KEGG   PATHWAY: cpg00790Help
Entry
cpg00790                    Pathway                                

Name
Folate biosynthesis - Corynebacterium pseudotuberculosis 316
Class
Metabolism; Metabolism of cofactors and vitamins
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Pathway map
Folate biosynthesis
cpg00790

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BSID: 
GO: 
Organism
Corynebacterium pseudotuberculosis 316 [GN:cpg]
Gene
folE; GTP cyclohydrolase 1 [KO:K01495] [EC:3.5.4.16]
folB; Dihydroneopterin aldolase [KO:K01633] [EC:1.13.11.81 5.1.99.8 4.1.2.25]
folK; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [KO:K00950] [EC:2.7.6.3]
folP; Dihydropteroate synthase [KO:K00796] [EC:2.5.1.15]
folP1; Dihydropteroate synthase [KO:K00796] [EC:2.5.1.15]
folA; Dihydrofolate reductase [KO:K00287] [EC:1.5.1.3]
folC; Bifunctional protein folC [KO:K11754] [EC:6.3.2.17 6.3.2.12]
ribA; Riboflavin biosynthesis protein ribBA [KO:K14652] [EC:3.5.4.25 4.1.99.12]
pabB; Para-aminobenzoate synthase component I [KO:K13950] [EC:2.6.1.85]
pabC; 4-Amino-4-deoxychorismate lyase [KO:K02619] [EC:4.1.3.38]
moaA; Molybdenum cofactor biosynthesis protein A [KO:K03639] [EC:4.1.99.22]
moeA; Molybdopterin molybdenumtransferase [KO:K03750] [EC:2.10.1.1]
Compound
C00044  
GTP
C00101  
Tetrahydrofolate
C00119  
5-Phospho-alpha-D-ribose 1-diphosphate
C00156  
4-Hydroxybenzoate
C00251  
Chorismate
C00266  
Glycolaldehyde
C00268  
Dihydrobiopterin
C00272  
Tetrahydrobiopterin
C00415  
Dihydrofolate
C00504  
Folate
C00568  
4-Aminobenzoate
C00835  
Sepiapterin
C00921  
Dihydropteroate
C01217  
5,6,7,8-Tetrahydromethanopterin
C01300  
6-(Hydroxymethyl)-7,8-dihydropterin
C01304  
2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C02587  
Pyrimidodiazepine
C02953  
7,8-Dihydrobiopterin
C03541  
THF-polyglutamate
C03684  
6-Pyruvoyltetrahydropterin
C04244  
6-Lactoyl-5,6,7,8-tetrahydropterin
C04807  
6-Hydroxymethyl-7,8-dihydropterin diphosphate
C04874  
7,8-Dihydroneopterin
C04895  
7,8-Dihydroneopterin 3'-triphosphate
C05922  
Formamidopyrimidine nucleoside triphosphate
C05923  
2,5-Diaminopyrimidine nucleoside triphosphate
C05924  
Molybdopterin
C05925  
Dihydroneopterin phosphate
C05926  
Neopterin
C05927  
7,8-Dihydromethanopterin
C06148  
2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
C09332  
THF-L-glutamate
C11355  
4-Amino-4-deoxychorismate
C15522  
4a-Hydroxytetrahydrobiopterin
C15996  
7-Cyano-7-carbaguanine
C16675  
7-Aminomethyl-7-carbaguanine
C18237  
Molybdoenzyme molybdenum cofactor
C18239  
Precursor Z
C18802  
Tetrahydrosarcinapterin
C19848  
Adenylated molybdopterin
C19871  
Guanylyl molybdenum cofactor
C20239  
6-Carboxy-5,6,7,8-tetrahydropterin
C20248  
7-Carboxy-7-carbaguanine
C20264  
L-threo-Tetrahydrobiopterin
C20559  
4-(beta-D-Ribofuranosyl)aniline 5'-phosphate
C20562  
N-[(7,8-Dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate
C20566  
7,8-Dihydroneopterin 2'-phosphate
C20567  
7,8-Dihydroneopterin 2',3'-cyclic phosphate
C21007  
5,6,7,8-Tetrahydromonapterin
C21008  
7,8-Dihydromonapterin
C21065  
7,8-Dihydroxanthopterin
C21094  
7,8-Dihydromonapterin 3'-triphosphate
C21107  
4-(beta-D-Ribofuranosyl)phenol 5'-phosphate
C21310  
(8S)-3',8-Cyclo-7,8-dihydroguanosine 5'-triphosphate
C21485  
Cytidylyl molybdenum cofactor
C21486  
Thio-molybdenum cofactor
C21640  
6-(1'-Hydroxy-2'-oxopropyl)-tetrahydropterin
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Schwarz G, Mendel RR, Ribbe MW
  Title
Molybdenum cofactors, enzymes and pathways.
  Journal
Nature 460:839-47 (2009)
DOI:10.1038/nature08302
Reference
  Authors
Hanzelmann P, Schindelin H
  Title
Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism.
  Journal
Proc Natl Acad Sci U S A 103:6829-34 (2006)
DOI:10.1073/pnas.0510711103
Reference
  Authors
Daniels JN, Wuebbens MM, Rajagopalan KV, Schindelin H
  Title
Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency.
  Journal
Biochemistry 47:615-26 (2008)
DOI:10.1021/bi701734g
Reference
  Authors
Wuebbens MM, Rajagopalan KV
  Title
Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis.
  Journal
J Biol Chem 278:14523-32 (2003)
DOI:10.1074/jbc.M300453200
Reference
  Authors
Werner ER, Blau N, Thony B
  Title
Tetrahydrobiopterin: biochemistry and pathophysiology.
  Journal
Biochem J 438:397-414 (2011)
DOI:10.1042/BJ20110293
Reference
  Authors
Iino T, Tabata M, Takikawa S, Sawada H, Shintaku H, Ishikura S, Hara A
  Title
Tetrahydrobiopterin is synthesized from 6-pyruvoyl-tetrahydropterin by the human aldo-keto reductase AKR1 family members.
  Journal
Arch Biochem Biophys 416:180-7 (2003)
DOI:10.1016/S0003-9861(03)00295-9
Reference
PMID:1902669
  Authors
Park YS, Heizmann CW, Wermuth B, Levine RA, Steinerstauch P, Guzman J, Blau N
  Title
Human carbonyl and aldose reductases: new catalytic functions in tetrahydrobiopterin biosynthesis.
  Journal
Biochem Biophys Res Commun 175:738-44 (1991)
DOI:10.1016/0006-291X(91)91628-P
KO pathway
 

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