KEGG   PATHWAY: cfa04145
Entry
cfa04145                    Pathway                                
Name
Phagosome - Canis lupus familiaris (dog)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
cfa04145  Phagosome
cfa04145

Other DBs
GO: 0045335
Organism
Canis lupus familiaris (dog) [GN:cfa]
Gene
102154970  VAMP3; vesicle-associated membrane protein 3 [KO:K13505]
478168  STX12; syntaxin-12 [KO:K13813]
483987  STX7; syntaxin-7 isoform X1 [KO:K08488]
403580  ACTB; actin, cytoplasmic 1 [KO:K05692]
475923  ACTG1; actin, cytoplasmic 2 [KO:K05692]
489949  CORO1A; coronin-1A [KO:K13882]
609342  STX18; syntaxin-18 isoform X2 [KO:K08492]
475816  SEC22B; vesicle-trafficking protein SEC22b isoform X1 [KO:K08517]
474836  DLA88; MHC class I DLA-88 precursor [KO:K06751]
483594  DLA-79; MHC class Ib precursor [KO:K06751]
474838  DLA-64; MHC class I DLA-64 precursor [KO:K06751]
541592  DLA-12; MHC class I DLA-12 precursor [KO:K06751]
100685196  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
474860  HLA-DRB1; DLA class II histocompatibility antigen, DR-1 beta chain precursor [KO:K06752]
481731  DLA-DRA; MHC class II DR alpha chain precursor [KO:K06752]
607786  DLA-DOB; major histocompatibility complex, class II, DO beta precursor [KO:K06752]
607827  DLA-DMB; major histocompatibility complex, class II, DM beta precursor [KO:K06752]
481732  DLA-DMA; major histocompatibility complex, class II, DM alpha precursor [KO:K06752]
474869  DLA-DOA; HLA class II histocompatibility antigen, DO alpha chain-like precursor [KO:K06752]
100856137  HLA class II histocompatibility antigen, DQ beta 2 chain isoform X1 [KO:K06752]
404008  RAB5A; ras-related protein Rab-5A [KO:K07887]
474394  RAB5B; ras-related protein Rab-5B [KO:K07888]
403941  RAB5C; ras-related protein Rab-5C [KO:K07889]
475424  EEA1; early endosome antigen 1 isoform X3 [KO:K12478]
490477  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
403703  TFRC; transferrin receptor protein 1 [KO:K06503]
483367  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform 1 [KO:K12182]
487981  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
474628  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform isoform X1 [KO:K02147]
486137  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
475061  ATP6V1C1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
475667  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X6 [KO:K02148]
480360  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
481359  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
477740  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
475199  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
474840  ATP6V1G2; V-type proton ATPase subunit G 1 [KO:K02152]
481939  V-type proton ATPase subunit G 1-like [KO:K02152]
490256  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
111090910  V-type proton ATPase subunit G 1-like [KO:K02152]
612591  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
403729  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
482789  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
102152234  V-type proton ATPase subunit e 1-like [KO:K02153]
486245  ATP6V0A2; V-type proton ATPase 116 kDa subunit a2 isoform X2 [KO:K02154]
607705  ATP6V0A1; V-type proton ATPase 116 kDa subunit a1 isoform X1 [KO:K02154]
482779  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
483691  TCIRG1; V-type proton ATPase 116 kDa subunit a3 [KO:K02154]
477929  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
479685  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
486953  ATP6V1H; V-type proton ATPase subunit H isoform X2 [KO:K02144]
479877  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
482528  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X2 [KO:K03661]
404007  RAB7A; ras-related protein Rab-7a [KO:K07897]
488576  RAB7B; ras-related protein Rab-7b isoform X1 [KO:K07898]
480649  RILP; rab-interacting lysosomal protein isoform X2 [KO:K13883]
480437  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
479461  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X17 [KO:K10414]
475236  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
478797  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X2 [KO:K10415]
477038  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 isoform X1 [KO:K10416]
479693  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
478918  TUBA4A; tubulin alpha-4A chain isoform X2 [KO:K07374]
486762  TUBA8; tubulin alpha-8 chain isoform X12 [KO:K07374]
608051  tubulin alpha-3 chain [KO:K07374]
477570  tubulin alpha-3 chain [KO:K07374]
487148  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
610636  tubulin alpha-1B chain isoform X2 [KO:K07374]
100856405  TUBA1C; tubulin alpha-1C chain [KO:K07374]
106557476  tubulin alpha-1A chain [KO:K07374]
100855995  tubulin alpha-8 chain-like isoform X3 [KO:K07374]
119866377  tubulin alpha-1B chain [KO:K07374]
474830  TUBB; tubulin beta chain [KO:K07375]
485950  TUBB1; tubulin beta-1 chain [KO:K07375]
