KEGG   PATHWAY: dre04140Help
Entry
dre04140                    Pathway                                

Name
Autophagy - animal - Danio rerio (zebrafish)
Description
Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily conserved among eukaryotes and exquisitely regulated. This progress initiates with production of the autophagosome, a double-membrane intracellular structure of reticular origin that engulfs cytoplasmic contents and ultimately fuses with lysosomes for cargo degradation. Autophagy is regulated in response to extra- or intracellular stress and signals such as starvation, growth factor deprivation and ER stress. Constitutive level of autophagy plays an important role in cellular homeostasis and maintains quality control of essential cellular components.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Autophagy - animal
dre04140

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BSID: 
GO: 
Organism
Danio rerio (zebrafish) [GN:dre]
Gene
30262  
ins; preproinsulin [KO:K04526]
566735  
insb; preproinsulin b [KO:K04526]
245701  
igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
245702  
igf1rb; insulin-like growth factor 1b receptor [KO:K05087] [EC:2.7.10.1]
559281  
irs1; insulin receptor substrate 1 [KO:K16172]
393285  
irs2a; insulin receptor substrate 2a [KO:K07187]
572001  
irs2b; insulin receptor substrate 2b [KO:K07187]
irs4a; insulin receptor substrate 4a [KO:K07187]
794462  
insulin receptor substrate 2-B-like [KO:K07187]
394174  
pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
561737  
pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
404211  
pik3r2; phosphoinositide-3-kinase, regulatory subunit 2 (beta) [KO:K02649]
pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) [KO:K02649]
557176  
pik3r1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [KO:K02649]
403000  
pdpk1b; 3-phosphoinositide dependent protein kinase 1b [KO:K06276] [EC:2.7.11.1]
403146  
akt2l; v-akt murine thymoma viral oncogene homolog 2, like [KO:K04456] [EC:2.7.11.1]
560549  
akt3a; v-akt murine thymoma viral oncogene homolog 3a [KO:K04456] [EC:2.7.11.1]
378972  
akt2; v-akt murine thymoma viral oncogene homolog 2 [KO:K04456] [EC:2.7.11.1]
akt3b; v-akt murine thymoma viral oncogene homolog 3b [KO:K04456] [EC:2.7.11.1]
akt1; v-akt murine thymoma viral oncogene homolog 1 [KO:K04456] [EC:2.7.11.1]
368415  
ptenb; phosphatase and tensin homolog B [KO:K01110] [EC:3.1.3.67 3.1.3.48 3.1.3.16]
794088  
ptena; phosphatase and tensin homolog A [KO:K01110] [EC:3.1.3.67 3.1.3.48 3.1.3.16]
553656  
hrasb; -Ha-ras Harvey rat sarcoma viral oncogene homolog b [KO:K02833]
550286  
hrasa; v-Ha-ras Harvey rat sarcoma viral oncogene homolog a [KO:K02833]
445289  
kras; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
393228  
zgc:55558 [KO:K07827]
K-ras; GTPase KRas [KO:K07827]
30380  
nras; neuroblastoma RAS viral (v-ras) oncogene homolog [KO:K07828]
si:ch73-116o1.2 [KO:K07831]
mras; muscle RAS oncogene homolog [KO:K07831]
449660  
rras; related RAS viral (r-ras) oncogene homolog [KO:K07830]
550513  
rras2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
30716  
raf1a; Raf-1 proto-oncogene, serine/threonine kinase a [KO:K04366] [EC:2.7.11.1]
557109  
raf1b; Raf-1 proto-oncogene, serine/threonine kinase b [KO:K04366] [EC:2.7.11.1]
406728  
map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
563181  
map2k2a; mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
map2k2b; mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
360144  
mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
