu00010  Glycolysis / Gluconeogenesis
cbu00010

Module
cbu_M00002  Glycolysis, core module involving three-carbon compounds [PATH:cbu00010]
cbu_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:cbu00010]
cbu_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:cbu00010]
Other DBs
GO: 0006096 0006094
Organism
Coxiella burnetii RSA 493 [GN:cbu]
Gene
CBU_0848  pgi; glucose-6 phosphate 1-epimerase [KO:K01810] [EC:5.3.1.9]
CBU_0341  pfkA; 6-phosphofructokinase [KO:K00850] [EC:2.7.1.11]
CBU_1273  pyrophosphate--fructose 6-phosphate 1-phosphotransferase [KO:K21071] [EC:2.7.1.11 2.7.1.90]
CBU_1778  fbaA; fructose-bisphosphate aldolase [KO:K01624] [EC:4.1.2.13]
CBU_0513  fructose-1,6-bisphosphatase [KO:K01622] [EC:4.1.2.13 3.1.3.11]
CBU_1450  tpiA; triosephosphate isomerase [KO:K01803] [EC:5.3.1.1]
CBU_1783  gap; glyceraldehyde 3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
CBU_1782  pgk; phosphoglycerate kinase [KO:K00927] [EC:2.7.2.3]
CBU_1536  yibO; phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
CBU_1674  eno; enolase [KO:K01689] [EC:4.2.1.11]
CBU_1781  pyk; pyruvate kinase [KO:K00873] [EC:2.7.1.40]
CBU_0461  pdhA; pyruvate dehydrogenase E1 component [KO:K00163] [EC:1.2.4.1]
CBU_0686  pyruvate dehydrogenase E1 component subunit beta [KO:K00162] [EC:1.2.4.1]
CBU_0462  pdhC; dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex [KO:K00627] [EC:2.3.1.12]
CBU_0463  lpdA; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
CBU_0294  phosphoglucomutase [KO:K15778] [EC:5.4.2.8 5.4.2.2]
CBU_2092  pckA; phosphoenolpyruvate carboxykinase (ATP) [KO:K01610] [EC:4.1.1.49]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00033  Acetate
C00036  Oxaloacetate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00084  Acetaldehyde
C00085  D-Fructose 6-phosphate
C00103  D-Glucose 1-phosphate
C00111  Glycerone phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00186  (S)-Lactate
C00197  3-Phospho-D-glycerate
C00221  beta-D-Glucose
C00236  3-Phospho-D-glyceroyl phosphate
C00267  alpha-D-Glucose
C00354  D-Fructose 1,6-bisphosphate
C00469  Ethanol
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C01159  2,3-Bisphospho-D-glycerate
C01172  beta-D-Glucose 6-phosphate
C01451  Salicin
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
cbu00020  Citrate cycle (TCA cycle)
cbu00030  Pentose phosphate pathway
cbu00500  Starch and sucrose metabolism
cbu00620  Pyruvate metabolism
cbu00640  Propanoate metabolism
KO pathway
ko00010   

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