KEGG   PATHWAY: dra03430
Entry
dra03430                    Pathway                                
Name
Mismatch repair - Deinococcus radiodurans
Description
DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preventing mutations from becoming permanent in dividing cells. MMR also suppresses homologous recombination and was recently shown to play a role in DNA damage signaling. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems.
The Escherichia coli MMR pathway has been extensively studied and is well characterized. In E. coli, the mismatch-activated MutS-MutL-ATP complex licenses MutH to incise the nearest unmethylated GATC sequence. UvrD and an exonuclease generate a gap. This gap is filled by pol III and DNA ligase. The GATC sites are then methylated by Dam. Several human MMR proteins have been identified based on their homology to E. coli MMR proteins. These include human homologs of MutS and MutL. Although E. coli MutS and MutL proteins are homodimers, human MutS and MutL homologs are heterodimers. The role of hemimethylated dGATC sites as a signal for strand discrimination is not conserved from E. coli to human. Human MMR is presumed to be nick-directed in vivo, and is thought to discriminate daughter and template strands using a strand-specific nick.
Class
Genetic Information Processing; Replication and repair
Pathway map
dra03430  Mismatch repair
dra03430

Other DBs
GO: 0006298
Organism
Deinococcus radiodurans [GN:dra]
Gene
DR_1039  DNA mismatch repair protein MutS [KO:K03555]
DR_1976  DNA mismatch repair protein MutS [KO:K07456]
DR_1696  DNA mismatch repair protein MutL [KO:K03572]
DR_1775  DNA helicase II [KO:K03657] [EC:5.6.2.4]
DR_0186  xseA; exodeoxyribonuclease VII large subunit [KO:K03601] [EC:3.1.11.6]
DR_2586  hypothetical protein [KO:K03602] [EC:3.1.11.6]
DR_1126  single-stranded-DNA-specific exonuclease [KO:K07462] [EC:3.1.-.-]
DR_0099  single-stranded DNA-binding protein [KO:K03111]
DR_0100  ssb; single-stranded DNA-binding protein [KO:K03111]
DR_0507  DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
DR_0001  DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
DR_2410  DNA polymerase III, tau/gamma subunit [KO:K02343] [EC:2.7.7.7]
DR_1244  hypothetical protein [KO:K02340] [EC:2.7.7.7]
DR_0856  DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
DR_2069  DNA ligase [KO:K01972] [EC:6.5.1.2]
Reference
  Authors
Jiricny J.
  Title
The multifaceted mismatch-repair system.
  Journal
Nat Rev Mol Cell Biol 7:335-46 (2006)
DOI:10.1038/nrm1907
Reference
  Authors
Li GM.
  Title
Mechanisms and functions of DNA mismatch repair.
  Journal
Cell Res 18:85-98 (2008)
DOI:10.1038/cr.2007.115
Reference
  Authors
Marti TM, Kunz C, Fleck O.
  Title
DNA mismatch repair and mutation avoidance pathways.
  Journal
J Cell Physiol 191:28-41 (2002)
DOI:10.1002/jcp.10077
Reference
  Authors
Ikejima M, Shimada T.
  Title
[Molecular mechanism of mismatch repair]
  Journal
Tanpakushitsu Kakusan Koso 46:1124-9 (2001)
KO pathway
ko03430   

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