Nucleotide excision repair - Chromobacterium violaceum
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Genetic Information Processing; Replication and repair
Nucleotide excision repair
Chromobacterium violaceum [GN:
mfd; transcription-repair coupling factor [KO:
uvrA; excinuclease ABC subunit A [KO:
uvrB; excinuclease ABC subunit B [KO:
uvrC; excinuclease ABC subunit C [KO:
uvrD; DNA helicase II [KO:
polA; DNA-directed DNA polymerase I [KO:
lig; DNA ligase [KO:
[Molecular mechanism of mammalian nucleotide excision repair] Japanese
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
[Transcription-coupled repair and Cockayne syndrome] Japanese
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Nakagawa N, Masui R, Kuramitsu S.
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8] Japanese
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
Neuroscience 145:1388-96 (2007)
Saldivar JS, Wu X, Follen M, Gershenson D.
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
Gynecol Oncol 107:S56-71 (2007)
[DNA repair pathways involving Cul4A ubiquitin ligases] Japanese
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Ito S, Ando D, Tanaka K.
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders] Japanese
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
KEGG GENES (7)
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