KEGG   PATHWAY: cfa05132Help
Entry
cfa05132                    Pathway                                

Name
Salmonella infection - Canis familiaris (dog)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious diseases
BRITE hierarchy
Pathway map
Salmonella infection
cfa05132

All organismsOrtholog table
Organism
Canis familiaris (dog) [GN:cfa]
Gene
607076  
CD14; CD14 molecule [KO:K04391]
403417  
TLR4; toll-like receptor 4 [KO:K10160]
485869  
LBP; lipopolysaccharide binding protein [KO:K05399]
477024  
MYD88; myeloid differentiation primary response 88 [KO:K04729]
488605  
TLR5; toll-like receptor 5 [KO:K10168]
PYCARD; PYD and CARD domain containing [KO:K12799]
403955  
RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
403934  
CDC42; cell division cycle 42 (GTP binding protein, 25kDa) [KO:K04393]
485217  
RHOG; ras homolog family member G [KO:K07863]
491949  
rho-related GTP-binding protein RhoG-like; K07863 Ras homolog gene family, member G [KO:K07863]
403856  
MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
607019  
MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
607023  
MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
612821  
MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
477575  
MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
479790  
MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
477746  
MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
478464  
MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
474652  
MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
490792  
FOS; FBJ murine osteosarcoma viral oncogene homolog [KO:K04379]
609429  
JUN; jun proto-oncogene [KO:K04448]
442859  
NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 [KO:K02580]
483729  
RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735]
403796  
IL18; interleukin 18 (interferon-gamma-inducing factor) [KO:K05482]
403974  
IL1B; interleukin 1, beta [KO:K04519]
403782  
IL1A; interleukin 1, alpha [KO:K04383]
403985  
IL6; interleukin 6 (interferon, beta 2) [KO:K05405]
403850  
CXCL8; interleukin 8 [KO:K10030]
448787  
CCL3; chemokine (C-C motif) ligand 3 [KO:K05408]
480600  
chemokine (C-C motif) ligand 3; K05408 C-C motif chemokine 3 [KO:K05408]
448786  
CCL4; chemokine (C-C motif) ligand 4 [KO:K12964]
403923  
CSF2; colony stimulating factor 2 (granulocyte-macrophage) [KO:K05427]
475024  
WASF1; WAS protein family, member 1 [KO:K05753]
487343  
WASF2; WAS protein family, member 2 [KO:K05748]
475213  
WASL; Wiskott-Aldrich syndrome-like [KO:K05747]
491867  
WAS; Wiskott-Aldrich syndrome [KO:K05747]
480037  
ARPC5; actin related protein 2/3 complex, subunit 5, 16kDa [KO:K05754]
612856  
ARPC5L; actin related protein 2/3 complex, subunit 5-like [KO:K05754]
ARPC3; actin related protein 2/3 complex, subunit 3, 21kDa [KO:K05756]
479744  
ARPC1B; actin related protein 2/3 complex, subunit 1B, 41kDa [KO:K05757]
479745  
ARPC1A; actin related protein 2/3 complex, subunit 1A, 41kDa [KO:K05757]
478907  
ARPC2; actin related protein 2/3 complex, subunit 2, 34kDa [KO:K05758]
403752  
TJP1; tight junction protein 1 (zona occludens 1) [KO:K05701]
442937  
ACTG1; actin, gamma 1 [KO:K05692]
403580  
ACTB; actin, beta [KO:K05692]
475923  
ACTG1; actin, gamma 1 [KO:K05692]
491313  
PKN3; protein kinase N3 [KO:K06071] [EC:2.7.11.13]
490174  
PKN2; protein kinase N2 [KO:K06071] [EC:2.7.11.13]
PKN1; protein kinase N1 [KO:K06071] [EC:2.7.11.13]
480181  
ROCK1; Rho-associated, coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.1]
482970  
ROCK2; Rho-associated, coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.1]
PLEKHM2; pleckstrin homology domain containing, family M (with RUN domain) member 2 [KO:K15348]
474909  
KLC4; kinesin light chain 4 [KO:K10407]
483715  
KLC2; kinesin light chain 2 [KO:K10407]
484448  
KLC3; kinesin light chain 3 [KO:K10407]
KLC1; kinesin light chain 1 [KO:K10407]
404007  
RAB7A; RAB7A, member RAS oncogene family [KO:K07897]
488576  
ras-related protein Rab-7b-like; K07898 Ras-related protein Rab-7B [KO:K07898]
480649  
RILP; Rab interacting lysosomal protein [KO:K13883]
480437  
DYNC1H1; dynein, cytoplasmic 1, heavy chain 1 [KO:K10413]
479461  
DYNC2H1; dynein, cytoplasmic 2, heavy chain 1 [KO:K10414]
475236  
DYNC1I1; dynein, cytoplasmic 1, intermediate chain 1 [KO:K10415]
478797  
DYNC1I2; dynein, cytoplasmic 1, intermediate chain 2 [KO:K10415]
477038  
DYNC1LI1; dynein, cytoplasmic 1, light intermediate chain 1 [KO:K10416]
479693  
DYNC1LI2; dynein, cytoplasmic 1, light intermediate chain 2 [KO:K10416]
607397  
PFN1; profilin 1 [KO:K05759]
610829  
PFN4; profilin family, member 4 [KO:K05759]
489091  
PFN3; profilin 3 [KO:K05759]
PFN2; profilin 2 [KO:K05759]
484713  
FLNB; filamin B, beta [KO:K04437]
481084  
FLNA; filamin A, alpha [KO:K04437]
482266  
FLNC; filamin C, gamma [KO:K04437]
403801  
IFNG; interferon gamma [KO:K04687]
IFNGR1; interferon gamma receptor 1 [KO:K05132]
