KEGG   PATHWAY: dra00730Help
Entry
dra00730                    Pathway                                

Name
Thiamine metabolism - Deinococcus radiodurans
Class
Metabolism; Metabolism of cofactors and vitamins
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Thiamine metabolism
dra00730

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Organism
Deinococcus radiodurans [GN:dra]
Gene
thiamine biosynthesis protein ThiC; K03147 phosphomethylpyrimidine synthase [EC:4.1.99.17] [KO:K03147] [EC:4.1.99.17]
phosphomethylpyrimidine kinase; K00941 hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [EC:2.7.1.49 2.7.4.7] [KO:K00941] [EC:2.7.4.7 2.7.1.49]
class V aminotransferase; K04487 cysteine desulfurase [EC:2.8.1.7] [KO:K04487] [EC:2.8.1.7]
1-deoxy-D-xylulose-5-phosphate synthase; K01662 1-deoxy-D-xylulose-5-phosphate synthase [EC:2.2.1.7] [KO:K01662] [EC:2.2.1.7]
thiG; thiazole synthase [KO:K03149] [EC:2.8.1.10]
thiamin-phosphate pyrophosphorylase; K00788 thiamine-phosphate pyrophosphorylase [EC:2.5.1.3] [KO:K00788] [EC:2.5.1.3]
Compound
C00003  
NAD+
C00018  
Pyridoxal phosphate
C00022  
Pyruvate
C00037  
Glycine
C00068  
Thiamin diphosphate
C00082  
L-Tyrosine
C00097  
L-Cysteine
C00118  
D-Glyceraldehyde 3-phosphate
C00378  
Thiamine
C01081  
Thiamin monophosphate
C01279  
4-Amino-5-hydroxymethyl-2-methylpyrimidine
C02691  
Heteropyrithiamine
C02892  
Thiamine acetic acid
C03028  
Thiamin triphosphate
C03373  
Aminoimidazole ribotide
C04294  
5-(2-Hydroxyethyl)-4-methylthiazole
C04327  
4-Methyl-5-(2-phosphoethyl)thiazole
C04556  
4-Amino-2-methyl-5-phosphomethylpyrimidine
C04752  
2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphate
C05856  
Thiamine aldehyde
C11437  
1-Deoxy-D-xylulose 5-phosphate
C15809  
Iminoglycine
C15810  
C15811  
[Enzyme]-cysteine
C15812  
[Enzyme]-S-sulfanylcysteine
C15813  
C15814  
C20246  
2-[(2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate
C20247  
2-(2-Carboxy-4-methylthiazol-5-yl)ethyl phosphate
C20784  
ADP-5-ethyl-4-methylthiazole-2-carboxylate
Reference
  Authors
Kawasaki Y, Onozuka M, Mizote T, Nosaka K.
  Title
Biosynthesis of hydroxymethylpyrimidine pyrophosphate in Saccharomyces cerevisiae.
  Journal
Curr Genet 47:156-62 (2005)
Reference
  Authors
Park JH, Dorrestein PC, Zhai H, Kinsland C, McLafferty FW, Begley TP.
  Title
Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1).
  Journal
Biochemistry 42:12430-8 (2003)
Reference
  Authors
Begley TP, Ealick SE, McLafferty FW
  Title
Thiamin biosynthesis: still yielding fascinating biological chemistry.
  Journal
Biochem Soc Trans 40:555-60 (2012)
Reference
  Authors
Wightman R, Meacock PA
  Title
The THI5 gene family of Saccharomyces cerevisiae: distribution of homologues among the hemiascomycetes and functional redundancy in the aerobic biosynthesis of thiamin from pyridoxine.
  Journal
Microbiology 149:1447-60 (2003)
Reference
  Authors
Chatterjee A, Abeydeera ND, Bale S, Pai PJ, Dorrestein PC, Russell DH, Ealick SE, Begley TP
  Title
Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase.
  Journal
Nature 478:542-6 (2011)
Reference
  Authors
Jurgenson CT, Begley TP, Ealick SE
  Title
The structural and biochemical foundations of thiamin biosynthesis.
  Journal
Annu Rev Biochem 78:569-603 (2009)
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