KEGG   PATHWAY: ccx03410Help
Entry
ccx03410                    Pathway                                
Name
Base excision repair - Corallococcus coralloides
Description
Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.
Class
Genetic Information Processing; Replication and repair
BRITE hierarchy
Pathway map
Base excision repair
ccx03410

All organismsOrtholog table
Module
DNA polymerase delta complex [PATH:ccx03410]
BER complex [PATH:ccx03410]
Other DBs
Organism
Corallococcus coralloides [GN:ccx]
Gene
mutM; formamidopyrimidine-DNA glycosylase [KO:K10563] [EC:4.2.99.18 3.2.2.23]
fpgX; formamidopyrimidine DNA-glyxosylase [KO:K10563] [EC:4.2.99.18 3.2.2.23]
nei; DNA glycosylase/AP lyase [KO:K05522] [EC:4.2.99.18 3.2.2.-]
nth1; endonuclease III [KO:K10773] [EC:4.2.99.18]
nth1a; base excision DNA repair protein [KO:K10773] [EC:4.2.99.18]
nth; endonuclease III [KO:K10773] [EC:4.2.99.18]
yfjP; putative DNA-3-methyladenine glycosylase [KO:K01247] [EC:3.2.2.21]
ada1; putative ada regulatory protein [KO:K13529] [EC:3.2.2.21]
tag; DNA-3-methyladenine glycosylase [KO:K01246] [EC:3.2.2.20]
ung; uracil-DNA glycosylase [KO:K03648] [EC:3.2.2.27]
mug; G/U mismatch-specific DNA glycosylase [KO:K03649] [EC:3.2.2.-]
mutY; A/G-specific adenine glycosylase [KO:K03575] [EC:3.2.2.-]
DNA-3-methyladenine glycosylase; K03652 DNA-3-methyladenine glycosylase [EC:3.2.2.21] [KO:K03652] [EC:3.2.2.21]
xth1; exodeoxyribonuclease III [KO:K01142] [EC:3.1.11.2]
xth; exodeoxyribonuclease III [KO:K01142] [EC:3.1.11.2]
nfo; endonuclease IV [KO:K01151] [EC:3.1.21.2]
polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
recJ; single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
ligB; ATP-dependent DNA ligase [KO:K01971] [EC:6.5.1.1]
ligD; ATP dependent DNA ligase [KO:K01971] [EC:6.5.1.1]
ligA; DNA ligase [KO:K01972] [EC:6.5.1.2]
Reference
  Authors
Krwawicz J, Arczewska KD, Speina E, Maciejewska A, Grzesiuk E.
  Title
Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease.
  Journal
Acta Biochim Pol 54:413-34 (2007)
Reference
  Authors
Almeida KH, Sobol RW.
  Title
A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification.
  Journal
DNA Repair (Amst) 6:695-711 (2007)
Reference
  Authors
Ikeda S, Seki S.
  Title
[Base excision repair: DNA glycosylase and AP endonuclease] Japanese
  Journal
Tanpakushitsu Kakusan Koso 46:916-23 (2001)
KO pathway
 
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