KEGG   PATHWAY: ded03440
Entry
ded03440                    Pathway                                
Name
Homologous recombination - Dehalobacter sp. DCA
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
ded03440  Homologous recombination
ded03440

Other DBs
GO: 0000724
Organism
Dehalobacter sp. DCA [GN:ded]
Gene
DHBDCA_p841  Single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
DHBDCA_p2962  Single-stranded DNA-binding protein [KO:K03111]
DHBDCA_p3  recF; DNA recombination and repair protein RecF [KO:K03629]
DHBDCA_p2538  DNA recombination and repair protein RecO [KO:K03584]
DHBDCA_p205  recR; Recombination protein RecR [KO:K06187]
DHBDCA_p315  recA; RecA protein [KO:K03553]
DHBDCA_p855  ruvA; Holliday junction DNA helicase RuvA [KO:K03550]
DHBDCA_p854  ruvB; Holliday junction DNA helicase RuvB [KO:K03551] [EC:5.6.2.4]
DHBDCA_p856  ruvC; Crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.21.10]
DHBDCA_p2158  recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
DHBDCA_p930  DNA polymerase III alpha subunit [KO:K02337] [EC:2.7.7.7]
DHBDCA_p2077  polC; DNA polymerase III alpha subunit [KO:K03763] [EC:2.7.7.7]
DHBDCA_p2  dnaN; DNA polymerase III beta subunit [KO:K02338] [EC:2.7.7.7]
DHBDCA_p203  dnaX; DNA polymerase III subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
DHBDCA_p2573  DNA polymerase III delta subunit [KO:K02340] [EC:2.7.7.7]
DHBDCA_p211  DNA polymerase III delta prime subunit [KO:K02341] [EC:2.7.7.7]
DHBDCA_p2181  priA; primosomal protein N'' [KO:K04066] [EC:5.6.2.4]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG GENES (17)   
All databases (18)   

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