KEGG PATHWAY: dmo00980

PATHWAY: dmo00980

Entry

dmo00980 Pathway

Name

Metabolism of xenobiotics by cytochrome P450 - Drosophila mojavensis

Class

Metabolism; Xenobiotics biodegradation and metabolism

Pathway map

dmo00980

Metabolism of xenobiotics by cytochrome P450

Organism

Drosophila mojavensis [GN:dmo]

Gene

Dmoj_GI24379	GI24379 gene product from transcript GI24379-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
Dmoj_GI23193	GI23193 gene product from transcript GI23193-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
Dmoj_GI23196	GI23196 gene product from transcript GI23196-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
Dmoj_GI19388	GI19388 gene product from transcript GI19388-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
Dmoj_GI20121	GI20121 gene product from transcript GI20121-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
Dmoj_GI20122	GI20122 gene product from transcript GI20122-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
Dmoj_GI20123	GI20123 gene product from transcript GI20123-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
Dmoj_GI20124	GI20124 gene product from transcript GI20124-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
Dmoj_GI22356	GI22356 gene product from transcript GI22356-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
Dmoj_GI20072	GI20072 gene product from transcript GI20072-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
Dmoj_GI20064	GI20064 gene product from transcript GI20064-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
Dmoj_GI16624	GI16624 gene product from transcript GI16624-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
Dmoj_GI11974	GI11974 gene product from transcript GI11974-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
Dmoj_GI11973	GI11973 gene product from transcript GI11973-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
Dmoj_GI14608	GI14608 gene product from transcript GI14608-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
Dmoj_GI15739	GI15739 gene product from transcript GI15739-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
Dmoj_GI16623	GI16623 gene product from transcript GI16623-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
Dmoj_GI15481	GI15481 gene product from transcript GI15481-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
Dmoj_GI19515	GI19515 gene product from transcript GI19515-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
Dmoj_GI20133	GI20133 gene product from transcript GI20133-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
Dmoj_GI22354	GI22354 gene product from transcript GI22354-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
Dmoj_GI18422	GI18422 gene product from transcript GI18422-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
Dmoj_GI24516	GI24516 gene product from transcript GI24516-RA; K00799 glutathione S-transferase [EC:2.5.1.18] [KO:K00799] [EC:2.5.1.18]
Dmoj_GI17186	GI17186 gene product from transcript GI17186-RA; K00078 dihydrodiol dehydrogenase / D-xylose 1-dehydrogenase (NADP) [EC:1.3.1.20 1.1.1.179] [KO:K00078] [EC:1.1.1.179 1.3.1.20]
Dmoj_GI24655	GI24655 gene product from transcript GI24655-RA; K00121 S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase [EC:1.1.1.284 1.1.1.1] [KO:K00121] [EC:1.1.1.1 1.1.1.284]
Dmoj_GI17643	Dmoj_Adh2; Alcohol dehydrogenase-2 [KO:K00001] [EC:1.1.1.1]
Dmoj_GI20954	GI20954 gene product from transcript GI20954-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
Dmoj_GI14134	GI14134 gene product from transcript GI14134-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
Dmoj_GI19212	GI19212 gene product from transcript GI19212-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
Dmoj_GI14390	GI14390 gene product from transcript GI14390-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
Dmoj_GI17058	GI17058 gene product from transcript GI17058-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
Dmoj_GI17057	GI17057 gene product from transcript GI17057-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
Dmoj_GI10820	GI10820 gene product from transcript GI10820-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
Dmoj_GI20965	GI20965 gene product from transcript GI20965-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
Dmoj_GI22630	GI22630 gene product from transcript GI22630-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
Dmoj_GI22628	GI22628 gene product from transcript GI22628-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
Dmoj_GI22626	GI22626 gene product from transcript GI22626-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
Dmoj_GI10122	GI10122 gene product from transcript GI10122-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
Dmoj_GI20004	GI20004 gene product from transcript GI20004-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
Dmoj_GI19214	GI19214 gene product from transcript GI19214-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
Dmoj_GI11811	GI11811 gene product from transcript GI11811-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
Dmoj_GI17059	GI17059 gene product from transcript GI17059-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
Dmoj_GI20943	GI20943 gene product from transcript GI20943-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
Dmoj_GI22627	GI22627 gene product from transcript GI22627-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
Dmoj_GI17523	GI17523 gene product from transcript GI17523-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]

