KEGG PATHWAY: dme04391

PATHWAY: dme04391

Entry

dme04391 Pathway

Name

Hippo signaling pathway - fly - Drosophila melanogaster (fruit fly)

Description

Hippo signaling is an evolutionarily conserved signaling pathway that controls organ size during development from flies to humans. The core of the drosophila pathway is a kinase cascade consisting of four proteins including Hippo, Salvador, Warts and Mats. Upon activation by stimuli such as high cell density in cell culture, the Hippo pathway kinase cascade phosphorylates and inhibits the transcriptional co-activator Yorkie, thereby promoting cell apoptosis and restricting organ size overgrowth. When the Hippo pathway is inactivated, Yorkie translocates into the nucleus to bind to transcriptional factors to promote cell growth and proliferation.

Class

Environmental Information Processing; Signal transduction

Pathway map

dme04391

Hippo signaling pathway - fly

Other DBs

BSID:

731800

GO:

0035329

Organism

Drosophila melanogaster (fruit fly) [GN:dme]

Gene

Dmel_CG13139	lft; lowfat [KO:K16673]
Dmel_CG10917	fj; four-jointed [KO:K16674]
Dmel_CG17941	ds; dachsous [KO:K16507]
Dmel_CG3352	ft; fat [KO:K16669]
Dmel_CG2048	dco; discs overgrown [KO:K08960] [EC:2.7.11.1]
Dmel_CG6964	Gug; Grunge [KO:K05628]
Dmel_CG42318	app; approximated [KO:K16675] [EC:2.3.1.-]
Dmel_CG32018	Zyx; Zyxin [KO:K16676]
Dmel_CG42840	d; dachs [KO:K16677]
Dmel_CG2671	l(2)gl; lethal (2) giant larvae [KO:K06094]
Dmel_CG42783	aPKC; atypical protein kinase C [KO:K06069] [EC:2.7.11.13]
Dmel_CG4656	Rassf; Ras association family member [KO:K09851]
Dmel_CG7109	mts; microtubule star [KO:K04382] [EC:3.1.3.16]
Dmel_CG17291	Pp2A-29B; Protein phosphatase 2A at 29B [KO:K03456]
Dmel_CG6235	tws; twins [KO:K04354]
Dmel_CG33336	p53; CG33336 gene product from transcript CG33336-RB [KO:K10149]
Dmel_CG12919	egr; eiger [KO:K16678]
Dmel_CG6531	wgn; wengen [KO:K16679]
Dmel_CG5680	bsk; basket [KO:K04440] [EC:2.7.11.24]
Dmel_CG12676	ed; echinoid [KO:K16680]
Dmel_CG10067	Act57B; Actin 57B [KO:K05692]
Dmel_CG12051	Act42A; Actin 42A [KO:K05692]
Dmel_CG18290	Act87E; Actin 87E [KO:K05692]
Dmel_CG4027	Act5C; Actin 5C [KO:K05692]
Dmel_CG5178	Act88F; Actin 88F [KO:K05692]
Dmel_CG6383	crb; crumbs [KO:K16681]
Dmel_CG5055	baz; bazooka [KO:K04237]
Dmel_CG5884	par-6; CG5884 gene product from transcript CG5884-RA [KO:K06093]
Dmel_CG32717	sdt; stardust [KO:K06091]
Dmel_CG12021	Patj; CG12021 gene product from transcript CG12021-RC [KO:K06095]
Dmel_CG11063	jub; Ajuba LIM protein [KO:K16682]
Dmel_CG43398	scrib; scribbled [KO:K16175]
Dmel_CG1725	dlg1; discs large 1 [KO:K12076]
Dmel_CG4114	ex; expanded [KO:K16683]
Dmel_CG14228	Mer; Merlin [KO:K16684]
Dmel_CG33967	kibra; kibra ortholog [KO:K16685]
Dmel_CG11228	hpo; hippo [KO:K04412]
Dmel_CG33193	sav; salvador [KO:K16686]
Dmel_CG12072	wts; warts [KO:K08791] [EC:2.7.11.1]
Dmel_CG13852	mats; mob as tumor suppressor [KO:K06685]
Dmel_CG4005	yki; yorkie [KO:K16687]
Dmel_CG17870	14-3-3zeta; CG17870 gene product from transcript CG17870-RE [KO:K16197]
Dmel_CG31196	14-3-3epsilon; CG31196 gene product from transcript CG31196-RB [KO:K06630]
Dmel_CG12399	Mad; Mothers against dpp [KO:K04676]
Dmel_CG8544	sd; scalloped [KO:K09448]
Dmel_CG17117	hth; homothorax [KO:K16672]
Dmel_CG1374	tsh; teashirt [KO:K09236]
Dmel_CR43018	ban; bantam [KO:K16736]
Dmel_CG1768	dia; diaphanous [KO:K16688]
Dmel_CG3938	CycE; Cyclin E [KO:K06626]
Dmel_CG10798	dm; diminutive [KO:K04377]
Dmel_CG4974	dally; division abnormally delayed [KO:K02306]
Dmel_CG4889	wg; wingless [KO:K03209]
Dmel_CG5988	upd2; unpaired 2 [KO:K16689]
Dmel_CG33542	upd3; unpaired 3 [KO:K16689]
Dmel_CG10491	vn; vein [KO:K16690]
Dmel_CG32179	Krn; Keren [KO:K16691]

Reference

PMID:21138973

Authors

Halder G, Johnson RL

Title

Hippo signaling: growth control and beyond.