487739  
IFNGR2; interferon gamma receptor 2-like [KO:K05133]
interferon gamma receptor 2-like; K05133 interferon gamma receptor 2 [KO:K05133]
403822  
NOS2; nitric oxide synthase 2, inducible [KO:K13241] [EC:1.14.13.39]
Compound
C00062  
L-Arginine
C00338  
Lipopolysaccharide
C00533  
Nitric oxide
C04637  
1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
Reference
  Authors
Trebichavsky I, Splichal I, Splichalova A
  Title
Innate immune response in the gut against Salmonella - review.
  Journal
Folia Microbiol (Praha) 55:295-300 (2010)
Reference
  Authors
Talbot S, Totemeyer S, Yamamoto M, Akira S, Hughes K, Gray D, Barr T, Mastroeni P, Maskell DJ, Bryant CE
  Title
Toll-like receptor 4 signalling through MyD88 is essential to control Salmonella  enterica serovar typhimurium infection, but not for the initiation of bacterial clearance.
  Journal
Immunology 128:472-83 (2009)
Reference
  Authors
Ibarra JA, Steele-Mortimer O
  Title
Salmonella--the ultimate insider. Salmonella virulence factors that modulate intracellular survival.
  Journal
Cell Microbiol 11:1579-86 (2009)
Reference
  Authors
Gewirtz AT, Navas TA, Lyons S, Godowski PJ, Madara JL
  Title
Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression.
  Journal
J Immunol 167:1882-5 (2001)
Reference
  Authors
Vijay-Kumar M, Wu H, Jones R, Grant G, Babbin B, King TP, Kelly D, Gewirtz AT, Neish AS
  Title
Flagellin suppresses epithelial apoptosis and limits disease during enteric infection.
  Journal
Am J Pathol 169:1686-700 (2006)
Reference
  Authors
Miao EA, Andersen-Nissen E, Warren SE, Aderem A
  Title
TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system.
  Journal
Semin Immunopathol 29:275-88 (2007)
Reference
  Authors
Bueno SM, Riedel CA, Carreno LJ, Kalergis AM
  Title
Virulence mechanisms displayed by Salmonella to impair dendritic cell function.
  Journal
Curr Med Chem 17:1156-66 (2010)
Reference
  Authors
Haraga A, Ohlson MB, Miller SI
  Title
Salmonellae interplay with host cells.
  Journal
Nat Rev Microbiol 6:53-66 (2008)
Reference
  Authors
Kimbrough TG, Miller SI
  Title
Assembly of the type III secretion needle complex of Salmonella typhimurium.
  Journal
Microbes Infect 4:75-82 (2002)
Reference
  Authors
Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
  Journal
J Cell Biol 175:453-63 (2006)
Reference
  Authors
Bulgin R, Raymond B, Garnett JA, Frankel G, Crepin VF, Berger CN, Arbeloa A
  Title
Bacterial guanine nucleotide exchange factors SopE-like and WxxxE effectors.
  Journal
Infect Immun 78:1417-25 (2010)
Reference
  Authors
Bakowski MA, Braun V, Brumell JH
  Title
Salmonella-containing vacuoles: directing traffic and nesting to grow.
  Journal
Traffic 9:2022-31 (2008)
Reference
  Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
Reference
  Authors
Nikolaus T, Deiwick J, Rappl C, Freeman JA, Schroder W, Miller SI, Hensel M
  Title
SseBCD proteins are secreted by the type III secretion system of Salmonella pathogenicity island 2 and function as a translocon.
  Journal
J Bacteriol 183:6036-45 (2001)
Reference
  Authors
Eckmann L, Kagnoff MF
  Title
Cytokines in host defense against Salmonella.
  Journal
Microbes Infect 3:1191-200 (2001)
Reference
  Authors
Fu Y, Galan JE
  Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
  Journal
Nature 401:293-7 (1999)
Reference
  Authors
Du F, Galan JE
  Title
Selective inhibition of type III secretion activated signaling by the Salmonella  effector AvrA.
  Journal
PLoS Pathog 5:e1000595 (2009)
Reference
  Authors
Jones RM, Wu H, Wentworth C, Luo L, Collier-Hyams L, Neish AS
  Title
Salmonella AvrA Coordinates Suppression of Host Immune and Apoptotic Defenses via JNK Pathway Blockade.
  Journal
Cell Host Microbe 3:233-44 (2008)
Reference
  Authors
Haraga A, Miller SI
  Title
A Salmonella type III secretion effector interacts with the mammalian serine/threonine protein kinase PKN1.
  Journal
Cell Microbiol 8:837-46 (2006)
Reference
  Authors
Abrahams GL, Muller P, Hensel M
  Title
Functional dissection of SseF, a type III effector protein involved in positioning the salmonella-containing vacuole.
  Journal
Traffic 7:950-65 (2006)
Reference
  Authors
Henry T, Couillault C, Rockenfeller P, Boucrot E, Dumont A, Schroeder N, Hermant A, Knodler LA, Lecine P, Steele-Mortimer O, Borg JP, Gorvel JP, Meresse S
  Title
The Salmonella effector protein PipB2 is a linker for kinesin-1.
  Journal
Proc Natl Acad Sci U S A 103:13497-502 (2006)
Reference
  Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
  Title
Salmonella effectors translocated across the vacuolar membrane interact with the  actin cytoskeleton.
  Journal
Mol Microbiol 48:401-15 (2003)
Reference
  Authors
Prior K, Hautefort I, Hinton JC, Richardson DJ, Rowley G
  Title
All stressed out. Salmonella pathogenesis and reactive nitrogen species.
  Journal
Adv Microb Physiol 56:1-28 (2009)
KO pathway
 

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