KEGG PATHWAY: dpo00980

PATHWAY: dpo00980

Entry

dpo00980                    Pathway

Name

Metabolism of xenobiotics by cytochrome P450 - Drosophila pseudoobscura

Class

Metabolism; Xenobiotics biodegradation and metabolism

Pathway map

dpo00980

Metabolism of xenobiotics by cytochrome P450

Organism

Drosophila pseudoobscura [GN:dpo]

Gene

117183789

glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]

6896921

glutathione S-transferase T2 [KO:K00799] [EC:2.5.1.18]

4803342

glutathione S-transferase E14 isoform X1 [KO:K00799] [EC:2.5.1.18]

4804585

glutathione S-transferase 1 isoform X1 [KO:K00799] [EC:2.5.1.18]

4804703

glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]

4804804

glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]

4804806

glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]

4804805

glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]

4804808

glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]

5495503

glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]

5495515

glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]

4804810

glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]

4804809

glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]

4805124

glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]

4812798

pyrimidodiazepine synthase isoform X2 [KO:K00799] [EC:2.5.1.18]

4814426

glutathione S-transferase theta-3 [KO:K00799] [EC:2.5.1.18]

4814313

microsomal glutathione S-transferase 1 isoform X1 [KO:K00799] [EC:2.5.1.18]

6901928

microsomal glutathione S-transferase 1 isoform X2 [KO:K00799] [EC:2.5.1.18]

6901929

microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]

6901645

glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]

6897849

uncharacterized protein LOC6897849 isoform X1 [KO:K00799] [EC:2.5.1.18]

4800808

glutathione S-transferase 1-1 [KO:K00799] [EC:2.5.1.18]

4800811

glutathione S-transferase D2 [KO:K00799] [EC:2.5.1.18]

4800814

glutathione S-transferase 1-1 [KO:K00799] [EC:2.5.1.18]

4800816

glutathione S-transferase D7 isoform X1 [KO:K00799] [EC:2.5.1.18]

6898657

glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]

6898790

glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]

4805388

glutathione S-transferase S1 [KO:K04097] [EC:5.3.99.2 2.5.1.18]

4816794

trans-1,2-dihydrobenzene-1,2-diol dehydrogenase [KO:K00078] [EC:1.3.1.20 1.1.1.179]

4817398

trans-1,2-dihydrobenzene-1,2-diol dehydrogenase [KO:K00078] [EC:1.3.1.20 1.1.1.179]

4817478

trans-1,2-dihydrobenzene-1,2-diol dehydrogenase [KO:K00078] [EC:1.3.1.20 1.1.1.179]

4803126

UDP-glucuronosyltransferase 2B15 [KO:K00699] [EC:2.4.1.17]

4803128

UDP-glucuronosyltransferase 2B31 [KO:K00699] [EC:2.4.1.17]

4803130

UDP-glucuronosyltransferase [KO:K00699] [EC:2.4.1.17]

4803131

UDP-glucuronosyltransferase [KO:K00699] [EC:2.4.1.17]

4803136

UDP-glucuronosyltransferase 1-8 isoform X1 [KO:K00699] [EC:2.4.1.17]

6902430

UDP-glucuronosyltransferase 2B15 [KO:K00699] [EC:2.4.1.17]

4803763

UDP-glucuronosyltransferase 2B13 [KO:K00699] [EC:2.4.1.17]

4803762

UDP-glucuronosyltransferase 2C1 [KO:K00699] [EC:2.4.1.17]

4812352

UDP-glucuronosyltransferase [KO:K00699] [EC:2.4.1.17]

6903296

UDP-glucuronosyltransferase 1-1 [KO:K00699] [EC:2.4.1.17]

6902878

UDP-glucuronosyltransferase 2B9 [KO:K00699] [EC:2.4.1.17]

4816157

UDP-glucuronosyltransferase 1-7C [KO:K00699] [EC:2.4.1.17]

6903244

UDP-glucuronosyltransferase 2A3 isoform X2 [KO:K00699] [EC:2.4.1.17]

6902429

UDP-glucuronosyltransferase 2B15 [KO:K00699] [EC:2.4.1.17]

