KEGG PATHWAY: dmo04145

PATHWAY: dmo04145

Entry

dmo04145 Pathway

Name

Phagosome - Drosophila mojavensis

Description

Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.

Class

Cellular Processes; Transport and catabolism

Pathway map

dmo04145

Phagosome

Module

dmo_M00401

Sec61 complex [PATH:dmo04145]

Other DBs

BSID:

153975

GO:

0045335

Organism

Drosophila mojavensis [GN:dmo]

Gene

Dmoj_GI12362	GI12362 gene product from transcript GI12362-RA; K08488 syntaxin 7 [KO:K08488]
Dmoj_GI23222	GI23222 gene product from transcript GI23222-RA; K05692 actin beta/gamma 1 [KO:K05692]
Dmoj_GI24339	GI24339 gene product from transcript GI24339-RA; K05692 actin beta/gamma 1 [KO:K05692]
Dmoj_GI19711	GI19711 gene product from transcript GI19711-RA; K05692 actin beta/gamma 1 [KO:K05692]
Dmoj_GI19595	GI19595 gene product from transcript GI19595-RA; K05692 actin beta/gamma 1 [KO:K05692]
Dmoj_GI15312	GI15312 gene product from transcript GI15312-RA; K05692 actin beta/gamma 1 [KO:K05692]
Dmoj_GI22603	GI22603 gene product from transcript GI22603-RA; K08492 syntaxin 18 [KO:K08492]
Dmoj_GI15600	GI15600 gene product from transcript GI15600-RA; K08517 vesicle transport protein SEC22 [KO:K08517]
Dmoj_GI17188	GI17188 gene product from transcript GI17188-RA; K07889 Ras-related protein Rab-5C [KO:K07889]
Dmoj_GI20497	GI20497 gene product from transcript GI20497-RA; K00914 phosphatidylinositol 3-kinase [EC:2.7.1.137] [KO:K00914] [EC:2.7.1.137]
Dmoj_GI17877	GI17877 gene product from transcript GI17877-RA; K12182 hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
Dmoj_GI18088	GI18088 gene product from transcript GI18088-RA; K02145 V-type H+-transporting ATPase subunit A [EC:3.6.3.14] [KO:K02145] [EC:3.6.3.14]
Dmoj_GI18089	GI18089 gene product from transcript GI18089-RA; K02145 V-type H+-transporting ATPase subunit A [EC:3.6.3.14] [KO:K02145] [EC:3.6.3.14]
Dmoj_GI21237	GI21237 gene product from transcript GI21237-RA; K02145 V-type H+-transporting ATPase subunit A [EC:3.6.3.14] [KO:K02145] [EC:3.6.3.14]
Dmoj_GI24752	GI24752 gene product from transcript GI24752-RA; K02147 V-type H+-transporting ATPase subunit B [EC:3.6.3.14] [KO:K02147] [EC:3.6.3.14]
Dmoj_GI19629	GI19629 gene product from transcript GI19629-RA; K02148 V-type H+-transporting ATPase subunit C [EC:3.6.3.14] [KO:K02148] [EC:3.6.3.14]
Dmoj_GI20255	GI20255 gene product from transcript GI20255-RA; K02149 V-type H+-transporting ATPase subunit D [EC:3.6.3.14] [KO:K02149] [EC:3.6.3.14]
Dmoj_GI18533	GI18533 gene product from transcript GI18533-RA; K02149 V-type H+-transporting ATPase subunit D [EC:3.6.3.14] [KO:K02149] [EC:3.6.3.14]
Dmoj_GI15892	GI15892 gene product from transcript GI15892-RA; K02149 V-type H+-transporting ATPase subunit D [EC:3.6.3.14] [KO:K02149] [EC:3.6.3.14]
Dmoj_GI23674	GI23674 gene product from transcript GI23674-RA; K02150 V-type H+-transporting ATPase subunit E [EC:3.6.3.14] [KO:K02150] [EC:3.6.3.14]
Dmoj_GI23969	GI23969 gene product from transcript GI23969-RA; K02151 V-type H+-transporting ATPase subunit F [EC:3.6.3.14] [KO:K02151] [EC:3.6.3.14]
Dmoj_GI24384	GI24384 gene product from transcript GI24384-RA; K02151 V-type H+-transporting ATPase subunit F [EC:3.6.3.14] [KO:K02151] [EC:3.6.3.14]
Dmoj_GI24620	GI24620 gene product from transcript GI24620-RA; K02152 V-type H+-transporting ATPase subunit G [EC:3.6.3.14] [KO:K02152] [EC:3.6.3.14]
Dmoj_GI23846	GI23846 gene product from transcript GI23846-RA; K02153 V-type H+-transporting ATPase subunit H [EC:3.6.3.14] [KO:K02153] [EC:3.6.3.14]
Dmoj_GI11843	Dmoj_Tes122; GI11843 gene product from transcript GI11843-RA [KO:K02153] [EC:3.6.3.14]
Dmoj_GI16589	GI16589 gene product from transcript GI16589-RA; K02153 V-type H+-transporting ATPase subunit H [EC:3.6.3.14] [KO:K02153] [EC:3.6.3.14]
Dmoj_GI16823	GI16823 gene product from transcript GI16823-RA; K02153 V-type H+-transporting ATPase subunit H [EC:3.6.3.14] [KO:K02153] [EC:3.6.3.14]
Dmoj_GI21410	GI21410 gene product from transcript GI21410-RA; K02153 V-type H+-transporting ATPase subunit H [EC:3.6.3.14] [KO:K02153] [EC:3.6.3.14]
Dmoj_GI24258	GI24258 gene product from transcript GI24258-RA; K02154 V-type H+-transporting ATPase subunit I [EC:3.6.3.14] [KO:K02154] [EC:3.6.3.14]
Dmoj_GI24259	GI24259 gene product from transcript GI24259-RA; K02154 V-type H+-transporting ATPase subunit I [EC:3.6.3.14] [KO:K02154] [EC:3.6.3.14]
Dmoj_GI18075	GI18075 gene product from transcript GI18075-RA; K02154 V-type H+-transporting ATPase subunit I [EC:3.6.3.14] [KO:K02154] [EC:3.6.3.14]