399480  
mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
393202  
hif1ab; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b [KO:K08268]
378866  
ddit4; DNA-damage-inducible transcript 4 [KO:K08270]
567524  
tsc2; tuberous sclerosis 2 [KO:K07207]
337167  
tsc1a; tuberous sclerosis 1a [KO:K07206]
tsc1b; tuberous sclerosis 1b [KO:K07206]
336116  
bnip3; BCL2/adenovirus E1B interacting protein 3 [KO:K15464]
402792  
nip2; zgc:73226 [KO:K15464]
568155  
bnip4; BCL2/adenovirus E1B interacting protein 4 [KO:K15464]
393702  
rheb; Ras homolog enriched in brain [KO:K07208]
767781  
rhebl1; Ras homolog enriched in brain like 1 [KO:K07208]
560455  
rptor; regulatory associated protein of MTOR, complex 1 [KO:K07204]
768177  
deptor; DEP domain containing MTOR-interacting protein [KO:K20402]
324254  
mtor; mechanistic target of rapamycin (serine/threonine kinase) [KO:K07203] [EC:2.7.11.1]
566559  
akt1s1; AKT1 substrate 1 (proline-rich) [KO:K16184]
792689  
mlst8; MTOR associated protein, LST8 homolog (S. cerevisiae) [KO:K08266]
562242  
rps6kb1a; ribosomal protein S6 kinase b, polypeptide 1a [KO:K04688] [EC:2.7.11.1]
406349  
rps6kb1b; ribosomal protein S6 kinase b, polypeptide 1b [KO:K04688] [EC:2.7.11.1]
406843  
igbp1; immunoglobulin (CD79A) binding protein 1 [KO:K17606]
393885  
Ppp2ca; zgc:56064 [KO:K04382] [EC:3.1.3.16]
406582  
ppp2cb; protein phosphatase 2, catalytic subunit, beta isozyme [KO:K04382] [EC:3.1.3.16]
550585  
ppp2ca; protein phosphatase 2, catalytic subunit, alpha isozyme [KO:K04382] [EC:3.1.3.16]
558848  
ulk1b; unc-51 like autophagy activating kinase 1 [KO:K08269] [EC:2.7.11.1]
ulk3; unc-51 like kinase 3 [KO:K08269] [EC:2.7.11.1]
ulk2; unc-51 like autophagy activating kinase 2 [KO:K08269] [EC:2.7.11.1]
393405  
atg13; ATG13 autophagy related 13 homolog (S. cerevisiae) [KO:K08331]
567680  
atg101; autophagy related 101 [KO:K19730]
rb1cc1; RB1-inducible coiled-coil 1 [KO:K17589]
atg2a; si:ch73-45o6.2 [KO:K17906]
WD repeat domain phosphoinositide-interacting protein 1-like [KO:K17908]
393362  
wipi1; WD repeat domain, phosphoinositide interacting 1 [KO:K17908]
437002  
wipi2; WD repeat domain, phosphoinositide interacting 2 [KO:K17908]
atg9a; ATG9 autophagy related 9 homolog A (S. cerevisiae) [KO:K17907]
791223  
atg9b; autophagy related 9B [KO:K17907]
568453  
supt20; SPT20 homolog, SAGA complex component [KO:K21245]
325358  
rraga; Ras-related GTP binding A [KO:K16185]
rragcb; Ras-related GTP binding Cb [KO:K16186]
573492  
rragca; Ras-related GTP binding Ca [KO:K16186]
570568  
rragd; ras-related GTP binding D [KO:K16186]
550537  
stk11; serine/threonine kinase 11 [KO:K07298] [EC:2.7.11.1]
572074  
prkaa2; protein kinase, AMP-activated, alpha 2 catalytic subunit [KO:K07198] [EC:2.7.11.11]
prkaa1; protein kinase, AMP-activated, alpha 1 catalytic subunit [KO:K07198] [EC:2.7.11.11]
393998  
prkacba; protein kinase, cAMP-dependent, catalytic, beta a [KO:K04345] [EC:2.7.11.11]
445076  
prkacab; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b [KO:K04345] [EC:2.7.11.11]
563147  
prkacbb; protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
564064  
prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a [KO:K04345] [EC:2.7.11.11]
cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
334571  
prkcda; protein kinase C, delta a [KO:K06068] [EC:2.7.11.13]
prkcdb; protein kinase C, delta b [KO:K06068] [EC:2.7.11.13]
569698  
mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
562720  
mapk8a; mitogen-activated protein kinase 8a [KO:K04440] [EC:2.7.11.24]
