KEGG   PATHWAY: cqu04745
Entry
cqu04745                    Pathway                                
Name
Phototransduction - fly - Culex quinquefasciatus (southern house mosquito)
Description
Phototransduction is the process that converts the signal of light (photons) into a change of membrane potential in photoreceptor cells. Drosophila visual signaling is initiated with the activation of rhodopsin by light. Rhodopsin is composed of a protein, opsin, covalently linked to a chromophore, 3-hydroxy-11-cis-retinal. Upon absorption of a light photon the chromophore is isomerized from the 11-cis to the all-trans configuration which induces a structural change that activates the opsin. This photoconversion activates heterotrimeric Gq protein via GTP-GDP exchange, releasing the G(alpha)q subunit. G(alpha)q activates PLC, generating InsP3 and DAG from PIP2. DAG may further release polyunsaturated fatty acids (PUFAs) via action of DAG lipase. This reaction leads to the opening of cation-selective channels (trp and trpl genes) and causes the depolarization of the photoreceptor cells. The transduction proteins rhodopsin, G(alpha)q, PLC, PKC, TRP, and TRPL are coordinated by a polymer of INAD scaffold proteins.
Class
Organismal Systems; Sensory system
Pathway map
cqu04745  Phototransduction - fly
cqu04745

Organism
Culex quinquefasciatus (southern house mosquito) [GN:cqu]
Gene
CpipJ_CPIJ010818  GTP-binding protein alpha subunit, gna [KO:K04634]
CpipJ_CPIJ012724  guanine nucleotide-binding protein beta 2 [KO:K07972]
CpipJ_CPIJ000394  G-protein, gamma-subunit [KO:K04547]
CpipJ_CPIJ008403  phospholipase c beta [KO:K05858] [EC:3.1.4.11]
CpipJ_CPIJ000778  phospholipase c [KO:K05858] [EC:3.1.4.11]
CpipJ_CPIJ001522  transient receptor potential channel [KO:K04967]
CpipJ_CPIJ018599  transient receptor potential channel [KO:K04967]
CpipJ_CPIJ005741  calmodulin-binding protein trpl [KO:K13803]
CpipJ_CPIJ018366  calmodulin [KO:K02183]
CpipJ_CPIJ007602  calmodulin [KO:K02183]
CpipJ_CPIJ015812  calcium-binding protein E63-1 [KO:K02183]
CpipJ_CPIJ017380  calmodulin [KO:K02183]
CpipJ_CPIJ011379  calmodulin [KO:K02183]
CpipJ_CPIJ019224  calmodulin [KO:K02183]
CpipJ_CPIJ015810  calcium-binding protein E63-1 [KO:K02183]
CpipJ_CPIJ019225  calmodulin [KO:K02183]
CpipJ_CPIJ009730  calmodulin [KO:K02183]
CpipJ_CPIJ005840  myosin IIIA [KO:K08834] [EC:2.7.11.1]
CpipJ_CPIJ007814  myosin iii [KO:K08834] [EC:2.7.11.1]
CpipJ_CPIJ009808  conserved hypothetical protein [KO:K05692]
CpipJ_CPIJ012143  phosrestin-1 [KO:K13805]
CpipJ_CPIJ014777  phosrestin-1 [KO:K13805]
CpipJ_CPIJ012217  inositol 1,4,5-trisphosphate receptor [KO:K04958]
CpipJ_CPIJ004658  beta-adrenergic receptor kinase [KO:K00910] [EC:2.7.11.15]
CpipJ_CPIJ017648  calcium/calmodulin-dependent protein kinase type II alpha chain [KO:K04515] [EC:2.7.11.17]
CpipJ_CPIJ015557  Sn1-specific diacylglycerol lipase alpha [KO:K13806] [EC:3.1.1.116]
CpipJ_CPIJ010991  neural stem cell-derived dendrite regulator [KO:K13806] [EC:3.1.1.116]
CpipJ_CPIJ002819  phosphatase-7 [KO:K13807] [EC:3.1.3.16]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01530  Octadecanoic acid
C02112  2-Acylglycerol
C18195  (3R)-11-cis-3-Hydroxyretinal
C18196  (3R)-all-trans-3-Hydroxyretinal
C20428  (3S)-11-cis-3-Hydroxyretinal
C20429  (3S)-all-trans-3-Hydroxyretinal
Reference
PMID:19623243
  Authors
Katz B, Minke B
  Title
Drosophila photoreceptors and signaling mechanisms.
