KEGG   PATHWAY: cin00983Help
Entry
cin00983                    Pathway                                

Name
Drug metabolism - other enzymes - Ciona intestinalis (sea squirt)
Class
Metabolism; Xenobiotics biodegradation and metabolism
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Pathway map
Drug metabolism - other enzymes
cin00983

All organismsOrtholog table
Organism
Ciona intestinalis (sea squirt) [GN:cin]
Gene
hypoxanthine-guanine phosphoribosyltransferase-like; K00760 hypoxanthine phosphoribosyltransferase [EC:2.4.2.8] [KO:K00760] [EC:2.4.2.8]
impdh2; IMP (inosine 5'-monophosphate) dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
gmps; GMP synthase [glutamine-hydrolyzing]-like [KO:K01951] [EC:6.3.5.2]
thiopurine S-methyltransferase-like; K00569 thiopurine S-methyltransferase [EC:2.1.1.67] [KO:K00569] [EC:2.1.1.67]
xanthine dehydrogenase/oxidase-like; K00106 xanthine dehydrogenase/oxidase [EC:1.17.1.4 1.17.3.2] [KO:K00106] [EC:1.17.3.2 1.17.1.4]
ITPase; inosine triphosphate pyrophosphatase-like [KO:K01519] [EC:3.6.1.19]
cocaine esterase-like; K03927 carboxylesterase 2 [EC:3.1.1.1 3.1.1.84 3.1.1.56] [KO:K03927] [EC:3.1.1.56 3.1.1.84 3.1.1.1]
liver carboxylesterase 4-like; K03927 carboxylesterase 2 [EC:3.1.1.1 3.1.1.84 3.1.1.56] [KO:K03927] [EC:3.1.1.56 3.1.1.84 3.1.1.1]
cytidine deaminase-like; K01489 cytidine deaminase [EC:3.5.4.5] [KO:K01489] [EC:3.5.4.5]
cytidine deaminase-like; K01489 cytidine deaminase [EC:3.5.4.5] [KO:K01489] [EC:3.5.4.5]
dpyd; dihydropyrimidine dehydrogenase [KO:K00207] [EC:1.3.1.2]
dpys; dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
upb1; ureidopropionase, beta [KO:K01431] [EC:3.5.1.6]
uridine phosphorylase 2-like; K00757 uridine phosphorylase [EC:2.4.2.3] [KO:K00757] [EC:2.4.2.3]
uridine-cytidine kinase-like 1-like; K00876 uridine kinase [EC:2.7.1.48] [KO:K00876] [EC:2.7.1.48]
uridine-cytidine kinase 2-B-like; K00876 uridine kinase [EC:2.7.1.48] [KO:K00876] [EC:2.7.1.48]
thymidine kinase; K00857 thymidine kinase [EC:2.7.1.21] [KO:K00857] [EC:2.7.1.21]
uridine 5'-monophosphate synthase-like; K13421 uridine monophosphate synthetase [EC:2.4.2.10 4.1.1.23] [KO:K13421] [EC:4.1.1.23 2.4.2.10]
Compound
C02380  
6-Mercaptopurine
C04242  
5-Fluorodeoxyuridine monophosphate
C04646  
6-Thioinosine-5'-monophosphate
C05361  
Hydrazine
C06837  
Azathioprine
C07054  
Isoniazid
C07446  
Isonicotinic acid
C07447  
Acetylhydrazine
C07585  
N-Acetylisoniazid
C07648  
Thioguanine
C07649  
5-FU
C11173  
SN-38
C11376  
SN38 glucuronide
C11736  
5-Fluorodeoxyuridine
C12650  
Capecitabine
C12673  
Tegafur
C12739  
5'-Deoxy-5-fluorouridine
C16542  
APC
C16543  
NPC
C16613  
6-Thiourate
C16614  
6-Methylmercaptopurine
C16615  
6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  
6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  
6-Mercaptopurine ribonucleoside triphosphate
C16618  
6-Thioxanthine 5'-monophosphate
C16619  
6-Thioguanosine monophosphate
C16620  
6-Methylthioguanosine monophosphate
C16621  
1-Methyl-4-nitroimidazole
C16622  
N,N'-Diacetylhydrazine
C16623  
Isonicotinylglycine
C16624  
Isoniazid pyruvate
C16625  
Isoniazid alpha-ketoglutaric acid
C16630  
5,6-Dihydro-5-fluorouracil
C16631  
alpha-Fluoro-beta-ureidopropionic acid
C16632  
alpha-Fluoro-beta-alanine
C16633  
5-Fluorouridine
C16634  
5-Fluorouridine monophosphate
C16635  
5'-Deoxy-5-fluorocytidine
C16641  
Irinotecan
D00238  
Azathioprine (JP16/USP/INN)
D00346  
Isoniazid (JP16/USP/INN)
D00584  
Fluorouracil (JP16/USP/INN)
D01223  
Capecitabine (JAN/USAN/INN)
D01244  
Tegafur (JP16/USAN/INN)
D01309  
Doxifluridine (JP16/INN)
D04197  
Floxuridine (USP/INN)
D04931  
Mercaptopurine (INN)
D08086  
Irinotecan (INN)
D08603  
Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
KO pathway
 

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