Dmoj_GI20149	GI20149 gene product from transcript GI20149-RA; K02154 V-type H+-transporting ATPase subunit I [EC:3.6.3.14] [KO:K02154] [EC:3.6.3.14]
Dmoj_GI22777	GI22777 gene product from transcript GI22777-RA; K02154 V-type H+-transporting ATPase subunit I [EC:3.6.3.14] [KO:K02154] [EC:3.6.3.14]
Dmoj_GI16480	GI16480 gene product from transcript GI16480-RA; K02146 V-type H+-transporting ATPase subunit AC39 [EC:3.6.3.14] [KO:K02146] [EC:3.6.3.14]
Dmoj_GI21354	GI21354 gene product from transcript GI21354-RA; K02144 V-type H+-transporting ATPase 54 kD subunit [EC:3.6.3.14] [KO:K02144] [EC:3.6.3.14]
Dmoj_GI13313	GI13313 gene product from transcript GI13313-RA; K02155 V-type H+-transporting ATPase 16kDa proteolipid subunit [EC:3.6.3.14] [KO:K02155] [EC:3.6.3.14]
Dmoj_GI11612	GI11612 gene product from transcript GI11612-RA; K02155 V-type H+-transporting ATPase 16kDa proteolipid subunit [EC:3.6.3.14] [KO:K02155] [EC:3.6.3.14]
Dmoj_GI21278	GI21278 gene product from transcript GI21278-RA; K02155 V-type H+-transporting ATPase 16kDa proteolipid subunit [EC:3.6.3.14] [KO:K02155] [EC:3.6.3.14]
Dmoj_GI22994	GI22994 gene product from transcript GI22994-RA; K03661 V-type H+-transporting ATPase 21kDa proteolipid subunit [EC:3.6.3.14] [KO:K03661] [EC:3.6.3.14]
Dmoj_GI22996	GI22996 gene product from transcript GI22996-RA; K03661 V-type H+-transporting ATPase 21kDa proteolipid subunit [EC:3.6.3.14] [KO:K03661] [EC:3.6.3.14]
Dmoj_GI20366	GI20366 gene product from transcript GI20366-RA; K03662 V-type H+-transporting ATPase S1 subunit [EC:3.6.3.14] [KO:K03662] [EC:3.6.3.14]
Dmoj_GI24142	GI24142 gene product from transcript GI24142-RA; K07897 Ras-related protein Rab-7A [KO:K07897]
Dmoj_GI12568	GI12568 gene product from transcript GI12568-RA; K10413 dynein heavy chain 1, cytosolic [KO:K10413]
Dmoj_GI22290	GI22290 gene product from transcript GI22290-RA; K10414 dynein heavy chain 2, cytosolic [KO:K10414]
Dmoj_GI11093	GI11093 gene product from transcript GI11093-RA; K10415 dynein intermediate chain, cytosolic [KO:K10415]
Dmoj_GI14862	GI14862 gene product from transcript GI14862-RA; K10416 dynein light intermediate chain 1, cytosolic [KO:K10416]
Dmoj_GI23057	GI23057 gene product from transcript GI23057-RA; K07374 tubulin alpha [KO:K07374]
Dmoj_GI13261	GI13261 gene product from transcript GI13261-RA; K07374 tubulin alpha [KO:K07374]
Dmoj_GI23599	GI23599 gene product from transcript GI23599-RA; K07375 tubulin beta [KO:K07375]
Dmoj_GI20729	GI20729 gene product from transcript GI20729-RA; K07375 tubulin beta [KO:K07375]
Dmoj_GI24852	GI24852 gene product from transcript GI24852-RA; K07375 tubulin beta [KO:K07375]
Dmoj_GI21321	GI21321 gene product from transcript GI21321-RA; K07375 tubulin beta [KO:K07375]
Dmoj_GI14752	GI14752 gene product from transcript GI14752-RA; K07375 tubulin beta [KO:K07375]
Dmoj_GI12441	GI12441 gene product from transcript GI12441-RA; K06528 lysosomal-associated membrane protein 1/2 [KO:K06528]
Dmoj_GI20437	GI20437 gene product from transcript GI20437-RA; K00921 1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150] [KO:K00921] [EC:2.7.1.150]
Dmoj_GI21205	GI21205 gene product from transcript GI21205-RA; K01365 cathepsin L [EC:3.4.22.15] [KO:K01365] [EC:3.4.22.15]
Dmoj_GI17288	GI17288 gene product from transcript GI17288-RA; K10956 protein transport protein SEC61 subunit alpha [KO:K10956]
Dmoj_GI20777	GI20777 gene product from transcript GI20777-RA; K09481 protein transport protein SEC61 subunit beta [KO:K09481]
Dmoj_GI18672	GI18672 gene product from transcript GI18672-RA; K07342 protein transport protein SEC61 subunit gamma and related proteins [KO:K07342]
Dmoj_GI21533	GI21533 gene product from transcript GI21533-RA; K07342 protein transport protein SEC61 subunit gamma and related proteins [KO:K07342]
Dmoj_GI23963	GI23963 gene product from transcript GI23963-RA; K08057 calreticulin [KO:K08057]
Dmoj_GI22345	GI22345 gene product from transcript GI22345-RA; K08054 calnexin [KO:K08054]
Dmoj_GI23240	GI23240 gene product from transcript GI23240-RA; K05719 integrin beta 1 [KO:K05719]
Dmoj_GI15296	GI15296 gene product from transcript GI15296-RA; K05719 integrin beta 1 [KO:K05719]
Dmoj_GI17544	GI17544 gene product from transcript GI17544-RA; K04659 thrombospondin 2/3/4/5 [KO:K04659]
Dmoj_GI22015	GI22015 gene product from transcript GI22015-RA; K04392 Ras-related C3 botulinum toxin substrate 1 [KO:K04392]
Dmoj_GI12458	GI12458 gene product from transcript GI12458-RA; K04392 Ras-related C3 botulinum toxin substrate 1 [KO:K04392]
Dmoj_GI12273	GI12273 gene product from transcript GI12273-RA; K04392 Ras-related C3 botulinum toxin substrate 1 [KO:K04392]