  Journal
Front Cell Neurosci 3:2 (2009)
DOI:10.3389/neuro.03.002.2009
Reference
PMID:19138592
  Authors
Borst A
  Title
Drosophila's view on insect vision.
  Journal
Curr Biol 19:R36-47 (2009)
DOI:10.1016/j.cub.2008.11.001
Reference
PMID:19837030
  Authors
Yau KW, Hardie RC
  Title
Phototransduction motifs and variations.
  Journal
Cell 139:246-64 (2009)
DOI:10.1016/j.cell.2009.09.029
Reference
PMID:19011871
  Authors
Frings S
  Title
Primary processes in sensory cells: current advances.
  Journal
J Comp Physiol A Neuroethol Sens Neural Behav Physiol 195:1-19 (2009)
DOI:10.1007/s00359-008-0389-0
Reference
PMID:17487503
  Authors
Wang T, Montell C
  Title
Phototransduction and retinal degeneration in Drosophila.
  Journal
Pflugers Arch 454:821-47 (2007)
DOI:10.1007/s00424-007-0251-1
Reference
PMID:12765684
  Authors
Hardie RC
  Title
TRP channels in Drosophila photoreceptors: the lipid connection.
  Journal
Cell Calcium 33:385-93 (2003)
DOI:10.1016/S0143-4160(03)00051-4
Reference
PMID:16460287
  Authors
Minke B, Parnas M
  Title
Insights on TRP channels from in vivo studies in Drosophila.
  Journal
Annu Rev Physiol 68:649-84 (2006)
DOI:10.1146/annurev.physiol.68.040204.100939
Reference
PMID:10611962
  Authors
Montell C
  Title
Visual transduction in Drosophila.
  Journal
Annu Rev Cell Dev Biol 15:231-68 (1999)
DOI:10.1146/annurev.cellbio.15.1.231
Reference
PMID:20144772
  Authors
Fain GL, Hardie R, Laughlin SB
  Title
Phototransduction and the evolution of photoreceptors.
  Journal
Curr Biol 20:R114-24 (2010)
DOI:10.1016/j.cub.2009.12.006
Reference
PMID:14761309
  Authors
Kim C
  Title
Transient receptor potential ion channels and animal sensation: lessons from Drosophila functional research.
  Journal
J Biochem Mol Biol 37:114-21 (2004)
DOI:10.5483/bmbrep.2004.37.1.114
Reference
PMID:18579072
  Authors
Montell C
  Title
In search of the holy grail for Drosophila TRP.
  Journal
Neuron 58:825-7 (2008)
DOI:10.1016/j.neuron.2008.06.006
Reference
PMID:15620638
  Authors
Osorio D, Nilsson DE
  Title
Visual pigments: trading noise for fast recovery.
  Journal
Curr Biol 14:R1051-3 (2004)
DOI:10.1016/j.cub.2004.11.044
Reference
PMID:20045325
  Authors
Wang X, Wang T, Jiao Y, von Lintig J, Montell C
  Title
Requirement for an enzymatic visual cycle in Drosophila.
  Journal
Curr Biol 20:93-102 (2010)
DOI:10.1016/j.cub.2009.12.022
Reference
PMID:18786361
  Authors
Liu CH, Satoh AK, Postma M, Huang J, Ready DF, Hardie RC
  Title
Ca2+-dependent metarhodopsin inactivation mediated by calmodulin and NINAC myosin III.
  Journal
Neuron 59:778-89 (2008)
DOI:10.1016/j.neuron.2008.07.007
Reference
PMID:18579079
  Authors
Leung HT, Tseng-Crank J, Kim E, Mahapatra C, Shino S, Zhou Y, An L, Doerge RW, Pak WL
  Title
DAG lipase activity is necessary for TRP channel regulation in Drosophila photoreceptors.
  Journal
Neuron 58:884-96 (2008)
DOI:10.1016/j.neuron.2008.05.001
Reference
PMID:16914683
  Authors
Popescu DC, Ham AJ, Shieh BH
  Title
Scaffolding protein INAD regulates deactivation of vision by promoting phosphorylation of transient receptor potential by eye protein kinase C in Drosophila.
  Journal
J Neurosci 26:8570-7 (2006)
DOI:10.1523/JNEUROSCI.1478-06.2006
KO pathway
ko04745   

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Genome (1)   
   KEGG GENOME (1)   
Gene (28)   
   KEGG GENES (28)   
All databases (29)   

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