KEGG PATHWAY: cfa03013

PATHWAY: cfa03013

Entry

cfa03013 Pathway

Name

RNA transport - Canis familiaris (dog)

Description

RNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) via mobile export receptors. The majority of RNAs, such as tRNAs, rRNAs, and U snRNAs, are transported by specific export receptors, which belong to the karyopherin-beta family proteins. A feature of karyopherins is their regulation by the small GTPase Ran. However, general mRNA export is mechanistically different. Nuclear export of mRNAs is functionally coupled to different steps in gene expression processes, such as transcription, splicing, 3'-end formation and even translation.

Class

Genetic Information Processing; Translation

Pathway map

cfa03013

RNA transport

Module

cfa_M00399	Cap binding complex [PATH:cfa03013]
cfa_M00405	THC complex [PATH:cfa03013]
cfa_M00406	TREX complex [PATH:cfa03013]
cfa_M00426	Survival motor neuron (SMN) complex [PATH:cfa03013]
cfa_M00427	Nuclear pore complex [PATH:cfa03013]
cfa_M00428	eIF4F complex [PATH:cfa03013]
cfa_M00430	Exon junction complex (EJC) [PATH:cfa03013]

Other DBs

BSID:

177895

GO:

0050658

Organism

Canis familiaris (dog) [GN:cfa]

