KEGG   PATHWAY: dmo00980Help
Entry
dmo00980                    Pathway                                

Name
Metabolism of xenobiotics by cytochrome P450 - Drosophila mojavensis
Class
Metabolism; Xenobiotics biodegradation and metabolism
BRITE hierarchy
Pathway map
Metabolism of xenobiotics by cytochrome P450
dmo00980

All organismsOrtholog table
Organism
Drosophila mojavensis [GN:dmo]
Gene
GI24379 gene product from transcript GI24379-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
GI23193 gene product from transcript GI23193-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
GI23196 gene product from transcript GI23196-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
GI20064 gene product from transcript GI20064-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
GI19388 gene product from transcript GI19388-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
GI20121 gene product from transcript GI20121-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
GI20122 gene product from transcript GI20122-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
GI20123 gene product from transcript GI20123-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
GI20124 gene product from transcript GI20124-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
GI18422 gene product from transcript GI18422-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
GI15739 gene product from transcript GI15739-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
GI22356 gene product from transcript GI22356-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
GI20072 gene product from transcript GI20072-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
GI15481 gene product from transcript GI15481-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
GI16624 gene product from transcript GI16624-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
GI14608 gene product from transcript GI14608-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
GI16623 gene product from transcript GI16623-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
GI19515 gene product from transcript GI19515-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
GI20133 gene product from transcript GI20133-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
GI22354 gene product from transcript GI22354-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
GI24516 gene product from transcript GI24516-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
GI23195 gene product from transcript GI23195-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
GI23194 gene product from transcript GI23194-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
GI24095 gene product from transcript GI24095-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
GI21687 gene product from transcript GI21687-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
GI21688 gene product from transcript GI21688-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
GI17186 gene product from transcript GI17186-RA; K00078 dihydrodiol dehydrogenase / D-xylose 1-dehydrogenase (NADP) [EC:1.3.1.20 1.1.1.179] [KO:K00078] [EC:1.1.1.179 1.3.1.20]
GI17180 gene product from transcript GI17180-RA; K00078 dihydrodiol dehydrogenase / D-xylose 1-dehydrogenase (NADP) [EC:1.3.1.20 1.1.1.179] [KO:K00078] [EC:1.1.1.179 1.3.1.20]
GI17187 gene product from transcript GI17187-RA; K00078 dihydrodiol dehydrogenase / D-xylose 1-dehydrogenase (NADP) [EC:1.3.1.20 1.1.1.179] [KO:K00078] [EC:1.1.1.179 1.3.1.20]
GI20954 gene product from transcript GI20954-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GI14134 gene product from transcript GI14134-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GI19212 gene product from transcript GI19212-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GI14390 gene product from transcript GI14390-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GI17058 gene product from transcript GI17058-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GI17057 gene product from transcript GI17057-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GI10820 gene product from transcript GI10820-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GI20965 gene product from transcript GI20965-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GI22630 gene product from transcript GI22630-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GI22628 gene product from transcript GI22628-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GI22626 gene product from transcript GI22626-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GI10122 gene product from transcript