4817450

UDP-glucuronosyltransferase 1-1 [KO:K00699] [EC:2.4.1.17]

4817037

UDP-glucuronosyltransferase 2A1 [KO:K00699] [EC:2.4.1.17]

4816902

UDP-glucuronosyltransferase 2B13 [KO:K00699] [EC:2.4.1.17]

4816868

2-hydroxyacylsphingosine 1-beta-galactosyltransferase [KO:K00699] [EC:2.4.1.17]

4816869

UDP-glucuronosyltransferase 1-3 [KO:K00699] [EC:2.4.1.17]

4817331

UDP-glucuronosyltransferase 2B17 [KO:K00699] [EC:2.4.1.17]

4817186

UDP-glucuronosyltransferase [KO:K00699] [EC:2.4.1.17]

6897937

UDP-glucuronosyltransferase 2A2 [KO:K00699] [EC:2.4.1.17]

4803114

alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]

4818070

alcohol dehydrogenase [KO:K00001] [EC:1.1.1.1]

Compound

C00745

Nicotine

C00829

Naphthalene

C02617

1,4-Naphthoquinone

C03012

Naphthalene-1,2-diol

C06205

1,2-Dihydronaphthalene-1,2-diol

C06755

Chloroacetic acid

C06790

Trichloroethene

C06800

Aflatoxin B1

C06899

Chloral hydrate

C07490

Trichloroethanol

C07535

Benzo[a]pyrene

C11036

Bromobenzene

C11088

1,2-Dibromoethane

C11148

TCE epoxide

C11149

Dichloroacetate

C11150

Trichloroacetate

C11278

Aflatoxin B1exo-8,9-epoxide-GSH

C11713

2-Naphthol

C11714

1-Naphthol

C14039

1,1-Dichloroethylene

C14040

1-Nitronaphthalene

C14453

4-Bromophenol

C14556

9-Hydroxybenzo[a]pyrene

C14783

1,2-Naphthoquinone

C14784

1,2-Dihydroxy-3,4-epoxy-1,2,3,4-tetrahydronaphthalene

C14785

1,4-Dihydroxynaphthalene

C14786

(1R,2S)-Naphthalene 1,2-oxide

C14787

(1S,2R)-Naphthalene 1,2-oxide

C14788

1-Nitrosonaphthalene

C14789

N-Hydroxy-1-aminonaphthalene

C14790

1-Naphthylamine

C14791

(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene

C14792

(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene

C14793

(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene

C14796

(1R)-Hydroxy-(2R)-N-acetyl-L-cysteinyl-1,2-dihydronaphthalene

C14797

(1R)-N-Acetyl-L-cysteinyl-(2R)-hydroxy-1,2-dihydronaphthalene

C14798

(1S)-Hydroxy-(2S)-N-acetyl-L-cysteinyl-1,2-dihydronaphthalene

C14799

(1R,2R)-3-[(1,2-Dihydro-2-hydroxy-1-naphthalenyl)thio]-2-oxopropanoic acid

C14800

1-Nitronaphthalene-5,6-oxide

C14801

1-Nitro-5,6-dihydroxy-dihydronaphthalene

C14802

1-Nitronaphthalene-7,8-oxide

C14803

1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene

C14804

1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene

C14805

1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene

C14806

1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene

C14839

Bromobenzene-3,4-oxide

C14840

Bromobenzene-2,3-oxide

C14841

2-Bromophenol

C14842

Bromobenzene-2,3-dihydrodiol

C14843

4-Bromocatechol

C14844

Bromobenzene-3,4-dihydrodiol

C14845

4-Bromophenol-2,3-epoxide

C14846

4-Bromo-3,5-cyclohexadiene-1,2-dione

C14847

3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene

C14848

2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene

C14849

Benzo[a]pyrene-9,10-oxide

C14850

Benzo[a]pyrene-7,8-oxide

C14851

Benzo[a]pyrene-4,5-oxide

C14852

Benzo[a]pyrene-7,8-dihydrodiol

C14853

Benzo[a]pyrene-7,8-dihydrodiol-9,10-oxide

C14854

9-Hydroxybenzo[a]pyrene-4,5-oxide

C14855

4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene

C14856

7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene

C14857

1,1-Dichloroethylene epoxide

C14858

2,2-Dichloroacetaldehyde

C14859

Chloroacetyl chloride

C14860

2,2-Dichloro-1,1-ethanediol

C14861

S-(2,2-Dichloro-1-hydroxy)ethyl glutathione

C14862

2-S-Glutathionyl acetate

C14863

2-(S-Glutathionyl)acetyl glutathione

C14864

S-(2-Chloroacetyl)glutathione

C14865

2-(S-Glutathionyl)acetyl chloride

C14866

Chloral

C14867

Dichloroacetyl chloride

C14868

S-(1,2-Dichlorovinyl)glutathione

C14869

Trichloroethanol glucuronide

C14870

2-Bromoacetaldehyde

C14871

S-(Formylmethyl)glutathione

C14872

Thiodiacetic acid

C14873

Thiodiacetic acid sulfoxide

C14874

Glutathione episulfonium ion

C14875

S-(2-Hydroxyethyl)glutathione

C14876

S-(2-Hydroxyethyl)-N-acetyl-L-cysteine

C14877

S-[2-(N7-Guanyl)ethyl]-N-acetyl-L-cysteine

C16453

4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone

C16756

Aflatoxin M1

C19488

7,12-Dimethylbenz[a]anthracene

C19489

1a,11b-Dihydro-4,9-dimethylbenz[a]anthra[3,4-b]oxirene

C19490

trans-3,4-Dihydro-3,4-dihydroxy-7,12-dimethylbenz[a]anthracene

C19559

(1aalpha,2beta,3alpha,11calpha)-1a,2,3,11c-Tetrahydro-6,11-dimethylbenzo[6,7]phenanthro[3,4-b]oxirene-2,3-diol

C19561

7-Hydroxymethyl-12-methylbenz[a]anthracene

C19562

7-Hydroxymethyl-12-methylbenz[a]anthracene sulfate

C19563

4-[(Hydroxymethyl)nitrosoamino]-1-(3-pyridinyl)-1-butanone

C19564

4-(Nitrosoamino)-1-(3-pyridinyl)-1-butanone

C19565

4-Hydroxy-1-(3-pyridinyl)-1-butanone

C19566

4-Hydroxy-4-(methylnitrosoamino)-1-(3-pyridinyl)-1-butanone

C19567

4-Oxo-1-(3-pyridyl)-1-butanone

C19568

N-Nitrosomethanamine

C19569

3-Succinoylpyridine

C19574

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol

C19577

1-(Methylnitrosoamino)-4-(3-pyridinyl)-1,4-butanediol

C19578

5-(3-Pyridyl)-2-hydroxytetrahydrofuran

C19579

gamma-Hydroxy-3-pyridinebutanoate

C19580

alpha-[3-[(Hydroxymethyl)nitrosoamino]propyl]-3-pyridinemethanol

C19581

alpha-[3-(Nitrosoamino)propyl]-3-pyridinemethanol

C19582

1-(3-Pyridinyl)-1,4-butanediol

C19585

Aflatoxin Q1

C19586

Aflatoxin B1-exo-8,9-epoxide

C19588

Aflatoxin B1 diol

C19589

Aflatoxin B1 dialdehyde

C19590

6-[2,3-Dihydroxy-1-(hydroxymethyl)propyl]-1,2-dihydro-7-hydroxy-9-methoxy-cyclopenta[c][1]benzopyran-3,4-dione

C19591

1,2,3,4-Tetrahydro-alpha,7-dihydroxy-beta-(hydroxymethyl)-9-methoxy-3,4-dioxocyclopenta[c][1]benzopyran-6-propanal

C19592

alpha-(1,2-Dihydroxyethyl)-1,2,3,4-tetrahydro-7-hydroxy-9-methoxy-3,4-dioxocyclopenta[c][1]benzopyran-6-acetaldehyde