Compound

C00745	Nicotine
C00829	Naphthalene
C02617	1,4-Naphthoquinone
C03012	Naphthalene-1,2-diol
C06205	1,2-Dihydronaphthalene-1,2-diol
C06755	Chloroacetic acid
C06790	Trichloroethene
C06800	Aflatoxin B1
C06899	Chloral hydrate
C07490	Trichloroethanol
C07535	Benzo[a]pyrene
C11036	Bromobenzene
C11088	1,2-Dibromoethane
C11148	TCE epoxide
C11149	Dichloroacetate
C11150	Trichloroacetate
C11278	Aflatoxin B1exo-8,9-epoxide-GSH
C11713	2-Naphthol
C11714	1-Naphthol
C14039	1,1-Dichloroethylene
C14040	1-Nitronaphthalene
C14453	4-Bromophenol
C14556	9-Hydroxybenzo[a]pyrene
C14783	1,2-Naphthoquinone
C14784	1,2-Dihydroxy-3,4-epoxy-1,2,3,4-tetrahydronaphthalene
C14785	1,4-Dihydroxynaphthalene
C14786	(1R,2S)-Naphthalene 1,2-oxide
C14787	(1S,2R)-Naphthalene 1,2-oxide
C14788	1-Nitrosonaphthalene
C14789	N-Hydroxy-1-aminonaphthalene
C14790	1-Naphthylamine
C14791	(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
C14792	(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
C14793	(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
C14796	(1R)-Hydroxy-(2R)-N-acetyl-L-cysteinyl-1,2-dihydronaphthalene
C14797	(1R)-N-Acetyl-L-cysteinyl-(2R)-hydroxy-1,2-dihydronaphthalene
C14798	(1S)-Hydroxy-(2S)-N-acetyl-L-cysteinyl-1,2-dihydronaphthalene
C14799	(1R,2R)-3-[(1,2-Dihydro-2-hydroxy-1-naphthalenyl)thio]-2-oxopropanoic acid
C14800	1-Nitronaphthalene-5,6-oxide
C14801	1-Nitro-5,6-dihydroxy-dihydronaphthalene
C14802	1-Nitronaphthalene-7,8-oxide
C14803	1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene
C14804	1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene
C14805	1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene
C14806	1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene
C14839	Bromobenzene-3,4-oxide
C14840	Bromobenzene-2,3-oxide
C14841	2-Bromophenol
C14842	Bromobenzene-2,3-dihydrodiol
C14843	4-Bromocatechol
C14844	Bromobenzene-3,4-dihydrodiol
C14845	4-Bromophenol-2,3-epoxide
C14846	4-Bromo-3,5-cyclohexadiene-1,2-dione
C14847	3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene
C14848	2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene
C14849	Benzo[a]pyrene-9,10-oxide
C14850	Benzo[a]pyrene-7,8-oxide
C14851	Benzo[a]pyrene-4,5-oxide
C14852	Benzo[a]pyrene-7,8-diol
C14853	Benzo[a]pyrene-7,8-dihydrodiol-9,10-oxide
C14854	9-Hydroxybenzo[a]pyrene-4,5-oxide
C14855	4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene
C14856	7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene
C14857	1,1-Dichloroethylene epoxide
C14858	2,2-Dichloroacetaldehyde
C14859	Chloroacetyl chloride
C14860	2,2-Dichloro-1,1-ethanediol
C14861	S-(2,2-Dichloro-1-hydroxy)ethyl glutathione
