KEGG   PATHWAY: cdd00260
Entry
cdd00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Corynebacterium diphtheriae CDCE 8392
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
cdd00260  Glycine, serine and threonine metabolism
cdd00260

Module
cdd_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:cdd00260]
cdd_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:cdd00260]
cdd_M00555  Betaine biosynthesis, choline => betaine [PATH:cdd00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Corynebacterium diphtheriae CDCE 8392 [GN:cdd]
Gene
CDCE8392_0232  lysC; aspartate kinase [KO:K00928] [EC:2.7.2.4]
CDCE8392_0233  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
CDCE8392_0942  hom; Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
CDCE8392_0943  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
CDCE8392_1559  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
CDCE8392_0839  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
CDCE8392_1456  putative glycerate kinase [KO:K00865] [EC:2.7.1.165]
CDCE8392_0339  gpmA; phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
CDCE8392_1010  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
CDCE8392_0720  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
CDCE8392_1735  serB; Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
CDCE8392_0318  lpd; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
CDCE8392_2106  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
CDCE8392_2104  gbsA; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
CDCE8392_0440  sdaA; L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
CDCE8392_1260  sdaB; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
CDCE8392_1487  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
CDCE8392_2250  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
CDCE8392_2241  trpB1; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
CDCE8392_2249  trpB2; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
cdd00010  Glycolysis / Gluconeogenesis
cdd00020  Citrate cycle (TCA cycle)
cdd00230  Purine metabolism
cdd00250  Alanine, aspartate and glutamate metabolism
cdd00270  Cysteine and methionine metabolism
cdd00290  Valine, leucine and isoleucine biosynthesis
cdd00300  Lysine biosynthesis
cdd00330  Arginine and proline metabolism
cdd00460  Cyanoamino acid metabolism
cdd00470  D-Amino acid metabolism
cdd00564  Glycerophospholipid metabolism
cdd00600  Sphingolipid metabolism
cdd00620  Pyruvate metabolism
cdd00630  Glyoxylate and dicarboxylate metabolism
cdd00640  Propanoate metabolism
cdd00680  Methane metabolism
cdd00860  Porphyrin metabolism
cdd00920  Sulfur metabolism
KO pathway
ko00260   

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