480213  TUBB6; tubulin beta-6 chain [KO:K07375]
478702  tubulin beta-2B chain [KO:K07375]
491231  LOW QUALITY PROTEIN: tubulin beta chain [KO:K07375]
478701  TUBB2A; tubulin beta-2A chain [KO:K07375]
100855815  TUBB4A; tubulin beta-4A chain isoform X1 [KO:K07375]
102153202  TUBB4B; tubulin beta-4B chain isoform X2 [KO:K07375]
102154194  TUBB3; tubulin beta-3 chain [KO:K07375]
476995  LAMP1; lysosome-associated membrane glycoprotein 1 isoform X2 [KO:K06528]
481037  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
478890  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
477700  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
477498  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
609986  MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
102156614  CTSV; procathepsin L [KO:K01365] [EC:3.4.22.15]
100688895  LOW QUALITY PROTEIN: procathepsin L isoform X1 [KO:K01365] [EC:3.4.22.15]
484140  CTSL3; procathepsin L [KO:K01365] [EC:3.4.22.15]
403400  CTSS; cathepsin S precursor [KO:K01368] [EC:3.4.22.27]
404006  SEC61A1; protein transport protein Sec61 subunit alpha isoform 1 [KO:K10956]
478007  SEC61A2; protein transport protein Sec61 subunit alpha isoform X1 [KO:K10956]
404018  SEC61B; protein transport protein Sec61 subunit beta [KO:K09481]
404017  SEC61G; protein transport protein Sec61 subunit gamma [KO:K07342]
106559577  protein transport protein Sec61 subunit gamma-like [KO:K07342]
474866  TAP1; antigen peptide transporter 1 precursor [KO:K05653] [EC:7.4.2.14]
474864  TAP2; antigen peptide transporter 2 precursor [KO:K05654] [EC:7.4.2.14]
476694  CALR; calreticulin [KO:K08057]
403908  CANX; calnexin precursor [KO:K08054]
106559252  FCAR; LOW QUALITY PROTEIN: immunoglobulin alpha Fc receptor [KO:K06513]
403462  FCGR1A; high affinity immunoglobulin gamma Fc receptor I precursor [KO:K06498]
100856270  FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b isoform X3 [KO:K12560]
478984  low affinity immunoglobulin gamma Fc region receptor III isoform X4 [KO:K06463]
111097183  LOW QUALITY PROTEIN: immunoglobulin gamma-1 heavy chain-like isoform X1 [KO:K06856]
477707  C1R; complement C1r subcomponent [KO:K01330] [EC:3.4.21.41]
489928  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
403770  ITGB2; integrin beta-2 isoform X1 [KO:K06464]
476728  C3; complement C3 [KO:K03990]
482958  COLEC11; collectin-11 isoform X1 [KO:K10066]
607342  COLEC12; collectin-12 [KO:K10062]
479260  mannose-binding protein A isoform X2 [KO:K03991]
610540  pulmonary surfactant-associated protein A-like isoform X5 [KO:K10067]
489066  SFTPD; pulmonary surfactant-associated protein D [KO:K10068]
488437  ITGAV; integrin alpha-V isoform X5 [KO:K06487]
489208  ITGA2; integrin alpha-2 [KO:K06481]
486493  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
477956  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
403788  ITGB3; integrin beta-3 precursor [KO:K06493]
608977  ITGB5; integrin beta-5 [KO:K06588]
487486  THBS1; thrombospondin-1 [KO:K16857]
610359  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
484087  THBS2; thrombospondin-2 precursor [KO:K04659]
488930  THBS4; thrombospondin-4 [KO:K04659]
476665  COMP; cartilage oligomeric matrix protein [KO:K04659]
448807  TLR2; toll-like receptor 2 precursor [KO:K10159]
111089957  TLR6; toll-like receptor 6 isoform X1 [KO:K10169]
403417  TLR4; toll-like receptor 4 precursor [KO:K10160]
607076  CD14; monocyte differentiation antigen CD14 [KO:K04391]
487114  MRC1; macrophage mannose receptor 1 isoform X11 [KO:K06560]
488367  PLA2R1; secretory phospholipase A2 receptor [KO:K06560]
100688560  MRC2; C-type mannose receptor 2 isoform X2 [KO:K06560]
485000  CD209; CD209 antigen [KO:K06563]
611385  CLEC7A; C-type lectin domain family 7 member A isoform X2 [KO:K10074]
482891  MSR1; macrophage scavenger receptor types I and II isoform X2 [KO:K06558]
476117  MARCO; macrophage receptor MARCO isoform X1 [KO:K13884]
486694  OLR1; oxidized low-density lipoprotein receptor 1 [KO:K08763]
486241  SCARB1; scavenger receptor class B member 1 isoform X2 [KO:K13885]
475931  CD36; platelet glycoprotein 4 [KO:K06259]
489664  CYBA; cytochrome b-245 alpha chain [KO:K08009]
491825  CYBB; cytochrome b-245, beta polypeptide [KO:K21421] [EC:1.-.-.-]
403955  RAC1; ras-related C3 botulinum toxin substrate 1 precursor [KO:K04392]
607700  NCF1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
480036  NCF2; neutrophil cytosol factor 2 [KO:K08010]
481277  NCF4; neutrophil cytosol factor 4 isoform X2 [KO:K08012]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
cfa04142  Lysosome
cfa04144  Endocytosis
cfa04610  Complement and coagulation cascades
cfa04612  Antigen processing and presentation
cfa04620  Toll-like receptor signaling pathway
cfa04666  Fc gamma R-mediated phagocytosis
KO pathway
ko04145   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (145)   
   KEGG GENES (145)   
All databases (146)   

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