KEGG   PATHWAY: dre00190Help
Entry
dre00190                    Pathway                                

Name
Oxidative phosphorylation - Danio rerio (zebrafish)
Class
Metabolism; Energy metabolism
BRITE hierarchy
Pathway map
dre00190  Oxidative phosphorylation
dre00190

Ortholog table
Module
dre_M00142  NADH:ubiquinone oxidoreductase, mitochondria [PATH:dre00190]
dre_M00143  NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein complex, mitochondria [PATH:dre00190]
dre_M00146  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex [PATH:dre00190]
dre_M00147  NADH dehydrogenase (ubiquinone) 1 beta subcomplex [PATH:dre00190]
dre_M00148  Succinate dehydrogenase (ubiquinone) [PATH:dre00190]
dre_M00151  Cytochrome bc1 complex respiratory unit [PATH:dre00190]
dre_M00152  Cytochrome bc1 complex [PATH:dre00190]
dre_M00154  Cytochrome c oxidase [PATH:dre00190]
dre_M00158  F-type ATPase, eukaryotes [PATH:dre00190]
dre_M00160  V-type ATPase, eukaryotes [PATH:dre00190]
Organism
Danio rerio (zebrafish) [GN:dre]
Gene
140531  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:1.6.5.3]
140532  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:1.6.5.3]
140533  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:1.6.5.3]
140534  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:1.6.5.3]
140538  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:1.6.5.3]
140535  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:1.6.5.3]
140536  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:1.6.5.3]
493605  ndufs1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:1.6.99.3 1.6.5.3]
641476  zgc:123301; uncharacterized protein LOC641476 [KO:K03935] [EC:1.6.99.3 1.6.5.3]
553672  ndufs2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:1.6.99.3 1.6.5.3]
550451  ndufs3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:1.6.99.3 1.6.5.3]
573689  ndufs4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
553660  ndufs5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
447913  ndufs6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
796997  ndufs7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:1.6.99.3 1.6.5.3]
406413  ndufs8a; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:1.6.99.3 1.6.5.3]
554100  ndufs8b; NADH dehydrogenase (ubiquinone) Fe-S protein 8b [KO:K03941] [EC:1.6.99.3 1.6.5.3]
445291  ndufv1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:1.6.99.3 1.6.5.3]
641566  zgc:123290 [KO:K03942] [EC:1.6.99.3 1.6.5.3]
393720  ndufv2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:1.6.99.3 1.6.5.3]
100537318  ndufv3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
415243  ndufa1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
554125  ndufa2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
445122  ndufa3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
406726  ndufa4l; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 4, like [KO:K03948]
406298  ndufa4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
100003066  ndufa4l2a; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
541328  ndufa5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
393943  ndufa6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
445042  ndufa7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
393700  ndufa8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
541331  ndufa9a; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
321951  ndufa10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
325712  ndufab1b; acyl carrier protein, mitochondrial [KO:K03955]
573619  ndufab1a; NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex 1-like [KO:K03955]
393497  ndufa11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
556538  ndufa12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
393687  ndufa13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
393764  ndufb2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
100332034  ndufb3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
406306  ndufb4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
797063  ndufb5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
393781  ndufb6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
393821  ndufb7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
393829  ndufb8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
573021  ndufb9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
393703  ndufb10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
562219  ndufb11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
100000992  si:ch211-235e9.6; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
541390  ndufc2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
393884  sdha; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor [KO:K00234] [EC:1.3.5.1]
562149  sdhb; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor [KO:K00235] [EC:1.3.5.1]
445129  sdhc; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
436762  sdhda; succinate dehydrogenase [ubiquinone] cytochrome b small subunit A, mitochondrial [KO:K00237]
445500  sdhdb; succinate dehydrogenase [ubiquinone] cytochrome b small subunit B, mitochondrial [KO:K00237]
406359  uqcrfs1; cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:1.10.2.2]
140512  CYTB; cytochrome b [KO:K00412]
564379  cyc1; cytochrome c-1 [KO:K00413]
393793  uqcrc1; cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
436930  uqcrc2a; ubiquinol-cytochrome c reductase core protein II [KO:K00415]
322549  uqcrc2b; cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
566723  uqcrh; cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
554154  uqcrb; cytochrome b-c1 complex subunit 7 [KO:K00417]
436768  uqcrq; cytochrome b-c1 complex subunit 8 [KO:K00418]
100333064  uqcr10; cytochrome b-c1 complex subunit 9 [KO:K00419]
100333135  si:ch1073-325m22.2; cytochrome b-c1 complex subunit 10 [KO:K00420]