GI10122-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GI20004 gene product from transcript GI20004-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GI19214 gene product from transcript GI19214-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GI11811 gene product from transcript GI11811-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GI17059 gene product from transcript GI17059-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GI20943 gene product from transcript GI20943-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GI22627 gene product from transcript GI22627-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GI17523 gene product from transcript GI17523-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GI18315 gene product from transcript GI18315-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GI17522 gene product from transcript GI17522-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GI19213 gene product from transcript GI19213-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GI24655 gene product from transcript GI24655-RA; K00121 S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase [EC:1.1.1.284 1.1.1.1] [KO:K00121] [EC:1.1.1.1 1.1.1.284]
Dmoj_Adh2; Alcohol dehydrogenase-2 [KO:K00001] [EC:1.1.1.1]
Compound
C00745  
Nicotine
C00829  
Naphthalene
C02617  
1,4-Naphthoquinone
C03012  
Naphthalene-1,2-diol
C06205  
1,2-Dihydronaphthalene-1,2-diol
C06755  
Chloroacetic acid
C06790  
Trichloroethene
C06800  
Aflatoxin B1
C06899  
Chloral hydrate
C07490  
Trichloroethanol
C07535  
Benzo[a]pyrene
C11036  
Bromobenzene
C11088  
1,2-Dibromoethane
C11148  
TCE epoxide
C11149  
Dichloroacetate
C11150  
Trichloroacetate
C11278  
Aflatoxin B1exo-8,9-epoxide-GSH
C11713  
2-Naphthol
C11714  
1-Naphthol
C14039  
1,1-Dichloroethylene
C14040  
1-Nitronaphthalene
C14453  
4-Bromophenol
C14556  
9-Hydroxybenzo[a]pyrene
C14783  
1,2-Naphthoquinone
C14784  
1,2-Dihydroxy-3,4-epoxy-1,2,3,4-tetrahydronaphthalene
C14785  
1,4-Dihydroxynaphthalene
C14786  
(1R,2S)-Naphthalene 1,2-oxide
C14787  
(1S,2R)-Naphthalene 1,2-oxide
C14788  
1-Nitrosonaphthalene
C14789  
N-Hydroxy-1-aminonaphthalene
C14790  
1-Naphthylamine
C14791  
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
C14792  
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
C14793  
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
C14796  
(1R)-Hydroxy-(2R)-N-acetyl-L-cysteinyl-1,2-dihydronaphthalene
C14797  
(1R)-N-Acetyl-L-cysteinyl-(2R)-hydroxy-1,2-dihydronaphthalene
C14798  
(1S)-Hydroxy-(2S)-N-acetyl-L-cysteinyl-1,2-dihydronaphthalene
C14799  
(1R,2R)-3-[(1,2-Dihydro-2-hydroxy-1-naphthalenyl)thio]-2-oxopropanoic acid
C14800  
1-Nitronaphthalene-5,6-oxide
C14801  
1-Nitro-5,6-dihydroxy-dihydronaphthalene
C14802  
1-Nitronaphthalene-7,8-oxide
C14803  
1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene
C14804  
1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene
C14805  
1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene
C14806  
1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene
C14839  
Bromobenzene-3,4-oxide
C14840  
Bromobenzene-2,3-oxide
C14841  
2-Bromophenol
C14842  
Bromobenzene-2,3-dihydrodiol
C14843  
4-Bromocatechol
C14844  
Bromobenzene-3,4-dihydrodiol
C14845  
4-Bromophenol-2,3-epoxide
C14846  
4-Bromo-3,5-cyclohexadiene-1,2-dione
C14847  
3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene
C14848  
2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene
C14849  
Benzo[a]pyrene-9,10-oxide
C14850  
Benzo[a]pyrene-7,8-oxide
C14851  
Benzo[a]pyrene-4,5-oxide
C14852  
Benzo[a]pyrene-7,8-diol
C14853  
Benzo[a]pyrene-7,8-dihydrodiol-9,10-oxide
C14854  
9-Hydroxybenzo[a]pyrene-4,5-oxide
C14855  
4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene
C14856  
7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene
C14857  
1,1-Dichloroethylene epoxide
C14858  
2,2-Dichloroacetaldehyde
C14859  
Chloroacetyl chloride
C14860  
2,2-Dichloro-1,1-ethanediol
C14861  
S-(2,2-Dichloro-1-hydroxy)ethyl glutathione
C14862  
2-S-Glutathionyl acetate
C14863  
2-(S-Glutathionyl)acetyl glutathione
C14864  
S-(2-Chloroacetyl)glutathione
C14865  
2-(S-Glutathionyl)acetyl chloride
C14866  
Chloral
C14867  
Dichloroacetyl chloride
C14868  
S-(1,2-Dichlorovinyl)glutathione
C14869  
Trichloroethanol glucuronide
C14870  
2-Bromoacetaldehyde
C14871  
S-(Formylmethyl)glutathione
C14872  
Thiodiacetic acid
C14873  
Thiodiacetic acid sulfoxide
C14874  
Glutathione episulfonium ion
C14875  
S-(2-Hydroxyethyl)glutathione
C14876  
S-(2-Hydroxyethyl)-N-acetyl-L-cysteine
C14877  
S-[2-(N7-Guanyl)ethyl]-N-acetyl-L-cysteine
C16453  
