KEGG   PATHWAY: cci00020
Entry
cci00020                    Pathway                                
Name
Citrate cycle (TCA cycle) - Coprinopsis cinerea
Description
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:M00009], but contain genes for specific segments [MD:M00010 M00011].
Class
Metabolism; Carbohydrate metabolism
Pathway map
cci00020  Citrate cycle (TCA cycle)
cci00020

Module
cci_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:cci00020]
cci_M00009  Citrate cycle (TCA cycle, Krebs cycle) [PATH:cci00020]
cci_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:cci00020]
cci_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:cci00020]
cci_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:cci00020]
Other DBs
GO: 0006099
Organism
Coprinopsis cinerea [GN:cci]
Gene
CC1G_14401  citrate synthase I [KO:K01647] [EC:2.3.3.1]
CC1G_12964  citrate synthase [KO:K01647] [EC:2.3.3.1]
CC1G_13461  citrate synthase [KO:K01647] [EC:2.3.3.1]
CC1G_09654  ATP citrate lyase isoform 2 [KO:K01648] [EC:2.3.3.8]
CC1G_10805  aconitase [KO:K01681] [EC:4.2.1.3]
CC1G_11465  isocitrate dehydrogenase [KO:K00031] [EC:1.1.1.42]
CC1G_00350  isocitrate dehydrogenase [KO:K00030] [EC:1.1.1.41]
CC1G_00372  isocitrate dehydrogenase [KO:K00030] [EC:1.1.1.41]
CC1G_12439  oxoglutarate dehydrogenase [KO:K00164] [EC:1.2.4.2]
CC1G_07689  dihydrolipoamide succinyltransferase [KO:K00658] [EC:2.3.1.61]
CC1G_07310  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
CC1G_10272  succinate-CoA ligase [KO:K01899] [EC:6.2.1.4 6.2.1.5]
CC1G_04425  succinate-CoA ligase [KO:K01900] [EC:6.2.1.4 6.2.1.5]
CC1G_06084  succinate dehydrogenase flavoprotein subunit [KO:K00234] [EC:1.3.5.1]
CC1G_09250  succinate dehydrogenase iron-sulfur subunit [KO:K00235] [EC:1.3.5.1]
CC1G_06197  succinate dehydrogenase cytochrome b560 subunit [KO:K00236]
CC1G_02650  mitochondrial inner membrane protein [KO:K00237]
CC1G_03627  aspartate ammonia lyase [KO:K01679] [EC:4.2.1.2]
CC1G_09115  L-malate dehydrogenase [KO:K00026] [EC:1.1.1.37]
CC1G_06656  malate dehydrogenase [KO:K00026] [EC:1.1.1.37]
CC1G_05664  pyruvate carboxylase [KO:K01958] [EC:6.4.1.1]
CC1G_02063  phosphoenolpyruvate carboxykinase [KO:K01610] [EC:4.1.1.49]
CC1G_09082  pyruvate dehydrogenase e1 component alpha subunit [KO:K00161] [EC:1.2.4.1]
CC1G_00368  pyruvate dehydrogenase e1 component beta subunit [KO:K00162] [EC:1.2.4.1]
CC1G_06806  dihydrolipoyllysine-residue acetyltransferase [KO:K00627] [EC:2.3.1.12]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00036  Oxaloacetate
C00042  Succinate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00091  Succinyl-CoA
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00311  Isocitrate
C00417  cis-Aconitate
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05379  Oxalosuccinate
C05381  3-Carboxy-1-hydroxypropyl-ThPP
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16254  [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
cci00010  Glycolysis / Gluconeogenesis
cci00053  Ascorbate and aldarate metabolism
cci00061  Fatty acid biosynthesis
cci00062  Fatty acid elongation
cci00071  Fatty acid degradation
cci00190  Oxidative phosphorylation
cci00220  Arginine biosynthesis
cci00250  Alanine, aspartate and glutamate metabolism
cci00280  Valine, leucine and isoleucine degradation
cci00350  Tyrosine metabolism
cci00470  D-Amino acid metabolism
cci00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00020   

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