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ddi04145                    Pathway                                

Phagosome - Dictyostelium discoideum (cellular slime mold)
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Cellular Processes; Transport and catabolism
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All organismsOrtholog table
Sec61 complex [PATH:ddi04145]
Other DBs
Dictyostelium discoideum (cellular slime mold) [GN:ddi]
hypothetical protein; K08488 syntaxin 7 [KO:K08488]
hypothetical protein; K08488 syntaxin 7 [KO:K08488]
syn7A; syntaxin 7 [KO:K08488]
syn7B; hypothetical protein [KO:K08488]
act26; hypothetical protein [KO:K05692]
act25; hypothetical protein [KO:K05692]
hypothetical protein; K08492 syntaxin 18 [KO:K08492]
hypothetical protein; K08517 vesicle transport protein SEC22 [KO:K08517]
rab5A; Rab GTPase [KO:K07889]
pikE; phosphatidylinositol 3-kinase [KO:K00914] [EC:]
vatA; vacuolar H+-ATPase A subunit [KO:K02145] [EC:]
vatB; vacuolar H+ ATPase B subunit [KO:K02147]
vatC; H(+)-transporting ATPase [KO:K02148]
vacuolar ATP synthase subunit D; K02149 V-type H+-transporting ATPase subunit D [KO:K02149]
vatE; vacuolar H+-ATPase E subunit [KO:K02150]
vatF; vacuolar H+ ATPase F subunit [KO:K02151]
vacuolar ATP synthase subunit G; K02152 V-type H+-transporting ATPase subunit G [KO:K02152]
vatM; vacuolar ATPase transmembrane subunit [KO:K02154]
vatD-1; vacuolar ATPase subunit DVA41 [KO:K02146]
vatD-2; vacuolar ATPase subunit DVA41 [KO:K02146]
vatH; vacuolar ATP synthase subunit H [KO:K02144]
vatP; vacuolar ATPase proteolipid subunit [KO:K02155]
hypothetical protein; K03661 V-type H+-transporting ATPase 21kDa proteolipid subunit [KO:K03661]
rab7A; Rab GTPase [KO:K07897]
rabO; Rab GTPase [KO:K07897]
dhcA; cytoplasmic dynein heavy chain [KO:K10413]
dicA; cytoplasmic dynein intermediate chain [KO:K10415]
dync1li1; dynein light intermediate chain [KO:K10416]
tubA; alpha tubulin [KO:K07374]
hypothetical protein; K07374 tubulin alpha [KO:K07374]
tubB; beta tubulin [KO:K07375]
pip5k3; 1-phosphatidylinositol-3-phosphate 5-kinase [KO:K00921] [EC:]
cprC; cysteine proteinase 3 [KO:K01365] [EC:]
hypothetical protein; K01365 cathepsin L [EC:] [KO:K01365] [EC:]
cprB; cysteine protease [KO:K01365] [EC:]
cprE; cysteine proteinase 5 precursor [KO:K01365] [EC:]
sec61a; SecY family protein [KO:K10956]
sec61b; protein transport protein SEC61 beta subunit [KO:K09481]
sec61g; protein transport protein SEC61 gamma subunit [KO:K07342]
crtA; hypothetical protein [KO:K08057]
cnxA; hypothetical protein [KO:K08054]
cybA; flavocytochrome b small subunit [KO:K08009]
noxA; flavocytochrome b large subunit [KO:K08008]
noxB; flavocytochrome b large subunit [KO:K08008]
racD; Rho GTPase [KO:K04392]
racF1; Rho GTPase [KO:K04392]
racN; Rho GTPase [KO:K04392]
rac1B; Rho GTPase [KO:K04392]
rac1A; Rho GTPase [KO:K04392]
racB; Rho GTPase [KO:K04392]
rac1C; Rho GTPase [KO:K04392]
1-Phosphatidyl-1D-myo-inositol 3-phosphate
Stuart LM, Ezekowitz RA
Phagocytosis: elegant complexity.
Immunity 22:539-50 (2005)
Tjelle TE, Lovdal T, Berg T
Phagosome dynamics and function.
Bioessays 22:255-63 (2000)
Dupuy AG, Caron E
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
J Cell Sci 121:1773-83 (2008)
Brumell JH, Grinstein S
Salmonella redirects phagosomal maturation.
Curr Opin Microbiol 7:78-84 (2004)
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
LAMP proteins are required for fusion of lysosomes with phagosomes.
EMBO J 26:313-24 (2007)
Luzio JP, Pryor PR, Bright NA
Lysosomes: fusion and function.
Nat Rev Mol Cell Biol 8:622-32 (2007)
Sumimoto H
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
FEBS J 275:3249-77 (2008)
KO pathway

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