KEGG PATHWAY: cfa05162

PATHWAY: cfa05162

Entry

cfa05162 Pathway

Name

Measles - Canis familiaris (dog)

Description

Measles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacterial infections. Several MV proteins have been suggested to disturb host immunity. After infection of host lymphoid cells via SLAM, MV inhibits cytokine response by direct interference with host signaling systems. Three proteins (P, V, and C) associate with Jak/STAT proteins in interferon-triggered pathway and other important proteins related to apoptosis. Interaction between MV and host brings about the shift towards a Th2 response by decreasing IL-12 production and induces lymphopenia by suppressing cell proliferation.

Class

Human Diseases; Infectious diseases

Pathway map

cfa05162

Measles

Organism

Canis familiaris (dog) [GN:cfa]

Gene

491924	MSN; moesin [KO:K05763]
485000	CD209; CD209 molecule [KO:K06563]
403815	TACR1; tachykinin receptor 1 [KO:K04222]
609365	CD46; CD46 molecule, complement regulatory protein [KO:K04007]
403642	SLAMF1; signaling lymphocytic activation molecule family member 1 [KO:K06536]
612899	SH2D1A; SH2 domain containing 1A [KO:K07990]
475032	FYN; FYN oncogene related to SRC, FGR, YES [KO:K05703] [EC:2.7.10.2]
483100	DOK1; docking protein 1, 62kDa (downstream of tyrosine kinase 1) [KO:K14752]
442990	IL13; interleukin 13 [KO:K05435]
403785	IL4; interleukin 4 [KO:K05430]
490595	uncharacterized LOC490595; K10784 T cell receptor alpha chain V region [KO:K10784]
480788	T-cell receptor beta chain T17T-22-like; K10785 T-cell receptor beta chain V region [KO:K10785]
609004	uncharacterized LOC609004; K10785 T-cell receptor beta chain V region [KO:K10785]
479419	CD3D; CD3d molecule, delta (CD3-TCR complex) [KO:K06450]
442981	CD3E; CD3e molecule, epsilon (CD3-TCR complex) [KO:K06451]
489383	CD3G; CD3g molecule, gamma (CD3-TCR complex) [KO:K06452]
403646	CD28; CD28 molecule [KO:K06470]
403989	IL2; interleukin 2 [KO:K05429]
403870	IL2RA; interleukin 2 receptor, alpha [KO:K05068]
403439	IL2RB; interleukin 2 receptor, beta [KO:K05069]
403851	IL2RG; interleukin 2 receptor, gamma [KO:K05070]
609956	PIK3R2; phosphoinositide-3-kinase, regulatory subunit 2 (beta) [KO:K02649]
487235	PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [KO:K02649]
612805	PIK3R5; phosphoinositide-3-kinase, regulatory subunit 5 [KO:K02649]
100856339	phosphatidylinositol 3-kinase regulatory subunit gamma-like; K02649 phosphoinositide-3-kinase, regulatory subunit [KO:K02649]
488084	PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
489644	PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
477085	PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
483266	PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma [KO:K00922] [EC:2.7.1.153]
442964	AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) [KO:K04456] [EC:2.7.11.1]
449021	AKT2; v-akt murine thymoma viral oncogene homolog 2 [KO:K04456] [EC:2.7.11.1]
490878	AKT1; v-akt murine thymoma viral oncogene homolog 1 [KO:K04456] [EC:2.7.11.1]
478575	GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
442952	JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
610004	JAK3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2]
490967	STAT3; signal transducer and activator of transcription 3 (acute-phase response factor) [KO:K04692]
490968	STAT5A; signal transducer and activator of transcription 5A [KO:K11223]
490969	STAT5B; signal transducer and activator of transcription 5B [KO:K11224]
100855560	probable ATP-dependent RNA helicase DDX58-like; K12646 ATP-dependent RNA helicase DDX58 [EC:3.6.3.14] [KO:K12646] [EC:3.6.3.14]
488371	IFIH1; interferon induced with helicase C domain 1 [KO:K12647] [EC:3.6.4.13]
485789	MAVS; mitochondrial antiviral signaling protein [KO:K12648]
478950	IKBKE; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon [KO:K07211] [EC:2.7.11.10]
481145	TBK1; TANK-binding kinase 1 [KO:K05410] [EC:2.7.11.10]
476412	IRF3; interferon regulatory factor 3 [KO:K05411]
491743	TLR7; toll-like receptor 7 [KO:K05404]
403502	TLR9; toll-like receptor 9 [KO:K10161]
477024	MYD88; myeloid differentiation primary response gene (88) [KO:K04729]
492247	IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
486601	IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
477796	CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
448807	TLR2; toll-like receptor 2 [KO:K10159]
403417	TLR4; toll-like receptor 4 [KO:K10160]
100688110	TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase [KO:K03175]
484028	TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
484519	NFKBIB; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta [KO:K02581]
480291	NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha [KO:K04734]
442859	NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 [KO:K02580]
