KEGG   PATHWAY: cfa04810Help
Entry
cfa04810                    Pathway                                

Name
Regulation of actin cytoskeleton - Canis familiaris (dog)
Class
Cellular Processes; Cell motility
BRITE hierarchy
Pathway map
Regulation of actin cytoskeleton
cfa04810

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BSID: 
GO: 
Organism
Canis familiaris (dog) [GN:cfa]
Gene
prothrombin-like; K01313 coagulation factor II (thrombin) [EC:3.4.21.5] [KO:K01313] [EC:3.4.21.5]
488942  
F2R; coagulation factor II (thrombin) receptor [KO:K03914]
607076  
CD14; CD14 molecule [KO:K04391]
483665  
INS; insulin [KO:K04526]
403657  
EGF; epidermal growth factor [KO:K04357]
611641  
FGF18; fibroblast growth factor 18 [KO:K04358]
484395  
FGF21; fibroblast growth factor 21 [KO:K04358]
491974  
FGF16; fibroblast growth factor 16 [KO:K04358]
612454  
FGF10; fibroblast growth factor 10 [KO:K04358]
486735  
FGF6; fibroblast growth factor 6 [KO:K04358]
483680  
FGF4; fibroblast growth factor 4 [KO:K04358]
492174  
FGF13; fibroblast growth factor 13 [KO:K04358]
611707  
FGF3; fibroblast growth factor 3 [KO:K04358]
483681  
FGF19; fibroblast growth factor 19 [KO:K04358]
608459  
FGF5; fibroblast growth factor 5 [KO:K04358]
607952  
FGF17; fibroblast growth factor 17 [KO:K04358]
485537  
FGF14; fibroblast growth factor 14 [KO:K04358]
607829  
FGF11; fibroblast growth factor 11 [KO:K04358]
478676  
FGF12; fibroblast growth factor 12 [KO:K04358]
403915  
FGF7; fibroblast growth factor 7 [KO:K04358]
607724  
FGF1; fibroblast growth factor 1 (acidic) [KO:K04358]
477340  
FGF9; fibroblast growth factor 9 (glia-activating factor) [KO:K04358]
403868  
FGF8; fibroblast growth factor 8 (androgen-induced) [KO:K04358]
611773  
FGF23; fibroblast growth factor 23 [KO:K04358]
612404  
fibroblast growth factor 22-like; K04358 fibroblast growth factor [KO:K04358]
403857  
FGF2; fibroblast growth factor 2 (basic) [KO:K04358]
442986  
PDGFB; platelet-derived growth factor beta polypeptide [KO:K04359]
491597  
PDGFA; platelet-derived growth factor alpha polypeptide [KO:K04359]
479460  
PDGFD; platelet derived growth factor D [KO:K05450]
482666  
PDGFC; platelet derived growth factor C [KO:K05450]
490405  
INSRR; insulin receptor-related receptor [KO:K05086] [EC:2.7.10.1]
404306  
EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
fibroblast growth factor receptor 1-like; K04362 fibroblast growth factor receptor 1 [EC:2.7.10.1] [KO:K04362] [EC:2.7.10.1]
415125  
FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
488808  
FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
489095  
FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
442860  
PDGFRA; platelet-derived growth factor receptor, alpha polypeptide [KO:K04363] [EC:2.7.10.1]
442985  
PDGFRB; platelet-derived growth factor receptor, beta polypeptide [KO:K05089] [EC:2.7.10.1]
403845  
FN1; fibronectin 1 [KO:K05717]
489210  
ITGA1; integrin, alpha 1 [KO:K06480]
489208  
ITGA2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) [KO:K06481]
403789  
ITGA2B; integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) [KO:K06476]
491074  
ITGA3; integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) [KO:K06482]
488429  
ITGA4; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) [KO:K06483]
486493  
ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide) [KO:K06484]
integrin alpha-6-like; K06485 integrin alpha 6 [KO:K06485]
481097  
ITGA7; integrin, alpha 7 [KO:K06583]
487119  
ITGA8; integrin, alpha 8 [KO:K06584]
477021  
ITGA9; integrin, alpha 9 [KO:K06585]
608287  
ITGA10; integrin, alpha 10 [KO:K06586]
478353  
ITGA11; integrin, alpha 11 [KO:K06587]
488437  
ITGAV; integrin, alpha V [KO:K06487]
489905  
ITGAL; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1 [KO:K05718]
489928  
ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit) [KO:K06461]
489929  
ITGAX; integrin, alpha X (complement component 3 receptor 4 subunit) [KO:K06462]
489930  
ITGAD; integrin, alpha D [KO:K06594]
480659  
ITGAE; integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1 [KO:K06524]
477956  
ITGB1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) [KO:K05719]
403770  
ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) [KO:K06464]
403788  
ITGB3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) [KO:K06493]
483318  
ITGB4; integrin, beta 4 [KO:K06525]
608977  
ITGB5; integrin, beta 5 [KO:K06588]
488368  
ITGB6; integrin, beta 6 [KO:K06589]
477598  
ITGB7; integrin, beta 7 [KO:K06590]
475253  
ITGB8; integrin, beta 8 [KO:K06591]
490847  
BDKRB1; bradykinin receptor B1 [KO:K03915]
403658  
BDKRB2; bradykinin receptor B2 [KO:K03916]
483776  
CHRM1; cholinergic receptor, muscarinic 1 [KO:K04129]
403858  
CHRM2; cholinergic receptor, muscarinic 2 [KO:K04130]
403827  
CHRM3; cholinergic receptor, muscarinic 3 [KO:K04131]
611314  
CHRM4; cholinergic receptor, muscarinic 4 [KO:K04132]
487472  
CHRM5; cholinergic receptor, muscarinic 5 [KO:K04133]
490901  
GNA13; guanine nucleotide binding protein (G protein), alpha 13 [KO:K04639]
611002  
guanine nucleotide binding protein (G protein); K04347 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like; K04347 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
491901  
FGD1; FYVE, RhoGEF and PH domain containing 1 [KO:K05720]
484213  
FGD3; FYVE, RhoGEF and PH domain containing 3 [KO:K05722]
475108  
PTK2; PTK2 protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
479648  
BCAR1; breast cancer anti-estrogen resistance 1 [KO:K05726]
608125  
CRKL; v-crk sarcoma virus CT10 oncogene homolog (avian)-like [KO:K04438]
CRK; v-crk sarcoma virus CT10 oncogene homolog (avian) [KO:K04438]
486934  
DOCK1; dedicator of cytokinesis 1 [KO:K13708]
485864  
SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [KO:K05704] [EC:2.7.10.2]
490682  
SOS2; son of sevenless homolog 2 (Drosophila) [KO:K03099]
483042  
SOS1; son of sevenless homolog 1 (Drosophila) [KO:K03099]
403735  
HRAS; v-Ha-ras Harvey rat sarcoma viral oncogene homolog [KO:K02833]
403871  
KRAS; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
403872  
NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog [KO:K07828]
476413  
RRAS; related RAS viral (r-ras) oncogene homolog [KO:K07829]
476865  
RRAS2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
477082  
MRAS; muscle RAS oncogene homolog [KO:K07831]
610290  
ARHGEF6; Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 [KO:K05729]
488084  
PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
489644  
PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
477085  
PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
483266  
PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma [KO:K00922] [EC:2.7.1.153]
609956  
PIK3R2; phosphoinositide-3-kinase, regulatory subunit 2 (beta) [KO:K02649]
487235  
PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [KO:K02649]
612805  
PIK3R5; phosphoinositide-3-kinase, regulatory subunit 5 [KO:K02649]
phosphatidylinositol 3-kinase regulatory subunit gamma-like; K02649 phosphoinositide-3-kinase, regulatory subunit [KO:K02649]
608060  
VAV2; vav 2 guanine nucleotide exchange factor [KO:K05730]
485016  
VAV1; vav 1 guanine nucleotide exchange factor [KO:K05730]
479921  
VAV3; vav 3 guanine nucleotide exchange factor [KO:K05730]
487731  
TIAM1; T-cell lymphoma invasion and metastasis 1 [KO:K05731]
491857  
ARAF; v-raf murine sarcoma 3611 viral oncogene homolog [KO:K08845] [EC:2.7.11.1]
475526  
BRAF; v-raf murine sarcoma viral oncogene homolog B1 [KO:K04365] [EC:2.7.11.1]
484648  
RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [KO:K04366] [EC:2.7.11.1]
