| Entry |
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| Name |
Mismatch repair - Coccidioides immitis
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| Description |
DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preventing mutations from becoming permanent in dividing cells. MMR also suppresses homologous recombination and was recently shown to play a role in DNA damage signaling. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems.
The Escherichia coli MMR pathway has been extensively studied and is well characterized. In E. coli, the mismatch-activated MutS-MutL-ATP complex licenses MutH to incise the nearest unmethylated GATC sequence. UvrD and an exonuclease generate a gap. This gap is filled by pol III and DNA ligase. The GATC sites are then methylated by Dam. Several human MMR proteins have been identified based on their homology to E. coli MMR proteins. These include human homologs of MutS and MutL. Although E. coli MutS and MutL proteins are homodimers, human MutS and MutL homologs are heterodimers. The role of hemimethylated dGATC sites as a signal for strand discrimination is not conserved from E. coli to human. Human MMR is presumed to be nick-directed in vivo, and is thought to discriminate daughter and template strands using a strand-specific nick.
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| Class |
Genetic Information Processing; Replication and repair
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| Pathway map |
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| Module |
| DNA polymerase III complex, bacteria [PATH: cim03430] | | | | | | BRCA1-associated genome surveillance complex (BASC) [PATH: cim03430] |
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| Other DBs |
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| Organism |
Coccidioides immitis [GN: cim]
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| Gene |
| hypothetical protein; K10858 DNA mismatch repair protein PMS2 [KO: K10858] | | hypothetical protein; K08734 DNA mismatch repair protein MLH1 [KO: K08734] | | hypothetical protein; K08737 DNA mismatch repair protein MSH6 [KO: K08737] | | hypothetical protein; K08735 DNA mismatch repair protein MSH2 [KO: K08735] | | hypothetical protein; K08736 DNA mismatch repair protein MSH3 [KO: K08736] | | hypothetical protein; K08739 DNA mismatch repair protein MLH3 [KO: K08739] | | hypothetical protein; K10754 replication factor C subunit 1 [KO: K10754] | | hypothetical protein; K10755 replication factor C subunit 2/4 [KO: K10755] | | hypothetical protein; K10755 replication factor C subunit 2/4 [KO: K10755] | | hypothetical protein; K10756 replication factor C subunit 3/5 [KO: K10756] | | hypothetical protein; K10756 replication factor C subunit 3/5 [KO: K10756] | | hypothetical protein; K04802 proliferating cell nuclear antigen [KO: K04802] | | hypothetical protein; K10746 exonuclease 1 [EC:3.1.-.-] [KO: K10746] [EC:3.1.-.-] | | replication factor-A protein 1; K07466 replication factor A1 [KO: K07466] | | hypothetical protein; K10739 replication factor A2 [KO: K10739] | | | | hypothetical protein; K02328 DNA polymerase delta subunit 2 [KO: K02328] | | hypothetical protein; K03504 DNA polymerase delta subunit 3 [KO: K03504] | | hypothetical protein; K03505 DNA polymerase delta subunit 4 [KO: K03505] | | | | |
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| Reference |
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| Authors |
Jiricny J. |
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| Title |
The multifaceted mismatch-repair system. |
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| Journal |
Nat Rev Mol Cell Biol 7:335-46 (2006) |
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| Reference |
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| Authors |
Li GM. |
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| Title |
Mechanisms and functions of DNA mismatch repair. |
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| Journal |
Cell Res 18:85-98 (2008) |
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| Reference |
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| Authors |
Marti TM, Kunz C, Fleck O. |
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| Title |
DNA mismatch repair and mutation avoidance pathways. |
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| Journal |
J Cell Physiol 191:28-41 (2002) |
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| Reference |
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| Authors |
Ikejima M, Shimada T. |
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| Title |
[Molecular mechanism of mismatch repair] Japanese |
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| Journal |
Tanpakushitsu Kakusan Koso 46:1124-9 (2001) |
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| Reference |
(Japanese ) |
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| Authors |
Hanaoka F. |
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| Title |
[DNA Replication and Repair] (In Japanese) |
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| Journal |
Yodosha (2004) |
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| KO pathway |
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