Compound

C00007	Oxygen
C00027	Hydrogen peroxide
C00533	Nitric oxide
C00704	O2.-
C04549	1-Phosphatidyl-1D-myo-inositol 3-phosphate

Reference

PMID:15894272

Authors

Stuart LM, Ezekowitz RA

Title

Phagocytosis: elegant complexity.

Journal

Immunity 22:539-50 (2005)

Reference

PMID:10684585

Authors

Tjelle TE, Lovdal T, Berg T

Title

Phagosome dynamics and function.

Journal

Bioessays 22:255-63 (2000)

Reference

PMID:18492791

Authors

Dupuy AG, Caron E

Title

Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.

Journal

J Cell Sci 121:1773-83 (2008)

Reference

PMID:15036145

Authors

Brumell JH, Grinstein S

Title

Salmonella redirects phagosomal maturation.

Journal

Curr Opin Microbiol 7:78-84 (2004)

Reference

PMID:17245426

Authors

Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S

Title

LAMP proteins are required for fusion of lysosomes with phagosomes.

Journal

EMBO J 26:313-24 (2007)

Reference

PMID:17637737

Authors

Luzio JP, Pryor PR, Bright NA

Title

Lysosomes: fusion and function.

Journal

Nat Rev Mol Cell Biol 8:622-32 (2007)

Reference

PMID:18513324

Authors

Sumimoto H

Title

Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.

Journal

FEBS J 275:3249-77 (2008)

KO pathway

ko04145

All links

Pathway (2)   
   KEGG MODULE (1)   
   BioSystems (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (68)   
   KEGG GENES (68)   
All databases (71)   

Download RDF

DBGET integrated database retrieval system