Journal

Development 138:9-22 (2011)

Reference

PMID:20439427

Authors

Zhao B, Li L, Lei Q, Guan KL

Title

The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version.

Journal

Genes Dev 24:862-74 (2010)

Reference

PMID:20951342

Authors

Pan D

Title

The hippo signaling pathway in development and cancer.

Journal

Dev Cell 19:491-505 (2010)

Reference

PMID:22750148

Authors

Schroeder MC, Halder G

Title

Regulation of the Hippo pathway by cell architecture and mechanical signals.

Journal

Semin Cell Dev Biol 23:803-11 (2012)

Reference

PMID:21808241

Authors

Zhao B, Tumaneng K, Guan KL

Title

The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal.

Journal

Nat Cell Biol 13:877-83 (2011)

Reference

PMID:22035868

Authors

Yin M, Zhang L

Title

Hippo signaling: a hub of growth control, tumor suppression and pluripotency maintenance.

Journal

J Genet Genomics 38:471-81 (2011)

Reference

PMID:20945341

Authors

Chan SW, Lim CJ, Chen L, Chong YF, Huang C, Song H, Hong W

Title

The Hippo pathway in biological control and cancer development.

Journal

J Cell Physiol 226:928-39 (2011)

Reference

PMID:21415026

Authors

Hilman D, Gat U

Title

The evolutionary history of YAP and the hippo/YAP pathway.

Journal

Mol Biol Evol 28:2403-17 (2011)

Reference

PMID:18955139

Authors

Zhao B, Lei QY, Guan KL

Title

The Hippo-YAP pathway: new connections between regulation of organ size and cancer.

Journal

Curr Opin Cell Biol 20:638-46 (2008)

Reference

PMID:19846288

Authors

Badouel C, Garg A, McNeill H

Title

Herding Hippos: regulating growth in flies and man.

Journal

Curr Opin Cell Biol 21:837-43 (2009)

Reference

PMID:19164949

Authors

Zhang L, Yue T, Jiang J

Title

Hippo signaling pathway and organ size control.

Journal

Fly (Austin) 3:68-73 (2009)

Reference

PMID:17318211

Authors

Harvey K, Tapon N

Title

The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network.

Journal

Nat Rev Cancer 7:182-91 (2007)

Reference

PMID:19517570

Authors

Kango-Singh M, Singh A

Title

Regulation of organ size: insights from the Drosophila Hippo signaling pathway.

Journal

Dev Dyn 238:1627-37 (2009)

Reference

PMID:21145886

Authors

Sun G, Irvine KD

Title

Regulation of Hippo signaling by Jun kinase signaling during compensatory cell proliferation and regeneration, and in neoplastic tumors.

Journal

Dev Biol 350:139-51 (2011)

Reference

PMID:22830020

Authors

Fausti F, Di Agostino S, Sacconi A, Strano S, Blandino G

Title

Hippo and rassf1a Pathways: A Growing Affair.

Journal

Mol Biol Int 2012:307628 (2012)

Reference

PMID:20452772

Authors

Oh H, Irvine KD

Title

Yorkie: the final destination of Hippo signaling.

Journal

Trends Cell Biol 20:410-7 (2010)

Reference

PMID:17975546

Authors

Buttitta LA, Edgar BA

Title

How size is controlled: from Hippos to Yorkies.

Journal

Nat Cell Biol 9:1225-7 (2007)

Reference

PMID:21213102

Authors

Chen L, Loh PG, Song H

Title

Structural and functional insights into the TEAD-YAP complex in the Hippo signaling pathway.

Journal

Protein Cell 1:1073-83 (2010)

Reference

PMID:19733165

Authors

Oh H, Reddy BV, Irvine KD

Title

Phosphorylation-independent repression of Yorkie in Fat-Hippo signaling.

Journal

Dev Biol 335:188-97 (2009)

Reference

PMID:18952051

Authors

Badouel C, McNeill H

Title

Apical junctions and growth control in Drosophila.

Journal

Biochim Biophys Acta 1788:755-60 (2009)

KO pathway

ko04391

All links

Pathway (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (57)   
   KEGG GENES (57)   
All databases (59)   

Download RDF

DBGET integrated database retrieval system