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dra00860                    Pathway                                

Porphyrin and chlorophyll metabolism - Deinococcus radiodurans
Metabolism; Metabolism of cofactors and vitamins
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Pathway map
dra00860  Porphyrin and chlorophyll metabolism

Ortholog table
dra_M00122  Cobalamin biosynthesis, cobinamide => cobalamin [PATH:dra00860]
Other DBs
BSID: 2627
GO: 0006778
Deinococcus radiodurans [GN:dra]
DR_0485  gltX; glutamyl-tRNA synthetase [KO:K01885] [EC:]
DR_1687  glutamyl-tRNA synthetase-like protein [KO:K01885] [EC:]
DR_2547  glutamyl-tRNA reductase [KO:K02492] [EC:]
DR_0555  glutamate-1-semialdehyde aminotransferase [KO:K01845] [EC:]
DR_2160  delta-aminolevulinic acid dehydratase [KO:K01698] [EC:]
DR_2352  hemC; porphobilinogen deaminase [KO:K01749] [EC:]
DR_0786  uroporphyrinogen-III synthase [KO:K01719] [EC:]
DR_1133  uroporphyrinogen decarboxylase [KO:K01599] [EC:]
DR_1130  protoporphyrinogen oxidase [KO:K00231] [EC:]
DR_1131  hemH; ferrochelatase [KO:K01772] [EC:]
DR_A0011  uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase [KO:K13542] [EC:]
DR_2618  protoheme IX farnesyltransferase [KO:K02257] [EC:]
DR_2617  cytochrome AA3-controlling protein CtaA [KO:K02259]
DR_B0009  cobyrinic acid a,c-diamide synthase [KO:K02224] [EC:]
DR_1638  hypothetical protein [KO:K00798] [EC:]
DR_B0008  cob(I)alamin adenosyltransferase [KO:K19221] [EC:]
DR_B0012  cobyric acid synthase [KO:K02232] [EC:]
DR_B0010  cobalamin biosynthesis protein CobD [KO:K02227] [EC:]
DR_A0020  cobinamide kinase/cobinamide phosphate guanylyltransferase [KO:K02231] [EC:]
DR_A0239  cobalamin synthase [KO:K02233] [EC:]
DR_A0240  nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase [KO:K00768] [EC:]
DR_0278  phosphoglycerate mutase [KO:K02226] [EC:]
DR_2594  magnesium protoporphyrin chelatase [KO:K03405] [EC:]
C00025  L-Glutamate
C00032  Heme
C00037  Glycine
C00188  L-Threonine
C00194  Cobamide coenzyme
C00430  5-Aminolevulinate
C00486  Bilirubin
C00500  Biliverdin
C00524  Cytochrome c
C00541  Cob(II)alamin
C00748  Siroheme
C00853  Cob(I)alamin
C00931  Porphobilinogen
C00992  Aquacob(III)alamin
C01024  Hydroxymethylbilane
C01051  Uroporphyrinogen III
C01079  Protoporphyrinogen IX
C01708  Hemoglobin
C02139  Chlorophyllide
C02191  Protoporphyrin
C02463  Precorrin 2
C02469  Uroporphyrin III
C02800  4,5-Dioxopentanoate
C02823  Cyanocobalamin
C02880  Protochlorophyllide
C02987  L-Glutamyl-tRNA(Glu)
C03029  Transferrin[Fe(II)]2
C03114  Dimethylbenzimidazole
C03179  Transferrin[Fe(III)]2
C03194  (R)-1-Aminopropan-2-ol
C03263  Coproporphyrinogen III
C03516  Magnesium protoporphyrin
C03741  (S)-4-Amino-5-oxopentanoate
C04122  D-1-Aminopropan-2-ol O-phosphate
C04536  Magnesium protoporphyrin monomethyl ester
C04778  N1-(5-Phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole
C05306  Chlorophyll a
C05307  Chlorophyll b
C05766  Uroporphyrinogen I
C05767  Uroporphyrin I
C05768  Coproporphyrinogen I
C05769  Coproporphyrin I
C05770  Coproporphyrin III
C05772  Precorrin 3A
C05773  Cobyrinate
C05774  Cobinamide
C05775  alpha-Ribazole
C05777  Coenzyme F430
C05778  Sirohydrochlorin
C05779  Apoferritin
C05780  Apotransferrin
C05781  Oxyhemoglobin
C05782  Myoglobin
C05783  Cytochrome a
C05784  Catalase
C05785  Peroxidase
C05786  (3Z)-Phycocyanobilin
C05787  Bilirubin beta-diglucuronide
C05789  L-Urobilinogen
C05790  I-Urobilinogen
C05791  D-Urobilinogen
C05793  L-Urobilin
C05794  Urobilin
C05795  D-Urobilin
C05797  Pheophytin a
C05798  Bacteriopheophytin
C05912  (3Z)-Phycoerythrobilin
C05913  (3Z)-Phytochromobilin
C06319  Precorrin 6Y
C06320  Precorrin 6X
C06399  Hydrogenobyrinate
C06406  Precorrin 3B
C06407  Precorrin 4
C06408  Precorrin 8X
C06416  Precorrin 5
C06503  Hydrogenobyrinate a,c diamide
C06504  Cob(II)yrinate a,c diamide
C06505  Cob(I)yrinate a,c diamide
C06506  Adenosyl cobyrinate a,c diamide
C06507  Adenosyl cobyrinate hexaamide
C06508  Adenosyl cobinamide
C06509  Adenosyl cobinamide phosphate
C06510  Adenosine-GDP-cobinamide
C11242  Bacteriochlorophyll a
C11243  Bacteriochlorophyll b
C11538  Cobalt-sirohydrochlorin
C11539  Cobalt-precorrin 3
C11540  Cobalt-precorrin 4
C11542  Cobalt-precorrin 6
C11543  Cobalt-dihydro-precorrin 6
C11545  Cobalt-precorrin 8
