Entry
Name
Protein digestion and absorption - Canis lupus familiaris (dog)
Description
Protein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancreatic and small intestinal enzymes. The result of this proteolytic activity is a mixture of amino acids and small peptides. Amino acids (AAs) are transported into the enterocyte (intestinal epithelial cell) by a variety of AA transporters that are specific for cationic (basic) AA, neutral AA, and anionic (acidic) AA. Small peptides are absorbed into enterocytes by the PEPT1 transporter. Inside enterocytes peptides are hydrolyzed, and the resulting amino acids are released together with those absorbed by AA transporters into blood via multiple, basolateral, AA transporters. Hydrolysis-resistant peptides, however, are transported out of the cells by a basolateral peptide transporter that has not been identified molecularly.
Class
Organismal Systems; Digestive system
BRITE hierarchy
Pathway map
cfa04974 Protein digestion and absorption
Ortholog table
Other DBs
Organism
Canis lupus familiaris (dog) [GN:
cfa ]
Gene
611100 CTRL; chymotrypsin-like protease CTRL-1 [KO:K09632 ] [EC:3.4.21.-]
488073 SLC9A3; sodium/hydrogen exchanger 3 isoform X1 [KO:K12040 ]
403561 SLC15A1; solute carrier family 15 member 1 [KO:K14206 ]
488636 ATP1A4; sodium/potassium-transporting ATPase subunit alpha-2 isoform X3 [KO:K01539 ] [EC:7.2.2.13 ]
612463 ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 isoform X1 [KO:K01539 ] [EC:7.2.2.13 ]
403966 ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540 ]
489479 ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 isoform X2 [KO:K01540 ]
477098 ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540 ]
608594 FXYD2; sodium/potassium-transporting ATPase subunit gamma [KO:K01538 ]
484464 KCNN4; intermediate conductance calcium-activated potassium channel protein 4 isoform X3 [KO:K04945 ]
481780 KCNK5; potassium channel subfamily K member 5 isoform X1 [KO:K04916 ]
485197 KCNE3; potassium voltage-gated channel subfamily E member 3 [KO:K04897 ]
483669 KCNQ1; potassium voltage-gated channel subfamily KQT member 1 isoform X3 [KO:K04926 ]
477411 KCNJ13; inward rectifier potassium channel 13 [KO:K05006 ]
486596 SLC38A2; sodium-coupled neutral amino acid transporter 2 isoform X2 [KO:K14207 ]
403751 SLC1A1; excitatory amino acid transporter 3 [KO:K05612 ]
484425 SLC1A5; neutral amino acid transporter B(0) [KO:K05616 ]
475738 SLC8A1; sodium/calcium exchanger 1 precursor [KO:K05849 ]
490755 SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849 ]
484420 SLC8A2; sodium/calcium exchanger 2 isoform X1 [KO:K05849 ]
100683912 SLC6A19; sodium-dependent neutral amino acid transporter B(0)AT1 [KO:K05334 ]
483777 SLC3A2; 4F2 cell-surface antigen heavy chain [KO:K06519 ]
490608 SLC7A8; large neutral amino acids transporter small subunit 2 [KO:K13781 ]
489173 SLC36A1; proton-coupled amino acid transporter 1 [KO:K14209 ]
489174 SLC36A2; proton-coupled amino acid transporter 2 [KO:K14209 ]
607790 SLC36A4; proton-coupled amino acid transporter 4 [KO:K14209 ]
489175 SLC36A3; proton-coupled amino acid transporter 3 isoform X4 [KO:K14209 ]
612335 SLC16A10; monocarboxylate transporter 10 isoform X2 [KO:K08187 ]
403700 SLC3A1; neutral and basic amino acid transport protein rBAT [KO:K14210 ]
484601 SLC7A9; B(0,+)-type amino acid transporter 1 [KO:K13868 ]
482987 b(0,+)-type amino acid transporter 1-like isoform X3 [KO:K13868 ]
403651 COL1A1; collagen alpha-1(I) chain precursor [KO:K06236 ]
403824 COL1A2; collagen alpha-2(I) chain precursor [KO:K06236 ]
403826 COL2A1; collagen alpha-1(II) chain precursor [KO:K19719 ]
478835 COL3A1; collagen alpha-1(III) chain isoform X1 [KO:K19720 ]