Gene

481978	POP1; processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae) [KO:K01164] [EC:3.1.26.5]
100683678	RPP38; ribonuclease P/MRP 38kDa subunit [KO:K14523] [EC:3.1.26.5]
612732	POP4; processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae) [KO:K03538] [EC:3.1.26.5]
477515	POP5; processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) [KO:K03537] [EC:3.1.26.5]
481586	C11H9orf23; chromosome 11 open reading frame, human C9orf23 [KO:K14525] [EC:3.1.26.5]
486757	alba-like protein C9orf23 homolog; K14525 ribonucleases P/MRP protein subunit RPP25 [EC:3.1.26.5] [KO:K14525] [EC:3.1.26.5]
611587	RPP25; ribonuclease P/MRP 25kDa subunit [KO:K14525] [EC:3.1.26.5]
489832	POP7; processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) [KO:K14527] [EC:3.1.26.5]
612771	RPP14; ribonuclease P/MRP 14kDa subunit [KO:K14529] [EC:3.1.26.5]
477763	RPP30; ribonuclease P/MRP 30kDa subunit [KO:K03539] [EC:3.1.26.5]
474824	RPP21; ribonuclease P/MRP 21kDa subunit [KO:K03540] [EC:3.1.26.5]
478709	RPP40; ribonuclease P/MRP 40kDa subunit [KO:K14530] [EC:3.1.26.5]
489511	ELAC2; elaC homolog 2 (E. coli) [KO:K00784] [EC:3.1.26.11]
476197	ELAC1; elaC homolog 1 (E. coli) [KO:K00784] [EC:3.1.26.11]
476552	TRNT1; tRNA nucleotidyl transferase, CCA-adding, 1 [KO:K00974] [EC:3.1.4.- 3.1.3.- 2.7.7.72]
100499482	RAN; RAN, member RAS oncogene family [KO:K07936]
474427	XPOT; exportin, tRNA [KO:K14288]
474913	XPO5; exportin 5 [KO:K14289]
403506	EEF1A1; eukaryotic translation elongation factor 1 alpha 1 [KO:K03231]
612521	uncharacterized LOC612521; K03231 elongation factor 1-alpha [KO:K03231]
474609	XPO1; exportin 1 (CRM1 homolog, yeast) [KO:K14290]
479305	PHAX; phosphorylated adaptor for RNA export [KO:K14291]
474772	NCBP1; nuclear cap binding protein subunit 1, 80kDa [KO:K12882]
478603	NCBP2; nuclear cap binding protein subunit 2, 20kDa [KO:K12883]
403971	CLNS1A; chloride channel, nucleotide-sensitive, 1A [KO:K05019]
480242	PRMT5; protein arginine methyltransferase 5 [KO:K02516] [EC:2.1.1.125]
477885	TGS1; trimethylguanosine synthase 1 [KO:K14292] [EC:2.1.1.-]
491042	KPNB1; karyopherin (importin) beta 1 [KO:K14293]
487655	SNUPN; snurportin 1 [KO:K13151]
488137	NMD3; NMD3 homolog (S. cerevisiae) [KO:K07562]
481101	WIBG; within bgcn homolog (Drosophila) [KO:K14294]
480045	TPR; translocated promoter region, nuclear basket protein [KO:K09291]
474470	NUP50; nucleoporin 50kDa [KO:K14295]
478732	NUP153; nucleoporin 153kDa [KO:K14296]
478661	SENP2; SUMO1/sentrin/SMT3 specific peptidase 2 [KO:K03345] [EC:3.4.22.68]
476822	NUP98; nucleoporin 98kDa [KO:K14297]
485942	RAE1; RAE1 RNA export 1 homolog (S. pombe) [KO:K14298]
607653	SEC13; SEC13 homolog (S. cerevisiae) [KO:K14004]
490564	SEH1L; SEH1-like (S. cerevisiae) [KO:K14299]
479208	NUP133; nucleoporin 133kDa [KO:K14300]
474440	NUP107; nucleoporin 107kDa [KO:K14301]
475445	NUP37; nucleoporin 37kDa [KO:K14302]
483618	NUP160; nucleoporin 160kDa [KO:K14303]
475913	NUP85; nucleoporin 85kDa [KO:K14304]
484031	NUP43; nucleoporin 43kDa [KO:K14305]
484370	NUP62; nucleoporin 62kDa [KO:K14306]
477334	NUPL1; nucleoporin like 1 [KO:K14307]
487813	NUP54; nucleoporin 54kDa [KO:K14308]
478119	NUP93; nucleoporin 93kDa [KO:K14309]
475506	NUP205; nucleoporin 205kDa [KO:K14310]
491307	NUP188; nucleoporin 188kDa [KO:K14311]
479360	NUP155; nucleoporin 155kDa [KO:K14312]
478830	NUP35; nucleoporin 35kDa [KO:K14313]
484632	NUP210; nucleoporin 210kDa [KO:K14314]
490448	NUP210L; nucleoporin 210kDa-like [KO:K14314]
100684187	TMEM48; transmembrane protein 48 [KO:K14315]
489812	POM121; POM121 transmembrane nucleoporin [KO:K14316]
608534	NUP214; nucleoporin 214kDa [KO:K14317]
607268	NUP88; nucleoporin 88kDa [KO:K14318]
474539	RANBP2; RAN binding protein 2 [KO:K12172]
481234	RANGAP1; Ran GTPase activating protein 1 [KO:K14319]
491332	UBE2I; ubiquitin-conjugating enzyme E2I [KO:K10577] [EC:6.3.2.19]
490297	SUMO3; small ubiquitin-related modifier 2-like [KO:K12160]
491788	small ubiquitin-related modifier 1-like; K12160 small ubiquitin-related modifier [KO:K12160]
474963	SUMO2; SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) [KO:K12160]
478874	SUMO1; SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) [KO:K12160]
100682962	small ubiquitin-related modifier 2-like; K12160 small ubiquitin-related modifier [KO:K12160]
100856530	small ubiquitin-related modifier 3-like; K12160 small ubiquitin-related modifier [KO:K12160]
607867	AAAS; achalasia, adrenocortical insufficiency, alacrimia [KO:K14320]
100855902	nucleoporin-like protein 2-like; K14321 nucleoporin-like protein 2 [KO:K14321]
403896	SMN; survival motor neuron [KO:K13129]
610087	GEMIN2; gem (nuclear organelle) associated protein 2 [KO:K13130]
100856065	probable ATP-dependent RNA helicase DDX20-like; K13131 ATP-dependent RNA helicase DDX20 [EC:3.6.4.13] [KO:K13131] [EC:3.6.4.13]
611189	GEMIN4; gem (nuclear organelle) associated protein 4 [KO:K13132]
479321	GEMIN5; gem (nuclear organelle) associated protein 5 [KO:K13133]
475732	GEMIN6; gem (nuclear organelle) associated protein 6 [KO:K13134]
100855650	gem-associated protein 7-like; K13135 gem associated protein 7 [KO:K13135]
480843	GEMIN8; gem (nuclear organelle) associated protein 8 [KO:K13136]
486663	STRAP; serine/threonine kinase receptor associated protein [KO:K13137]
487532	EIF3J; eukaryotic translation initiation factor 3, subunit J [KO:K03245]
478152	EIF3I; eukaryotic translation initiation factor 3, subunit I [KO:K03246]