486959  
MOS; v-mos Moloney murine sarcoma viral oncogene homolog [KO:K04367] [EC:2.7.11.1]
478347  
MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
611939  
MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
477575  
MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
479790  
MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
rho guanine nucleotide exchange factor 1-like; K12330 Rho guanine nucleotide exchange factor 1 [KO:K12330]
479409  
ARHGEF12; Rho guanine nucleotide exchange factor (GEF) 12 [KO:K07532]
403543  
ARHGAP35; Rho GTPase activating protein 35 [KO:K05732]
403954  
RHOA; ras homolog family member A [KO:K04513]
403955  
RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
481271  
RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
403934  
CDC42; cell division cycle 42 (GTP binding protein, 25kDa) [KO:K04393]
607885  
PAK1; p21 protein (Cdc42/Rac)-activated kinase 1 [KO:K04409] [EC:2.7.11.1]
612814  
PAK2; p21 protein (Cdc42/Rac)-activated kinase 2 [KO:K04410] [EC:2.7.11.1]
492067  
PAK3; p21 protein (Cdc42/Rac)-activated kinase 3 [KO:K05733] [EC:2.7.11.1]
484513  
PAK4; p21 protein (Cdc42/Rac)-activated kinase 4 [KO:K05734] [EC:2.7.11.1]
serine/threonine-protein kinase PAK 6-like; K05735 p21-activated kinase 6 [EC:2.7.11.1] [KO:K05735] [EC:2.7.11.1]
485772  
PAK7; p21 protein (Cdc42/Rac)-activated kinase 7 [KO:K05736] [EC:2.7.11.1]
485552  
ARHGEF7; Rho guanine nucleotide exchange factor (GEF) 7 [KO:K13710]
491180  
GIT1; G protein-coupled receptor kinase interacting ArfGAP 1 [KO:K05737]
480181  
ROCK1; Rho-associated, coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.1]
482970  
ROCK2; Rho-associated, coiled-coil containing protein kinase 2 [KO:K04514] [EC:2.7.11.1]
488012  
MYLK; myosin light chain kinase [KO:K00907] [EC:2.7.11.18]
477187  
MYLK2; myosin light chain kinase 2 [KO:K00907] [EC:2.7.11.18]
475345  
MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
488190  
MYLK4; myosin light chain kinase family, member 4 [KO:K00907] [EC:2.7.11.18]
403557  
PPP1CC; protein phosphatase 1, catalytic subunit, gamma isozyme [KO:K06269] [EC:3.1.3.16]
403558  
PPP1CB; protein phosphatase 1, catalytic subunit, beta isozyme [KO:K06269] [EC:3.1.3.16]
403609  
PPP1CA; protein phosphatase 1, catalytic subunit, alpha isozyme [KO:K06269] [EC:3.1.3.16]
475411  
PPP1R12A; protein phosphatase 1, regulatory subunit 12A [KO:K06270]
490230  
PPP1R12B; protein phosphatase 1, regulatory subunit 12B [KO:K12329]
403614  
MYL2; myosin, light chain 2, regulatory, cardiac, slow [KO:K10351]
479135  
MYL5; myosin, light chain 5, regulatory [KO:K12753]
MYL7; myosin, light chain 7, regulatory [KO:K12754]
485856  
MYL9; myosin, light chain 9, regulatory [KO:K12755]
608177  
MYL10; myosin, light chain 10, regulatory [KO:K12756]
480193  
MYL12B; myosin regulatory light polypeptide 9-like [KO:K12757]
607207  
MYL12A; myosin regulatory light polypeptide 9-like [KO:K12757]
479772  
MYLPF; myosin regulatory light chain 2, skeletal muscle isoform type 2-like [KO:K12758]
DIAPH1; diaphanous homolog 1 (Drosophila) [KO:K05740]
480977  
uncharacterized LOC480977; K05741 diaphanous 2 [KO:K05741]
478171  
SLC9A1; solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 [KO:K05742]
476331  
PIP5K1B; phosphatidylinositol-4-phosphate 5-kinase, type I, beta [KO:K00889] [EC:2.7.1.68]
485054  
PIP5K1C; phosphatidylinositol-4-phosphate 5-kinase, type I, gamma [KO:K00889] [EC:2.7.1.68]
475846  
PIP5K1A; phosphatidylinositol-4-phosphate 5-kinase, type I, alpha [KO:K00889] [EC:2.7.1.68]
474417  
PIP4K2C; phosphatidylinositol-5-phosphate 4-kinase, type II, gamma [KO:K00920] [EC:2.7.1.149]
608414  
PIP4K2A; phosphatidylinositol-5-phosphate 4-kinase, type II, alpha [KO:K00920] [EC:2.7.1.149]
491034  