483729	RELA; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735]
477185	CSNK2A1; casein kinase 2, alpha 1 polypeptide [KO:K03097] [EC:2.7.11.1]
478108	CSNK2A2; casein kinase 2, alpha prime polypeptide [KO:K03097] [EC:2.7.11.1]
474844	CSNK2B; casein kinase 2, beta polypeptide [KO:K03115]
484006	TNFAIP3; tumor necrosis factor, alpha-induced protein 3 [KO:K11859] [EC:3.-.-.-]
444848	IFNA6; interferon, alpha 6 [KO:K05414]
474181	IFNA7; interferon, alpha 7 [KO:K05414]
474182	IFNA8; interferon, alpha 8 [KO:K05414]
442934	IFNA5; interferon, alpha 5 [KO:K05414]
611406	interferon alpha-1/2-like; K05414 interferon alpha [KO:K05414]
100856394	interferon alpha-1/2-like; K05414 interferon alpha [KO:K05414]
100686162	interferon alpha-2-like; K05414 interferon alpha [KO:K05414]
481558	IFNB1; interferon, beta 1, fibroblast [KO:K05415]
403782	IL1A; interleukin 1, alpha [KO:K04383]
403974	IL1B; interleukin 1, beta [KO:K04519]
403985	IL6; interleukin 6 (interferon, beta 2) [KO:K05405]
403977	IL12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) [KO:K05406]
403976	IL12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) [KO:K05425]
607427	uncharacterized LOC607427; K06856 immunoglobulin heavy chain [KO:K06856]
100856270	low affinity immunoglobulin gamma Fc region receptor II-b-like; K12560 low affinity immunoglobulin gamma Fc region receptor II-b [KO:K12560]
609830	IFNAR1; interferon (alpha, beta and omega) receptor 1 [KO:K05130]
100856529	interferon alpha/beta receptor 1-like; K05130 interferon receptor 1 [KO:K05130]
487737	IFNAR2; interferon (alpha, beta and omega) receptor 2 [KO:K05131]
100856468	interferon alpha/beta receptor 2-like; K05131 interferon receptor 2 [KO:K05131]
480818	GNB2L1; guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 [KO:K14753]
476714	TYK2; tyrosine kinase 2 [KO:K11219] [EC:2.7.10.2]
488449	STAT1; signal transducer and activator of transcription 1, 91kDa [KO:K11220]
481111	STAT2; signal transducer and activator of transcription 2, 113kDa [KO:K11221]
607899	IRF9; interferon regulatory factor 9 [KO:K04693]
403801	IFNG; interferon gamma [KO:K04687]
100856077	interferon gamma receptor 1-like; K05132 interferon gamma receptor 1 [KO:K05132]
487739	IFNGR2; interferon gamma receptor 2 (interferon gamma transducer 1) [KO:K05133]
100856276	interferon gamma receptor 2-like; K05133 interferon gamma receptor 2 [KO:K05133]
484185	JAK2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
608778	OAS1; 2'-5'-oligoadenylate synthetase 1, 40/46kDa [KO:K14216]
611051	OAS2; 2'-5'-oligoadenylate synthetase 2, 69/71kDa [KO:K14216]
477490	OAS3; 2'-5'-oligoadenylate synthetase 3, 100kDa [KO:K14216]
403745	MX1; myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) [KO:K14754]
449028	CCND1; cyclin D1 [KO:K04503]
611782	CCND2; cyclin D2 [KO:K10151]
608847	CCND3; cyclin D3 [KO:K10152]
484610	CCNE1; cyclin E1 [KO:K06626]
487057	CCNE2; cyclin E2 [KO:K06626]
481131	CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
609920	CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
100855704	cyclin-dependent kinase 2-like; K02206 cyclin-dependent kinase 2 [EC:2.7.11.22] [KO:K02206] [EC:2.7.11.22]
403429	CDKN1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1) [KO:K06624]
403947	RAB9A; RAB9A, member RAS oncogene family [KO:K07899]
481003	RAB9B; RAB9B, member RAS oncogene family [KO:K07900]
474850	HSPA1L; heat shock 70kDa protein 1-like [KO:K03283]
403612	HSP70; heat shock protein 70 [KO:K03283]
607182	heat shock cognate 71 kDa protein-like; K03283 heat shock 70kDa protein 1/8 [KO:K03283]
480355	HSPA2; heat shock 70kDa protein 2 [KO:K03283]
479406	HSPA8; heat shock 70kDa protein 8 [KO:K03283]
475081	EIF3H; eukaryotic translation initiation factor 3, subunit H [KO:K03247]
100302056	EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
611397	EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 [KO:K16195] [EC:2.7.11.1]
475756	EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
478257	EIF2AK4; eukaryotic translation initiation factor 2 alpha kinase 4 [KO:K16196] [EC:2.7.11.1]
480361	EIF2S1; eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa [KO:K03237]
612746	RCHY1; ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase [KO:K10144] [EC:6.3.2.19]
403869	TP53; tumor protein p53 [KO:K04451]
489620	TP73; tumor protein p73 [KO:K10148]
612153	BBC3; BCL2 binding component 3 [KO:K10132]
442968	FASLG; Fas ligand (TNF superfamily, member 6) [KO:K04389]
486469	FAS; Fas (TNF receptor superfamily, member 6) [KO:K04390]
100174780	TNFSF10; tumor necrosis factor (ligand) superfamily, member 10 [KO:K04721]

Compound

C05981	Phosphatidylinositol-3,4,5-trisphosphate
C18991	Protein P
C18997	Protein C
C18998	Non-structural protein V

Reference

PMID:19203113

Authors

Schneider-Schaulies S, Schneider-Schaulies J

Title

Measles virus-induced immunosuppression.