C14862	2-S-Glutathionyl acetate
C14863	2-(S-Glutathionyl)acetyl glutathione
C14864	S-(2-Chloroacetyl)glutathione
C14865	2-(S-Glutathionyl)acetyl chloride
C14866	Chloral
C14867	Dichloroacetyl chloride
C14868	S-(1,2-Dichlorovinyl)glutathione
C14869	Trichloroethanol glucuronide
C14870	2-Bromoacetaldehyde
C14871	S-(Formylmethyl)glutathione
C14872	Thiodiacetic acid
C14873	Thiodiacetic acid sulfoxide
C14874	Glutathione episulfonium ion
C14875	S-(2-Hydroxyethyl)glutathione
C14876	S-(2-Hydroxyethyl)-N-acetyl-L-cysteine
C14877	S-[2-(N7-Guanyl)ethyl]-N-acetyl-L-cysteine
C16453	4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16756	Aflatoxin M1
C19488	7,12-Dimethylbenz[a]anthracene
C19489	1a,11b-Dihydro-4,9-dimethylbenz[a]anthra[3,4-b]oxirene
C19490	trans-3,4-Dihydro-3,4-dihydroxy-7,12-dimethylbenz[a]anthracene
C19559	(1aalpha,2beta,3alpha,11calpha)-1a,2,3,11c-Tetrahydro-6,11-dimethylbenzo[6,7]phenanthro[3,4-b]oxirene-2,3-diol
C19561	7-Hydroxymethyl-12-methylbenz[a]anthracene
C19562	7-Hydroxymethyl-12-methylbenz[a]anthracene sulfate
C19563	4-[(Hydroxymethyl)nitrosoamino]-1-(3-pyridinyl)-1-butanone
C19564	4-(Nitrosoamino)-1-(3-pyridinyl)-1-butanone
C19565	4-Hydroxy-1-(3-pyridinyl)-1-butanone
C19566	4-Hydroxy-4-(methylnitrosoamino)-1-(3-pyridinyl)-1-butanone
C19567	4-Oxo-1-(3-pyridyl)-1-butanone
C19568	N-nitrosomethanamine
C19569	3-Succinoylpyridine
C19574	4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol
C19577	1-(Methylnitrosoamino)-4-(3-pyridinyl)-1,4-butanediol
C19578	5-(3-Pyridyl)-2-hydroxytetrahydrofuran
C19579	gamma-Hydroxy-3-pyridinebutanoate
C19580	alpha-[3-[(Hydroxymethyl)nitrosoamino]propyl]-3-pyridinemethanol
C19581	alpha-[3-(Nitrosoamino)propyl]-3-pyridinemethanol
C19582	1-(3-Pyridinyl)-1,4-butanediol
C19585	Aflatoxin Q1
C19586	Aflatoxin B1-exo-8,9-epoxide
C19588	Aflatoxin B1 diol
C19589	Aflatoxin B1 dialdehyde
C19590	6-[2,3-Dihydroxy-1-(hydroxymethyl)propyl]-1,2-dihydro-7-hydroxy-9-methoxy-cyclopenta[c][1]benzopyran-3,4-dione
C19591	1,2,3,4-Tetrahydro-alpha,7-dihydroxy-beta-(hydroxymethyl)-9-methoxy-3,4-dioxocyclopenta[c][1]benzopyran-6-propanal
C19592	alpha-(1,2-Dihydroxyethyl)-1,2,3,4-tetrahydro-7-hydroxy-9-methoxy-3,4-dioxocyclopenta[c][1]benzopyran-6-acetaldehyde
C19594	Aflatoxin-M1-8,9-epoxide
C19595	Aflatoxin B1-endo-8,9-epoxide
C19602	4-(Methylnitrosamino)-1-(1-oxido-3-pyridinyl)-1-butanone
C19603	4-(Methylnitrosamino)-1-(3-pyridyl-N-oxide)-1-butanol
C19604	7,12-Dimethylbenz[a]anthracene 5,6-oxide
C19605	4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronide
C19606	NNAL-N-glucuronide
C19607	trans-5,6-Dihydro-5,6-dihydroxy-7,12-dimethylbenz[a]anthracene