475081	EIF3H; eukaryotic translation initiation factor 3, subunit H [KO:K03247]
612971	EIF3G; eukaryotic translation initiation factor 3, subunit G [KO:K03248]
476840	EIF3F; eukaryotic translation initiation factor 3, subunit F [KO:K03249]
475070	EIF3E; eukaryotic translation initiation factor 3, subunit E [KO:K03250]
608665	EIF3D; eukaryotic translation initiation factor 3, subunit D [KO:K03251]
479795	EIF3C; eukaryotic translation initiation factor 3, subunit C [KO:K03252]
479766	EIF3B; eukaryotic translation initiation factor 3, subunit B [KO:K03253]
486914	EIF3A; eukaryotic translation initiation factor 3, subunit A [KO:K03254]
611715	EIF1AX; eukaryotic translation initiation factor 1A, X-linked [KO:K03236]
477030	EIF1B; eukaryotic translation initiation factor 1B [KO:K03113]
403674	EIF1; eukaryotic translation initiation factor 1 [KO:K03113]
480442	EIF5; eukaryotic translation initiation factor 5 [KO:K03262]
480361	EIF2S1; eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa [KO:K03237]
477197	EIF2S2; eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa [KO:K03238]
480866	EIF2S3; eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa [KO:K03242]
477447	EIF2B1; eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa [KO:K03239]
490789	EIF2B2; eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa [KO:K03754]
475702	EIF2B4; eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa [KO:K03680]
475379	EIF2B3; eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa [KO:K03241]
100856343	translation initiation factor eIF-2B subunit epsilon-like; K03240 translation initiation factor eIF-2B subunit epsilon [KO:K03240]
474556	EIF5B; eukaryotic translation initiation factor 5B [KO:K03243]
478202	EIF4G3; eukaryotic translation initiation factor 4 gamma, 3 [KO:K03260]
100688785	EIF4G1; eukaryotic translation initiation factor 4 gamma, 1 [KO:K03260]
100855511	eukaryotic translation initiation factor 4 gamma 2-like; K03260 translation initiation factor 4G [KO:K03260]
487870	EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
610238	EIF4E2; eukaryotic translation initiation factor 4E family member 2 [KO:K03259]
489099	EIF4E1B; eukaryotic translation initiation factor 4E family member 1B [KO:K03259]
488118	EIF4A2; eukaryotic translation initiation factor 4A2 [KO:K03257]
100688577	EIF4A1; eukaryotic translation initiation factor 4A1 [KO:K03257]
477600	EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
612751	PABPC1; poly(A) binding protein, cytoplasmic 1 [KO:K13126]
492002	PABPC5; poly(A) binding protein, cytoplasmic 5 [KO:K13126]
482464	PABPC4; poly(A) binding protein, cytoplasmic 4 (inducible form) [KO:K13126]
477238	PABPC1L; poly(A) binding protein, cytoplasmic 1-like [KO:K13126]
483825	PABPC4L; uncharacterized LOC483825 [KO:K13126]
479343	PAIP1; poly(A) binding protein interacting protein 1 [KO:K14322]
475590	EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1 [KO:K07205]
479079	TACC3; transforming, acidic coiled-coil containing protein 3 [KO:K14283]
479001	CYFIP1; cytoplasmic FMR1 interacting protein 1 [KO:K05749]
479317	CYFIP2; cytoplasmic FMR1 interacting protein 2 [KO:K05749]
481070	FMR1; fragile X mental retardation 1 [KO:K15516]
489478	FXR2; fragile X mental retardation, autosomal homolog 2 [KO:K15516]
100855907	fragile X mental retardation syndrome-related protein 1-like; K15516 fragile X mental retardation protein [KO:K15516]
475827	RBM8A; RNA binding motif protein 8A [KO:K12876]
479562	MAGOH; mago-nashi homolog, proliferation-associated (Drosophila) [KO:K12877]
477695	protein mago nashi homolog 2-like; K12877 protein mago nashi [KO:K12877]
480528	CASC3; cancer susceptibility candidate 3 [KO:K14323]
475922	EIF4A3; eukaryotic translation initiation factor 4A3 [KO:K13025] [EC:3.6.4.13]
609404	SAP18; Sin3A-associated protein, 18kDa [KO:K14324]
403907	PNN; pinin, desmosome associated protein [KO:K13114]
480247	ACIN1; apoptotic chromatin condensation inducer 1 [KO:K12875]
479880	RNPS1; RNA binding protein S1, serine-rich domain [KO:K14325]
607948	THOC4; Aly/REF export factor [KO:K12881]
100855479	THO complex subunit 4-like; K12881 THO complex subunit 4 [KO:K12881]
474839	DDX39B; DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B [KO:K12812] [EC:3.6.4.13]
490529	THOC1; THO complex 1 [KO:K12878]
481042	THOC2; THO complex 2 [KO:K12879]
477534	THOC5; THO complex 5 [KO:K13174]
479871	THOC6; THO complex 6 homolog (Drosophila) [KO:K13175]
476567	THOC7; THO complex 7 homolog (Drosophila) [KO:K13176]
480781	THOC3; THO complex 3 [KO:K12880]
478185	SRRM1; serine/arginine repetitive matrix 1 [KO:K13171]
483780	NXF1; nuclear RNA export factor 1 [KO:K14284]
492026	nuclear RNA export factor 2-like; K14284 nuclear RNA export factor 1/2 [KO:K14284]
609849	NXF5; nuclear RNA export factor 5 [KO:K14284]
609814	nuclear RNA export factor 2-like; K14284 nuclear RNA export factor 1/2 [KO:K14284]
492024	nuclear RNA export factor 2-like; K14284 nuclear RNA export factor 1/2 [KO:K14284]
491441	NXF3; nuclear RNA export factor 3 [KO:K14284]
477132	NXT1; NTF2-like export factor 1 [KO:K14285]
612945	NXT2; nuclear transport factor 2-like export factor 2 [KO:K14285]
476664	UPF1; UPF1 regulator of nonsense transcripts homolog (yeast) [KO:K14326] [EC:3.6.4.-]
487130	UPF2; UPF2 regulator of nonsense transcripts homolog (yeast) [KO:K14327]
607836	UPF3A; UPF3 regulator of nonsense transcripts homolog A (yeast) [KO:K14328]
481031	UPF3B; UPF3 regulator of nonsense transcripts homolog B (yeast) [KO:K14328]

