KEGG   PATHWAY: cli03440
Entry
cli03440                    Pathway                                
Name
Homologous recombination - Chlorobium limicola
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
cli03440  Homologous recombination
cli03440

Other DBs
GO: 0000724
Organism
Chlorobium limicola [GN:cli]
Gene
Clim_0558  single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
Clim_0148  single-strand binding protein [KO:K03111]
Clim_2149  single-strand binding protein [KO:K03111]
Clim_0003  DNA replication and repair protein RecF [KO:K03629]
Clim_2393  DNA repair protein RecO [KO:K03584]
Clim_0876  recombination protein RecR [KO:K06187]
Clim_2133  recA protein [KO:K03553]
Clim_0473  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
Clim_0321  Holliday junction DNA helicase RuvA [KO:K03550]
Clim_0616  Holliday junction DNA helicase RuvB [KO:K03551] [EC:5.6.2.4]
Clim_0476  crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.21.10]
Clim_0386  ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
Clim_2269  putative transcriptional regulator [KO:K03655] [EC:5.6.2.4]
Clim_2462  putative transcriptional regulator [KO:K03655] [EC:5.6.2.4]
Clim_0785  putative transcriptional regulator [KO:K03655] [EC:5.6.2.4]
Clim_1467  putative transcriptional regulator [KO:K03655] [EC:5.6.2.4]
Clim_1359  exodeoxyribonuclease V, beta subunit [KO:K03582] [EC:3.1.11.5]
Clim_1360  exodeoxyribonuclease V, gamma subunit [KO:K03583] [EC:3.1.11.5]
Clim_1358  exodeoxyribonuclease V, alpha subunit [KO:K03581] [EC:3.1.11.5]
Clim_0947  helicase, RecD/TraA family [KO:K03581] [EC:3.1.11.5]
Clim_0812  DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
Clim_0002  DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
Clim_2150  DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
Clim_1870  DNA-directed DNA polymerase [KO:K02341] [EC:2.7.7.7]
Clim_1265  DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
Clim_1445  DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
Clim_1417  primosomal protein N' [KO:K04066] [EC:5.6.2.4]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

DBGET integrated database retrieval system