403840 COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237 ]
403466 COL4A5; collagen alpha-5(IV) chain precursor [KO:K06237 ]
403843 COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237 ]
403496 COL4A1; collagen alpha-1(IV) chain isoform X3 [KO:K06237 ]
480684 COL5A1; LOW QUALITY PROTEIN: collagen alpha-1(V) chain isoform X2 [KO:K19721 ]
478836 COL5A2; collagen alpha-2(V) chain isoform X1 [KO:K19721 ]
484961 COL5A3; collagen alpha-3(V) chain isoform X1 [KO:K19721 ]
481734 COL11A2; collagen alpha-2(XI) chain isoform X2 [KO:K19721 ]
479965 COL24A1; collagen alpha-1(XXIV) chain isoform X4 [KO:K19721 ]
474811 COL27A1; collagen alpha-1(XXVII) chain isoform X1 [KO:K19721 ]
403582 COL6A3; collagen alpha-3(VI) chain precursor [KO:K06238 ]
610649 COL6A6; collagen alpha-6(VI) chain isoform X1 [KO:K06238 ]
610614 collagen alpha-4(VI) chain-like isoform X4 [KO:K06238 ]
485659 COL6A5; collagen alpha-5(VI) chain isoform X2 [KO:K06238 ]
403467 COL7A1; collagen alpha-1(VII) chain precursor [KO:K16628 ]
478538 CMSS1; collagen alpha-1(VIII) chain isoform X1 [KO:K23455 ]
481873 COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131 ]
607609 COL9A2; collagen alpha-2(IX) chain precursor [KO:K08131 ]
612430 COL9A3; collagen alpha-3(IX) chain precursor [KO:K08131 ]
481881 COL12A1; collagen alpha-1(XII) chain isoform X7 [KO:K08132 ]
609516 COL13A1; collagen alpha-1(XIII) chain isoform X5 [KO:K16617 ]
475085 COL14A1; collagen alpha-1(XIV) chain isoform X1 [KO:K08133 ]
474778 COL15A1; collagen alpha-1(XV) chain isoform X4 [KO:K08135 ]
487318 COL16A1; collagen alpha-1(XVI) chain isoform X1 [KO:K24339 ]
481872 COL19A1; collagen alpha-1(XIX) chain isoform X1 [KO:K24340 ]
474945 COL21A1; collagen alpha-1(XXI) chain isoform X1 [KO:K16629 ]
482056 COL22A1; collagen alpha-1(XXII) chain isoform X1 [KO:K16630 ]
608184 COL26A1; collagen alpha-1(XXVI) chain isoform X4 [KO:K24358 ]
482315 COL28A1; collagen alpha-1(XXVIII) chain isoform X1 [KO:K23619 ]
Compound
C05996 Branched chain fatty acid
Reference
Authors
Broer S
Title
Amino acid transport across mammalian intestinal and renal epithelia.
Journal
Reference
Authors
Palacin M, Nunes V, Font-Llitjos M, Jimenez-Vidal M, Fort J, Gasol E, Pineda M, Feliubadalo L, Chillaron J, Zorzano A
Title
The genetics of heteromeric amino acid transporters.
Journal
Reference
Authors
Goodman BE
Title
Insights into digestion and absorption of major nutrients in humans.
Journal
Reference
Authors
Wagner CA, Lang F, Broer S
Title
Function and structure of heterodimeric amino acid transporters.
Journal
Reference
Authors
Broer S
Title
Apical transporters for neutral amino acids: physiology and pathophysiology.
Journal
Reference
Authors
Wu G
Title
Intestinal mucosal amino acid catabolism.
Journal
Reference
Authors
Daniel H
Title
Molecular and integrative physiology of intestinal peptide transport.
Journal
Reference
Authors
Rubio-Aliaga I, Daniel H
Title
Mammalian peptide transporters as targets for drug delivery.
Journal
Reference
Authors
Bai JP
Title
Distribution of brush-border membrane peptidases along the rat intestine.
Journal
Reference
Authors
Guarner F, Malagelada JR
Title
Gut flora in health and disease.
Journal
Reference
Authors
Smith EA, Macfarlane GT
Title
Dissimilatory amino Acid metabolism in human colonic bacteria.
Journal
Reference
Authors
Schepers E, Glorieux G, Vanholder R
Title
The gut: the forgotten organ in uremia?
Journal
Reference
Authors
John H.Cummings
Title
The large intestine in nutrition and disease
Journal
Institut Danone
Reference
Authors
Heitzmann D, Warth R
Title
Physiology and pathophysiology of potassium channels in gastrointestinal epithelia.
Journal
Related pathway
cfa00250 Alanine, aspartate and glutamate metabolism
KO pathway