4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16756  
Aflatoxin M1
C19488  
7,12-Dimethylbenz[a]anthracene
C19489  
1a,11b-Dihydro-4,9-dimethylbenz[a]anthra[3,4-b]oxirene
C19490  
trans-3,4-Dihydro-3,4-dihydroxy-7,12-dimethylbenz[a]anthracene
C19559  
(1aalpha,2beta,3alpha,11calpha)-1a,2,3,11c-Tetrahydro-6,11-dimethylbenzo[6,7]phenanthro[3,4-b]oxirene-2,3-diol
C19561  
7-Hydroxymethyl-12-methylbenz[a]anthracene
C19562  
7-Hydroxymethyl-12-methylbenz[a]anthracene sulfate
C19563  
4-[(Hydroxymethyl)nitrosoamino]-1-(3-pyridinyl)-1-butanone
C19564  
4-(Nitrosoamino)-1-(3-pyridinyl)-1-butanone
C19565  
4-Hydroxy-1-(3-pyridinyl)-1-butanone
C19566  
4-Hydroxy-4-(methylnitrosoamino)-1-(3-pyridinyl)-1-butanone
C19567  
4-Oxo-1-(3-pyridyl)-1-butanone
C19568  
N-Nitrosomethanamine
C19569  
3-Succinoylpyridine
C19574  
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol
C19577  
1-(Methylnitrosoamino)-4-(3-pyridinyl)-1,4-butanediol
C19578  
5-(3-Pyridyl)-2-hydroxytetrahydrofuran
C19579  
gamma-Hydroxy-3-pyridinebutanoate
C19580  
alpha-[3-[(Hydroxymethyl)nitrosoamino]propyl]-3-pyridinemethanol
C19581  
alpha-[3-(Nitrosoamino)propyl]-3-pyridinemethanol
C19582  
1-(3-Pyridinyl)-1,4-butanediol
C19585  
Aflatoxin Q1
C19586  
Aflatoxin B1-exo-8,9-epoxide
C19588  
Aflatoxin B1 diol
C19589  
Aflatoxin B1 dialdehyde
C19590  
6-[2,3-Dihydroxy-1-(hydroxymethyl)propyl]-1,2-dihydro-7-hydroxy-9-methoxy-cyclopenta[c][1]benzopyran-3,4-dione
C19591  
1,2,3,4-Tetrahydro-alpha,7-dihydroxy-beta-(hydroxymethyl)-9-methoxy-3,4-dioxocyclopenta[c][1]benzopyran-6-propanal
C19592  
alpha-(1,2-Dihydroxyethyl)-1,2,3,4-tetrahydro-7-hydroxy-9-methoxy-3,4-dioxocyclopenta[c][1]benzopyran-6-acetaldehyde
C19594  
Aflatoxin-M1-8,9-epoxide
C19595  
Aflatoxin B1-endo-8,9-epoxide
C19602  
4-(Methylnitrosamino)-1-(1-oxido-3-pyridinyl)-1-butanone
C19603  
4-(Methylnitrosamino)-1-(3-pyridyl-N-oxide)-1-butanol
C19604  
7,12-Dimethylbenz[a]anthracene 5,6-oxide
C19605  
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronide
C19606  
NNAL-N-glucuronide
C19607  
trans-5,6-Dihydro-5,6-dihydroxy-7,12-dimethylbenz[a]anthracene
Reference
  Authors
Buckpitt A, Boland B, Isbell M, Morin D, Shultz M, Baldwin R, Chan K, Karlsson A, Lin C, Taff A, West J, Fanucchi M, Van Winkle L, Plopper C.
  Title
Naphthalene-induced respiratory tract toxicity: metabolic mechanisms of toxicity.
  Journal
Drug Metab Rev 34:791-820 (2002)
Reference
  Authors
Bolton JL, Trush MA, Penning TM, Dryhurst G, Monks TJ.
  Title
Role of quinones in toxicology.
  Journal
Chem Res Toxicol 13:135-60 (2000)
Reference
  Authors
Halladay JS, Sauer JM, Sipes IG.
  Title
Metabolism and disposition of [(14)C]1-nitronaphthalene in male Sprague-Dawley rats.
  Journal
Drug Metab Dispos 27:1456-65 (1999)
Reference
  Authors
Watt KC, Morin DM, Kurth MJ, Mercer RS, Plopper CG, Buckpitt AR.
  Title
Glutathione conjugation of electrophilic metabolites of 1-nitronaphthalene in rat tracheobronchial airways and liver: identification by mass spectrometry and proton nuclear magnetic resonance spectroscopy.
  Journal
Chem Res Toxicol 12:831-9 (1999)
Reference
  Authors
Simmonds AC, Reilly CA, Baldwin RM, Ghanayem BI, Lanza DL, Yost GS, Collins KS, Forkert PG.
  Title
Bioactivation of 1,1-dichloroethylene to its epoxide by CYP2E1 and CYP2F enzymes.
  Journal
Drug Metab Dispos 32:1032-9 (2004)
Reference
  Authors
Forkert PG, Baldwin RM, Millen B, Lash LH, Putt DA, Shultz MA, Collins KS.
  Title
Pulmonary bioactivation of trichloroethylene to chloral hydrate: relative contributions of CYP2E1, CYP2F, and CYP2B1.
  Journal
Drug Metab Dispos 33:1429-37 (2005)
Reference
PMID:9107551
  Authors
Wormhoudt LW, Commandeur JN, Ploemen JH, Abdoelgafoer RS, Makansi A, Van Bladeren PJ, Vermeulen NP.
  Title
Urinary thiodiacetic acid. A selective biomarker for the cytochrome P450-catalyzed oxidation of 1,2-dibromoethane in the rat.
  Journal
Drug Metab Dispos 25:508-15 (1997)
Reference
PMID:4395686
  Authors
Brodie BB, Reid WD, Cho AK, Sipes G, Krishna G, Gillette JR.
  Title
Possible mechanism of liver necrosis caused by aromatic organic compounds.
  Journal
Proc Natl Acad Sci U S A 68:160-4 (1971)
Reference
  Authors
Lodovici M, Luceri C, Guglielmi F, Bacci C, Akpan V, Fonnesu ML, Boddi V, Dolara P.
  Title
Benzo(a)pyrene diolepoxide (BPDE)-DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1, GSTM1, GSTP1, GSTT1, and mEH.
  Journal
Cancer Epidemiol Biomarkers Prev 13:1342-8 (2004)
Reference
  Authors
Omura T, Ishimura Y, Fujii Y (eds).
  Title
[Molecular Biology of P450] (In Japanese)
  Journal
Kodansya (2003)
KO pathway
 

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