Compound

C00035	GDP
C00044	GTP
C01647	tRNA(Met)

Reference

PMID:15519698

Authors

Rodriguez MS, Dargemont C, Stutz F

Title

Nuclear export of RNA.

Journal

Biol Cell 96:639-55 (2004)

Reference

PMID:20733056

Authors

Suzuki T, Izumi H, Ohno M

Title

Cajal body surveillance of U snRNA export complex assembly.

Journal

J Cell Biol 190:603-12 (2010)

Reference

PMID:18313922

Authors

Palancade B, Doye V

Title

Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?

Journal

Trends Cell Biol 18:174-83 (2008)

Reference

PMID:17401408

Authors

Pellizzoni L

Title

Chaperoning ribonucleoprotein biogenesis in health and disease.

Journal

EMBO Rep 8:340-5 (2007)

Reference

PMID:10872469

Authors

Gingras AC, Raught B, Sonenberg N

Title

eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation.

Journal

Annu Rev Biochem 68:913-63 (1999)

Reference

PMID:11018020

Authors

Asano K, Clayton J, Shalev A, Hinnebusch AG

Title

A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivo.

Journal

Genes Dev 14:2534-46 (2000)

Reference

PMID:9548260

Authors

Craig AW, Haghighat A, Yu AT, Sonenberg N

Title

Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation.

Journal

Nature 392:520-3 (1998)

Reference

PMID:15901496

Authors

Reed R, Cheng H

Title

TREX, SR proteins and export of mRNA.

Journal

Curr Opin Cell Biol 17:269-73 (2005)

Reference

PMID:16314458

Authors

Tange TO, Shibuya T, Jurica MS, Moore MJ

Title

Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.

Journal

RNA 11:1869-83 (2005)

KO pathway

ko03013

All links

Pathway (8)   
   KEGG MODULE (7)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (155)   
   KEGG GENES (155)   
All databases (164)   

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