Reference

PMID:12487150

Authors

Buckpitt A, Boland B, Isbell M, Morin D, Shultz M, Baldwin R, Chan K, Karlsson A, Lin C, Taff A, West J, Fanucchi M, Van Winkle L, Plopper C.

Title

Naphthalene-induced respiratory tract toxicity: metabolic mechanisms of toxicity.

Journal

Drug Metab Rev 34:791-820 (2002)

Reference

PMID:10725110

Authors

Bolton JL, Trush MA, Penning TM, Dryhurst G, Monks TJ.

Title

Role of quinones in toxicology.

Journal

Chem Res Toxicol 13:135-60 (2000)

Reference

PMID:10570027

Authors

Halladay JS, Sauer JM, Sipes IG.

Title

Metabolism and disposition of [(14)C]1-nitronaphthalene in male Sprague-Dawley rats.

Journal

Drug Metab Dispos 27:1456-65 (1999)

Reference

PMID:10490505

Authors

Watt KC, Morin DM, Kurth MJ, Mercer RS, Plopper CG, Buckpitt AR.

Title

Glutathione conjugation of electrophilic metabolites of 1-nitronaphthalene in rat tracheobronchial airways and liver: identification by mass spectrometry and proton nuclear magnetic resonance spectroscopy.

Journal

Chem Res Toxicol 12:831-9 (1999)

Reference

PMID:15319346

Authors

Simmonds AC, Reilly CA, Baldwin RM, Ghanayem BI, Lanza DL, Yost GS, Collins KS, Forkert PG.

Title

Bioactivation of 1,1-dichloroethylene to its epoxide by CYP2E1 and CYP2F enzymes.

Journal

Drug Metab Dispos 32:1032-9 (2004)

Reference

PMID:15987776

Authors

Forkert PG, Baldwin RM, Millen B, Lash LH, Putt DA, Shultz MA, Collins KS.

Title

Pulmonary bioactivation of trichloroethylene to chloral hydrate: relative contributions of CYP2E1, CYP2F, and CYP2B1.

Journal

Drug Metab Dispos 33:1429-37 (2005)

Reference

PMID:9107551

Authors

Wormhoudt LW, Commandeur JN, Ploemen JH, Abdoelgafoer RS, Makansi A, Van Bladeren PJ, Vermeulen NP.

Title

Urinary thiodiacetic acid. A selective biomarker for the cytochrome P450-catalyzed oxidation of 1,2-dibromoethane in the rat.

Journal

Drug Metab Dispos 25:508-15 (1997)

Reference

PMID:4395686

Authors

Brodie BB, Reid WD, Cho AK, Sipes G, Krishna G, Gillette JR.

Title

Possible mechanism of liver necrosis caused by aromatic organic compounds.

Journal

Proc Natl Acad Sci U S A 68:160-4 (1971)

Reference

PMID:15298956

Authors

Lodovici M, Luceri C, Guglielmi F, Bacci C, Akpan V, Fonnesu ML, Boddi V, Dolara P.

Title

Benzo(a)pyrene diolepoxide (BPDE)-DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1, GSTM1, GSTP1, GSTT1, and mEH.

Journal

Cancer Epidemiol Biomarkers Prev 13:1342-8 (2004)

Reference

Authors

Omura T, Ishimura Y, Fujii Y (eds).

Title

[Molecular Biology of P450] (In Japanese)

Journal

Kodansya (2003)

KO pathway

ko00980

All links

Pathway (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (45)   
   KEGG GENES (45)   
All databases (47)   

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