Journal

Curr Top Microbiol Immunol 330:243-69 (2009)

Reference

PMID:19198562

Authors

Navaratnarajah CK, Leonard VH, Cattaneo R

Title

Measles virus glycoprotein complex assembly, receptor attachment, and cell entry.

Journal

Curr Top Microbiol Immunol 329:59-76 (2009)

Reference

PMID:19203114

Authors

Hahm B

Title

Hostile communication of measles virus with host innate immunity and dendritic cells.

Journal

Curr Top Microbiol Immunol 330:271-87 (2009)

Reference

PMID:19203109

Authors

Naniche D

Title

Human immunology of measles virus infection.

Journal

Curr Top Microbiol Immunol 330:151-71 (2009)

Reference

PMID:19198566

Authors

Gerlier D, Valentin H

Title

Measles virus interaction with host cells and impact on innate immunity.

Journal

Curr Top Microbiol Immunol 329:163-91 (2009)

Reference

PMID:12620806

Authors

Yokota S, Saito H, Kubota T, Yokosawa N, Amano K, Fujii N

Title

Measles virus suppresses interferon-alpha signaling pathway: suppression of Jak1 phosphorylation and association of viral accessory proteins, C and V, with interferon-alpha receptor complex.

Journal

Virology 306:135-46 (2003)

Reference

PMID:16963735

Authors

Yanagi Y, Takeda M, Ohno S

Title

Measles virus: cellular receptors, tropism and pathogenesis.

Journal

J Gen Virol 87:2767-79 (2006)

Reference

PMID:16237742

Authors

Kerdiles YM, Sellin CI, Druelle J, Horvat B

Title

Immunosuppression caused by measles virus: role of viral proteins.

Journal

Rev Med Virol 16:49-63 (2006)

Reference

PMID:16690907

Authors

Schneider-Schaulies S, Dittmer U

Title

Silencing T cells or T-cell silencing: concepts in virus-induced immunosuppression.

Journal

J Gen Virol 87:1423-38 (2006)

Reference

PMID:20376484

Authors

Avota E, Gassert E, Schneider-Schaulies S

Title

Measles virus-induced immunosuppression: from effectors to mechanisms.

Journal

Med Microbiol Immunol 199:227-37 (2010)

Reference

PMID:11582511

Authors

Schneider-Schaulies J, ter Meulen V, Schneider-Schaulies S

Title

Measles virus interactions with cellular receptors: consequences for viral pathogenesis.

Journal

J Neurovirol 7:391-9 (2001)

Reference

PMID:20636817

Authors

Griffin DE

Title

Measles virus-induced suppression of immune responses.

Journal

Immunol Rev 236:176-89 (2010)

Reference

PMID:11385511

Authors

Avota E, Avots A, Niewiesk S, Kane LP, Bommhardt U, ter Meulen V, Schneider-Schaulies S

Title

Disruption of Akt kinase activation is important for immunosuppression induced by measles virus.

Journal

Nat Med 7:725-31 (2001)

Reference

PMID:18922877

Authors

Pfaller CK, Conzelmann KK

Title

Measles virus V protein is a decoy substrate for IkappaB kinase alpha and prevents Toll-like receptor 7/9-mediated interferon induction.

Journal

J Virol 82:12365-73 (2008)

Reference

PMID:17720800

Authors

Yokota S, Okabayashi T, Yokosawa N, Fujii N

Title

Measles virus P protein suppresses Toll-like receptor signal through up-regulation of ubiquitin-modifying enzyme A20.

Journal

FASEB J 22:74-83 (2008)

Reference

PMID:12804771

Authors

Takeuchi K, Kadota SI, Takeda M, Miyajima N, Nagata K

Title

Measles virus V protein blocks interferon (IFN)-alpha/beta but not IFN-gamma signaling by inhibiting STAT1 and STAT2 phosphorylation.

Journal

FEBS Lett 545:177-82 (2003)

Reference

PMID:12410527

Authors

Gotoh B, Komatsu T, Takeuchi K, Yokoo J

Title

Paramyxovirus strategies for evading the interferon response.

Journal

Rev Med Virol 12:337-57 (2002)

Reference

PMID:12805463

Authors

Palosaari H, Parisien JP, Rodriguez JJ, Ulane CM, Horvath CM

Title

STAT protein interference and suppression of cytokine signal transduction by measles virus V protein.

Journal

J Virol 77:7635-44 (2003)

Reference

PMID:14585342

Authors

Shaffer JA, Bellini WJ, Rota PA

Title

The C protein of measles virus inhibits the type I interferon response.

Journal

Virology 315:389-97 (2003)

KO pathway

ko05162

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Pathway (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (124)   
   KEGG GENES (124)   
All databases (126)   

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