553384  cox10; protoheme IX farnesyltransferase, mitochondrial [KO:K02257] [EC:2.5.1.141]
140541  COX3; cytochrome c oxidase subunit III [KO:K02262]
140539  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:1.9.3.1]
140540  COX2; cytochrome c oxidase subunit II [KO:K02261]
326975  cox4i1; cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
393776  cox4i2; cytochrome c oxidase subunit IV isoform 2 [KO:K02263]
402880  cox4i1l; cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
554101  cox5aa; cytochrome c oxidase subunit Vaa [KO:K02264]
326962  cox5ab; cytochrome c oxidase subunit Vab [KO:K02264]
100002384  cox5b1; cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
415253  zgc:86599; uncharacterized protein LOC415253 [KO:K02265]
751638  cox5b2; cytochrome c oxidase subunit Vb 2 [KO:K02265]
447942  cox6a2; cytochrome c oxidase subunit VIa-like [KO:K02266]
335774  cox6a1; cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
393478  cox6b2; cytochrome c oxidase subunit VIb polypeptide 2 [KO:K02267]
436968  cox6b1; cytochrome c oxidase subunit VIb-like [KO:K02267]
494577  cox6c; cytochrome c oxidase polypeptide VIc-like [KO:K02268]
335751  cox7a3; cytochrome c oxidase subunit VIIa polypeptide 3 [KO:K02270]
554103  cox7a2a; cytochrome c oxidase subunit VIIa polypeptide 2a (liver) [KO:K02270]
563476  cox7b; cytochrome c oxidase subunit VIIb [KO:K02271]
336118  cox7c; cytochrome c oxidase, subunit VIIc [KO:K02272]
569770  cox8b; uncharacterized protein LOC569770 [KO:K02273]
557348  cox8a; cytochrome c oxidase subunit VIIIA (ubiquitous) [KO:K02273]
100005158  cox11; COX11 homolog, cytochrome c oxidase assembly protein [KO:K02258]
394181  cox15; COX15 homolog [KO:K02259]
447914  cox17; COX17 homolog, cytochrome c oxidase assembly protein [KO:K02260]
553755  atp5fa1; ATP synthase subunit alpha, mitochondrial [KO:K02132]
554135  atp5f1b; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:3.6.3.14]
100038785  zgc:163069; mitochondrial ATP synthase beta subunit [KO:K02133] [EC:3.6.3.14]
336957  atp5f1c; ATP synthase subunit gamma, mitochondrial isoform b [KO:K02136]
335709  atp5f1d; ATP synthase subunit delta, mitochondrial [KO:K02134]
798291  atp5f1e; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
335191  atp5po; ATP synthase subunit O, mitochondrial [KO:K02137]
140519  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
449787  atp5pb; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
81541  atp5mc3b; ATP synthase membrane subunit c locus 3b [KO:K02128]
394151  atp5mc3a; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
406301  atp5mc1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
393675  atp5pd; ATP synthase subunit d, mitochondrial [KO:K02138]
767750  atp5meb; ATP synthase subunit e, mitochondrial [KO:K02129]
559659  atp5mea; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit E-like [KO:K02129]
402883  atp5mf; ATP synthase subunit f, mitochondrial [KO:K02130]
326977  atp5l; ATP synthase subunit g, mitochondrial [KO:K02140]
406599  atp5pf; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
140520  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
394110  atp6v1aa; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:3.6.3.14]
337583  atp6v1ab; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:3.6.3.14]
359840  atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
359839  atp6v1ba; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
368907  atp6v1c1a; V-type proton ATPase subunit C 1-A [KO:K02148]
449655  atp6v1c1b; V-type proton ATPase subunit C 1-B [KO:K02148]
393935  atp6v1d; V-type proton ATPase subunit D [KO:K02149]
192335  atp6v1e1b; V-type proton ATPase subunit E 1 [KO:K02150]
436799  atp6v1f; V-type proton ATPase subunit F [KO:K02151]
335025  atp6v1g1; V-type proton ATPase subunit G 1 [KO:K02152]
286779  atp6v1h; V-type proton ATPase subunit H isoform 1 [KO:K02144]
324307  atp6v0a1a; V-type proton ATPase 116 kDa subunit a [KO:K02154]
553691  atp6v0a1b; ATPase H+ transporting V0 subunit a1b [KO:K02154]
406342  tcirg1b; T-cell immune regulator 1 [KO:K02154]
100003139  tcirg1a; V-type proton ATPase 116 kDa subunit a [KO:K02154]
561469  atp6v0a2a; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
561117  atp6v0a2b; V-type proton ATPase 116 kDa subunit a isoform 2 [KO:K02154]
192336  atp6v0ca; ATPase, H+ transporting, lysosomal, V0 subunit c, a [KO:K02155]
325402  atp6v0cb; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
321724  atp6v0b; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
322811  atp6v0d1; V-type proton ATPase subunit d 1 [KO:K02146]
553767  atpv0e2; ATPase, H+ transporting, V0 subunit [KO:K02153]
450017  atp6v0e1; V-type proton ATPase subunit e 1 [KO:K02153]
195824  atp6ap1b; ATPase, H+ transporting, lysosomal accessory protein 1b [KO:K03662]
100004566  atp6ap1a; V-type proton ATPase subunit S1 [KO:K03662]
550531  ppa1b; inorganic pyrophosphatase [KO:K01507] [EC:3.6.1.1]
402961  ppa2; inorganic pyrophosphatase 2, mitochondrial [KO:K01507] [EC:3.6.1.1]
393706  ppa1a; inorganic pyrophosphatase 2, mitochondrial [KO:K01507] [EC:3.6.1.1]
100073345  lhpp; phospholysine phosphohistidine inorganic pyrophosphate phosphatase [KO:K11725] [EC:3.1.3.- 3.6.1.1]
Compound
C00001  H2O
C00002  ATP
C00003  NAD+
C00004  NADH
C00007  Oxygen
C00008  ADP
C00009  Orthophosphate
C00013  Diphosphate
C00042  Succinate
C00061  FMN
C00080  H+
C00122  Fumarate
C00390  Ubiquinol
C00399  Ubiquinone
C00524  Cytochrome c
C00536  Triphosphate
Reference
  Authors
Sazanov LA, Hinchliffe P.
  Title
Structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus.
  Journal
Science 311:1430-6 (2006)
DOI:10.1126/science.1123809
Reference
  Authors
Hinchliffe P, Carroll J, Sazanov LA.
  Title
Identification of a novel subunit of respiratory complex I from Thermus thermophilus.
  Journal
Biochemistry 45:4413-20 (2006)
DOI:10.1021/bi0600998
KO pathway
ko00190   

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