KEGG   PATHWAY: dme04711Help
Entry
dme04711                    Pathway                                

Name
Circadian rhythm - fly - Drosophila melanogaster (fruit fly)
Description
Circadian rhythm is an internal biological clock, which enables to sustain an approximately 24-hour rhythm in the absence of environmental cues. In the fruit fly Drosophila melanogaster, seven genes that contribute to the central clock function are known: period (per), timeless (tim), Clock (Clk), cycle (cyc), vrille (vri), double-time (dbt), and shaggy (sgg). The core of the circadian clock consists of molecular feedback loops where per and tim gene products (PER and TIM proteins) eventually turn off their own transcription. The CLK/CYC heterodimer activates transcription of per and tim genes, while the PER and TIM repressor proteins accumulate in the cytoplasm. After nuclear entry of PER and TIM, transcription is inhibited by direct binding of the PER/TIM heterodimer to the CLK/CYC heterodimer. This shutoff lasts until the PER and TIM proteins are degraded allowing a new round of transcription to occur.
Class
Organismal Systems; Environmental adaptation
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Pathway map
Circadian rhythm - fly
dme04711

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Organism
Drosophila melanogaster (fruit fly) [GN:dme]
Gene
dco; discs overgrown [KO:K08960] [EC:2.7.11.1]
per; period [KO:K02633]
tim; timeless [KO:K12074]
Clk; Clock [KO:K02223] [EC:2.3.1.48]
cyc; cycle [KO:K02296]
vri; vrille [KO:K12114]
Pdp1; PAR-domain protein 1 [KO:K09057]
sgg; shaggy [KO:K03083] [EC:2.7.11.26]
gskt; gasket [KO:K03083] [EC:2.7.11.26]
Reference
  Authors
Panda S, Hogenesch JB, Kay SA.
  Title
Circadian rhythms from flies to human.
  Journal
Nature 417:329-35 (2002)
Reference
  Authors
Harmer SL, Panda S, Kay SA.
  Title
Molecular bases of circadian rhythms.
  Journal
Annu Rev Cell Dev Biol 17:215-53 (2001)
Reference
  Authors
Young MW, Kay SA.
  Title
Time zones: a comparative genetics of circadian clocks.
  Journal
Nat Rev Genet 2:702-15 (2001)
Reference
  Authors
Cyran SA, Buchsbaum AM, Reddy KL, Lin MC, Glossop NR, Hardin PE, Young MW, Storti RV, Blau J.
  Title
vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock.
  Journal
Cell 112:329-41 (2003)
Reference
  Authors
Helfrich-Forster C
  Title
The circadian system of Drosophila melanogaster and its light input pathways.
  Journal
Zoology (Jena) 105:297-312 (2002)
Reference
  Authors
Stanewsky R
  Title
Genetic analysis of the circadian system in Drosophila melanogaster and mammals.
  Journal
J Neurobiol 54:111-47 (2003)
KO pathway
 

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