KEGG   PATHWAY: clu03015Help
Entry
clu03015                    Pathway                                
Name
mRNA surveillance pathway - Clavispora lusitaniae
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These  pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
BRITE hierarchy
Pathway map
mRNA surveillance pathway
clu03015

All organismsOrtholog table
Module
Cap binding complex [PATH:clu03015]
Exon junction complex (EJC) [PATH:clu03015]
Other DBs
BSID: 
GO: 
Organism
Clavispora lusitaniae [GN:clu]
Gene
hypothetical protein; K12882 nuclear cap-binding protein subunit 1 [KO:K12882]
hypothetical protein; K12883 nuclear cap-binding protein subunit 2 [KO:K12883]
hypothetical protein; K14328 regulator of nonsense transcripts 3 [KO:K14328]
similar to ATP-dependent RNA helicase; K13025 ATP-dependent RNA helicase [EC:3.6.4.13] [KO:K13025] [EC:3.6.4.13]
hypothetical protein; K14284 nuclear RNA export factor 1/2 [KO:K14284]
hypothetical protein; K12812 ATP-dependent RNA helicase UAP56/SUB2 [EC:3.6.4.13] [KO:K12812] [EC:3.6.4.13]
hypothetical protein; K13171 serine/arginine repetitive matrix protein 1 [KO:K13171]
hypothetical protein; K00565 mRNA (guanine-N7-)-methyltransferase [EC:2.1.1.56] [KO:K00565] [EC:2.1.1.56]
hypothetical protein; K14396 polyadenylate-binding protein 2 [KO:K14396]
hypothetical protein; K14376 poly(A) polymerase [EC:2.7.7.19] [KO:K14376] [EC:2.7.7.19]
hypothetical protein; K14399 polyribonucleotide 5'-hydroxyl-kinase [EC:2.7.1.78] [KO:K14399] [EC:2.7.1.78]
hypothetical protein; K14400 pre-mRNA cleavage complex 2 protein Pcf11 [KO:K14400]
hypothetical protein; K14401 cleavage and polyadenylation specificity factor subunit 1 [KO:K14401]
hypothetical protein; K14402 cleavage and polyadenylation specificity factor subunit 2 [KO:K14402]
hypothetical protein; K14403 cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-] [KO:K14403] [EC:3.1.27.-]
hypothetical protein; K14404 cleavage and polyadenylation specificity factor subunit 4 [KO:K14404]
hypothetical protein; K14405 pre-mRNA 3'-end-processing factor FIP1 [KO:K14405]
hypothetical protein; K15541 protein MPE1 [KO:K15541]
hypothetical protein; K15542 polyadenylation factor subunit 2 [KO:K15542]
hypothetical protein; K14962 COMPASS component SWD2 [KO:K14962]
serine/threonine protein phosphatase PP1; K06269 protein phosphatase 1, catalytic subunit [EC:3.1.3.16] [KO:K06269] [EC:3.1.3.16]
hypothetical protein; K15544 RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [EC:3.1.3.16] [KO:K15544] [EC:3.1.3.16]
hypothetical protein; K14407 cleavage stimulation factor subunit 2 [KO:K14407]
hypothetical protein; K14407 cleavage stimulation factor subunit 2 [KO:K14407]
hypothetical protein; K14408 cleavage stimulation factor subunit 3 [KO:K14408]
hypothetical protein; K06100 symplekin [KO:K06100]
hypothetical protein; K14411 RNA-binding protein Musashi [KO:K14411]
hypothetical protein; K13126 polyadenylate-binding protein [KO:K13126]
hypothetical protein; K03265 peptide chain release factor subunit 1 [KO:K03265]
hypothetical protein; K03267 peptide chain release factor subunit 3 [KO:K03267]
hypothetical protein; K14326 regulator of nonsense transcripts 1 [EC:3.6.4.-] [KO:K14326] [EC:3.6.4.-]
hypothetical protein; K14327 regulator of nonsense transcripts 2 [KO:K14327]
serine/threonine protein phosphatase PP2A-2 catalytic subunit; K04382 protein phosphatase 2 (formerly 2A), catalytic subunit [EC:3.1.3.16] [KO:K04382] [EC:3.1.3.16]
hypothetical protein; K03456 protein phosphatase 2 (formerly 2A), regulatory subunit A [KO:K03456]
hypothetical protein; K04354 protein phosphatase 2 (formerly 2A), regulatory subunit B [KO:K04354]
hypothetical protein; K11584 protein phosphatase 2 (formerly 2A), regulatory subunit B' [KO:K11584]
hypothetical protein; K14416 elongation factor 1 alpha-like protein [KO:K14416]
hypothetical protein; K06965 protein pelota [KO:K06965]
Reference
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
Reference
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
Reference
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
Reference
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
Reference
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
KO pathway
 
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