C19594

Aflatoxin-M1-8,9-epoxide

C19595

Aflatoxin B1-endo-8,9-epoxide

C19602

4-(Methylnitrosamino)-1-(1-oxido-3-pyridinyl)-1-butanone

C19603

4-(Methylnitrosamino)-1-(3-pyridyl-N-oxide)-1-butanol

C19604

7,12-Dimethylbenz[a]anthracene 5,6-oxide

C19605

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronide

C19606

NNAL-N-glucuronide

C19607

trans-5,6-Dihydro-5,6-dihydroxy-7,12-dimethylbenz[a]anthracene

Reference

PMID:12487150

Authors

Buckpitt A, Boland B, Isbell M, Morin D, Shultz M, Baldwin R, Chan K, Karlsson A, Lin C, Taff A, West J, Fanucchi M, Van Winkle L, Plopper C.

Title

Naphthalene-induced respiratory tract toxicity: metabolic mechanisms of toxicity.

Journal

Drug Metab Rev 34:791-820 (2002)
DOI:10.1081/DMR-120015694

Reference

PMID:10725110

Authors

Bolton JL, Trush MA, Penning TM, Dryhurst G, Monks TJ.

Title

Role of quinones in toxicology.

Journal

Chem Res Toxicol 13:135-60 (2000)
DOI:10.1021/tx9902082

Reference

PMID:10570027

Authors

Halladay JS, Sauer JM, Sipes IG.

Title

Metabolism and disposition of [(14)C]1-nitronaphthalene in male Sprague-Dawley rats.

Journal

Drug Metab Dispos 27:1456-65 (1999)

Reference

PMID:10490505

Authors

Watt KC, Morin DM, Kurth MJ, Mercer RS, Plopper CG, Buckpitt AR.

Title

Glutathione conjugation of electrophilic metabolites of 1-nitronaphthalene in rat tracheobronchial airways and liver: identification by mass spectrometry and proton nuclear magnetic resonance spectroscopy.

Journal

Chem Res Toxicol 12:831-9 (1999)
DOI:10.1021/tx990023v

Reference

PMID:15319346

Authors

Simmonds AC, Reilly CA, Baldwin RM, Ghanayem BI, Lanza DL, Yost GS, Collins KS, Forkert PG.

Title

Bioactivation of 1,1-dichloroethylene to its epoxide by CYP2E1 and CYP2F enzymes.

Journal

Drug Metab Dispos 32:1032-9 (2004)

Reference

PMID:15987776

Authors

Forkert PG, Baldwin RM, Millen B, Lash LH, Putt DA, Shultz MA, Collins KS.

Title

Pulmonary bioactivation of trichloroethylene to chloral hydrate: relative contributions of CYP2E1, CYP2F, and CYP2B1.

Journal

Drug Metab Dispos 33:1429-37 (2005)
DOI:10.1124/dmd.105.005074

Reference

PMID:9107551

Authors

Wormhoudt LW, Commandeur JN, Ploemen JH, Abdoelgafoer RS, Makansi A, Van Bladeren PJ, Vermeulen NP.

Title

Urinary thiodiacetic acid. A selective biomarker for the cytochrome P450-catalyzed oxidation of 1,2-dibromoethane in the rat.

Journal

Drug Metab Dispos 25:508-15 (1997)

Reference

PMID:4395686

Authors

Brodie BB, Reid WD, Cho AK, Sipes G, Krishna G, Gillette JR.

Title

Possible mechanism of liver necrosis caused by aromatic organic compounds.

Journal

Proc Natl Acad Sci U S A 68:160-4 (1971)
DOI:10.1073/pnas.68.1.160

Reference

PMID:15298956

Authors

Lodovici M, Luceri C, Guglielmi F, Bacci C, Akpan V, Fonnesu ML, Boddi V, Dolara P.

Title

Benzo(a)pyrene diolepoxide (BPDE)-DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1, GSTM1, GSTP1, GSTT1, and mEH.

Journal

Cancer Epidemiol Biomarkers Prev 13:1342-8 (2004)

Reference

Authors

Omura T, Ishimura Y, Fujii Y (eds).

Title

[Molecular Biology of P450] (In Japanese)

Journal

Kodansya (2003)

KO pathway

ko00980

All links

Genome (1)   
   KEGG GENOME (1)   
Gene (55)   
   KEGG GENES (55)   
All databases (56)   

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