KEGG   PATHWAY: dse00983Help
Entry
dse00983                    Pathway                                
Name
Drug metabolism - other enzymes - Drosophila sechellia
Class
Metabolism; Xenobiotics biodegradation and metabolism
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Pathway map
Drug metabolism - other enzymes
dse00983

All organismsOrtholog table
Organism
Drosophila sechellia [GN:dse]
Gene
GM11429 gene product from transcript GM11429-RA; K00088 IMP dehydrogenase [EC:1.1.1.205] [KO:K00088] [EC:1.1.1.205]
GM23268 gene product from transcript GM23268-RA; K01951 GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2] [KO:K01951] [EC:6.3.5.2]
GM24078 gene product from transcript GM24078-RA; K00106 xanthine dehydrogenase/oxidase [EC:1.17.1.4 1.17.3.2] [KO:K00106] [EC:1.17.3.2 1.17.1.4]
GM18051 gene product from transcript GM18051-RA; K01519 inosine triphosphate pyrophosphatase [EC:3.6.1.19] [KO:K01519] [EC:3.6.1.19]
GM17296 gene product from transcript GM17296-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GM17278 gene product from transcript GM17278-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GM15739 gene product from transcript GM15739-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GM23331 gene product from transcript GM23331-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GM16333 gene product from transcript GM16333-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GM23921 gene product from transcript GM23921-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GM26122 gene product from transcript GM26122-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GM26123 gene product from transcript GM26123-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GM26124 gene product from transcript GM26124-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GM26133 gene product from transcript GM26133-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GM20028 gene product from transcript GM20028-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GM11008 gene product from transcript GM11008-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GM18614 gene product from transcript GM18614-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GM17207 gene product from transcript GM17207-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GM15740 gene product from transcript GM15740-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GM15628 gene product from transcript GM15628-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GM14898 gene product from transcript GM14898-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GM12089 gene product from transcript GM12089-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GM17209 gene product from transcript GM17209-RA; K00699 glucuronosyltransferase [EC:2.4.1.17] [KO:K00699] [EC:2.4.1.17]
GM19850 gene product from transcript GM19850-RA; K01195 beta-glucuronidase [EC:3.2.1.31] [KO:K01195] [EC:3.2.1.31]
GM16415 gene product from transcript GM16415-RA; K01195 beta-glucuronidase [EC:3.2.1.31] [KO:K01195] [EC:3.2.1.31]
GM16857 gene product from transcript GM16857-RA; K01489 cytidine deaminase [EC:3.5.4.5] [KO:K01489] [EC:3.5.4.5]
GM16858 gene product from transcript GM16858-RA; K01489 cytidine deaminase [EC:3.5.4.5] [KO:K01489] [EC:3.5.4.5]
GM16862 gene product from transcript GM16862-RA; K01489 cytidine deaminase [EC:3.5.4.5] [KO:K01489] [EC:3.5.4.5]
GM13670 gene product from transcript GM13670-RA; K00207 dihydropyrimidine dehydrogenase (NADP+) [EC:1.3.1.2] [KO:K00207] [EC:1.3.1.2]
GM10816 gene product from transcript GM10816-RA; K01464 dihydropyrimidinase [EC:3.5.2.2] [KO:K01464] [EC:3.5.2.2]
GM10462 gene product from transcript GM10462-RA; K01431 beta-ureidopropionase [EC:3.5.1.6] [KO:K01431] [EC:3.5.1.6]
GM18176 gene product from transcript GM18176-RA; K00757 uridine phosphorylase [EC:2.4.2.3] [KO:K00757] [EC:2.4.2.3]
GM15599 gene product from transcript GM15599-RA; K00757 uridine phosphorylase [EC:2.4.2.3] [KO:K00757] [EC:2.4.2.3]
GM10155 gene product from transcript GM10155-RA; K00757 uridine phosphorylase [EC:2.4.2.3] [KO:K00757] [EC:2.4.2.3]
GM26584 gene product from transcript GM26584-RA; K00876 uridine kinase [EC:2.7.1.48] [KO:K00876] [EC:2.7.1.48]
GM21771 gene product from transcript GM21771-RA; K00876 uridine kinase [EC:2.7.1.48] [KO:K00876] [EC:2.7.1.48]
GM15107 gene product from transcript GM15107-RA; K13421 uridine monophosphate synthetase [EC:2.4.2.10 4.1.1.23] [KO:K13421] [EC:4.1.1.23 2.4.2.10]
Compound
C02380  
6-Mercaptopurine
C04242  
5-Fluorodeoxyuridine monophosphate
C04646  
6-Thioinosine-5'-monophosphate
C05361  
Hydrazine
C06837  
Azathioprine
C07054  
Isoniazid
C07446  
Isonicotinic acid
C07447  
Acetylhydrazine
C07585  
N-Acetylisoniazid
C07648  
Thioguanine
C07649  
5-FU
C11173  
SN-38
C11376  
SN38 glucuronide
C11736  
5-Fluorodeoxyuridine
C12650  
Capecitabine
C12673  
Tegafur
C12739  
5'-Deoxy-5-fluorouridine
C16542  
APC
C16543  
NPC
C16613  
6-Thiourate
C16614  
6-Methylmercaptopurine
C16615  
6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  
6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  
6-Mercaptopurine ribonucleoside triphosphate
C16618  
6-Thioxanthine 5'-monophosphate
C16619  
6-Thioguanosine monophosphate
C16620  
6-Methylthioguanosine monophosphate
C16621  
1-Methyl-4-nitroimidazole
C16622  
N,N'-Diacetylhydrazine
C16623  
Isonicotinylglycine
C16624  
Isoniazid pyruvate
C16625  
Isoniazid alpha-ketoglutaric acid
C16630  
5,6-Dihydro-5-fluorouracil
C16631  
alpha-Fluoro-beta-ureidopropionic acid
C16632  
alpha-Fluoro-beta-alanine
C16633  
5-Fluorouridine
C16634  
5-Fluorouridine monophosphate
C16635  
5'-Deoxy-5-fluorocytidine
C16641  
Irinotecan
D00238  
Azathioprine (JP16/USP/INN)
D00346  
Isoniazid (JP16/USP/INN)
D00584  
Fluorouracil (JP16/USP/INN)
D01223  
Capecitabine (JAN/USAN/INN)
D01244  
Tegafur (JP16/USAN/INN)
D01309  
Doxifluridine (JP16/INN)
D04197  
Floxuridine (USP/INN)
D04931  
Mercaptopurine (INN)
D08086  
Irinotecan (INN)
D08603  
Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR.
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A.
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
KO pathway
 
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