KEGG   PATHWAY: dra00790Help
Entry
dra00790                    Pathway                                

Name
Folate biosynthesis - Deinococcus radiodurans
Class
Metabolism; Metabolism of cofactors and vitamins
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Pathway map
Folate biosynthesis
dra00790

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BSID: 
GO: 
Organism
Deinococcus radiodurans [GN:dra]
Gene
folE; GTP cyclohydrolase I [KO:K01495] [EC:3.5.4.16]
dihydroneopterin aldolase [KO:K01633] [EC:5.1.99.8 4.1.2.25]
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase [KO:K00950] [EC:2.7.6.3]
dihydropteroate synthase [KO:K00796] [EC:2.5.1.15]
dihydrofolate reductase [KO:K00287] [EC:1.5.1.3]
folC; folyl-polyglutamate synthetase [KO:K11754] [EC:6.3.2.17 6.3.2.12]
folyl-polyglutamate synthetase [KO:K11754] [EC:6.3.2.17 6.3.2.12]
moaA; molybdenum cofactor biosynthesis protein A [KO:K03639] [EC:4.1.99.22]
moaC; molybdenum cofactor biosynthesis protein MoaC [KO:K03637] [EC:4.6.1.17]
molybdenum cofactor biosynthesis protein D/E [KO:K21142] [EC:2.8.1.12]
molybdopterin biosynthesis MoeA [KO:K03750] [EC:2.10.1.1]
hypothetical protein [KO:K07141] [EC:2.7.7.76]
molybdopterin-guanine dinucleotide biosynthesis protein A [KO:K03752] [EC:2.7.7.77]
Compound
C00044  
GTP
C00101  
Tetrahydrofolate
C00251  
Chorismate
C00266  
Glycolaldehyde
C00268  
Dihydrobiopterin
C00272  
Tetrahydrobiopterin
C00415  
Dihydrofolate
C00504  
Folate
C00568  
4-Aminobenzoate
C00921  
Dihydropteroate
C01217  
5,6,7,8-Tetrahydromethanopterin
C01300  
6-(Hydroxymethyl)-7,8-dihydropterin
C02587  
Pyrimidodiazepine
C03541  
THF-polyglutamate
C03684  
6-Pyruvoyltetrahydropterin
C04244  
6-Lactoyl-5,6,7,8-tetrahydropterin
C04807  
6-Hydroxymethyl-7,8-dihydropterin diphosphate
C04874  
7,8-Dihydroneopterin
C04895  
7,8-Dihydroneopterin 3'-triphosphate
C05922  
Formamidopyrimidine nucleoside triphosphate
C05923  
2,5-Diaminopyrimidine nucleoside triphosphate
C05924  
Molybdopterin
C05925  
Dihydroneopterin phosphate
C05926  
Neopterin
C05927  
7,8-Dihydromethanopterin
C06148  
2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
C06149  
6-(3'-Triphosphoryl-1'-methylglyceryl)-7-methyl-7,8-dihydrobiopterin
C09332  
THF-L-glutamate
C11355  
4-Amino-4-deoxychorismate
C15996  
7-Cyano-7-carbaguanine
C16675  
7-Aminomethyl-7-carbaguanine
C18237  
Molybdoenzyme molybdenum cofactor
C18239  
Precursor Z
C18802  
Tetrahydrosarcinapterin
C19848  
Adenylated molybdopterin
C19871  
Guanylyl molybdenum cofactor
C20239  
6-Carboxy-5,6,7,8-tetrahydropterin
C20248  
7-Carboxy-7-carbaguanine
C21310  
(8S)-3',8-Cyclo-7,8-dihydroguanosine 5'-triphosphate
C21485  
Cytidylyl molybdenum cofactor
C21486  
Thio-molybdenum cofactor
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Schwarz G, Mendel RR, Ribbe MW
  Title
Molybdenum cofactors, enzymes and pathways.
  Journal
Nature 460:839-47 (2009)
DOI:10.1038/nature08302
Reference
  Authors
Hanzelmann P, Schindelin H
  Title
Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism.
  Journal
Proc Natl Acad Sci U S A 103:6829-34 (2006)
DOI:10.1073/pnas.0510711103
Reference
  Authors
Daniels JN, Wuebbens MM, Rajagopalan KV, Schindelin H
  Title
Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency.
  Journal
Biochemistry 47:615-26 (2008)
DOI:10.1021/bi701734g
Reference
  Authors
Wuebbens MM, Rajagopalan KV
  Title
Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis.
  Journal
J Biol Chem 278:14523-32 (2003)
DOI:10.1074/jbc.M300453200
KO pathway
 

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