65236  
mapk8b; mitogen-activated protein kinase 8b [KO:K04440] [EC:2.7.11.24]
mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
bcl2b; B-cell CLL/lymphoma 2b [KO:K02161]
570772  
bcl2a; B-cell CLL/lymphoma 2a [KO:K02161]
114401  
bcl2l1; bcl2-like 1 [KO:K04570]
58100  
badb; BCL2-associated agonist of cell death b [KO:K02158]
393846  
becn1; beclin 1, autophagy related [KO:K08334]
436886  
nrbf2b; nuclear receptor binding factor 2b [KO:K21246]
564088  
pik3r4; phosphoinositide-3-kinase, regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
548346  
pik3c3; phosphatidylinositol 3-kinase, catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
407686  
zgc:113944 [KO:K17889]
ambra1a; autophagy/beclin-1 regulator 1a [KO:K17985]
559106  
ambra1b; autophagy/beclin-1 regulator 1b [KO:K17985]
554561  
traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
569441  
tumor protein p53-inducible nuclear protein 2 [KO:K21247]
336789  
vmp1; vacuole membrane protein 1 [KO:K21248]
492808  
stx17; syntaxin 17 [KO:K08491]
394044  
uvrag; UV radiation resistance associated gene [KO:K21249]
792229  
sh3glb1a; SH3-domain GRB2-like endophilin B1a [KO:K11248]
334911  
sh3glb1b; SH3-domain GRB2-like endophilin B1b [KO:K11248]
rubcn; RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein [KO:K19330]
calcium/calmodulin-dependent protein kinase kinase 2-like [KO:K07359] [EC:2.7.11.17]
camkk1b; calcium/calmodulin-dependent protein kinase kinase 1, alpha b [KO:K07359] [EC:2.7.11.17]
553788  
map3k7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
567021  
ern2; endoplasmic reticulum to nucleus signaling 2 [KO:K08852] [EC:3.1.26.- 2.7.11.1]
itpr1b; inositol 1,4,5-trisphosphate receptor, type 1b [KO:K04958]
567611  
itpr1a; inositol 1,4,5-trisphosphate receptor, type 1a [KO:K04958]
558314  
dapk1; death-associated protein kinase 1 [KO:K08803] [EC:2.7.11.1]
562194  
dapk3; death-associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
555536  
si:dkey-240h12.4 [KO:K08803] [EC:2.7.11.1]
556756  
dapk2b; death-associated protein kinase 2b [KO:K08803] [EC:2.7.11.1]
571352  
dapk2a; death-associated protein kinase 2a [KO:K08803] [EC:2.7.11.1]
321622  
hmgb1a; high mobility group box 1a [KO:K10802]
795095  
hmgb1b; high mobility group box 1b [KO:K10802]
559564  
eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
eif2ak4; eukaryotic translation initiation factor 2 alpha kinase 4 [KO:K16196] [EC:2.7.11.1]
321564  
eif2s1b; eukaryotic translation initiation factor 2, subunit 1 alpha b [KO:K03237]
myotubularin-related protein 3-like [KO:K18082] [EC:3.1.3.95 3.1.3.64 3.1.3.48]
393584  
mtmr4; myotubularin related protein 4 [KO:K18082] [EC:3.1.3.95 3.1.3.64 3.1.3.48]
393838  
mtmr3; myotubularin related protein 3 [KO:K18082] [EC:3.1.3.95 3.1.3.64 3.1.3.48]
323929  
mtmr14; myotubularin related protein 14 [KO:K18086] [EC:3.1.3.95 3.1.3.64]
563140  
im:7136055; si:ch211-11n16.2 [KO:K17603]
zfyve1; zinc finger, FYVE domain containing 1 [KO:K17603]
570965  
atg12; ATG12 autophagy related 12 homolog (S. cerevisiae) [KO:K08336]
494180  
atg5; ATG5 autophagy related 5 homolog (S. cerevisiae) [KO:K08339]
550552  
atg16l1; ATG16 autophagy related 16-like 1 (S. cerevisiae) [KO:K17890]
atg16l2; ATG16 autophagy related 16-like 2 (S. cerevisiae) [KO:K20868]
atg7; ATG7 autophagy related 7 homolog (S. cerevisiae) [KO:K08337]
641330  
atg10; ATG10 autophagy related 10 homolog (S. cerevisiae) [KO:K17888]
336632  
atg3; autophagy related 3 [KO:K08343]
373114  
cflara; CASP8 and FADD-like apoptosis regulator a [KO:K04724]