PIP4K2B; phosphatidylinositol-5-phosphate 4-kinase, type II, beta [KO:K00920] [EC:2.7.1.149]
478890  
PIKFYVE; phosphoinositide kinase, FYVE finger containing [KO:K00921] [EC:2.7.1.150]
489800  
LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
486363  
LIMK2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
485474  
DIAPH3; diaphanous homolog 3 (Drosophila) [KO:K05745]
403473  
BAIAP2; BAI1-associated protein 2 [KO:K05627]
490390  
uncharacterized LOC490390; K05746 enabled [KO:K05746]
475213  
WASL; Wiskott-Aldrich syndrome-like [KO:K05747]
491867  
WAS; Wiskott-Aldrich syndrome [KO:K05747]
487343  
WASF2; WAS protein family, member 2 [KO:K05748]
479001  
CYFIP1; cytoplasmic FMR1 interacting protein 1 [KO:K05749]
479317  
CYFIP2; cytoplasmic FMR1 interacting protein 2 [KO:K05749]
486492  
NCKAP1L; NCK-associated protein 1-like [KO:K05750]
478828  
NCKAP1; NCK-associated protein 1 [KO:K05750]
488485  
ABI2; abl-interactor 2 [KO:K05751]
607701  
probable protein BRICK1-like; K05752 chromosome 3 open reading frame 10 [KO:K05752]
475024  
WASF1; WAS protein family, member 1 [KO:K05753]
480037  
ARPC5; actin related protein 2/3 complex, subunit 5, 16kDa [KO:K05754]
612856  
ARPC5L; actin related protein 2/3 complex, subunit 5-like [KO:K05754]
476540  
ARPC4; actin related protein 2/3 complex, subunit 4, 20kDa [KO:K05755]
actin-related protein 2/3 complex subunit 3-like; K05756 actin related protein 2/3 complex, subunit 3 [KO:K05756]
479744  
ARPC1B; actin related protein 2/3 complex, subunit 1B, 41kDa [KO:K05757]
479745  
ARPC1A; actin related protein 2/3 complex, subunit 1A, 41kDa [KO:K05757]
478907  
ARPC2; actin related protein 2/3 complex, subunit 2, 34kDa [KO:K05758]
442937  
ACTG1; actin, gamma 1 [KO:K05692]
403580  
ACTB; actin, beta [KO:K05692]
607397  
profilin-1-like; K05759 profilin [KO:K05759]
610829  
PFN4; profilin family, member 4 [KO:K05759]
489091  
PFN3; profilin 3 [KO:K05759]
uncharacterized LOC100683352; K05759 profilin [KO:K05759]
486299  
PXN; paxillin [KO:K05760]
484056  
EZR; ezrin [KO:K08007]
479446  
RDX; radixin [KO:K05762]
491924  
MSN; moesin [KO:K05763]
thymosin beta-4-like; K05764 thymosin, beta 4 [KO:K05764]
490649  
CFL2; cofilin 2 (muscle) [KO:K05765]
476022  
CFL1; cofilin 1 (non-muscle) [KO:K05765]
609010  
cofilin-1-like; K05765 cofilin [KO:K05765]
483699  
SSH3; slingshot homolog 3 (Drosophila) [KO:K05766]
491183  
SSH2; slingshot homolog 2 (Drosophila) [KO:K05766]
477526  
SSH1; slingshot homolog 1 (Drosophila) [KO:K05766]
479252  
VCL; vinculin [KO:K05700]
479050  
IQGAP1; IQ motif containing GTPase activating protein 1 [KO:K16848]
490412  
IQGAP3; IQ motif containing GTPase activating protein 3 [KO:K05767]
479177  
IQGAP2; IQ motif containing GTPase activating protein 2 [KO:K05767]
474819  
GSN; gelsolin [KO:K05768]
480369  
ACTN1; actinin, alpha 1 [KO:K05699]
479191  
ACTN2; actinin, alpha 2 [KO:K05699]
484526  
ACTN4; actinin, alpha 4 [KO:K05699]
483707  
ACTN3; actinin, alpha 3 [KO:K05699]
479139  
APC; adenomatous polyposis coli [KO:K02085]
485084  
APC2; adenomatosis polyposis coli 2 [KO:K02085]
483856  
ARHGEF4; Rho guanine nucleotide exchange factor (GEF) 4 [KO:K05769]
Compound
C00306  
Bradykinin
C00338  
Lipopolysaccharide
C01996  
Acetylcholine
C04637  
1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
C11554  
1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
Reference
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
Reference
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
Reference
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
Reference
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
Reference
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
Reference
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
KO pathway
 

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