C11630  15,16-Dihydrobiliverdin
C11829  13(1)-Hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester
C11830  13(1)-Oxo-magnesium-protoporphyrin IX 13-monomethyl ester
C11831  Divinylprotochlorophyllide
C11832  Divinyl chlorophyllide a
C11850  Divinylchlorophyll a
C11851  Zn-Bacteriochlorophyll a
C12147  L-Threonine O-3-phosphate
C14818  Fe2+
C14819  Fe3+
C15670  Heme A
C15672  Heme O
C16242  Cobalt-precorrin 5A
C16243  Cobalt-precorrin 5B
C16244  Cobalt-precorrin 7
C16540  7(1)-Hydroxychlorophyllide a
C16541  Chlorophyllide b
C17401  Cobalt-factor III
C18021  Pheophorbide a
C18022  Red chlorophyll catabolite
C18064  Pyropheophorbide a
C18098  Primary fluorescent chlorophyll catabolite
C18151  7(1)-Hydroxychlorophyll a
C18152  3-Vinylbacteriochlorophyllide a
C18153  3-Hydroxyethylbacteriochlorophyllide a
C18154  3-Hydroxyethylchlorophyllide a
C18155  Bacteriochlorophyllide a
C18156  Bacteriochlorophyllide b
C18157  8-Ethyl-12-methyl-3-vinylbacteriochlorophyllide d
C18160  Bacteriochlorophyllide d
C18161  Bacteriochlorophyllide c
C18162  Bacteriochlorophyll d
C18163  Bacteriochlorophyll c
C20666  5-Oxo-delta-bilirubin
C21217  Geranylgeranyl bacteriochlorophyllide a
C21284  Fe-coproporphyrin III
C21427  8,12-Diethyl-3-vinylbacteriochlorophyllide d
C21428  12-Ethyl-8-propyl-3-vinylbacteriochlorophyllide d
C21429  12-Ethyl-8-isobutyl-3-vinylbacteriochlorophyllide d
C21431  8-Ethyl-12-methylbacteriochlorophyllide d
C21432  8,12-Diethylbacteriochlorophyllide d
C21433  12-Ethyl-8-propylbacteriochlorophyllide d
C21434  12-Ethyl-8-isobutylbacteriochlorophyllide d
C21435  Geranylgeranyl bacteriochlorophyllide b
C21510  Nickel-sirohydrochlorin
C21511  Nickel-sirohydrochlorin a,c-diamide
C21512  15,17(3)-Seco-F430-17(3)-acid
C21582  Bacteriochlorophyllide e
C21723  Biliverdin-IX-delta
C21724  Biliverdin-IX-beta
C21835  12,18-Didecarboxysiroheme
Woodcock SC, Raux E, Levillayer F, Thermes C, Rambach A, Warren MJ.
Effect of mutations in the transmethylase and dehydrogenase/chelatase domains of sirohaem synthase (CysG) on sirohaem and cobalamin biosynthesis.
Biochem J 330:121-9 (1998)
Johansson P, Hederstedt L
Organization of genes for tetrapyrrole biosynthesis in gram--positive bacteria.
Microbiology 145 ( Pt 3):529-38 (1999)
Maggio-Hall LA, Escalante-Semerena JC.
In vitro synthesis of the nucleotide loop of cobalamin by Salmonella typhimurium enzymes.
Proc Natl Acad Sci USA 96:11798-803 (1999)
Roper JM, Raux E, Brindley AA, Schubert HL, Gharbia SE, Shah HN, Warren MJ.
The enigma of cobalamin (Vitamin B12) biosynthesis in Porphyromonas gingivalis. Identification and characterization of a functional corrin pathway.
J Biol Chem 275:40316-23 (2000)
Scott AI, Roessner CA.
Biosynthesis of cobalamin (vitamin B(12)).
Biochem Soc Trans 30:613-20 (2002)
Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC.
The biosynthesis of adenosylcobalamin (vitamin B12).
Nat Prod Rep 19:390-412 (2002)
Roessner CA, Huang KX, Warren MJ, Raux E, Scott AI.
Isolation and characterization of 14 additional genes specifying the anaerobic biosynthesis of cobalamin (vitamin B12) in Propionibacterium freudenreichii (P. shermanii).
Microbiology 148:1845-53 (2002)
Frankenberg N, Mukougawa K, Kohchi T, Lagarias JC.
Functional genomic analysis of the HY2 family of ferredoxin-dependent bilin reductases from oxygenic photosynthetic organisms.
Plant Cell 13:965-78 (2001)
Chew AG, Bryant DA
Chlorophyll biosynthesis in bacteria: the origins of structural and functional diversity.
Annu Rev Microbiol 61:113-29 (2007)
Frigaard NU, Chew AG, Li H, Maresca JA, Bryant DA
Chlorobium tepidum: insights into the structure, physiology, and metabolism of a green sulfur bacterium derived from the complete genome sequence.
Photosynth Res 78:93-117 (2003)
Deery E, Schroeder S, Lawrence AD, Taylor SL, Seyedarabi A, Waterman J, Wilson KS, Brown D, Geeves MA, Howard MJ, Pickersgill RW, Warren MJ
An enzyme-trap approach allows isolation of intermediates in cobalamin biosynthesis.
Nat Chem Biol 8:933-40 (2012)
Moore SJ, Lawrence AD, Biedendieck R, Deery E, Frank S, Howard MJ, Rigby SE, Warren MJ
Elucidation of the anaerobic pathway for the corrin component of cobalamin (vitamin B12).
Proc Natl Acad Sci U S A 110:14906-11 (2013)
KO pathway

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