572060  
rab33ba; RAB33B, member RAS oncogene family a [KO:K07920]
555521  
prkcq; protein kinase C, theta [KO:K18052] [EC:2.7.11.13]
403036  
gabarapl2; GABA(A) receptor-associated protein like 2 [KO:K08341]
793200  
gabarapb; GABA(A) receptor-associated protein b [KO:K08341]
326974  
gabarapa; GABA(A) receptor-associated protein a [KO:K08341]
554140  
atg4a; autophagy related 4A, cysteine peptidase [KO:K08342] [EC:3.4.22.-]
415193  
atg4c; autophagy related 4C, cysteine peptidase [KO:K08342] [EC:3.4.22.-]
448859  
atg4b; autophagy related 4B, cysteine peptidase [KO:K08342] [EC:3.4.22.-]
795933  
atg4da; autophagy related 4D, cysteine peptidase a [KO:K08342] [EC:3.4.22.-]
324985  
fc50e01; zgc:64072 [KO:K06528]
563328  
lamp1; lysosomal-associated membrane protein 1 [KO:K06528]
393902  
rab7; RAB7, member RAS oncogene family [KO:K07897]
431725  
wu:fj84g10; zgc:91909 [KO:K07897]
449549  
zgc:100918 [KO:K07897]
327007  
vamp8; vesicle-associated membrane protein 8 (endobrevin) [KO:K08512]
553460  
snap29; synaptosomal-associated protein 29 [KO:K08509]
65225  
ctsd; cathepsin D [KO:K01379] [EC:3.4.23.5]
336746  
fa94d12; zgc:63831 [KO:K01379] [EC:3.4.23.5]
321453  
ctsla; cathepsin La [KO:K01365] [EC:3.4.22.15]
30443  
ctslb; cathepsin Lb [KO:K01365] [EC:3.4.22.15]
436641  
ctsl.1; cathepsin L.1 [KO:K01365] [EC:3.4.22.15]
406645  
ctsba; cathepsin Ba [KO:K01363] [EC:3.4.22.1]
569298  
ctsbb; cathepsin Bb [KO:K01363] [EC:3.4.22.1]
Compound
C00350  
Phosphatidylethanolamine
C01194  
1-Phosphatidyl-D-myo-inositol
C04549  
1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Meijer AJ, Codogno P.
  Title
Regulation and role of autophagy in mammalian cells.
  Journal
Int J Biochem Cell Biol 36:2445-62 (2004)
Reference
  Authors
Deretic V.
  Title
Autophagy in innate and adaptive immunity.
  Journal
Trends Immunol 26:523-8 (2005)
Reference
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
Reference
  Authors
Tanida I, Ueno T, Kominami E.
  Title
LC3 conjugation system in mammalian autophagy.
  Journal
Int J Biochem Cell Biol 36:2503-18 (2004)
Reference
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
Reference
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
Reference
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
Reference
  Authors
Bechet D, Tassa A, Taillandier D, Combaret L, Attaix D.
  Title
Lysosomal proteolysis in skeletal muscle.
  Journal
Int J Biochem Cell Biol 37:2098-114 (2005)
Reference
  Authors
He C, Klionsky DJ
  Title
Regulation mechanisms and signaling pathways of autophagy.
  Journal
Annu Rev Genet 43:67-93 (2009)
Reference
  Authors
Yang Z, Klionsky DJ
  Title
An overview of the molecular mechanism of autophagy.
  Journal
Curr Top Microbiol Immunol 335:1-32 (2009)
Reference
  Authors
Yang Z, Klionsky DJ
  Title
Mammalian autophagy: core molecular machinery and signaling regulation.
  Journal
Curr Opin Cell Biol 22:124-31 (2010)
Reference
  Authors
Chen Y, Klionsky DJ
  Title
The regulation of autophagy - unanswered questions.
  Journal
J Cell Sci 124:161-70 (2011)
Reference
  Authors
Mizushima N, Yoshimori T, Ohsumi Y
  Title
The role of Atg proteins in autophagosome formation.
  Journal
Annu Rev Cell Dev Biol 27:107-32 (2011)
Reference
  Authors
Russell RC, Yuan HX, Guan KL
  Title
Autophagy regulation by nutrient signaling.
  Journal
Cell Res 24:42-57 (2014)
Reference
  Authors
Noda NN, Fujioka Y
  Title
Atg1 family kinases in autophagy initiation.
  Journal
Cell Mol Life Sci 72:3083-96 (2015)
KO pathway
 

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